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  1. Anthropomorphic torso phantoms, including a cardiac insert, are frequently used to investigate the imaging performance of SPECT and PET systems. These phantom solutions are generally featuring a simple anatomi...

    Authors: Janos Kiss, Laszlo Balkay, Kornel Kukuts, Marton Miko, Attila Forgacs, Gyorgy Trencsenyi and Aron K. Krizsan
    Citation: EJNMMI Physics 2022 9:34
  2. Given the recent and rapid development of peptide receptor radionuclide therapy (PRRT), increasing emphasis should be placed on the early identification and quantification of therapeutic radiopharmaceutical (t...

    Authors: Christophe Mazzara, Julien Salvadori, Florian Ritzenthaler, Simon Martin, Clémence Porot and Alessio Imperiale
    Citation: EJNMMI Physics 2022 9:33
  3. Neuronal damage and synapse loss in the spinal cord (SC) have been implicated in spinal cord injury (SCI) and neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS). Current standards of diagn...

    Authors: Samantha Rossano, Takuya Toyonaga, Jason Bini, Nabeel Nabulsi, Jim Ropchan, Zhengxin Cai, Yiyun Huang and Richard E. Carson
    Citation: EJNMMI Physics 2022 9:32
  4. Absolute myocardial perfusion imaging (MPI) is beneficial in the diagnosis and prognosis of patients with suspected or known coronary artery disease. However, validation and standardization of perfusion estima...

    Authors: Marije E. Kamphuis, Henny Kuipers, Jacqueline Verschoor, Johannes C. G. van Hespen, Marcel J. W. Greuter, Riemer H. J. A. Slart and Cornelis H. Slump
    Citation: EJNMMI Physics 2022 9:31
  5. Partition modeling allows personalized activity calculation for holmium-166 (166Ho) radioembolization. However, it requires the definition of tumor and non-tumorous liver, by segmentation and registration of a se...

    Authors: Martina Stella, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong and Rob van Rooij
    Citation: EJNMMI Physics 2022 9:30
  6. Most current whole-body positron emission tomography (PET) scanners use detectors with high timing resolution to measure the time-of-flight of two 511 keV photons, improving the signal-to-noise ratio of PET im...

    Authors: Zheng Liu, Ming Niu, Zhonghua Kuang, Ning Ren, San Wu, Longhan Cong, Xiaohui Wang, Ziru Sang, Crispin Williams and Yongfeng Yang
    Citation: EJNMMI Physics 2022 9:29
  7. To develop a model of the internal vasculature of the adult liver and demonstrate its application to the differentiation of radiopharmaceutical decay sites within liver parenchyma from those within organ blood.

    Authors: Camilo M. Correa-Alfonso, Julia D. Withrow, Sean J. Domal, Shu Xing, Jungwook Shin, Clemens Grassberger, Harald Paganetti and Wesley E. Bolch
    Citation: EJNMMI Physics 2022 9:28
  8. There has been an ongoing need to compare and combine the results of new PET imaging studies conducted with [11C]raclopride with older data. This typically means harmonizing data across different scanners. Previo...

    Authors: Jocelyn Hoye, Takuya Toyonaga, Yasmin Zakiniaeiz, Gelsina Stanley, Michelle Hampson and Evan D. Morris
    Citation: EJNMMI Physics 2022 9:27
  9. Our aim was to determine sets of reconstruction parameters for the Biograph Vision Quadra (Siemens Healthineers) PET/CT system that result in quantitative images compliant with the European Association of Nucl...

    Authors: George A. Prenosil, Michael Hentschel, Thilo Weitzel, Hasan Sari, Kuangyu Shi, Ali Afshar-Oromieh and Axel Rominger
    Citation: EJNMMI Physics 2022 9:26
  10. Selective internal radiation therapy with Yttrium-90 microspheres is an effective therapy for liver cancer and liver metastases. Yttrium-90 is mainly a high-energy beta particle emitter. These beta particles e...

    Authors: Daniel Deidda, Ana M. Denis-Bacelar, Andrew J. Fenwick, Kelley M. Ferreira, Warda Heetun, Brian F. Hutton, Andrew P. Robinson, James Scuffham and Kris Thielemans
    Citation: EJNMMI Physics 2022 9:25
  11. Recent reports personalizing the administered activity (AA) of each cycle of peptide receptor radionuclide therapy based on the predicted absorbed dose (AD) to the kidneys (dose-limiting organ) have been promi...

    Authors: Javian C. Malcolm, Nadia Falzone, Jennifer E. Gains, Matthew D. Aldridge, David Mirando, Boon Q. Lee, Mark N. Gaze and Katherine A. Vallis
    Citation: EJNMMI Physics 2022 9:24
  12. To investigate the influence of small voxel Bayesian penalized likelihood (SVB) reconstruction on small lesion detection compared to ordered subset expectation maximization (OSEM) reconstruction using a clinic...

    Authors: Lei Xu, Ru-Shuai Li, Run-Ze Wu, Rui Yang, Qin-Qin You, Xiao-Chen Yao, Hui-Fang Xie, Yang Lv, Yun Dong, Feng Wang and Qing-Le Meng
    Citation: EJNMMI Physics 2022 9:23
  13. A Vereos PET/CT device was adapted to be compatible with the experimentation in large animals within BSL-3 environment. The aim of this study was to investigate the impact of this modification on the performan...

    Authors: Nidhal Kahlaoui, Thibaut Naninck, Roger Le Grand and Catherine Chapon
    Citation: EJNMMI Physics 2022 9:22
  14. To perform precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model and to compare extracted dose metrics to those produced from conventional PE...

    Authors: E. Courtney Henry, Matthew Strugari, George Mawko, Kimberly Brewer, David Liu, Andrew C. Gordon, Jeffrey N. Bryan, Charles Maitz, Robert Abraham, S. Cheenu Kappadath and Alasdair Syme
    Citation: EJNMMI Physics 2022 9:21
  15. Quantitative whole-body PET/MRI relies on accurate patient-specific MRI-based attenuation correction (AC) of PET, which is a non-trivial challenge, especially for the anatomically complex head and neck region....

    Authors: Anders B. Olin, Adam E. Hansen, Jacob H. Rasmussen, Björn Jakoby, Anne K. Berthelsen, Claes N. Ladefoged, Andreas Kjær, Barbara M. Fischer and Flemming L. Andersen
    Citation: EJNMMI Physics 2022 9:20
  16. 161Tb draws an increasing interest in nuclear medicine for therapeutic applications. More than 99% of the emitted gamma and X-rays of 161Tb have an energy below 100 keV. Consequently, precise activity measurement...

    Authors: Frédéric Juget, Zeynep Talip, Youcef Nedjadi, M. Teresa Durán, Pascal V. Grundler, Jan Rijn Zeevaart, Nicholas P. van der Meulen and Claude Bailat
    Citation: EJNMMI Physics 2022 9:19
  17. The purpose of this study was to investigate the image quality and diagnostic performance of different reconstructions over a wide range of patient body mass indices (BMIs) obtained by total-body PET/CT with u...

    Authors: Xiuli Sui, Hui Tan, Haojun Yu, Jie Xiao, Chi Qi, Yanyan Cao, Shuguang Chen, Yiqiu Zhang, Pengcheng Hu and Hongcheng Shi
    Citation: EJNMMI Physics 2022 9:17
  18. Low photon count in 89Zr-Immuno-PET results in images with a low signal-to-noise ratio (SNR). Since PET radiomics are sensitive to noise, this study focuses on the impact of noise on radiomic features from 89Zr-I...

    Authors: Ananthi Somasundaram, David Vállez García, Elisabeth Pfaehler, Yvonne W. S. Jauw, Josée M. Zijlstra, Guus A. M. S. van Dongen, Willemien C. Menke-van der Houven van Oordt, Marc C. Huisman, Elisabeth G. E. de Vries and Ronald Boellaard
    Citation: EJNMMI Physics 2022 9:16
  19. Due to comparatively long measurement times in simultaneous positron emission tomography and magnetic resonance (PET/MR) imaging, patient movement during the measurement can be challenging. This leads to artif...

    Authors: Eric Einspänner, Thies H. Jochimsen, Johanna Harries, Andreas Melzer, Michael Unger, Richard Brown, Kris Thielemans, Osama Sabri and Bernhard Sattler
    Citation: EJNMMI Physics 2022 9:15
  20. In order to acquire accurate drug pharmacokinetic information, which is required for tissue dosimetry, micro-SPECT must be quantitative to allow for an accurate assessment of radioligand activity in the releva...

    Authors: Clarita Saldarriaga Vargas, Lara Struelens, Matthias D’Huyvetter, Vicky Caveliers and Peter Covens
    Citation: EJNMMI Physics 2022 9:13
  21. Whole-body bone scintigraphy is a clinically useful non-invasive and highly sensitive imaging method enabling detection of metabolic changes at an early stage of disease, often earlier than with conventional r...

    Authors: Agnetha Gustafsson, Eva Örndahl, David Minarik, Kerstin Cederholm, Sophia Frantz, Jessica Hagerman, Lena Johansson, Johan Fredén Lindqvist and Cathrine Jonsson
    Citation: EJNMMI Physics 2022 9:12
  22. The free-breathing T1-weighted 3D Stack of Stars GRE (StarVIBE) MR sequence potentially reduces artifacts in chest MRI. The purpose of this study was to evaluate StarVIBE for the detection of pulmonary nodules...

    Authors: Nils Martin Bruckmann, Julian Kirchner, Janna Morawitz, Lale Umutlu, Wolfgang P. Fendler, Ken Herrmann, Ann-Kathrin Bittner, Oliver Hoffmann, Tanja Fehm, Maike E. Lindemann, Christian Buchbender, Gerald Antoch and Lino M. Sawicki
    Citation: EJNMMI Physics 2022 9:11
  23. Non-human primates (NHP) are critical in biomedical research to better understand the pathophysiology of diseases and develop new therapies. Based on its translational and longitudinal abilities along with its...

    Authors: Frédéric Boisson, Sophie Serriere, Liji Cao, Sylvie Bodard, Alessandro Pilleri, Lionel Thomas, Giancarlo Sportelli, Johnny Vercouillie, Patrick Emond, Clovis Tauber, Nicola Belcari, Jean-Luc Lefaucheur, David Brasse and Laurent Galineau
    Citation: EJNMMI Physics 2022 9:10
  24. Multicentre clinical trials evaluating the role of 18F-Fluoroethyl-l-tyrosine (18F-FET) PET as a diagnostic biomarker in glioma management have highlighted a need for standardised methods of data analysis. 18F-FE...

    Authors: Caterina Brighi, Simon Puttick, Shenpeng Li, Paul Keall, Katherine Neville, David Waddington, Pierrick Bourgeat, Ashley Gillman and Michael Fay
    Citation: EJNMMI Physics 2022 9:9
  25. The aim of the study was to assess the accuracy of quantitative SPECT/CT imaging in a clinical setting and to compare test results from two nuclear medicine departments.

    Authors: Hanna Piwowarska-Bilska, Aleksandra Supińska and Bożena Birkenfeld
    Citation: EJNMMI Physics 2022 9:8
  26. This study aimed to investigate the impact of a deep learning (DL)-based denoising method on the image quality and lesion detectability of 18F-FDG positron emission tomography (PET) images.

    Authors: Yan Xing, Wenli Qiao, Taisong Wang, Ying Wang, Chenwei Li, Yang Lv, Chen Xi, Shu Liao, Zheng Qian and Jinhua Zhao
    Citation: EJNMMI Physics 2022 9:7
  27. Metabolic positron emission tomography/computed tomography (PET/CT) parameters describing tumour activity contain valuable prognostic information, but to perform the measurements manually leads to both intra- ...

    Authors: Pablo Borrelli, José Luis Loaiza Góngora, Reza Kaboteh, Johannes Ulén, Olof Enqvist, Elin Trägårdh and Lars Edenbrandt
    Citation: EJNMMI Physics 2022 9:6
  28. Current 18F-NaF assessments of aortic valve microcalcification using 18F-NaF PET/CT are based on evaluations of end-diastolic or cardiac motion-corrected (ECG-MC) images, which are affected by both patient and re...

    Authors: Martin Lyngby Lassen, Evangelos Tzolos, Daniele Massera, Sebastien Cadet, Rong Bing, Jacek Kwiecinski, Damini Dey, Daniel S. Berman, Marc R. Dweck, David E. Newby and Piotr J. Slomka
    Citation: EJNMMI Physics 2022 9:4
  29. Selective internal radiation therapy (SIRT) requires a good liver registration of multi-modality images to obtain precise dose prediction and measurement. This study investigated the feasibility of liver regis...

    Authors: Xikai Tang, Esmaeel Jafargholi Rangraz, Richard’s Heeren, Walter Coudyzer, Geert Maleux, Kristof Baete, Chris Verslype, Mark J. Gooding, Christophe M. Deroose and Johan Nuyts
    Citation: EJNMMI Physics 2022 9:3
  30. Positron emission tomography (PET) with prostate specific membrane antigen (PSMA) have shown superior performance in detecting metastatic prostate cancers. Relative to [18F]fluorodeoxyglucose ([18F]FDG) PET image...

    Authors: Roberto Fedrigo, Dan J. Kadrmas, Patricia E. Edem, Lauren Fougner, Ivan S. Klyuzhin, M. Peter Petric, François Bénard, Arman Rahmim and Carlos Uribe
    Citation: EJNMMI Physics 2022 9:2
  31. Q.Clear is a block sequential regularized expectation maximization penalized-likelihood reconstruction algorithm for Positron Emission Tomography (PET). It has shown high potential in improving image reconstru...

    Authors: Defeng Tian, Hongwei Yang, Yan Li, Bixiao Cui and Jie Lu
    Citation: EJNMMI Physics 2022 9:1
  32. The calculation of time-integrated activities (TIAs) for tumours and organs is required for dosimetry in molecular radiotherapy. The accuracy of the calculated TIAs is highly dependent on the chosen fit functi...

    Authors: Deni Hardiansyah, Ade Riana, Peter Kletting, Nouran R. R. Zaid, Matthias Eiber, Supriyanto A. Pawiro, Ambros J. Beer and Gerhard Glatting
    Citation: EJNMMI Physics 2021 8:82
  33. We recently reported a new absorbed dose conversion method, RAP (RAtio of Pharmacokinetics), for 211At-meta-astatobenzylguanidine (211At-MABG) using a single biodistribution measurement, the percent injected dose...

    Authors: Tetsuya Sakashita, Shojiro Matsumoto, Shigeki Watanabe, Hirofumi Hanaoka, Yasuhiro Ohshima, Yoko Ikoma, Naoyuki Ukon, Ichiro Sasaki, Tatsuya Higashi, Tetsuya Higuchi, Yoshito Tsushima and Noriko S. Ishioka
    Citation: EJNMMI Physics 2021 8:80
  34. The whole brain is often covered in [18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) in oncology patients, but the covered brain abnormality is typically screened by visual interpretation witho...

    Authors: Wonseok Whi, Hongyoon Choi, Jin Chul Paeng, Gi Jeong Cheon, Keon Wook Kang and Dong Soo Lee
    Citation: EJNMMI Physics 2021 8:79
  35. Kidney dosimetry after peptide receptor radionuclide therapy using 177Lu-labelled somatostatin analogues is a procedure with multiple steps. We present the SPECT/CT-based implementation at Aarhus University Hospi...

    Authors: Peter Frøhlich Staanum, Anders Floor Frellsen, Marie Louise Olesen, Peter Iversen and Anne Kirstine Arveschoug
    Citation: EJNMMI Physics 2021 8:78
  36. The aim of this standard operational procedure is to standardize the methodology employed for the evaluation of pre- and post-treatment absorbed dose calculations in 90Y microsphere liver radioembolization. Basic...

    Authors: Carlo Chiesa, Katarina Sjogreen-Gleisner, Stephan Walrand, Lidia Strigari, Glenn Flux, Jonathan Gear, Caroline Stokke, Pablo Minguez Gabina, Peter Bernhardt and Mark Konijnenberg
    Citation: EJNMMI Physics 2021 8:77
  37. The present study tested the possible utility of fractal analysis from l-[methyl-11C]-methionine (MET) uptake in patients with newly diagnosed gliomas for differentiating glioma, especially in relation to isocitr...

    Authors: Yukito Maeda, Yuka Yamamoto, Takashi Norikane, Katsuya Mitamura, Tetsuhiro Hatakeyama, Keisuke Miyake, Yoshihiro Nishiyama and Nobuyuki Kudomi
    Citation: EJNMMI Physics 2021 8:76
  38. Simultaneous PET/MRIs vary in their quantitative PET performance due to inherent differences in the physical systems and differences in the image reconstruction implementation. This variability in quantitative...

    Authors: Richard Laforest, Mehdi Khalighi, Yutaka Natsuaki, Abhejit Rajagopal, Dharshan Chandramohan, Darrin Byrd, Hongyu An, Peder Larson, Sara St. James, John J. Sunderland, Paul E. Kinahan and Thomas A. Hope
    Citation: EJNMMI Physics 2021 8:75
  39. This work aims to train, validate, and test a dual-stream three-dimensional convolutional neural network (3D-CNN) based on fluorine 18 (18F)-fluorodeoxyglucose (FDG) PET/CT to distinguish benign lesions and invas...

    Authors: Xiaonan Shao, Rong Niu, Xiaoliang Shao, Jianxiong Gao, Yunmei Shi, Zhenxing Jiang and Yuetao Wang
    Citation: EJNMMI Physics 2021 8:74
  40. Accurate QSPECT is crucial in dosimetry-based, personalized radiopharmaceutical therapy with 177Lu and other radionuclides. We compared the quantitative performance of three NaI(Tl)-crystal SPECT/CT systems equip...

    Authors: Alessandro Desy, Guillaume F. Bouvet, Étienne Croteau, Nancy Lafrenière, Éric E. Turcotte, Philippe Després and Jean-Mathieu Beauregard
    Citation: EJNMMI Physics 2021 8:73
  41. This study was conducted to clarify how patient body mass affects the image quality and quantification accuracy of images obtained using 89Zr PET/CT. 89Zr PET/CT images from time-of-flight (TOF) PET/CT and semico...

    Authors: Ukihide Tateishi, Hiromitsu Daisaki, Junichi Tsuchiya, Yuji Kojima, Keisuke Takino, Naoki Shimada and Kota Yokoyama
    Citation: EJNMMI Physics 2021 8:72
  42. In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy...

    Authors: Kristian Valind, Jonas Jögi, David Minarik, Gustav Brolin and Elin Trägårdh
    Citation: EJNMMI Physics 2021 8:70
  43. This study aimed to evaluate the performance of a preclinical PET insert in three configurations: as a stand-alone unit outside the MRI bore, inside the bore of a cryogen-free 3T MRI and, finally, while perfor...

    Authors: Gaelle Emvalomenos, Sofie Trajanovska, Binh T. T. Pham, Peter Doughty, Jerome Burnet, Isabelle Smith, Ruslan Garipov, Marie-Claude Gregoire, Nana Sunn, John McGrath and Steven R. Meikle
    Citation: EJNMMI Physics 2021 8:68
  44. Metal artefact reduction (MAR) techniques still are in limited use in positron emission tomography/computed tomography (PET/CT). This study aimed to investigate the effect of Smart MAR on quantitative PET anal...

    Authors: Maarten Haemels, Delphine Vandendriessche, Jeroen De Geeter, James Velghe, Maxence Vandekerckhove and Frank De Geeter
    Citation: EJNMMI Physics 2021 8:67

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