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  1. Over the past five years, ultrafast high-frequency (HF) readout concepts have advanced the timing performance of silicon photomultipliers (SiPMs). The shown impact in time-of-flight (TOF) techniques can furthe...

    Authors: Vanessa Nadig, Matthias Hornisch, Jakob Oehm, Katrin Herweg, Volkmar Schulz and Stefan Gundacker
    Citation: EJNMMI Physics 2023 10:76
  2. Although a new generation of tomographs with a longer axial field-of-view called total-body PET have been developed, they are not widely utilized due to their high cost compared to conventional scanners. The n...

    Authors: Meysam Dadgar, Jens Maebe, Maya Abi Akl, Boris Vervenne and Stefaan Vandenberghe
    Citation: EJNMMI Physics 2023 10:75
  3. Authors: E. Courtney Henry, Matthew Strugari, George Mawko, Kimberly Brewer, David Liu, Andrew C. Gordon, Jeffrey N. Bryan, Charles Maitz, James J. Karnia, Robert Abraham, S. Cheenu Kappadath and Alasdair Syme
    Citation: EJNMMI Physics 2023 10:74

    The original article was published in EJNMMI Physics 2022 9:21

  4. Commissioning, calibration, and quality control procedures for nuclear medicine imaging systems are typically performed using hollow containers filled with radionuclide solutions. This leads to multiple source...

    Authors: Johannes Tran-Gia, Ana M. Denis-Bacelar, Kelley M. Ferreira, Andrew P. Robinson, Christophe Bobin, Lara M. Bonney, Nicholas Calvert, Sean M. Collins, Andrew J. Fenwick, Domenico Finocchiaro, Federica Fioroni, Katerina Giannopoulou, Elisa Grassi, Warda Heetun, Stephanie J. Jewitt, Maria Kotzasarlidou…
    Citation: EJNMMI Physics 2023 10:73
  5. Full quantification of Positron Emission Tomography (PET) requires an arterial input function (AIF) for measurement of certain targets, or using particular radiotracers, or for the quantification of specific o...

    Authors: Granville J. Matheson, Liner Ge, Mengyu Zhang, Bingyu Sun, Yuqi Tu, Francesca Zanderigo, Anton Forsberg Morèn and R. Todd Ogden
    Citation: EJNMMI Physics 2023 10:72
  6. The use of lutetium-177 (177Lu)-based radiopharmaceuticals in peptide receptor nuclear therapy is increasing, but so is the number of nuclear medicine workers exposed to higher levels of radiation. In recent year...

    Authors: Mercedes Riveira-Martin, Lara Struelens, José Muñoz Iglesias, Werner Schoonjans, Olga Tabuenca, José Manuel Nogueiras, Francisco Javier Salvador Gómez and Antonio López Medina
    Citation: EJNMMI Physics 2023 10:70
  7. Image harmonization has been proposed to minimize heterogeneity in brain PET scans acquired in multi-center studies. However, standard validated methods and software tools are lacking. Here, we assessed the pe...

    Authors: Mahnaz Shekari, Eline E. Verwer, Maqsood Yaqub, Marcel Daamen, Christopher Buckley, Giovanni B. Frisoni, Pieter Jelle Visser, Gill Farrar, Frederik Barkhof, Juan Domingo Gispert and Ronald Boellaard
    Citation: EJNMMI Physics 2023 10:68
  8. Dynamic positron emission tomography (PET) images are useful in clinical practice because they can be used to calculate the metabolic parameters (Ki) of tissues using graphical methods (such as Patlak plots). Ki ...

    Authors: Ganglin Liang, Jinpeng Zhou, Zixiang Chen, Liwen Wan, Xieraili Wumener, Yarong Zhang, Dong Liang, Ying Liang and Zhanli Hu
    Citation: EJNMMI Physics 2023 10:67
  9. Ultra-low-dose (ULD) computed tomography (CT) scans should be used when CT is performed only for attenuation correction (AC) of positron emission tomography (PET) data. A tin filter can be used in addition to ...

    Authors: Natalie Anne Bebbington, Kenneth Boye Christensen, Lone Lange Østergård and Paw Christian Holdgaard
    Citation: EJNMMI Physics 2023 10:66
  10. Q.Clear, a Bayesian penalized likelihood reconstruction algorithm, has shown high potential in improving quantitation accuracy in PET systems. The Q.Clear algorithm controls noise during the iterative reconstr...

    Authors: Elisabeth Kirkeby Lysvik, Lars Tore Gyland Mikalsen, Mona-Elisabeth Rootwelt-Revheim, Kyrre Eeg Emblem and Trine Hjørnevik
    Citation: EJNMMI Physics 2023 10:65
  11. Dosimetry after radiopharmaceutical therapy with 177Lu (177Lu-RPT) relies on quantitative SPECT/CT imaging, for which suitable reconstruction protocols are required. In this study, we characterized for the first ...

    Authors: Rachele Danieli, Martina Stella, Julian Leube, Johannes Tran-Gia, Clementine Marin, Carlos F. Uribe, Bruno Vanderlinden, Nick Reynaert, Patrick Flamen and Hugo Levillain
    Citation: EJNMMI Physics 2023 10:64
  12. The Q.Clear algorithm is a fully convergent iterative image reconstruction technique. We hypothesize that different PET/CT scanners with distinct crystal properties will require different optimal settings for ...

    Authors: Fatemeh Sadeghi, Peyman Sheikhzadeh, Saeed Farzanehfar, Pardis Ghafarian, Yalda Moafpurian and Mohammadreza Ay
    Citation: EJNMMI Physics 2023 10:63
  13. Alongside the benefits of Total-Body imaging modalities, such as higher sensitivity, single-bed position, low dose imaging, etc., their final construction cost prevents worldwide utilization. The main aim of t...

    Authors: M. Dadgar, S. Parzych, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, K. Dulski, K. Elyan, A. Gajos, B. C. Hiesmayr, Ł. Kapłon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemien…
    Citation: EJNMMI Physics 2023 10:62
  14. Monte Carlo (MC) simulations are used in nuclear medicine imaging as they provide unparalleled insight into processes that are not directly experimentally measurable, such as scatter and attenuation in an acqu...

    Authors: Sophia Pells, David M. Cullen, Daniel Deidda, Ana M. Denis-Bacelar, Andrew Fenwick, Kelley M. Ferreira, David Hamilton, Warda Heetun, Peter Julyan, George Needham, Ben Pietras, Emlyn Price, James Scuffham, Jill Tipping and Andrew P. Robinson
    Citation: EJNMMI Physics 2023 10:60
  15. Dynamic PET is an essential tool in oncology due to its ability to visualize and quantify radiotracer uptake, which has the potential to improve imaging quality. However, image noise caused by a low photon cou...

    Authors: Lin Xin, Weihai Zhuo, Haikuan Liu and Tianwu Xie
    Citation: EJNMMI Physics 2023 10:59
  16. Lung lobar ventilation and perfusion (V/Q) quantification is generally obtained by generating planar scintigraphy images and then imposing three equally sized regions of interest on the data of each lung. This...

    Authors: Emilie Verrecchia-Ramos, Olivier Morel, Merwan Ginet, Paul Retif and Sinan Ben Mahmoud
    Citation: EJNMMI Physics 2023 10:57
  17. Current guidelines of the radioiodine uptake (RAIU) test allow the use of different equipment, isotopes, activity and region-of-interest (ROI). We evaluated presence and extent of these differences in clinical...

    Authors: Jurgen E. M. Mourik, Mark Derks, Erik T. te Beek and Marc R. J. ten Broek
    Citation: EJNMMI Physics 2023 10:55
  18. Total-body PET imaging with ultra-high sensitivity makes high-temporal-resolution framing protocols possible for the first time, which allows to capture rapid tracer dynamic changes. However, whether protocols...

    Authors: Qing Ye, Hao Zeng, Yizhang Zhao, Weiguang Zhang, Yun Dong, Wei Fan and Yihuan Lu
    Citation: EJNMMI Physics 2023 10:54
  19. Over recent years, [225Ac]Ac-PSMA and [177Lu]Lu-PSMA radiopharmaceutical therapy have evolved as a promising treatment option for advanced prostate cancer. Especially for alpha particle emitter treatments, there ...

    Authors: Mikhail Rumiantcev, Wei Bo Li, Simon Lindner, Grigory Liubchenko, Sandra Resch, Peter Bartenstein, Sibylle I. Ziegler, Guido Böning and Astrid Delker
    Citation: EJNMMI Physics 2023 10:53
  20. Despite being thirteen years since the installation of the first PET-MR system, the scanners constitute a very small proportion of the total hybrid PET systems installed. This is in stark contrast to the rapid...

    Authors: Georgios Krokos, Jane MacKewn, Joel Dunn and Paul Marsden
    Citation: EJNMMI Physics 2023 10:52
  21. Conventional clinical PET scanners typically have an axial field of view (AFOV) of 15–30 cm, resulting in limited coverage and relatively low photon detection efficiency. Taking advantage of the development of...

    Authors: Huiran Hu, Yanchao Huang, Hongyan Sun, Kemin Zhou, Li Jiang, Jinmei Zhong, Li Chen, Lijuan Wang, Yanjiang Han and Hubing Wu
    Citation: EJNMMI Physics 2023 10:51
  22. As for any other nuclear medicine treatment, patients treated with [177Lu]Lu-DOTA-TATE should be given some radiation protection recommendations after being discharged to limit the dose received by family members...

    Authors: Teresa Monserrat Fuertes, Borja Santos Zorrozua, Emilia Rodeño Ortiz de Zarate, Miguel Ángel Peinado Montes, Carmen Vigil Díaz and Pablo Mínguez Gabiña
    Citation: EJNMMI Physics 2023 10:50
  23. The use of CT images for attenuation correction of myocardial perfusion imaging with single photon emission computer tomography (SPECT) increases diagnostic confidence. However, acquiring a CT image registered...

    Authors: Tamino Huxohl, Gopesh Patel, Reinhard Zabel and Wolfgang Burchert
    Citation: EJNMMI Physics 2023 10:49
  24. Prediction of [177Lu]Lu-HA-DOTATATE kidney and tumor uptake based on diagnostic [68Ga]Ga-HA-DOTATATE imaging would be a crucial step for precision dosing of [177Lu]Lu-HA-DOTATATE. In this study, the population ph...

    Authors: Hinke Siebinga, Berlinda J. de Wit-van der Veen, Jos H. Beijnen, Marcel P. M. Stokkel, Thomas P. C. Dorlo, Alwin D. R. Huitema and Jeroen J. M. A. Hendrikx
    Citation: EJNMMI Physics 2023 10:48
  25. 212Pb is a promising radionuclide for targeted alpha therapy. Here, the feasibility of visualising the tumour uptake and biodistribution of 212Pb-NG001 in mice with a clinical SPECT/CT scanner was investigated.

    Authors: Monika Kvassheim, Anna Julie Kjøl Tornes, Asta Juzeniene, Caroline Stokke and Mona-Elisabeth R. Revheim
    Citation: EJNMMI Physics 2023 10:47
  26. Radiopharmaceutical therapy (RPT) with alpha-emitting radionuclides has shown great promise in treating metastatic cancers. The successive emission of four alpha particles in the 225Ac decay chain leads to highly...

    Authors: Helena Koniar, Cassandra Miller, Arman Rahmim, Paul Schaffer and Carlos Uribe
    Citation: EJNMMI Physics 2023 10:46
  27. The main objective of this study was to evaluate the ability of a large field Cadmium Zinc Telluride (CZT) camera to estimate thyroid uptake (TU) on single photon emission computed tomography (SPECT) images wi...

    Authors: Benjamin Serrano, Régis Amblard, Tiffany Beaumont, Florent Hugonnet, Matthieu Dietz, Frédéric Berthier, Nicolas Garnier, Rémy Villeneuve, Valérie Nataf, François Mocquot, Christopher Montemagno, Marc Faraggi and Benoît Paulmier
    Citation: EJNMMI Physics 2023 10:45
  28. Estimation of brain amyloid accumulation is valuable for evaluation of patients with cognitive impairment in both research and clinical routine. The development of high throughput and accurate strategies for t...

    Authors: Claes Nøhr Ladefoged, Lasse Anderberg, Karine Madsen, Otto Mølby Henriksen, Steen Gregers Hasselbalch, Flemming Littrup Andersen, Liselotte Højgaard and Ian Law
    Citation: EJNMMI Physics 2023 10:44
  29. Positron emission tomography (PET) requires a high signal-to-noise ratio (SNR) to improve image quality, with time-of-flight (TOF) being an effective way to boost the SNR. However, the scanner sensitivity and ...

    Authors: Konstantin Weindel, Vanessa Nadig, Katrin Herweg, Volkmar Schulz and Stefan Gundacker
    Citation: EJNMMI Physics 2023 10:43
  30. This study evaluated, as a snapshot, the variability in quantification and image quality (IQ) of the clinically utilized PET [18F]FDG whole-body protocols in Finland using a NEMA/IEC IQ phantom permanently filled...

    Authors: O. Sipilä, J. Liukkonen, H.-L. Halme, T. Tolvanen, A. Sohlberg, M. Hakulinen, A.-L. Manninen, K. Tahvanainen, V. Tunninen, T. Ollikainen, T. Kangasmaa, A. Kangasmäki and J. Vuorela
    Citation: EJNMMI Physics 2023 10:38
  31. In light of the milestones achieved in PET design so far, further sensitivity improvements aim to optimise factors such as the dose, throughput, and detection of small lesions. While several longer axial field...

    Authors: Maya Abi-Akl, Meysam Dadgar, Yassine Toufique, Othmane Bouhali and Stefaan Vandenberghe
    Citation: EJNMMI Physics 2023 10:37
  32. Early cancer detection is crucial for patients’ survival. The image quality in 111In-octreotide SPECT imaging could be improved by using Monte Carlo (MC)-based reconstruction. The aim of this observational study ...

    Authors: Emma Wikberg, Martijn van Essen, Tobias Rydén, Johanna Svensson, Peter Gjertsson and Peter Bernhardt
    Citation: EJNMMI Physics 2023 10:36
  33. The Cubresa Spark is a novel benchtop silicon-photomultiplier (SiPM)-based preclinical SPECT system. SiPMs in SPECT significantly improve resolution and reduce detector size compared to preclinical cameras wit...

    Authors: Matthew E. Strugari, Drew R. DeBay, Steven D. Beyea and Kimberly D. Brewer
    Citation: EJNMMI Physics 2023 10:35
  34. Image optimization is a key step in clinical nuclear medicine, and phantoms play an essential role in this process. However, most phantoms do not accurately reflect the complexity of human anatomy, and this pr...

    Authors: Daniel Gillett, Daniel Marsden, Rosy Crawford, Safia Ballout, James MacFarlane, Merel van der Meulen, Bethany Gillett, Nick Bird, Sarah Heard, Andrew S. Powlson, Thomas Santarius, Richard Mannion, Angelos Kolias, Ines Harper, Iosif A. Mendichovszky, Luigi Aloj…
    Citation: EJNMMI Physics 2023 10:34
  35. Total-body PET scanners with axial field of views (FOVs) longer than 1 m enable new applications to study multiple organs (e.g., the brain-gut-axis) simultaneously. As the spatial resolution and the associated...

    Authors: Julia G. Mannheim, Ivo Rausch, Maurizio Conti, Christian la Fougère and Fabian P. Schmidt
    Citation: EJNMMI Physics 2023 10:33
  36. While diagnostic reference levels (DRLs) are well-established for the radiopharmaceutical part, published DRLs for the CT component of positron emission tomography/computed tomography (PET/CT) and single photo...

    Authors: Gwenny Verfaillie, Caro Franck, An De Crop, Laurence Beels, Yves D’Asseler and Klaus Bacher
    Citation: EJNMMI Physics 2023 10:32
  37. 18F-FDG PET/CT imaging allows to study oncological patients and their relative diagnosis through the standardised uptake value (SUV) evaluation. During radiopharmaceutical injection, an extravasation event may o....

    Authors: Mauro Iori, Elisa Grassi, Lorenzo Piergallini, Greta Meglioli, Andrea Botti, Giada Sceni, Noemi Cucurachi, Laura Verzellesi, Domenico Finocchiaro, Annibale Versari, Beatrice Fraboni and Federica Fioroni
    Citation: EJNMMI Physics 2023 10:31
  38. Nuclear medicine imaging modalities like computed tomography (CT), single photon emission CT (SPECT) and positron emission tomography (PET) are employed in the field of theranostics to estimate and plan the do...

    Authors: Daniel Deidda, Ana M. Denis-Bacelar, Andrew J. Fenwick, Kelley M. Ferreira, Warda Heetun, Brian F. Hutton, Daniel R. McGowan, Andrew P. Robinson, James Scuffham, Kris Thielemans and Robert Twyman
    Citation: EJNMMI Physics 2023 10:30
  39. In this retrospective study, we compared the maximum standardized uptake values (SUVmax) of parathyroid lesions and the target-to-background ratio (TBR) of parathyroid lesions to thyroid tissue in early-phase ...

    Authors: Yuhua Wang, Ye Liu, Na Li, Kang Xu and Wanchun Zhang
    Citation: EJNMMI Physics 2023 10:29
  40. The Jagiellonian Positron Emission Tomograph is the 3-layer prototype of the first scanner based on plastic scintillators, consisting of 192 half-metre-long strips with readouts at both ends. Compared to cryst...

    Authors: S. Sharma, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, K. Eliyan, A. Gajos, N. Gupta-Sharma, B. C. Hiesmayr, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, P. Konieczka, G. Korcyl…
    Citation: EJNMMI Physics 2023 10:28
  41. Monte Carlo (MC) simulation in Nuclear Medicine is a powerful tool for modeling many physical phenomena which are difficult to track or measure directly. MC simulation in SPECT/CT imaging is particularly suita...

    Authors: Giovanni Di Domenico, Simona Di Biaso, Lorenzo Longo, Alessandro Turra, Eugenia Tonini, MariaConcetta Longo, Licia Uccelli and Mirco Bartolomei
    Citation: EJNMMI Physics 2023 10:27

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