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EJNMMI Physics
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  3. Since it was first approved in Europe in 2016, the gallium-68 (68Ga) radiopharmaceutical [68Ga]Ga-DOTA-TOC has been widely used for imaging of somatostatin receptor (SSTR) positive tumours using positron emission...

    Authors: Mercedes Riveira-Martin, Lara Struelens, Werner Schoonjans, Isaac Sánchez-Díaz, Jose Muñoz Iglesias, Óscar Ferreira Dávila, Francisco Javier Salvador Gómez, Manuel Salgado Fernández and Antonio López Medina
    Citation: EJNMMI Physics 2022 9:75
    Content type: Young investigators Published on:

  4. Excellent performance characteristics of the Vision Quadra PET/CT, e.g. a substantial increase in sensitivity, allow for precise measurements of image-derived input functions (IDIF) and tissue time activity cu...

    Authors: Joyce van Sluis, Johannes H. van Snick, Adrienne H. Brouwers, Walter Noordzij, Rudi A. J. O. Dierckx, Ronald J. H. Borra, Adriaan A. Lammertsma, Andor W. J. M. Glaudemans, Riemer H. J. A. Slart, Maqsood Yaqub, Charalampos Tsoumpas and Ronald Boellaard
    Citation: EJNMMI Physics 2022 9:74
    Content type: Original research Published on:

  5. The 2018 BNMS Glomerular Filtration Rate (GFR) guidelines recommend a single-sample technique with the sampling time dictated by the expected renal function, but this is not known with any accuracy before the ...

    Authors: Helena McMeekin, Sam Townrow, Mark Barnfield, Andy Bradley, Ben Fongenie, Daniel R. McGowan, Matthew Memmott, Charlotte A. Porter, Fred Wickham, Nick Vennart and Maria Burniston
    Citation: EJNMMI Physics 2022 9:73
    Content type: Original research Published on:

  6. An open-source, extensible medical viewing platform is described, called the TriDFusion image viewer (3DF). The 3DF addresses many broad unmet needs in nuclear medicine research; it provides a viewer with seve...

    Authors: Daniel Lafontaine, C. Ross Schmidtlein, Assen Kirov, Ryan P. Reddy, Simone Krebs, Heiko Schöder and John L. Humm
    Citation: EJNMMI Physics 2022 9:72
    Content type: Commentary Published on:

  8. PET/MRI is an attractive imaging modality due to the complementary nature of MRI and PET. Obtaining high quality small animal PET/MRI results is key for the translation of novel PET/MRI agents and techniques t...

    Authors: Alyssa C. Pollard, Jorge de la Cerda, F. William Schuler, Charles V. Kingsley, Seth T. Gammon and Mark D. Pagel
    Citation: EJNMMI Physics 2022 9:70
    Content type: Original research Published on:

  9. To confirm the performance of the first hemispherical positron emission tomography (PET) for the brain (Vrain) that we developed to visualise the small nuclei in the deep brain area, we compared 18F-fluorodeoxygl...

    Authors: Miwako Takahashi, Go Akamatsu, Yuma Iwao, Hideaki Tashima, Eiji Yoshida and Taiga Yamaya
    Citation: EJNMMI Physics 2022 9:69
    Content type: Original research Published on:

  10. Performance assessment of positron emission tomography (PET) scanners is crucial to guide clinical practice with efficiency. Even though clinical data are the final target, their use to characterize systems re...

    Authors: Quentin Maronnier, Frédéric Courbon and Olivier Caselles
    Citation: EJNMMI Physics 2022 9:68
    Content type: Original research Published on:

  11. The aim of this study is to elucidate the difference in absorbed dose (Dabs) patterns in radiopharmaceutical therapies between alpha emitters (225Ac) and beta emitters (177Lu) when targeting cancer-associated fib...

    Authors: Jonathan Tranel, Stig Palm, Stephen A. Graves, Felix Y. Feng and Thomas A. Hope
    Citation: EJNMMI Physics 2022 9:67
    Content type: Original research Published on:

  12. [18F] FDG PET-CT has an important role in the initial staging of lung cancer; however, accurate differentiation between activity in malignant and benign intrathoracic lymph nodes on PET-CT scans can be challengin...

    Authors: Sara S. A. Laros, Dennis Dieckens, Stephan P. Blazis and Johannes A. van der Heide
    Citation: EJNMMI Physics 2022 9:66
    Content type: Original research Published on:

  13. Based on theoretical and preclinical results, terbium-161 may be a valid alternative to lutetium-177 and yttrium-90 in radionuclide therapies. The large low-energy electron emission from terbium-161 is a favor...

    Authors: Jens Hemmingsson, Johanna Svensson, Nicholas P. van der Meulen, Cristina Müller and Peter Bernhardt
    Citation: EJNMMI Physics 2022 9:65
    Content type: Original research Published on:

  14. The clinical utility of radiomics is hampered by a high correlation between the large number of features analysed which may result in the “bouncing beta” phenomenon which could in part explain why in a similar...

    Authors: DeLeu Anne-Leen, Sathekge Machaba, Maes Alex, De Spiegeleer Bart, Beels Laurence, Sathekge Mike, Pottel Hans and Christophe Van de Wiele
    Citation: EJNMMI Physics 2022 9:64
    Content type: Original research Published on:

  15. Efforts have been made both to avoid invasive blood sampling and to shorten the scan duration for dynamic positron emission tomography (PET) imaging. A total-body scanner, such as the uEXPLORER PET/CT, can rel...

    Authors: Zhenguo Wang, Yaping Wu, Xiaochen Li, Yan Bai, Hongzhao Chen, Jie Ding, Chushu Shen, Zhanli Hu, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang, Yun Zhou, Meiyun Wang and Tao Sun
    Citation: EJNMMI Physics 2022 9:63
    Content type: Original research Published on:

  16. The total-body positron emission tomography (PET) scanner provides an unprecedented opportunity to scan the whole body simultaneously, thanks to its long axial field of view and ultrahigh temporal resolution. ...

    Authors: Tao Sun, Yaping Wu, Wei Wei, Fangfang Fu, Nan Meng, Hongzhao Chen, Xiaochen Li, Yan Bai, Zhenguo Wang, Jie Ding, Debin Hu, Chaojie Chen, Zhanli Hu, Dong Liang, Xin Liu, Hairong Zheng…
    Citation: EJNMMI Physics 2022 9:62
    Content type: Original research Published on:

  17. Radiotracer extravasations, caused largely by faulty tracer injections, can occur in up to 23% of 18F-fluorodeoxyglucose (FDG) PET/CT scans and negatively impact radiological review and tracer quantification. Con...

    Authors: Steve Perrin, Jackson W. Kiser, Josh Knowland and Spencer L. Bowen
    Citation: EJNMMI Physics 2022 9:61
    Content type: Original research Published on:

  18. Contemporary PET/CT scanners can use 70-min dynamic whole-body (D-WB) PET to generate more quantitative information about FDG uptake than just the SUV by generating parametric images of FDG metabolic rate (MRFDG)...

    Authors: André H. Dias, Anne M. Smith, Vijay Shah, David Pigg, Lars C. Gormsen and Ole L. Munk
    Citation: EJNMMI Physics 2022 9:60
    Content type: Original research Published on:

  19. Currently, there is no consensus on the optimal partial volume correction (PVC) algorithm for oncology imaging. Several existing PVC methods require knowledge of the reconstructed resolution, usually as the po...

    Authors: Rebecca Gillen, Kjell Erlandsson, Ana M. Denis-Bacelar, Kris Thielemans, Brian F. Hutton and Sarah J. McQuaid
    Citation: EJNMMI Physics 2022 9:59
    Content type: Original research Published on:

  20. PET nuclides can have a considerable influence on the spatial resolution and image quality of PET/CT scans, which can influence diagnostics in oncology, for example. The individual impact of the positron energ...

    Authors: Anja Braune, Liane Oehme, Robert Freudenberg, Frank Hofheinz, Jörg van den Hoff, Jörg Kotzerke and Sebastian Hoberück
    Citation: EJNMMI Physics 2022 9:58
    Content type: Original research Published on:

  21. In 2016, the International Commission on Radiological Protection (ICRP) published the results of Monte Carlo simulations performed using updated and anatomically realistic voxelized phantoms. The resulting spe...

    Authors: Shalini Subramanian, Bin He, Eric Frey, Derek W. Jokisch, Wesley Bolch and George Sgouros
    Citation: EJNMMI Physics 2022 9:57
    Content type: Original research Published on:

  22. To evaluate the effect of combining positron range correction (PRC) with point-spread-function (PSF) correction and to compare different methods of implementation into iterative image reconstruction for 124I-PET ...

    Authors: Hunor Kertész, Maurizio Conti, Vladimir Panin, Jorge Cabello, Deepak Bharkhada, Thomas Beyer, Laszlo Papp, Walter Jentzen, Jacobo Cal-Gonzalez, Joaquín L. Herraiz, Alejandro López-Montes and Ivo Rausch
    Citation: EJNMMI Physics 2022 9:56
    Content type: Original research Published on:

  23. Deep convolutional neural networks have demonstrated robust and reliable PET attenuation correction (AC) as an alternative to conventional AC methods in integrated PET/MRI systems. However, its whole-body impl...

    Authors: Sahar Ahangari, Anders Beck Olin, Marianne Kinggård Federspiel, Bjoern Jakoby, Thomas Lund Andersen, Adam Espe Hansen, Barbara Malene Fischer and Flemming Littrup Andersen
    Citation: EJNMMI Physics 2022 9:55
    Content type: Original research Published on:

  24. Dead-time correction is required for accurate quantitative SPECT-based dosimetry in the context of personalised 177Lu radiopharmaceutical therapy. We aimed to evaluate the impact of applying dead-time correction ...

    Authors: Alessandro Desy, Guillaume F. Bouvet, Nancy Lafrenière, Atefeh Zamanian, Philippe Després and Jean-Mathieu Beauregard
    Citation: EJNMMI Physics 2022 9:54
    Content type: Short communication Published on:

  25. Machine learning studies require a large number of images often obtained on different PET scanners. When merging these images, the use of harmonized images following EARL-standards is essential. However, when ...

    Authors: Elisabeth Pfaehler, Daniela Euba, Andreas Rinscheid, Otto S. Hoekstra, Josee Zijlstra, Joyce van Sluis, Adrienne H. Brouwers, Constantin Lapa and Ronald Boellaard
    Citation: EJNMMI Physics 2022 9:53
    Content type: Original research Published on:

  26. Lead-212 (212Pb) is a promising radionuclide for targeted therapy, as it decays to α-particle emitter bismuth-212 (212Bi) via β-particle emission. This extends the problematic short half-life of 212Bi. In prepara...

    Authors: Monika Kvassheim, Mona-Elisabeth R. Revheim and Caroline Stokke
    Citation: EJNMMI Physics 2022 9:52
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Physics 2022 9:71

  27. Myocardial perfusion imaging (MPI) using positron emission tomography (PET) tracers is an essential tool in investigating diseases and treatment responses in cardiology. 82Rubidium (82Rb)-PET imaging is advantage...

    Authors: Malte Jensen, Simon Bentsen, Andreas Clemmensen, Jacob Kildevang Jensen, Johanne Madsen, Jonas Rossing, Anna Laier, Philip Hasbak, Andreas Kjaer and Rasmus Sejersten Ripa
    Citation: EJNMMI Physics 2022 9:51
    Content type: Original research Published on:

  28. Partial volume correction with anatomical magnetic resonance (MR) images (MR-PVC) is useful for accurately quantifying tracer uptake on brain positron emission tomography (PET) images. However, MR segmentation...

    Authors: Keisuke Matsubara, Masanobu Ibaraki and Toshibumi Kinoshita
    Citation: EJNMMI Physics 2022 9:50
    Content type: Original research Published on:

  29. The prediction of response is one of the major challenges in radiation-based therapies. Although the selection of accurate linear–quadratic model parameters is essential for the estimation of radiation respons...

    Authors: Yaser H. Gholami, Kathy P. Willowson and Dale L. Bailey
    Citation: EJNMMI Physics 2022 9:49
    Content type: Original research Published on:

  30. SwiftScan single-photon emission computed tomography (SPECT) is a recently released scanning technique with data acquired when the detector is stationary and when it moves from one view to the next. The influe...

    Authors: Takuro Shiiba, Yuya Sekikawa, Shinji Tateoka, Nobutaka Shinohara, Yuuki Inoue, Yasuyoshi Kuroiwa, Takashi Tanaka, Yasushi Kihara and Takuroh Imamura
    Citation: EJNMMI Physics 2022 9:48
    Content type: Short communication Published on:

  31. In recent years, a lot of effort has been put in the enhancement of medical imaging using artificial intelligence. However, limited patient data in combination with the unavailability of a ground truth often p...

    Authors: Julian Leube, Johan Gustafsson, Michael Lassmann, Maikol Salas-Ramirez and Johannes Tran-Gia
    Citation: EJNMMI Physics 2022 9:47
    Content type: Original research Published on:

  32. The development of new targeted alpha therapies motivates improving alpha particle dosimetry. For alpha particles, microscopic targets must be considered to estimate dosimetric quantities that can predict the ...

    Authors: Emma Mellhammar, Magnus Dahlbom, Oskar Vilhelmsson-Timmermand and Sven-Erik Strand
    Citation: EJNMMI Physics 2022 9:46
    Content type: Original research Published on:

  33. The present study aimed to explore the boundary of acquisition time and propose an optimized acquisition time range for total-body positron emission tomography (PET)/computed tomography (CT) oncological imagin...

    Authors: Yibo He, Yushen Gu, Haojun Yu, Bing Wu, Siyang Wang, Hui Tan, Yanyan Cao, Shuguang Chen, Xiuli Sui, Yiqiu Zhang and Hongcheng Shi
    Citation: EJNMMI Physics 2022 9:45
    Content type: Original research Published on:

  34. To evaluate if satisfactory post-therapeutic image-based dosimetry can be achieved for Lu-177-DOTATATE treatments using a reduced number of image acquisitions to improve patient comfort and reduce economical c...

    Authors: Oscar Ardenfors, Joachim N. Nilsson, Daniel Thor and Cecilia Hindorf
    Citation: EJNMMI Physics 2022 9:44
    Content type: Original research Published on:

  36. The SAFIR prototype insert is a preclinical Positron Emission Tomography (PET) scanner built to acquire dynamic images simultaneously with a 7 T Bruker Magnetic Resonance Imaging (MRI) scanner. The insert is d...

    Authors: Parisa Khateri, Werner Lustermann, Christian Ritzer, Charalampos Tsoumpas and Günther Dissertori
    Citation: EJNMMI Physics 2022 9:42
    Content type: Original research Published on:

  39. 211At, a promising alpha-particle-emitting radionuclide, can easily volatilize and contaminate the environment. To safely manage this unique alpha-particle-emitting radionuclide, we investigated the permeability ...

    Authors: Kazunobu Ohnuki, Mitsuyoshi Yoshimoto, Hiromitsu Haba, Shino Manabe, Hiroki Takashima, Masahiro Yasunaga, Yasumasa Takenaka and Hirofumi Fujii
    Citation: EJNMMI Physics 2022 9:39
    Content type: Short communication Published on:

  40. Organs-on-Chips (OOCs), microdevices mimicking in vivo organs, find growing applications in disease modeling and drug discovery. With the increasing number of uses comes a strong demand for imaging capabilitie...

    Authors: Christoph Clement, Gabriele Birindelli, Marco Pizzichemi, Fiammetta Pagano, Marianna Kruithof-De Julio, Sibylle Ziegler, Axel Rominger, Etiennette Auffray and Kuangyu Shi
    Citation: EJNMMI Physics 2022 9:38
    Content type: Original research Published on:

  41. The number of SPECT/CT time-points is important for accurate patient dose estimation in peptide receptor radionuclide therapy. However, it may be limited by the patient’s health and logistical reasons. Here,  ...

    Authors: Laure Vergnaud, Anne-Laure Giraudet, Aurélie Moreau, Julien Salvadori, Alessio Imperiale, Thomas Baudier, Jean-Noël Badel and David Sarrut
    Citation: EJNMMI Physics 2022 9:37
    Content type: Original research Published on:

  42. PET/CT image quality is directly influenced by the F-18-FDG injected activity. The higher the injected activity, the less noise in the reconstructed images but the more radioactive staff exposition. A new FDA ...

    Authors: Gerald Bonardel, Axel Dupont, Pierre Decazes, Mathieu Queneau, Romain Modzelewski, Jeremy Coulot, Nicolas Le Calvez and Sébastien Hapdey
    Citation: EJNMMI Physics 2022 9:36
    Content type: Original research Published on:

  43. Semiconductor gamma-camera systems based on cadmium zinc telluride (CZT) detectors present new challenges due to an energy-response that includes effects of low-energy tailing. In particular, such energy tails...

    Authors: Daniel Roth, Erik Larsson, Michael Ljungberg and Katarina Sjögreen Gleisner
    Citation: EJNMMI Physics 2022 9:35
    Content type: Original research Published on:

  44. Anthropomorphic torso phantoms, including a cardiac insert, are frequently used to investigate the imaging performance of SPECT and PET systems. These phantom solutions are generally featuring a simple anatomi...

    Authors: Janos Kiss, Laszlo Balkay, Kornel Kukuts, Marton Miko, Attila Forgacs, Gyorgy Trencsenyi and Aron K. Krizsan
    Citation: EJNMMI Physics 2022 9:34
    Content type: Original research Published on:

  45. Given the recent and rapid development of peptide receptor radionuclide therapy (PRRT), increasing emphasis should be placed on the early identification and quantification of therapeutic radiopharmaceutical (t...

    Authors: Christophe Mazzara, Julien Salvadori, Florian Ritzenthaler, Simon Martin, Clémence Porot and Alessio Imperiale
    Citation: EJNMMI Physics 2022 9:33
    Content type: Original research Published on:

  46. Neuronal damage and synapse loss in the spinal cord (SC) have been implicated in spinal cord injury (SCI) and neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS). Current standards of diagn...

    Authors: Samantha Rossano, Takuya Toyonaga, Jason Bini, Nabeel Nabulsi, Jim Ropchan, Zhengxin Cai, Yiyun Huang and Richard E. Carson
    Citation: EJNMMI Physics 2022 9:32
    Content type: Original research Published on:

  47. Absolute myocardial perfusion imaging (MPI) is beneficial in the diagnosis and prognosis of patients with suspected or known coronary artery disease. However, validation and standardization of perfusion estima...

    Authors: Marije E. Kamphuis, Henny Kuipers, Jacqueline Verschoor, Johannes C. G. van Hespen, Marcel J. W. Greuter, Riemer H. J. A. Slart and Cornelis H. Slump
    Citation: EJNMMI Physics 2022 9:31
    Content type: Original research Published on:

  48. Partition modeling allows personalized activity calculation for holmium-166 (166Ho) radioembolization. However, it requires the definition of tumor and non-tumorous liver, by segmentation and registration of a se...

    Authors: Martina Stella, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong and Rob van Rooij
    Citation: EJNMMI Physics 2022 9:30
    Content type: Original research Published on:

  49. Most current whole-body positron emission tomography (PET) scanners use detectors with high timing resolution to measure the time-of-flight of two 511 keV photons, improving the signal-to-noise ratio of PET im...

    Authors: Zheng Liu, Ming Niu, Zhonghua Kuang, Ning Ren, San Wu, Longhan Cong, Xiaohui Wang, Ziru Sang, Crispin Williams and Yongfeng Yang
    Citation: EJNMMI Physics 2022 9:29
    Content type: Original research Published on:

  50. There has been an ongoing need to compare and combine the results of new PET imaging studies conducted with [11C]raclopride with older data. This typically means harmonizing data across different scanners. Previo...

    Authors: Jocelyn Hoye, Takuya Toyonaga, Yasmin Zakiniaeiz, Gelsina Stanley, Michelle Hampson and Evan D. Morris
    Citation: EJNMMI Physics 2022 9:27
    Content type: Short communication Published on:
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