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  1. SPECT quantification is important for dosimetry in targeted radionuclide therapy (TRT) and the calibration of SPECT images is a crucial stage for image quantification. The current standardized calibration prot...

    Authors: Adrien Halty, Jean-Noël Badel, Olga Kochebina and David Sarrut

    Citation: EJNMMI Physics 2018 5:11

    Content type: Original research

    Published on:

  2. Camera calibration, which translates reconstructed count map into absolute activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and tomographic scans using different phantom ge...

    Authors: Wei Zhao, Pedro L. Esquinas, Xinchi Hou, Carlos F. Uribe, Marjorie Gonzalez, Jean-Mathieu Beauregard, Yuni K. Dewaraja and Anna Celler

    Citation: EJNMMI Physics 2018 5:8

    Content type: Original research

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  3. A newly introduced PET/CT scanner (Discovery Meaningful Insights—DMI, GE Healthcare) includes the silicon photomultiplier (SiPM) with time-of-flight (TOF) technology first used in the GE SIGNA PET/MRI. In this...

    Authors: Ida Sonni, Lucia Baratto, Sonya Park, Negin Hatami, Shyam Srinivas, Guido Davidzon, Sanjiv Sam Gambhir and Andrei Iagaru

    Citation: EJNMMI Physics 2018 5:9

    Content type: Original research

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  4. Yttrium-90 (90Y) radioembolization involves the intra-arterial delivery of radioactive microspheres to treat hepatic malignancies. Though this therapy involves careful pre-treatment planning and imaging, little i...

    Authors: Nichole M. Maughan, Mootaz Eldib, David Faul, Maurizio Conti, Mattijs Elschot, Karin Knešaurek, Francesca Leek, David Townsend, Frank P. DiFilippo, Kimberly Jackson, Stephan G. Nekolla, Mathias Lukas, Michael Tapner, Parag J. Parikh and Richard Laforest

    Citation: EJNMMI Physics 2018 5:7

    Content type: Original research

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  5. The performance of a prototype novel digital single-photon emission computed tomography (SPECT) camera with multiple pixelated CZT detectors and high sensitivity collimators (Digital SPECT; Valiance X12 protot...

    Authors: Elinor Goshen, Leonid Beilin, Eli Stern, Tal Kenig, Ronen Goldkorn and Simona Ben-Haim

    Citation: EJNMMI Physics 2018 5:6

    Content type: Original research

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  6. Single-photon emission computed tomography (SPECT) imaging is an important diagnostic tool for the early detection of the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease (PD) and similar neur...

    Authors: M. K. Stam, E. E. Verwer, J. Booij, S. M. Adriaanse, C. M. de Bruin and T. C. de Wit

    Citation: EJNMMI Physics 2018 5:4

    Content type: Original research

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  7. Nuclear medicine imaging of neuroendocrine tumours is performed either by SPECT/CT imaging, using 111In-octreotide or by PET/CT imaging using 68Ga-radiolabelled somatostatin analogs. These imaging techniques will...

    Authors: L. Jönsson, A. Stenvall, E. Mattsson, E. Larsson, A. Sundlöv, T. Ohlsson and C. Hindorf

    Citation: EJNMMI Physics 2018 5:5

    Content type: Original research

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  8. Both cardiac and respiratory motions bias the kinetic parameters measured by dynamic PET. The aim of this study was to perform a realistic positron emission tomography-magnetic resonance (PET-MR) simulation st...

    Authors: Rong Guo, Yoann Petibon, Yixin Ma, Georges El Fakhri, Kui Ying and Jinsong Ouyang

    Citation: EJNMMI Physics 2018 5:3

    Content type: Original research

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  9. The aim of this study was to investigate the deadtime (DT) effects that are present in 177Lu images acquired after radionuclide therapy injection, assess differences in DT based on the full spectrum and the photo...

    Authors: Carlos F. Uribe, Pedro L. Esquinas, Marjorie Gonzalez, Wei Zhao, Jesse Tanguay and Anna Celler

    Citation: EJNMMI Physics 2018 5:2

    Content type: Original research

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  10. Full Monte Carlo (MC)-based SPECT reconstructions have a strong potential for correcting for image degrading factors, but the reconstruction times are long. The objective of this study was to develop a highly ...

    Authors: T. Rydén, J. Heydorn Lagerlöf, J. Hemmingsson, I. Marin, J. Svensson, M. Båth, P. Gjertsson and P. Bernhardt

    Citation: EJNMMI Physics 2018 5:1

    Content type: Original research

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  11. PET-MRI is under investigation as a new strategy for quantitative myocardial perfusion imaging. Consideration is required as to the maximum scanner count rate in order to limit dead-time losses resulting from ...

    Authors: Jim O’ Doherty, Zacharias Chalampalakis, Paul Schleyer, Muhummad Sohaib Nazir, Amedeo Chiribiri and Paul K. Marsden

    Citation: EJNMMI Physics 2017 4:31

    Content type: Original research

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  12.  Several criteria exist to identify the optimal model for quantification of tracer kinetics. The purpose of this study was to evaluate the correspondence in kinetic model preference identification for brain PE...

    Authors: Sandeep S. V. Golla, Sofie M. Adriaanse, Maqsood Yaqub, Albert D. Windhorst, Adriaan A. Lammertsma, Bart N. M. van Berckel and Ronald Boellaard

    Citation: EJNMMI Physics 2017 4:30

    Content type: Original research

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  13. Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availabili...

    Authors: Katarina Sjögreen Gleisner, Emiliano Spezi, Pavel Solny, Pablo Minguez Gabina, Francesco Cicone, Caroline Stokke, Carlo Chiesa, Maria Paphiti, Boudewijn Brans, Mattias Sandström, Jill Tipping, Mark Konijnenberg and Glenn Flux

    Citation: EJNMMI Physics 2017 4:28

    Content type: Original research

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  14. Semi-quantification methods are well established in the clinic for assisted reporting of (I123) Ioflupane images. Arguably, these are limited diagnostic tools. Recent research has demonstrated the potential fo...

    Authors: Jonathan Christopher Taylor and John Wesley Fenner

    Citation: EJNMMI Physics 2017 4:29

    Content type: Original research

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  15. The European directive on basic safety standards (Council directive 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. The directive comes into operation February 2...

    Authors: Caroline Stokke, Pablo Minguez Gabiña, Pavel Solný, Francesco Cicone, Mattias Sandström, Katarina Sjögreen Gleisner, Carlo Chiesa, Emiliano Spezi, Maria Paphiti, Mark Konijnenberg, Matt Aldridge, Jill Tipping, Michael Wissmeyer, Boudewijn Brans, Klaus Bacher, Carsten Kobe…

    Citation: EJNMMI Physics 2017 4:27

    Content type: Original research

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  16. Quantitative measurement of myocardial blood flow (MBF) is of increasing interest in the clinical assessment of patients with suspected coronary artery disease (CAD). 15O-water positron emission tomography (PET) ...

    Authors: Jonny Nordström, Tanja Kero, Hendrik Johannes Harms, Charles Widström, Frank A. Flachskampf, Jens Sörensen and Mark Lubberink

    Citation: EJNMMI Physics 2017 4:26

    Content type: Original research

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  17. In the planning of selective internal radiation therapy (SIRT) for liver cancer treatment, one major aspect is to determine the prescribed activity and to estimate the resulting absorbed dose inside normal liv...

    Authors: Nadine Spahr, Philipp Schilling, Smita Thoduka, Nasreddin Abolmaali and Andrea Schenk

    Citation: EJNMMI Physics 2017 4:25

    Content type: Original research

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  18. Technetium-99m-hydrazinonicotinamide-Tyr3-octreotide (99mTc-HYNIC-TOC) is recognized as a promising radiopharmaceutical for diagnosing neuroendocrine tumors (NETs). However, 99mTc-HYNIC-TOC dosimetry has been inv...

    Authors: Xinchi Hou, Bozena Birkenfeld, Hanna Piwowarska-Bilska and Anna Celler

    Citation: EJNMMI Physics 2017 4:24

    Content type: Original research

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  19. To date, there is no published detailed checklist with parameters referencing the DICOM tag information with respect to the quality control (QC) of PET/CT scans. The aims of these guidelines are to provide the...

    Authors: Ivalina Hristova, Ronald Boellaard, Paul Galette, Lalitha K. Shankar, Yan Liu, Sigrid Stroobants, Otto S. Hoekstra and Wim J.G. Oyen

    Citation: EJNMMI Physics 2017 4:23

    Content type: Opinion article

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  20. We have previously developed a novel and highly consistent PET segmentation algorithm using a multi-level Otsu method (MO-PET). The aim of this study was to evaluate the reliability of MO-PET compared to conve...

    Authors: Inki Lee, Hyung-Jun Im, Meiyappan Solaiyappan and Steve Y. Cho

    Citation: EJNMMI Physics 2017 4:22

    Content type: Original research

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  21. Implementation of PET/CT in diagnosis of primary prostate cancer (PCa) requires a profound knowledge about the tracer, preferably from a quantitative evaluation. Direct visual comparison of PET/CT slices to wh...

    Authors: F. Schiller, T. Fechter, C. Zamboglou, A. Chirindel, N. Salman, C.A. Jilg, V. Drendel, M. Werner, P.T. Meyer, A.-L. Grosu and M. Mix

    Citation: EJNMMI Physics 2017 4:21

    Content type: Original research

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  22. Developments in single photon emission tomography instrumentation and reconstruction methods present a potential for decreasing acquisition times. One of such recent options for myocardial perfusion imaging (M...

    Authors: Eero Hippeläinen, Teemu Mäkelä, Touko Kaasalainen and Erna Kaleva

    Citation: EJNMMI Physics 2017 4:20

    Content type: Original research

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  23. A prototype anthropomorphic head and neck phantom has been designed to simulate the adult head and neck anatomy including some internal organs and tissues of interest, such as thyroid gland and sentinel lymph ...

    Authors: Mohammed S. Alqahtani, John E. Lees, Sarah L. Bugby, Piyal Samara-Ratna, Aik H. Ng and Alan C. Perkins

    Citation: EJNMMI Physics 2017 4:19

    Content type: Original research

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  24. Robust quantitative analysis in positron emission tomography (PET) and in single-photon emission computed tomography (SPECT) typically requires the time-activity curve as an input function for the pharmacokine...

    Authors: Romain Espagnet, Andrea Frezza, Jean-Pierre Martin, Louis-André Hamel, Laëtitia Lechippey, Jean-Mathieu Beauregard and Philippe Després

    Citation: EJNMMI Physics 2017 4:18

    Content type: Original Research

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  25. This study evaluates the consistency of PET evaluation response criteria in solid tumours (PERCIST) and European Organisation for Research and Treatment of Cancer (EORTC) classification across different recons...

    Authors: Charline Lasnon, Elske Quak, Pierre-Yves Le Roux, Philippe Robin, Michael S. Hofman, David Bourhis, Jason Callahan, David S. Binns, Cédric Desmonts, Pierre-Yves Salaun, Rodney J. Hicks and Nicolas Aide

    Citation: EJNMMI Physics 2017 4:17

    Content type: Original research

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  26. The correction of γ-photon attenuation in PET-MRI remains a critical issue, especially for bone attenuation. This problem is of great importance for brain studies due to the density of the skull. Current techn...

    Authors: Vincent Lebon, Sébastien Jan, Yoann Fontyn, Brice Tiret, Géraldine Pottier, Emilie Jaumain and Julien Valette

    Citation: EJNMMI Physics 2017 4:16

    Content type: Original research

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  27. The year, 2016, marked the 75th anniversary of Dr. Saul Hertz first using radioiodine to treat a patient with thyroid disease. In November of 1936, a luncheon was held of the faculty of Harvard Medical School ...

    Authors: Frederic H. Fahey, Frederick D. Grant and James H. Thrall

    Citation: EJNMMI Physics 2017 4:15

    Content type: Commentary

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  28. A phantom in combination with an imaging protocol was developed to measure the limit of small lesion detection on different PET systems. Seven small spheres with inner diameters ranging from 3.95 up to 15.43 m...

    Authors: Stephen Adler, Jurgen Seidel, Peter Choyke, Michael V. Knopp, Katherine Binzel, Jun Zhang, Craig Barker, Shielah Conant and Roberto Maass-Moreno

    Citation: EJNMMI Physics 2017 4:13

    Content type: Original research

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  29. Accurate PET quantification demands attenuation correction (AC) for both patient and hardware attenuation of the 511 keV annihilation photons. In hybrid PET/MR imaging, AC for stationary hardware components su...

    Authors: Thorsten Heußer, Christopher M. Rank, Yannick Berker, Martin T. Freitag and Marc Kachelrieß

    Citation: EJNMMI Physics 2017 4:12

    Content type: Original Research

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  30. Monolithic scintillators read out by arrays of photodetectors represent a promising solution to obtain high spatial resolution and the depth of interaction (DOI) of the annihilation photon. We have recently in...

    Authors: Matteo Morrocchi, Giovanni Ambrosi, Maria Giuseppina Bisogni, Filippo Bosi, Marco Boretto, Piergiorgio Cerello, Maria Ionica, Ben Liu, Francesco Pennazio, Maria Antonietta Piliero, Giovanni Pirrone, Vasile Postolache, Richard Wheadon and Alberto Del Guerra

    Citation: EJNMMI Physics 2017 4:11

    Content type: Original research

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  31. Our aim was to characterize the influence of time-of-flight (TOF) and point spread function (PSF) recovery corrections, as well as ordered subset expectation maximization (OSEM) reconstruction parameters, in 82Rb...

    Authors: P. Chilra, S. Gnesin, G. Allenbach, M. Monteiro, J. O. Prior, L. Vieira and J. A. Pires Jorge

    Citation: EJNMMI Physics 2017 4:10

    Content type: Original research

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  32. Our aim was to evaluate if a recently introduced TOF PET system with digital photon counting technology (Philips Healthcare), potentially providing an improved image quality over analogue systems, can fulfil E...

    Authors: Daniëlle Koopman, Maureen Groot Koerkamp, Pieter L. Jager, Hester Arkies, Siert Knollema, Cornelis H. Slump, Pedro G. Sanches and Jorn A. van Dalen

    Citation: EJNMMI Physics 2017 4:9

    Content type: Short communication

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  33. [123I]FP-CIT is a well-established radiotracer for the diagnosis of dopaminergic degenerative disorders. The European Normal Control Database of DaTSCAN (ENC-DAT) of healthy controls has provided age and gender-s...

    Authors: Livia Tossici-Bolt, John C. Dickson, Terez Sera, Jan Booij, Susanne Asenbaun-Nan, Maria C. Bagnara, Thierry Vander Borght, Cathrine Jonsson, Robin de Nijs, Swen Hesse, Pierre M. Koulibaly, Umit O. Akdemir, Michel Koole, Klaus Tatsch and Andrea Varrone

    Citation: EJNMMI Physics 2017 4:8

    Content type: Original research

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  34. In order to obtain a reliable 177Lu-DOTATATE therapy dosimetry, it is crucial to acquire accurate and precise activity measurements with the radionuclide calibrator, the SPECT/CT camera, and the NaI(Tl) well coun...

    Authors: Gwennaëlle Marin, Bruno Vanderlinden, Ioannis Karfis, Thomas Guiot, Zena Wimana, Patrick Flamen and Stefaan Vandenberghe

    Citation: EJNMMI Physics 2017 4:7

    Content type: Original research

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  35. Radiolabeled OTSA101, a monoclonal antibody targeting synovial sarcoma (SS) developed by OncoTherapy Science, was used to treat relapsing SS metastases following a theranostic procedure: in case of significant 11...

    Authors: David Sarrut, Jean-Noël Badel, Adrien Halty, Gwenaelle Garin, David Perol, Philippe Cassier, Jean-Yves Blay, David Kryza and Anne-Laure Giraudet

    Citation: EJNMMI Physics 2017 4:6

    Content type: Original Research

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  36. Simultaneous cardiac perfusion studies are an increasing trend in PET-MR imaging. During dynamic PET imaging, the introduction of gadolinium-based MR contrast agents (GBCA) at high concentrations during a dual...

    Authors: Jim O’ Doherty and Paul Schleyer

    Citation: EJNMMI Physics 2017 4:4

    Content type: Short communication

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  37. Patients with somatostatin receptor-expressing neuroendocrine tumours can be treated with intravenously administered 177Lu-octreotate. Few patients are cured with the present protocol due to the current dose limi...

    Authors: Viktor Sandblom, Ingun Ståhl, Roger Olofsson Bagge and Eva Forssell-Aronsson

    Citation: EJNMMI Physics 2017 4:3

    Content type: Original research

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  38. The aim of the study is to assess accuracy of activity quantification of 177Lu studies performed according to recommendations provided by the committee on Medical Internal Radiation Dose (MIRD) pamphlets 23 and 2...

    Authors: Carlos F. Uribe, Pedro L. Esquinas, Jesse Tanguay, Marjorie Gonzalez, Emilie Gaudin, Jean-Mathieu Beauregard and Anna Celler

    Citation: EJNMMI Physics 2017 4:2

    Content type: Original research

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  39. The use of integrated PET-MR offers new opportunities for comprehensive assessment of cardiac morphology and function. However, little is known on the quantitative accuracy of cardiac PET imaging with integrat...

    Authors: Tanja Kero, Jonny Nordström, Hendrik J. Harms, Jens Sörensen, Håkan Ahlström and Mark Lubberink

    Citation: EJNMMI Physics 2017 4:1

    Content type: Original research

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  40. The convolution approach to thyroid time-activity curve (TAC) data fitting with a gamma distribution convolution (GDC) TAC model following bolus intravenous injection is presented and applied to 99mTc-MIBI data. ...

    Authors: Carl A. Wesolowski, Surajith N. Wanasundara, Michal J. Wesolowski, Belkis Erbas and Paul S. Babyn

    Citation: EJNMMI Physics 2016 3:31

    Content type: Original research

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  41. [18F]HX4 is a promising new PET tracer developed to identify hypoxic areas in tumor tissue. This study analyzes [18F]HX4 kinetics and assesses the performance of simplified methods for quantification of [18F]HX4 ...

    Authors: E. E. Verwer, C. M. L. Zegers, W. van Elmpt, R. Wierts, A. D. Windhorst, F. M. Mottaghy, P. Lambin and R. Boellaard

    Citation: EJNMMI Physics 2016 3:30

    Content type: Original research

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  42. Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nea...

    Authors: Wietske Woliner-van der Weg, Laura N. Deden, Antoi P. W. Meeuwis, Maaike Koenrades, Laura H. C. Peeters, Henny Kuipers, Geert Jan Laanstra, Martin Gotthardt, Cornelis H. Slump and Eric P. Visser

    Citation: EJNMMI Physics 2016 3:29

    Content type: Original Research

    Published on:

  43. Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) is now a routine procedure for the management of cancer patients. Intravenous administration of FDG is sometimes halted due to troubles. In suc...

    Authors: Kenta Sakaguchi, Makoto Hosono, Tomomi Imamura, Naomi Takahara, Misa Hayashi, Yuko Yakushiji, Kazunari Ishii, Tatsuro Uto and Takamichi Murakami

    Citation: EJNMMI Physics 2016 3:28

    Content type: Original research

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  44. The impact of increased energy resolution of cadmium–zinc–telluride (CZT) cameras on the assessment of left ventricular function under dual-isotope conditions (99mTc and 123I) remains unknown.

    Authors: Tanguy Blaire, Alban Bailliez, Fayçal Ben Bouallegue, Dimitri Bellevre, Denis Agostini and Alain Manrique

    Citation: EJNMMI Physics 2016 3:27

    Content type: Original research

    Published on:

  45. The point spread function (PSF) of positron emission tomography (PET) depends on the position across the field of view (FOV). Reconstruction based on PSF improves spatial resolution and quantitative accuracy. ...

    Authors: Taisuke Murata, Kenta Miwa, Noriaki Miyaji, Kei Wagatsuma, Tomoyuki Hasegawa, Keiichi Oda, Takuro Umeda, Takashi Iimori, Yoshitada Masuda, Takashi Terauchi and Mitsuru Koizumi

    Citation: EJNMMI Physics 2016 3:26

    Content type: Original article

    Published on:

  46. Both enantiomers of [18F]flubatine are new radioligands for neuroimaging of α4β2 nicotinic acetylcholine receptors with positron emission tomography (PET) exhibiting promising pharmacokinetics which makes them at...

    Authors: Mathias Kranz, Bernhard Sattler, Solveig Tiepolt, Stephan Wilke, Winnie Deuther-Conrad, Cornelius K. Donat, Steffen Fischer, Marianne Patt, Andreas Schildan, Jörg Patt, René Smits, Alexander Hoepping, Jörg Steinbach, Osama Sabri and Peter Brust

    Citation: EJNMMI Physics 2016 3:25

    Content type: Original research

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  47. Recent advancements in PET instrumentation have made the non-invasive assessment of cardiovascular function in small animals a reality. The majority of small animal PET systems use stationary detector gantries...

    Authors: Paul R. Territo, Amanda A. Riley, Brian P. McCarthy and Gary D. Hutchins

    Citation: EJNMMI Physics 2016 3:24

    Content type: Short communication

    Published on:

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