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  1. Original research

    Accuracy of 177Lu activity quantification in SPECT imaging: a phantom study

    The aim of the study is to assess accuracy of activity quantification of 177Lu studies performed according to recommendations provided by the committee on Medical Internal Radiation Dose (MIRD) pamphlets 23 and 2...

    Carlos F. Uribe, Pedro L. Esquinas, Jesse Tanguay, Marjorie Gonzalez, Emilie Gaudin, Jean-Mathieu Beauregard and Anna Celler

    EJNMMI Physics 2017 4:2

    Published on: 7 January 2017

  2. Original research

    Quantitative myocardial blood flow imaging with integrated time-of-flight PET-MR

    The use of integrated PET-MR offers new opportunities for comprehensive assessment of cardiac morphology and function. However, little is known on the quantitative accuracy of cardiac PET imaging with integrat...

    Tanja Kero, Jonny Nordström, Hendrik J. Harms, Jens Sörensen, Håkan Ahlström and Mark Lubberink

    EJNMMI Physics 2017 4:1

    Published on: 6 January 2017

  3. Original research

    A gamma-distribution convolution model of 99mTc-MIBI thyroid time-activity curves

    The convolution approach to thyroid time-activity curve (TAC) data fitting with a gamma distribution convolution (GDC) TAC model following bolus intravenous injection is presented and applied to 99mTc-MIBI data. ...

    Carl A. Wesolowski, Surajith N. Wanasundara, Michal J. Wesolowski, Belkis Erbas and Paul S. Babyn

    EJNMMI Physics 2016 3:31

    Published on: 16 December 2016

  4. Original research

    Pharmacokinetic modeling of a novel hypoxia PET tracer [18F]HX4 in patients with non-small cell lung cancer

    [18F]HX4 is a promising new PET tracer developed to identify hypoxic areas in tumor tissue. This study analyzes [18F]HX4 kinetics and assesses the performance of simplified methods for quantification of [18F]HX4 ...

    E. E. Verwer, C. M. L. Zegers, W. van Elmpt, R. Wierts, A. D. Windhorst, F. M. Mottaghy, P. Lambin and R. Boellaard

    EJNMMI Physics 2016 3:30

    Published on: 12 December 2016

  5. Original Research

    A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin

    Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nea...

    Wietske Woliner-van der Weg, Laura N. Deden, Antoi P. W. Meeuwis, Maaike Koenrades, Laura H. C. Peeters, Henny Kuipers, Geert Jan Laanstra, Martin Gotthardt, Cornelis H. Slump and Eric P. Visser

    EJNMMI Physics 2016 3:29

    Published on: 7 December 2016

  6. Original research

    Estimation of activity of administered 18F-fluorodeoxyglucose by measurement of the dose equivalent rate on the right temporal region of the head

    Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) is now a routine procedure for the management of cancer patients. Intravenous administration of FDG is sometimes halted due to troubles. In suc...

    Kenta Sakaguchi, Makoto Hosono, Tomomi Imamura, Naomi Takahara, Misa Hayashi, Yuko Yakushiji, Kazunari Ishii, Tatsuro Uto and Takamichi Murakami

    EJNMMI Physics 2016 3:28

    Published on: 14 November 2016

  7. Original research

    Left ventricular function assessment using 123I/99mTc dual-isotope acquisition with two semi-conductor cadmium–zinc–telluride (CZT) cameras: a gated cardiac phantom study

    The impact of increased energy resolution of cadmium–zinc–telluride (CZT) cameras on the assessment of left ventricular function under dual-isotope conditions (99mTc and 123I) remains unknown.

    Tanguy Blaire, Alban Bailliez, Fayçal Ben Bouallegue, Dimitri Bellevre, Denis Agostini and Alain Manrique

    EJNMMI Physics 2016 3:27

    Published on: 11 November 2016

  8. Original article

    Evaluation of spatial dependence of point spread function-based PET reconstruction using a traceable point-like 22Na source

    The point spread function (PSF) of positron emission tomography (PET) depends on the position across the field of view (FOV). Reconstruction based on PSF improves spatial resolution and quantitative accuracy. ...

    Taisuke Murata, Kenta Miwa, Noriaki Miyaji, Kei Wagatsuma, Tomoyuki Hasegawa, Keiichi Oda, Takuro Umeda, Takashi Iimori, Yoshitada Masuda, Takashi Terauchi and Mitsuru Koizumi

    EJNMMI Physics 2016 3:26

    Published on: 26 October 2016

  9. Original research

    Radiation dosimetry of the α4β2 nicotinic receptor ligand (+)-[18F]flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results

    Both enantiomers of [18F]flubatine are new radioligands for neuroimaging of α4β2 nicotinic acetylcholine receptors with positron emission tomography (PET) exhibiting promising pharmacokinetics which makes them at...

    Mathias Kranz, Bernhard Sattler, Solveig Tiepolt, Stephan Wilke, Winnie Deuther-Conrad, Cornelius K. Donat, Steffen Fischer, Marianne Patt, Andreas Schildan, Jörg Patt, René Smits, Alexander Hoepping, Jörg Steinbach, Osama Sabri and Peter Brust

    EJNMMI Physics 2016 3:25

    Published on: 21 October 2016

  10. Original research

    Technical note: how to determine the FDG activity for tumour PET imaging that satisfies European guidelines

    For tumour imaging with PET, the literature proposes to administer a patient-specific FDG activity that depends quadratically on a patient’s body weight. However, a practical approach on how to implement such ...

    Daniëlle Koopman, Jochen A. C. van Osch, Pieter L. Jager, Carlijn J. A. Tenbergen, Siert Knollema, Cornelis H. Slump and Jorn A. van Dalen

    EJNMMI Physics 2016 3:22

    Published on: 29 September 2016

  11. Original research

    A novel planar image-based method for bone marrow dosimetry in 177Lu-DOTATATE treatment correlates with haematological toxicity

    177Lu-DOTATATE is a valuable treatment option for patients with advanced neuroendocrine tumours overexpressing somatostatin receptors. Though well tolerated in general, bone marrow to...

    Johanna Svensson, Tobias Rydén, Linn Hagmarker, Jens Hemmingsson, Bo Wängberg and Peter Bernhardt

    EJNMMI Physics 2016 3:21

    Published on: 22 September 2016

  12. Original research

    Multimodality calibration for simultaneous fluoroscopic and nuclear imaging

    Simultaneous real-time fluoroscopic and nuclear imaging could benefit image-guided (oncological) procedures. To this end, a hybrid modality is currently being developed by our group, by combining a c-arm with ...

    Casper Beijst, Mattijs Elschot, Sandra van der Velden and Hugo W. A. M. de Jong

    EJNMMI Physics 2016 3:20

    Published on: 30 August 2016

  13. Review

    An overview of CEST MRI for non-MR physicists

    The search for novel image contrasts has been a major driving force in the magnetic resonance (MR) research community, in order to gain further information on the body’s physiological and pathological conditions.

    B. Wu, G. Warnock, M. Zaiss, C. Lin, M. Chen, Z. Zhou, L. Mu, D. Nanz, R. Tuura and G. Delso

    EJNMMI Physics 2016 3:19

    Published on: 26 August 2016

  14. Short communication

    A robust conversion method of radioactivities between plastic and NaI scintillation well counters for long-term quality control and quality assurance

    The purpose of this study is to specify a simple procedure for a robust data conversion of radioactivity value between plastic scintillator (PL) and NaI scintillator (NaI) devices.

    Takeshi Hara, Tadahiko Ishihara, Takahiko Asano, Masayuki Matsuo, Tetsuro Katafuchi and Hiroshi Fujita

    EJNMMI Physics 2016 3:18

    Published on: 15 August 2016

  15. Original research

    Abdo-Man: a 3D-printed anthropomorphic phantom for validating quantitative SIRT

    The use of selective internal radiation therapy (SIRT) is rapidly increasing, and the need for quantification and dosimetry is becoming more widespread to facilitate treatment planning and verification. The ai...

    Jonathan I. Gear, Craig Cummings, Allison J. Craig, Antigoni Divoli, Clive D. C. Long, Michael Tapner and Glenn D. Flux

    EJNMMI Physics 2016 3:17

    Published on: 5 August 2016

  16. Original research

    Effect of dosimeter’s position on occupational radiation extremity dose measurement for nuclear medicine workers during 18F-FDG preparation for PET/CT

    The recent spread of positron emission tomography-computed tomography (PET/CT) poses extremity dosimetry challenges. The question arose whether the radiation dose measured by the ring thermoluminescent dosimet...

    Fabien Salesses, Paul Perez, Aline E. Maillard, Julie Blanchard, Sabine Mallard and Laurence Bordenave

    EJNMMI Physics 2016 3:16

    Published on: 5 August 2016

  17. Original research

    Radiation exposure of the spleen during 177Lu-DOTATATE treatment and its correlation with haematological toxicity and spleen volume

    Somatostatin analogue-based radionuclide therapy with 177Lu-DOTATATE is an important treatment option for patients with advanced neuroendocrine tumours overexpressing somatostatin receptors. In addition to the ki...

    Johanna Svensson, Linn Hagmarker, Tobias Magnander, Bo Wängberg and Peter Bernhardt

    EJNMMI Physics 2016 3:15

    Published on: 5 August 2016

  18. Original research

    A study of SPECT/CT camera stability for quantitative imaging

    The purpose of this study was twofold: to evaluate the quantitative stability of a SPECT/CT gamma camera over time and to determine if daily flood acquisitions can reliably serve as calibration factors for qua...

    Wendy A. McDougald, Robert S. Miyaoka, Adam M. Alessio, Robert L. Harrison and Thomas K. Lewellen

    EJNMMI Physics 2016 3:14

    Published on: 29 July 2016

  19. Original Research

    Organ-specific SPECT activity calibration using 3D printed phantoms for molecular radiotherapy dosimetry

    Patient-specific absorbed dose calculations for molecular radiotherapy require accurate activity quantification. This is commonly derived from Single-Photon Emission Computed Tomography (SPECT) imaging using a...

    Andrew P. Robinson, Jill Tipping, David M. Cullen, David Hamilton, Richard Brown, Alex Flynn, Christopher Oldfield, Emma Page, Emlyn Price, Andrew Smith and Richard Snee

    EJNMMI Physics 2016 3:12

    Published on: 13 July 2016

  20. Original research

    Simultaneous Tc-99m and I-123 dual-radionuclide imaging with a solid-state detector-based brain-SPECT system and energy-based scatter correction

    A brain single-photon emission computed tomography (SPECT) system using cadmium telluride (CdTe) solid-state detectors was previously developed. This CdTe-SPECT system is suitable for simultaneous dual-radionu...

    Wataru Takeuchi, Atsuro Suzuki, Tohru Shiga, Naoki Kubo, Yuichi Morimoto, Yuichiro Ueno, Keiji Kobashi, Kikuo Umegaki and Nagara Tamaki

    EJNMMI Physics 2016 3:10

    Published on: 29 June 2016

  21. Original Research

    Lesion quantification and detection in myocardial 18F-FDG PET using edge-preserving priors and anatomical information from CT and MRI: a simulation study

    The limited spatial resolution of the clinical PET scanners results in image blurring and does not allow for accurate quantification of very thin or small structures (known as partial volume effect). In cardiac i...

    Anna Turco, Johan Nuyts, Olivier Gheysens, Jürgen Duchenne, Jens-Uwe Voigt, Piet Claus and Kathleen Vunckx

    EJNMMI Physics 2016 3:9

    Published on: 17 June 2016

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