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EJNMMI Physics
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  1. Silicon photomultiplier-positron emission tomography (SiPM-PET) has better sensitivity, spatial resolution, and timing resolution than photomultiplier tube (PMT)-PET. The present study aimed to clarify the adv...

    Authors: Kei Wagatsuma, Muneyuki Sakata, Kenji Ishibashi, Akira Hirayama, Hirofumi Kawakami, Kenta Miwa, Yukihisa Suzuki and Kenji Ishii

    Citation: EJNMMI Physics 2020 7:70

    Content type: Original research

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  2. Personalized molecular radiotherapy based on theragnostics requires accurate quantification of the amount of radiopharmaceutical activity administered to patients both in diagnostic and therapeutic application...

    Authors: Clarita Saldarriaga Vargas, Matthias Bauwens, Ivo N. A. Pooters, Stefaan Pommé, Steffie M. B. Peters, Marcel Segbers, Walter Jentzen, Andreas Vogg, Floris H. P. van Velden, Sebastiaan L. Meyer Viol, Martin Gotthardt, Felix M. Mottaghy, Joachim E. Wildberger, Peter Covens and Roel Wierts

    Citation: EJNMMI Physics 2020 7:69

    Content type: Original research

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  3. Attenuation correction of PET/MRI is a remaining problem for whole-body PET/MRI. The statistical decomposition algorithm (SDA) is a probabilistic atlas-based method that calculates synthetic CTs from T2-weight...

    Authors: Elin Wallstén, Jan Axelsson, Joakim Jonsson, Camilla Thellenberg Karlsson, Tufve Nyholm and Anne Larsson

    Citation: EJNMMI Physics 2020 7:68

    Content type: Original research

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  4. Arterial blood sampling is the gold standard method to obtain the arterial input function (AIF) for quantification of whole body (WB) dynamic 18F-FDG PET imaging. However, this procedure is invasive and not typic...

    Authors: Mika Naganawa, Jean-Dominique Gallezot, Vijay Shah, Tim Mulnix, Colin Young, Mark Dias, Ming-Kai Chen, Anne M. Smith and Richard E. Carson

    Citation: EJNMMI Physics 2020 7:67

    Content type: Original research

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  5. Halo artifacts from urinary catheters can occur due to inaccurate scatter correction, and the artifacts affect the tumor visibility in 18F-FDG PET/CT images. We investigated the incidence rate and the mechanisms ...

    Authors: Keiichi Magota, Naoto Numata, Daiki Shinyama, Junya Katahata, Yamato Munakata, Piotr J. Maniawski, Kentaro Kobayashi, Osamu Manabe, Kenji Hirata, Ukihide Tateishi, Kohsuke Kudo and Tohru Shiga

    Citation: EJNMMI Physics 2020 7:66

    Content type: Original research

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  6. The aim of this study was to compare brain perfusion SPECT obtained from a 360° CZT and a conventional Anger camera.

    Authors: Manon Bordonne, Mohammad B. Chawki, Pierre-Yves Marie, Timothée Zaragori, Véronique Roch, Rachel Grignon, Laetitia Imbert and Antoine Verger

    Citation: EJNMMI Physics 2020 7:65

    Content type: Original research

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  7. Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These syst...

    Authors: Jan V. Hoffmann, Jan P. Janssen, Takayuki Kanno, Takayuki Shibutani, Masahisa Onoguchi, Constantin Lapa, Jan-Peter Grunz, Andreas K. Buck and Takahiro Higuchi

    Citation: EJNMMI Physics 2020 7:64

    Content type: Original research

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  8. Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly igno...

    Authors: Domenico Finocchiaro, Jonathan I. Gear, Federica Fioroni, Glenn D. Flux, Iain Murray, Gastone Castellani, Annibale Versari, Mauro Iori and Elisa Grassi

    Citation: EJNMMI Physics 2020 7:63

    Content type: Original research

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  9. The CT of PET CT provides diagnostic information, anatomic localisation and attenuation correction (AC). When only AC is required, very lose dose CT is desirable. CT iterative reconstruction (IR) improves imag...

    Authors: Ivan Ho Shon, Christopher Reece, Thomas Hennessy, Megan Horsfield and Bruce McBride

    Citation: EJNMMI Physics 2020 7:62

    Content type: Original research

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  10. Differentiated thyroid cancer has been treated with radioiodine for almost 80 years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresol...

    Authors: Jan Taprogge, Francesca Leek, Tino Schurrat, Johannes Tran-Gia, Delphine Vallot, Manuel Bardiès, Uta Eberlein, Michael Lassmann, Susanne Schlögl, Alex Vergara Gil and Glenn D. Flux

    Citation: EJNMMI Physics 2020 7:61

    Content type: Original research

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  11. This article presents a new perspective on the development of inorganic scintillator-based fiber dosimeters (IOSFDs) for medical radiotherapy dosimetry (RTD) focusing on real-time in vivo dosimetry. The scinti...

    Authors: Liang Ding, Qiong Wu, Qun Wang, Yamei Li, Richard M. Perks and Liang Zhao

    Citation: EJNMMI Physics 2020 7:60

    Content type: Review

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  12. Quantitative evaluation of amyloid positron emission tomography (PET) with standardized uptake value ratio (SUVR) plays a key role in clinical studies of Alzheimer’s disease (AD). We have proposed a PET-only (...

    Authors: Yuma Tsubaki, Go Akamatsu, Natsumi Shimokawa, Suguru Katsube, Aya Takashima and Masayuki Sasaki

    Citation: EJNMMI Physics 2020 7:59

    Content type: Young investigators

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  13. 211At is one of the ideal nuclides for targeted radionuclide therapies (TRTs). Meta-[211At]astatobenzylguanidine (211At-MABG) has been proposed for the treatment of pheochromocytoma. To effectively use these radi...

    Authors: Naoyuki Ukon, Songji Zhao, Kohshin Washiyama, Noboru Oriuchi, Chengbo Tan, Saki Shimoyama, Miho Aoki, Hitoshi Kubo, Kazuhiro Takahashi and Hiroshi Ito

    Citation: EJNMMI Physics 2020 7:58

    Content type: Original research

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  14. Novel partial volume correction (PVC) algorithms have been validated by assuming ideal conditions of image processing; however, in real clinical PET studies, the input datasets include error sources which caus...

    Authors: Senri Oyama, Ayumu Hosoi, Masanobu Ibaraki, Colm J. McGinnity, Keisuke Matsubara, Shoichi Watanuki, Hiroshi Watabe, Manabu Tashiro and Miho Shidahara

    Citation: EJNMMI Physics 2020 7:57

    Content type: Original research

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  15. The Bayesian penalized likelihood (BPL) algorithm Q.Clear (GE Healthcare) allows fully convergent iterative reconstruction that results in better image quality and quantitative accuracy, while limiting image n...

    Authors: Tokiya Yoshii, Kenta Miwa, Masashi Yamaguchi, Kai Shimada, Kei Wagatsuma, Tensho Yamao, Yuto Kamitaka, Seiya Hiratsuka, Rinya Kobayashi, Hajime Ichikawa, Noriaki Miyaji, Tsuyoshi Miyazaki and Kenji Ishii

    Citation: EJNMMI Physics 2020 7:56

    Content type: Original research

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  16. The purpose of this work was to propose an approach based on noise measurement to adapt present clinical acquisition and reconstruction parameters adapted to a PMT-based system (Biograph mCT) to a SiPM-based s...

    Authors: Thomas Carlier, Ludovic Ferrer, Maurizio Conti, Caroline Bodet-Milin, Caroline Rousseau, Yanic Bercier, Bernard Bendriem and Françoise Kraeber-Bodéré

    Citation: EJNMMI Physics 2020 7:55

    Content type: Original research

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  17. In this study, we investigate the impact of increased PET acquisition time per bed position on lesion detectability, standard uptake value, and image noise in 68Ga-PSMA-11 PET/MRI scans.

    Authors: Vishnu Murthy, Raven L. Smith, Dora H. Tao, Courtney A. Lawhn-Heath, Dave E. Korenchan, Peder E. Z. Larson, Robert R. Flavell and Thomas A. Hope

    Citation: EJNMMI Physics 2020 7:54

    Content type: Original research

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  19. The combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) (PET-MRI) is a unique hybrid imaging modality mainly used in oncology and neurology. The MRI-based attenuation correct...

    Authors: Johanna Harries, Thies H. Jochimsen, Thomas Scholz, Tina Schlender, Henryk Barthel, Osama Sabri and Bernhard Sattler

    Citation: EJNMMI Physics 2020 7:52

    Content type: Original research

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  20. Artificial intelligence (AI) is about to transform medical imaging. The Research Consortium for Medical Image Analysis (RECOMIA), a not-for-profit organisation, has developed an online platform to facilitate c...

    Authors: Elin Trägårdh, Pablo Borrelli, Reza Kaboteh, Tony Gillberg, Johannes Ulén, Olof Enqvist and Lars Edenbrandt

    Citation: EJNMMI Physics 2020 7:51

    Content type: Original research

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  21. In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemi...

    Authors: Chang-Hoon Choi, Carina Stegmayr, Aliaksandra Shymanskaya, Wieland A. Worthoff, Nuno A. da Silva, Jörg Felder, Karl-Josef Langen and N. Jon Shah

    Citation: EJNMMI Physics 2020 7:50

    Content type: Original research

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  22. Myocardial perfusion imaging is a commonly performed SPECT protocol and hence it would be beneficial if its scan duration could be shortened. For traditional gamma cameras, two developments have separately sho...

    Authors: Martijn M. A. Dietze, Britt Kunnen, Martina Stella and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2020 7:49

    Content type: Original research

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  23. Accurate dosimetry is essential in radioembolization. To this purpose, an automatic protocol for healthy liver dosimetry based on dual isotope (DI) SPECT imaging, combining holmium-166 (166Ho)-microspheres, and t...

    Authors: M. Stella, AJAT Braat, MGEH Lam, HWAM de Jong and R. van Rooij

    Citation: EJNMMI Physics 2020 7:48

    Content type: Original research

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  24. An amendment to this paper has been published and can be accessed via the original article.

    Authors: J. E. Mackewn, J. Stirling, S. Jeljeli, S-M Gould, R. I. Johnstone, I. Merida, L. C. Pike, C. J. McGinnity, K. Beck, O. Howes, A. Hammers and P. K. Marsden

    Citation: EJNMMI Physics 2020 7:47

    Content type: Correction

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    The original article was published in EJNMMI Physics 2020 7:24

  26. It has been proposed, and preclinically demonstrated, that 161Tb is a better alternative to 177Lu for the treatment of small prostate cancer lesions due to its high emission of low-energy electrons. 161Tb also em...

    Authors: I. Marin, T. Rydèn, M. Van Essen, J. Svensson, N. Gracheva, U. Köster, J. R. Zeevaart, N. P. van der Meulen, C. Müller and P. Bernhardt

    Citation: EJNMMI Physics 2020 7:45

    Content type: Original research

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  27. In living organisms, the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conv...

    Authors: P. Moskal, D. Kisielewska, R. Y. Shopa, Z. Bura, J. Chhokar, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, R. Del Grande, B. C. Hiesmayr, B. Jasińska, K. Kacprzak…

    Citation: EJNMMI Physics 2020 7:44

    Content type: Original Research

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  29. Time-of-flight (TOF) positron emission tomography (PET) scanners can provide significant benefits by improving the noise properties of reconstructed images. In order to achieve this, the timing response of the...

    Authors: Nikos Efthimiou, Kris Thielemans, Elise Emond, Chris Cawthorne, Stephen J. Archibald and Charalampos Tsoumpas

    Citation: EJNMMI Physics 2020 7:42

    Content type: Original research

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  30. Individualized dosimetry is recommended for [177Lu]Lu-PSMA radioligand therapy (RLT) which is resource-intensive and protocols are often not optimized. Therefore, a simulation study was performed focusing on the ...

    Authors: Andreas Rinscheid, Peter Kletting, Matthias Eiber, Ambros J. Beer and Gerhard Glatting

    Citation: EJNMMI Physics 2020 7:41

    Content type: Original research

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  31. Block-sequential regularized expectation maximization (BSREM) is a fully convergent iterative image reconstruction algorithm. We hypothesize that tracers with different distribution patterns will result in dif...

    Authors: Elin Lindström, Lars Lindsjö, Anders Sundin, Jens Sörensen and Mark Lubberink

    Citation: EJNMMI Physics 2020 7:40

    Content type: Original research

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  32. The time-over-threshold (TOT) technique is being used widely due to itsimplications in developing the multi-channel readouts, mainly when fast signal processing is required. Using the TOT technique, as a measu...

    Authors: S. Sharma, J. Chhokar, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, N. Gupta-Sharma, R. Del Grande, B.C. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, H. Karimi…

    Citation: EJNMMI Physics 2020 7:39

    Content type: Original Research

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  33. Prostate cancer (PCa) represents one of the most common types of cancers facing the male population. Nowadays, to confirm PCa, systematic or multiparametric MRI-targeted transrectal or transperineal biopsies o...

    Authors: Gabriel Cañizares, Andrea Gonzalez-Montoro, Marta Freire, Efthymios Lamprou, John Barrio, Filomeno Sanchez, José M. Benlloch, Liczandro Hernandez, Laura Moliner, Luis F. Vidal, Irene Torres, Pablo Sopena, Cesar D. Vera-Donoso, Pilar Bello, Julio Barbera and Antonio J. Gonzalez

    Citation: EJNMMI Physics 2020 7:38

    Content type: Original research

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  34. Iodine-125 (125I) seeds can be used as landmarks to locate non-palpable breast lesions instead of implanting metal wires. This relatively new technique requires a nuclear probe usually used for technetium-99m (99...

    Authors: Christopher Hoog, Pierre-Malick Koulibaly, Catherine Dejean, Tom Desdoits, Olivier Humbert, Emmanuel Barranger and Jacques Darcourt

    Citation: EJNMMI Physics 2020 7:37

    Content type: Original research

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  35. Dosimetry after peptide receptor radionuclide therapy (PRRT) is increasing; however, comparing or pooling of dosimetric results can be challenging since different approaches are used. The aim of this study was...

    Authors: Daphne M. V. Huizing, Steffie M. B. Peters, Michelle W. J. Versleijen, Esther Martens, Marcel Verheij, Michiel Sinaasappel, Marcel P. M. Stokkel and Berlinda J. de Wit-van der Veen

    Citation: EJNMMI Physics 2020 7:36

    Content type: Original research

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  36. The idea of a very sensitive positron emission tomography (PET) system covering a large portion of the body of a patient already dates back to the early 1990s. In the period 2000–2010, only some prototypes wit...

    Authors: Stefaan Vandenberghe, Pawel Moskal and Joel S. Karp

    Citation: EJNMMI Physics 2020 7:35

    Content type: Review

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  37. This study investigated the impact of the size of the normal database on the classification performance of the specific binding ratio (SBR) in dopamine transporter (DAT) SPECT with [123I]FP-CIT in different setti...

    Authors: Helen Schmitz-Steinkrüger, Catharina Lange, Ivayla Apostolova, Holger Amthauer, Wencke Lehnert, Susanne Klutmann and Ralph Buchert

    Citation: EJNMMI Physics 2020 7:34

    Content type: Original research

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  38. Targeted radionuclide therapy (TRT) is gaining importance. For TRT to be also used as adjuvant therapy or for treating minimal residual disease, there is a need to increase the radiation dose to small tumours....

    Authors: Mario E. Alcocer-Ávila, Aymeric Ferreira, Michele A. Quinto, Clément Morgat, Elif Hindié and Christophe Champion

    Citation: EJNMMI Physics 2020 7:33

    Content type: Original Research

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  39. Dead time may affect the accuracy of quantitative SPECT (QPSECT), and thus of dosimetry. The aim of this study was to quantify the effect of dead time on 177Lu-QSPECT and renal dosimetry following peptide recepto...

    Authors: Alessandro Desy, Guillaume F. Bouvet, Andrea Frezza, Philippe Després and Jean-Mathieu Beauregard

    Citation: EJNMMI Physics 2020 7:32

    Content type: Short communication

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  40. Prostate-specific membrane antigen (PSMA) radiotracers such as [18F]PSMA-1007 used with positron emission tomography-computed tomography (PET-CT) is promising for initial staging and detection of recurrent diseas...

    Authors: Elin Trägårdh, David Minarik, Gustav Brolin, Ulrika Bitzén, Berit Olsson and Jenny Oddstig

    Citation: EJNMMI Physics 2020 7:31

    Content type: Original research

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  41. Quantitative imaging biomarkers are becoming usual in oncology for assessing therapy response. The harmonization of image quantitation reporting has become of utmost importance due to the multi-center trials i...

    Authors: Delphine Vallot, Elena De Ponti, Sabrina Morzenti, Anna Gramek, Anna Pieczonka, Gabriel Reynés Llompart, Jakub Siennicki, Paul Deak, Chiranjib Dutta, Jorge Uribe and Olivier Caselles

    Citation: EJNMMI Physics 2020 7:30

    Content type: Original research

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  42. Strong correlation has been demonstrated between tumor dose and response and between healthy liver dose and side effects. Individualized dosimetry is increasingly recommended in the current clinical routine. H...

    Authors: Nicolas Meyers, Alexandre Jadoul, Claire Bernard, Jean Delwaide, Anne Lamproye, Olivier Detry, Pierre Honoré, Laurent Gerard and Roland Hustinx

    Citation: EJNMMI Physics 2020 7:29

    Content type: Original research

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  43. To determine the impact of the Bayesian penalized likelihood (BPL) reconstruction algorithm in comparison to OSEM on hypoxia PET/CT images of NSCLC using 18F-MIZO and 18F-FAZA.

    Authors: Edgar Texte, Pierrick Gouel, Sébastien Thureau, Justine Lequesne, Bertrand Barres, Agathe Edet-Sanson, Pierre Decazes, Pierre Vera and Sébastien Hapdey

    Citation: EJNMMI Physics 2020 7:28

    Content type: Original research

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  44. For therapeutic applications of several isotopes (e.g., 131I, 153Sm, 177Lu) in nuclear medicine, the high activities typically applied require accurate dead time correction in early time point imaging. We present...

    Authors: Jan W. T. Heemskerk and Michel Defrise

    Citation: EJNMMI Physics 2020 7:27

    Content type: Original research

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  45. Over recent years, peptide receptor radiotherapy (PRRT) has been recognized as an effective treatment for patients with metastatic neuroendocrine tumors (NETs). Personalized dosimetry can contribute to improve...

    Authors: Nanette Freedman, Mattias Sandström, Jonathan Kuten, Natan Shtraus, Inna Ospovat, Albert Schlocker and Einat Even-Sapir

    Citation: EJNMMI Physics 2020 7:26

    Content type: Short communication

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  46. Arterial sampling in PET studies for the purposes of kinetic modeling remains an invasive, time-intensive, and expensive procedure. Alternatives to derive the blood time-activity curve (BTAC) non-invasively ar...

    Authors: Yassine Toufique, Othmane Bouhali, Pauline Negre and Jim O’ Doherty

    Citation: EJNMMI Physics 2020 7:25

    Content type: Original research

    Published on:

  47. Despite the advent of clinical PET-MR imaging for routine use in 2011 and the development of several methods to address the problem of attenuation correction, some challenges remain. We have identified and inv...

    Authors: J. E. Mackewn, J. Stirling, S. Jeljeli, S-M. Gould, R. I. Johnstone, I. Merida, L. C. Pike, C. J. McGinnity, K. Beck, O. Howes, A. Hammers and P. K. Marsden

    Citation: EJNMMI Physics 2020 7:24

    Content type: Original research

    Published on:

    The Correction to this article has been published in EJNMMI Physics 2020 7:47

  48. A GATE Monte Carlo model of the Philips Vereos digital photon counting PET imaging system using silicon photo-multiplier detectors was proposed. It was evaluated against experimental data in accordance with NE...

    Authors: Julien Salvadori, Joey Labour, Freddy Odille, Pierre-Yves Marie, Jean-Noël Badel, Laëtitia Imbert and David Sarrut

    Citation: EJNMMI Physics 2020 7:23

    Content type: Original Research

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  49. For multicenter clinical studies, PET/CT and SPECT/CT scanners need to be validated to ensure comparability between various scanner types and brands. This validation is usually performed using hollow phantoms ...

    Authors: Tilman Läppchen, Lorenz P. Meier, Markus Fürstner, George A. Prenosil, Thomas Krause, Axel Rominger, Bernd Klaeser and Michael Hentschel

    Citation: EJNMMI Physics 2020 7:22

    Content type: Original research

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  50. Optimization of injected gallium-68 (68Ga) activity for 68Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (68Ga-PSMA PET/CT) studies is relevant for image quality, radiation...

    Authors: J. Wielaard, J. B. A. Habraken, P. Brinks, J. Lavalaye and R. Boellaard

    Citation: EJNMMI Physics 2020 7:20

    Content type: Original research

    Published on:

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