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EJNMMI Physics
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  1. Early cancer detection is crucial for patients’ survival. The image quality in 111In-octreotide SPECT imaging could be improved by using Monte Carlo (MC)-based reconstruction. The aim of this observational study ...

    Authors: Emma Wikberg, Martijn van Essen, Tobias Rydén, Johanna Svensson, Peter Gjertsson and Peter Bernhardt
    Citation: EJNMMI Physics 2023 10:36
    Content type: Original research Published on:

  2. The Cubresa Spark is a novel benchtop silicon-photomultiplier (SiPM)-based preclinical SPECT system. SiPMs in SPECT significantly improve resolution and reduce detector size compared to preclinical cameras wit...

    Authors: Matthew E. Strugari, Drew R. DeBay, Steven D. Beyea and Kimberly D. Brewer
    Citation: EJNMMI Physics 2023 10:35
    Content type: Original research Published on:

  3. Image optimization is a key step in clinical nuclear medicine, and phantoms play an essential role in this process. However, most phantoms do not accurately reflect the complexity of human anatomy, and this pr...

    Authors: Daniel Gillett, Daniel Marsden, Rosy Crawford, Safia Ballout, James MacFarlane, Merel van der Meulen, Bethany Gillett, Nick Bird, Sarah Heard, Andrew S. Powlson, Thomas Santarius, Richard Mannion, Angelos Kolias, Ines Harper, Iosif A. Mendichovszky, Luigi Aloj…
    Citation: EJNMMI Physics 2023 10:34
    Content type: Original research Published on:

  4. Total-body PET scanners with axial field of views (FOVs) longer than 1 m enable new applications to study multiple organs (e.g., the brain-gut-axis) simultaneously. As the spatial resolution and the associated...

    Authors: Julia G. Mannheim, Ivo Rausch, Maurizio Conti, Christian la Fougère and Fabian P. Schmidt
    Citation: EJNMMI Physics 2023 10:33
    Content type: Original research Published on:

  5. While diagnostic reference levels (DRLs) are well-established for the radiopharmaceutical part, published DRLs for the CT component of positron emission tomography/computed tomography (PET/CT) and single photo...

    Authors: Gwenny Verfaillie, Caro Franck, An De Crop, Laurence Beels, Yves D’Asseler and Klaus Bacher
    Citation: EJNMMI Physics 2023 10:32
    Content type: Review Published on:

  6. 18F-FDG PET/CT imaging allows to study oncological patients and their relative diagnosis through the standardised uptake value (SUV) evaluation. During radiopharmaceutical injection, an extravasation event may o....

    Authors: Mauro Iori, Elisa Grassi, Lorenzo Piergallini, Greta Meglioli, Andrea Botti, Giada Sceni, Noemi Cucurachi, Laura Verzellesi, Domenico Finocchiaro, Annibale Versari, Beatrice Fraboni and Federica Fioroni
    Citation: EJNMMI Physics 2023 10:31
    Content type: Original research Published on:

  7. Nuclear medicine imaging modalities like computed tomography (CT), single photon emission CT (SPECT) and positron emission tomography (PET) are employed in the field of theranostics to estimate and plan the do...

    Authors: Daniel Deidda, Ana M. Denis-Bacelar, Andrew J. Fenwick, Kelley M. Ferreira, Warda Heetun, Brian F. Hutton, Daniel R. McGowan, Andrew P. Robinson, James Scuffham, Kris Thielemans and Robert Twyman
    Citation: EJNMMI Physics 2023 10:30
    Content type: Original research Published on:

  8. In this retrospective study, we compared the maximum standardized uptake values (SUVmax) of parathyroid lesions and the target-to-background ratio (TBR) of parathyroid lesions to thyroid tissue in early-phase ...

    Authors: Yuhua Wang, Ye Liu, Na Li, Kang Xu and Wanchun Zhang
    Citation: EJNMMI Physics 2023 10:29
    Content type: Original research Published on:

  9. The Jagiellonian Positron Emission Tomograph is the 3-layer prototype of the first scanner based on plastic scintillators, consisting of 192 half-metre-long strips with readouts at both ends. Compared to cryst...

    Authors: S. Sharma, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, K. Eliyan, A. Gajos, N. Gupta-Sharma, B. C. Hiesmayr, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, P. Konieczka, G. Korcyl…
    Citation: EJNMMI Physics 2023 10:28
    Content type: Original research Published on:

  10. Monte Carlo (MC) simulation in Nuclear Medicine is a powerful tool for modeling many physical phenomena which are difficult to track or measure directly. MC simulation in SPECT/CT imaging is particularly suita...

    Authors: Giovanni Di Domenico, Simona Di Biaso, Lorenzo Longo, Alessandro Turra, Eugenia Tonini, MariaConcetta Longo, Licia Uccelli and Mirco Bartolomei
    Citation: EJNMMI Physics 2023 10:27
    Content type: Original research Published on:

  12. The specific binding ratio (SBR) of 123I-FP-CIT in the putamen is widely used to support the interpretation of dopamine transporter (DAT) SPECT. Automatic methods for computation of the putamen SBR often include ...

    Authors: Ivayla Apostolova, Tassilo Schiebler, Catharina Lange, Franziska Lara Mathies, Wencke Lehnert, Susanne Klutmann and Ralph Buchert
    Citation: EJNMMI Physics 2023 10:25
    Content type: Original research Published on:

  13. In this study we evaluated the imaging capabilities of a novel Multi-pinhole collimator (MPH-Cardiac) specially designed for nuclear cardiology imaging on a Triple-NaI-detector based SPECT/CT system.

    Authors: Aron K. Krizsan, Kornel Kukuts, Walid Al-Muhanna, Zoltan Szoboszlai, Laszlo Balazs, Balazs Szabo, Janos Kiss, Stephan Nekolla, Sandor Barna, Ildiko Garai, Tamas Bukki and Attila Forgacs
    Citation: EJNMMI Physics 2023 10:24
    Content type: Original research Published on:

  14. Patient radioprotection in myocardial perfusion imaging (MPI)-SPECT is important but difficult to optimize. The aim of this study was to adjust injected activity according to patient size—weight or BMI—by usin...

    Authors: Emilie Verrecchia-Ramos, Olivier Morel, Valérie Beauchat, Sylvie Denet, Abdourahamane Djibo Sidikou, Merwan Ginet, Estelle Pfletschinger, Luminita Teodor, Maud Trombowsky, Jeany Verdier, Christelle Vère, Paul Retif and Sinan Ben Mahmoud
    Citation: EJNMMI Physics 2023 10:23
    Content type: Short communication Published on:

  15. Cardiac myxoma (CM), the most common cardiac tumor in adults, accounts for 50–75% of benign cardiac tumors. The diagnosis of CM is often elusive, especially in young stroke survivors and transthoracic echocard...

    Authors: Paweł Moskal, Ewelina Kubicz, Grzegorz Grudzień, Eryk Czerwiński, Kamil Dulski, Bartosz Leszczyński, Szymon Niedźwiecki and Ewa Ł. Stępień
    Citation: EJNMMI Physics 2023 10:22
    Content type: Original research Published on:

  16. Recent studies have shown that the right ventricular (RV) quantitative analysis in myocardial perfusion imaging (MPI) SPECT can be beneficial in the diagnosis of many cardiopulmonary diseases. This study propo...

    Authors: Seyed Mohammad Entezarmahdi, Reza Faghihi, Mehran Yazdi, Negar Shahamiri, Parham Geramifar and Mahdi Haghighatafshar
    Citation: EJNMMI Physics 2023 10:21
    Content type: Original research Published on:

  17. Quantitative thyroid single-photon emission computed tomography/computed tomography (SPECT/CT) requires computed tomography (CT)-based attenuation correction and manual thyroid segmentation on CT for %thyroid ...

    Authors: Kyounghyoun Kwon, Donghwi Hwang, Dongkyu Oh, Ji Hye Kim, Jihyung Yoo, Jae Sung Lee and Won Woo Lee
    Citation: EJNMMI Physics 2023 10:20
    Content type: Original research Published on:

  18. EQ.PET is a software package that overcomes the reconstruction-dependent variation of standard uptake values (SUV). In this study, we validated the use of EQ.PET for harmonizing SUVs between different positron...

    Authors: Yufei Song, Xiangxi Meng, Zhen Cao, Wei Zhao, Yan Zhang, Rui Guo, Xin Zhou, Zhi Yang and Nan Li
    Citation: EJNMMI Physics 2023 10:19
    Content type: Original research Published on:

  21. SimPET-L and SimPET-XL have recently been introduced with increased transaxial fields of view (FOV) compared with their predecessors (SimPET™ and SimPET-X), enabling whole-body positron emission tomography (PE...

    Authors: Minjee Seo, Guen Bae Ko, Kyeong Yun Kim, Jeong-Whan Son, Jung Woo Byun, Yun-Sang Lee, Kyeong Min Kim, Jang Woo Park, Kipom Kim, Taekwan Lee and Jae Sung Lee
    Citation: EJNMMI Physics 2023 10:16
    Content type: Original research Published on:

  22. Quantitative positron emission tomography (PET) scans of the brain typically require arterial blood sampling but this is complicated and logistically challenging. One solution to remove the need for arterial b...

    Authors: Peter Young, Lieuwe Appel, Andreas Tolf, Savvas Kosmidis, Joachim Burman, Anna Rieckmann, Michael Schöll and Mark Lubberink
    Citation: EJNMMI Physics 2023 10:15
    Content type: Original research Published on:

  23. Highly sensitive digital total-body PET/CT scanners (uEXPLORER) have great potential for clinical applications and fundamental research. Given their increasing sensitivity, low-dose scanning or snapshot imagin...

    Authors: Yanchao Huang, Meng Wang, Li Jiang, Lijuan Wang, Li Chen, Qiaoyu Wang, Jiatai Feng, Jingyi Wang, Wanbang Xu, Hubing Wu and Yanjiang Han
    Citation: EJNMMI Physics 2023 10:14
    Content type: Original research Published on:

  25. This project aims to develop and evaluate a method for accurately determining time-integrated activities (TIAs) in single-time-point (STP) dosimetry for molecular radiotherapy. It performs a model selection (M...

    Authors: Deni Hardiansyah, Ade Riana, Ambros J. Beer and Gerhard Glatting
    Citation: EJNMMI Physics 2023 10:12
    Content type: Original research Published on:

  26. 177Lu-PSMA therapy has been successfully used to prolong the survival of patients with metastatic castration-resistant prostate cancer. Patient-specific dosimetry based on serial quantitative SPECT/CT imaging can...

    Authors: Sandra Resch, Sarah Takayama Fouladgar, Mathias Zacherl, Gabriel T. Sheikh, Grigory Liubchenko, Mikhail Rumiantcev, Lena M. Unterrainer, Vera Wenter, Peter Bartenstein, Sibylle I. Ziegler, Harun Ilhan, Leonie Beyer, Guido Böning and Astrid Delker
    Citation: EJNMMI Physics 2023 10:11
    Content type: Original research Published on:

  27. The aim was to review available biokinetic data, collect own experimental data, and propose an updated compartmental model for 2-[18F]FDG in the frame of the revision of the ICRP report on dose coefficients for r...

    Authors: Alexandra Kamp, Martin Andersson, Sigrid Leide-Svegborn, Dietmar Noβke, Sören Mattsson and Augusto Giussani
    Citation: EJNMMI Physics 2023 10:10
    Content type: Original research Published on:

  28. Myocardial perfusion SPECT (MPS) images often suffer from artefacts caused by low-count statistics. Poor-quality images can lead to misinterpretations of perfusion defects. Deep learning (DL)-based methods hav...

    Authors: Antti Sohlberg, Tuija Kangasmaa, Chris Constable and Antti Tikkakoski
    Citation: EJNMMI Physics 2023 10:9
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Physics 2023 10:26

  29. In selective internal radiation therapy, 99mTc SPECT images are used to optimize patient treatment planning, but they are affected by respiratory motion. In this study, we evaluated on patient data the dosimetric...

    Authors: Laure Vergnaud, Antoine Robert, Thomas Baudier, Sandrine Parisse-Di Martino, Philippe Boissard, Simon Rit, Jean-Noël Badel and David Sarrut
    Citation: EJNMMI Physics 2023 10:8
    Content type: Original research Published on:

  30. Advances in hepatic radioembolization are based on a selective approach with radical intent and the use of multicompartment dosimetric analysis. The objective of this study is to assess the utility of voxel-ba...

    Authors: Javier Orcajo Rincón, Amanda Rotger Regi, Ana Matilla Peña, Laura Reguera Berenguer, Manuel González Leyte, Laura Carrión Martín, Jaime Atance García De La Santa, Miguel Echenagusia Boyra, Cristina González Ruiz, Arturo Colón Rodríguez and Juan Carlos Alonso Farto
    Citation: EJNMMI Physics 2023 10:7
    Content type: Original Research Published on:

  31. Deep learning (DL) has a growing popularity and is a well-established method of artificial intelligence for data processing, especially for images and videos. Its applications in nuclear medicine are broad and...

    Authors: Ioannis D. Apostolopoulos, Nikolaos I. Papandrianos, Anna Feleki, Serafeim Moustakidis and Elpiniki I. Papageorgiou
    Citation: EJNMMI Physics 2023 10:6
    Content type: Review Published on:

  32. Conventional calibration of the gamma camera consists of the calculation of calibration factors (CFs) (ratio of counts/cc and true concentration activity) as the function of the volume of interest (VOI). Howev...

    Authors: Stanislav Raskin, Dan Gamliel, David Abookasis, Simona Ben-Haim and Alexandre Chicheportiche
    Citation: EJNMMI Physics 2023 10:5
    Content type: Original research Published on:

  33. The Bayesian penalized likelihood PET reconstruction (BPL) algorithm, Q.Clear (GE Healthcare), has recently been clinically applied to clinical image reconstruction. The BPL includes a relative difference pena...

    Authors: Kenta Miwa, Tokiya Yoshii, Kei Wagatsuma, Shogo Nezu, Yuto Kamitaka, Tensho Yamao, Rinya Kobayashi, Shohei Fukuda, Yu Yakushiji, Noriaki Miyaji and Kenji Ishii
    Citation: EJNMMI Physics 2023 10:4
    Content type: Original research Published on:

  34. A strategy for management of radioactive waste associated with 177Lu-dotatate (Lutathera®) treatments was established in our institution, based on predicted storage times of 3–5 years extrapolated from the result...

    Authors: Sylviane Prevot, Inna Dygaï-Cochet, Jean-Marc Riedinger, Jean-Marc Vrigneaud, Myriam Quermonne, Matthieu Gallet and Alexandre Cochet
    Citation: EJNMMI Physics 2023 10:3
    Content type: Short communication Published on:

  36. To investigate the feasibility of ultra-low-dose CT (ULDCT) reconstructed with the artificial intelligence iterative reconstruction (AIIR) algorithm in total-body PET/CT imaging.

    Authors: Yan Hu, Zhe Zheng, Haojun Yu, Jingyi Wang, Xinlan Yang and Hongcheng Shi
    Citation: EJNMMI Physics 2023 10:1
    Content type: Original Research Published on:

  37. Molecular imaging of the dopamine transporters (DAT) provides valuable information about neurodegenerative diseases, such as Parkinson’s. This study assessed the accuracy and precision of DAT-SPECT quantificat...

    Authors: Leonardo Alexandre-Santos, Ana Carolina Trevisan, Felipe Arriva Pitella, Vitor Tumas, Jose Henrique Silvah, Mery Kato, Eder Rezende de Moraes and Lauro Wichert-Ana
    Citation: EJNMMI Physics 2022 9:91
    Content type: Original research Published on:

  38. The aim was to quantify inter- and intra-observer variability in manually delineated hepatocellular carcinoma (HCC) lesion contours and the resulting impact on radioembolization (RE) dosimetry.

    Authors: Elise C. Covert, Kellen Fitzpatrick, Justin Mikell, Ravi K. Kaza, John D. Millet, Daniel Barkmeier, Joseph Gemmete, Jared Christensen, Matthew J. Schipper and Yuni K. Dewaraja
    Citation: EJNMMI Physics 2022 9:90
    Content type: Original research Published on:

  39. 18F-FDG PET is often utilized to determine BNCT selection due to the limited availability of 18F-BPA PET, which is performed by synthesizing 18F into the boron drug used for BNCT, although the uptake mechanisms b...

    Authors: Tetsu Nakaichi, Satoshi Nakamura, Kimiteru Ito, Kana Takahashi, Mihiro Takemori, Tairo Kashihara, Kouji Kunito, Naoya Murakami, Kotaro Iijima, Takahito Chiba, Hiroki Nakayama, Shohei Mikasa, Teiji Nishio, Hiroyuki Okamoto, Jun Itami, Hiroaki Kurihara…
    Citation: EJNMMI Physics 2022 9:89
    Content type: Original research Published on:

  40. This study evaluated the physical performance of a positron emission tomography (PET) system dedicated to the head and breast according to the National Electrical Manufacturers Association (NEMA) NU2-2012 stan...

    Authors: Daisuke Morimoto-Ishikawa, Kohei Hanaoka, Shota Watanabe, Takahiro Yamada, Yoshiyuki Yamakawa, Suzuka Minagawa, Shiho Takenouchi, Atsushi Ohtani, Tetsuro Mizuta, Hayato Kaida and Kazunari Ishii
    Citation: EJNMMI Physics 2022 9:88
    Content type: Original Research Published on:

  41. Recently, total-body PET/CT systems with an extended axial field-of-view (aFOV) became commercially available which allow acquiring physiologic information of multiple organs simultaneously. However, the nomin...

    Authors: Ivo Rausch, Julia G. Mannheim, Jürgen Kupferschläger, Christian la Fougère and Fabian P. Schmidt
    Citation: EJNMMI Physics 2022 9:87
    Content type: Original research Published on:

  42. Accurate quantification of radioactivity in a source of interest relies on accurate registration between SPECT and anatomical images, and appropriate correction of partial volume effects (PVEs). For small volu...

    Authors: Lily Carnegie-Peake, Jan Taprogge, Iain Murray, Glenn D. Flux and Jonathan Gear
    Citation: EJNMMI Physics 2022 9:86
    Content type: Original Research Published on:

  43. We evaluated the effects of acquisition time, energy window width, and matrix size on the image quality, quantitation, and diagnostic performance of whole-body 99mTc-HMDP SPECT/CT in the primary metastasis stagin...

    Authors: Samuli Arvola, Marko Seppänen, Kirsi L. Timonen, Pentti Rautio, Otto Ettala, Mikael Anttinen, Peter J. Boström and Tommi Noponen
    Citation: EJNMMI Physics 2022 9:85
    Content type: Original research Published on:

  44. COVID-19 infection, especially in cases with pneumonia, is associated with a high rate of pulmonary embolism (PE). In patients with contraindications for CT pulmonary angiography (CTPA) or non-diagnostic CTPA,...

    Authors: Sonia Baeza, Debora Gil, Ignasi Garcia-Olivé, Maite Salcedo-Pujantell, Jordi Deportós, Carles Sanchez, Guillermo Torres, Gloria Moragas and Antoni Rosell
    Citation: EJNMMI Physics 2022 9:84
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Physics 2023 10:13

  45. The purpose of the present study was to elucidate the correlation between standardized uptake value (SUV) and volume-based parameters measured by quantitative [99mTc]Tc-methylene diphosphonate (MDP) single photon...

    Authors: Kenichi Tanaka, Takashi Norikane, Katsuya Mitamura, Yuka Yamamoto, Yukito Maeda, Kengo Fujimoto, Yasukage Takami, Mariko Ishimura, Hanae Arai-Okuda, Yoichiro Tohi, Nobuyuki Kudomi, Mikio Sugimoto and Yoshihiro Nishiyama
    Citation: EJNMMI Physics 2022 9:83
    Content type: Short communication Published on:

  47. To establish a proof-of-concept study using a phantom model to allow the fusion of preoperative single-photon emission computed tomography (SPECT) combined with computed tomography (CT), also known as SPECT/CT...

    Authors: Lise Lecointre, Juan Verde, Fabrice Hubele, Julien Salvadori, Laurent Goffin, Chérif Akladios and Benoît Gallix
    Citation: EJNMMI Physics 2022 9:81
    Content type: Short communication Published on:

  48. Patient’s breathing affects the quality of chest images acquired with positron emission tomography/computed tomography (PET/CT) studies. Movement correction is required to optimize PET quantification in clinic...

    Authors: Andrea Martinez-Movilla, Michael Mix, Irene Torres-Espallardo, Elena Teijeiro, Pilar Bello, Dimos Baltas, Luis Martí-Bonmatí and Montserrat Carles
    Citation: EJNMMI Physics 2022 9:80
    Content type: Original research Published on:

  49. We aimed to investigate the effect and significance of the rotation method with variable-angle anterior probe corrected for the depth of two kidneys on the determination of glomerular filtration rate (GFR) in ...

    Authors: Hua Wei, Ke Han, Jiaojiao Wu, Guang Hu, Zhifang Wu, Hongliang Wang, Xiaoshan Guo, Yansong Hou, Rui Wang and Sijin Li
    Citation: EJNMMI Physics 2022 9:79
    Content type: Original research Published on:
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