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  1. Content type: Original research

    The technology of modern positron emission tomography (PET) systems continuously improving, and with it the possibility to detect smaller lesions. Since first introduced in 2010, the number of hybrid PET/magne...

    Authors: Silje Kjærnes Øen, Lars Birger Aasheim, Live Eikenes and Anna Maria Karlberg

    Citation: EJNMMI Physics 2019 6:16

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  2. Content type: Original research

    Software for Tomographic Image Reconstruction (STIR) is an open-source library for PET and SPECT image reconstruction, implementing iterative reconstruction as well as 2D- and 3D-filtered back projection. Quan...

    Authors: Parisa Khateri, Jannis Fischer, Werner Lustermann, Charalampos Tsoumpas and Günther Dissertori

    Citation: EJNMMI Physics 2019 6:15

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  3. Content type: Original research

    Monte Carlo-based iterative reconstruction to correct for photon scatter and collimator effects has been proven to be superior over analytical correction schemes in single-photon emission computed tomography (...

    Authors: Martijn M. A. Dietze, Woutjan Branderhorst, Britt Kunnen, Max A. Viergever and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2019 6:14

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  4. Content type: Original research

    The α-emitting radionuclide radium-223 (223Ra) is widely used for the treatment of bone metastasis in patients with castration-resistant prostate cancer. However, 223Ra decays into radon-219 (219Rn) which is a no...

    Authors: Kazuhiro Ooe, Tadashi Watabe, Takashi Kamiya, Takashi Yoshimura, Makoto Hosono, Atsushi Shinohara and Jun Hatazawa

    Citation: EJNMMI Physics 2019 6:13

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  5. Content type: Original research

    The heart-to-mediastinum (H/M) ratio is a commonly used parameter to measure cardiac I-123 metaiodobenzylguanidine (MIBG) uptake. Since the H/M ratio is substantially influenced by the collimator type, we inve...

    Authors: Joachim Brumberg, Ganna Blazhenets, Nils Schröter, Lars Frings, Wolfgang H. Jost, Constantin Lapa and Philipp T. Meyer

    Citation: EJNMMI Physics 2019 6:12

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  6. Content type: Original research

    Fully integrated PET/MR systems are being used frequently in clinical research and routine. National Electrical Manufacturers Association (NEMA) characterization of these systems is generally done with 18F which ...

    Authors: Paulo R. R. V. Caribé, M. Koole, Yves D’Asseler, Timothy W. Deller, K. Van Laere and S. Vandenberghe

    Citation: EJNMMI Physics 2019 6:11

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  7. Content type: Original research

    Squamous cell carcinoma in the head and neck region is one of the most widespread cancers with high morbidity. Classic treatment comprises the complete removal of the lymphatics together with the cancerous tis...

    Authors: Peter A. von Niederhäusern, Simon Pezold, Uri Nahum, Carlo Seppi, Guillaume Nicolas, Michael Rissi, Stephan K. Haerle and Philippe C. Cattin

    Citation: EJNMMI Physics 2019 6:10

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  8. Content type: Original research

    Gadolinium nanoparticles (Gd-NP) combined with radiotherapy are investigated for radiation dose enhancement in radiotherapy treatment. Indeed, NPs concentrated in a tumor could enhance its radiosensitization. ...

    Authors: Olga Kochebina, Adrien Halty, Jacqueline Taleb, David Kryza, Marc Janier, Alexandre Bani Sadr, Thomas Baudier, Simon Rit and David Sarrut

    Citation: EJNMMI Physics 2019 6:9

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  9. Content type: Original research

    177Lu-DOTATATE peptide receptor radionuclide therapy is administered to patients on an inpatient and outpatient basis for the treatment of well-differentiated, metastatic neuroendocrine tumours. Following adminis...

    Authors: D. Levart, E. Kalogianni, B. Corcoran, N. Mulholland and G. Vivian

    Citation: EJNMMI Physics 2019 6:7

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  10. Content type: Original research

    Recently, the block-sequential regularized expectation maximization (BSREM) reconstruction algorithm was commercially introduced (Q.Clear, GE Healthcare, Milwaukee, WI, USA). However, the combination of noise-...

    Authors: Mimmi Bjöersdorff, Jenny Oddstig, Nina Karindotter-Borgendahl, Helén Almquist, Sophia Zackrisson, David Minarik and Elin Trägårdh

    Citation: EJNMMI Physics 2019 6:5

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  11. Content type: Opinion article

    Quantification is one of the key benefits of nuclear medicine imaging. Recently, driven by the demand for post radionuclide therapy imaging, quantitative SPECT has moved from relative and semiquantitative meas...

    Authors: John Dickson, James Ross and Stefan Vöö

    Citation: EJNMMI Physics 2019 6:4

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  12. Content type: Original research

    68Ga-labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC ([68Ga]PSMA-11) has been increasingly used to image prostate cancer using positron emission tomography (PET)/computed tomography (CT) both during diagnosis and treatment...

    Authors: Kristina Sandgren, Lennart Johansson, Jan Axelsson, Joakim Jonsson, Mattias Ögren, Margareta Ögren, Martin Andersson, Sara Strandberg, Tufve Nyholm, Katrine Riklund and Anders Widmark

    Citation: EJNMMI Physics 2019 6:2

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  13. Content type: Commentary

    PET imaging has been, and continues to be, an evolving diagnostic technology. In recent years, the modernizing digital landscape has opened new opportunities for data-driven innovation. One such facet has been...

    Authors: Adam Kesner, C. Ross Schmidtlein and Claudia Kuntner

    Citation: EJNMMI Physics 2019 6:3

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  14. Content type: Original research

    This study aims to assess both feasibility and accuracy of renal dosimetry imaging protocols in patients receiving Lutate therapy for neuroendocrine tumours (NETs), when data acquisition over multiple days is ...

    Authors: Kathy P. Willowson, Enid Eslick, Hyunju Ryu, Aurora Poon, Elizabeth J. Bernard and Dale L. Bailey

    Citation: EJNMMI Physics 2018 5:33

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  15. Content type: Original research

    15O-oxygen inhalation PET is unique in its ability to provide fundamental information regarding cerebral hemodynamics and energy metabolism in man. However, the use of 15O-oxygen has been limited in a clinical en...

    Authors: Satoshi Iguchi, Tetsuaki Moriguchi, Makoto Yamazaki, Yuki Hori, Kazuhiro Koshino, Kazunori Toyoda, Jarmo Teuho, Saeka Shimochi, Yusuke Terakawa, Tetsuya Fukuda, Jun C. Takahashi, Jyoji Nakagawara, Shigehiko Kanaya and Hidehiro Iida

    Citation: EJNMMI Physics 2018 5:37

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  16. Content type: Original research

    Radioiodine has been used for the treatment of benign thyroid diseases for over 70 years. However, internationally, there is no common standard for pretherapeutic dosimetry to optimally define the individual t...

    Authors: Jochen Hammes, Lutz van Heek, Melanie Hohberg, Manuel Reifegerst, Simone Stockter, Markus Dietlein, Markus Wild, Alexander Drzezga, Matthias Schmidt and Carsten Kobe

    Citation: EJNMMI Physics 2018 5:32

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  17. Content type: Original research

    The aim of this study was to evaluate the predictive power of the absorbed dose to kidneys after the first course of treatment with [177Lu]-DOTA-TATE for neuroendocrine tumors (NETs) on the cumulative kidney abso...

    Authors: Alexandre Chicheportiche, Simona Grozinsky-Glasberg, David J. Gross, Yodphat Krausz, Asher Salmon, Amichay Meirovitz, Nanette Freedman and Jeremy Godefroy

    Citation: EJNMMI Physics 2018 5:36

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  18. Content type: Original research

    The aim of this study was to compare liver and oncologic lesion standardized uptake values (SUV) obtained through two different reconstruction protocols, GE’s newest clinical lesion detection protocol (Q.Clear...

    Authors: Joke Devriese, Laurence Beels, Alex Maes, Christophe Van de Wiele and Hans Pottel

    Citation: EJNMMI Physics 2018 5:35

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  19. Content type: Original research

    Rhenium-188-labelled-Lipiodol radioembolization is a safe and cost-effective treatment for primary liver cancer. In order to determine correlations between treatment doses and patient response to therapy, accu...

    Authors: Pedro L. Esquinas, Ajit Shinto, Koramadai K. Kamaleshwaran, Jephy Joseph and Anna Celler

    Citation: EJNMMI Physics 2018 5:30

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  20. Content type: Young investigators

    Positron emission tomography (PET) imaging has a wide applicability in oncology, cardiology and neurology. However, a major drawback when imaging very active regions such as the bladder is the spill-in effect,...

    Authors: Mercy I. Akerele, Palak Wadhwa, Jesus Silva-Rodriguez, William Hallett and Charalampos Tsoumpas

    Citation: EJNMMI Physics 2018 5:34

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  21. Content type: Original research

    Generation of a SPECT scan during procedure may aid in the optimization of treatments as liver radioembolization by offering image-guided dosimetry. This, however, requires both shortened acquisition times and...

    Authors: Martijn M. A. Dietze, Sandra van der Velden, Marnix G. E. H. Lam, Max A. Viergever and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2018 5:28

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  22. Content type: Original research

    PoleStar m660 is a newly developed clinical PET/CT system with time-of-flight (TOF) capability. The aim of this study is to characterize the performance of the new system. Spatial resolution, sensitivity, scat...

    Authors: Li Huo, Nan Li, Heyu Wu, Wenjia Zhu, Haiqun Xing, Jiantao Ba, Tong Wang, Fang Li and Hui Zhang

    Citation: EJNMMI Physics 2018 5:29

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  23. Content type: Original research

    The purpose was to validate 90Y PET gradient-based tumor segmentation in phantoms and to evaluate the impact of the segmentation method on reported tumor absorbed dose (AD) and biological effective dose (BED) in

    Authors: Justin K. Mikell, Ravi K. Kaza, Peter L. Roberson, Kelly C. Younge, Ravi N. Srinivasa, Bill S. Majdalany, Kyle C. Cuneo, Dawn Owen, Theresa Devasia, Matthew J. Schipper and Yuni K. Dewaraja

    Citation: EJNMMI Physics 2018 5:31

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  24. Content type: Original research

    To develop and evaluate the feasibility of a data-driven deep learning approach (deepAC) for positron-emission tomography (PET) image attenuation correction without anatomical imaging. A PET attenuation correc...

    Authors: Fang Liu, Hyungseok Jang, Richard Kijowski, Gengyan Zhao, Tyler Bradshaw and Alan B. McMillan

    Citation: EJNMMI Physics 2018 5:24

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  25. Content type: Review

    Radioembolization is an established treatment for chemoresistant and unresectable liver cancers. Currently, treatment planning is often based on semi-empirical methods, which yield acceptable toxicity profiles...

    Authors: Remco Bastiaannet, S. Cheenu Kappadath, Britt Kunnen, Arthur J. A. T. Braat, Marnix G. E. H. Lam and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2018 5:22

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  26. Content type: Original research

    MRI does not offer a direct method to obtain attenuation correction maps as its predecessors (stand-alone PET and PET/CT), and bone visualisation is particularly challenging. Recently, zero-echo-time (ZTE) was...

    Authors: João M. Sousa, Lieuwe Appel, Mathias Engström, Stergios Papadimitriou, Dag Nyholm, Elna-Marie Larsson, Håkan Ahlström and Mark Lubberink

    Citation: EJNMMI Physics 2018 5:20

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  27. Content type: Original research

    Routine dosimetry is essential for personalized 177Lu-octreotate peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs), but practical and robust dosimetry methods are needed for wide clinic...

    Authors: Michela Del Prete, Frédéric Arsenault, Nassim Saighi, Wei Zhao, François-Alexandre Buteau, Anna Celler and Jean-Mathieu Beauregard

    Citation: EJNMMI Physics 2018 5:25

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  28. Content type: Original research

    [18F]Fluortriopride (FTP) was developed as a dopamine D3-selective radiotracer, thought to be important to neurobiological reward pathways and implicated in drug addiction, Parkinson’s disease, and schizophrenia....

    Authors: Robert K. Doot, Jacob G. Dubroff, Joshua S. Scheuermann, Kyle J. Labban, Jenny Cai, Chia-Ju Hsieh, Shihong Li, Hsiaoju Lee, Erin K. Schubert, Catherine Hou, Regan Sheffer, Alexander Schmitz, Kuiying Xu and Robert H. Mach

    Citation: EJNMMI Physics 2018 5:21

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  29. Content type: Original research

    The aim of this study was to evaluate and compare PET image reconstruction algorithms on novel digital silicon photomultiplier PET/CT in patients with newly diagnosed and histopathologically confirmed lung can...

    Authors: Michael Messerli, Paul Stolzmann, Michèle Egger-Sigg, Josephine Trinckauf, Stefano D’Aguanno, Irene A. Burger, Gustav K. von Schulthess, Philipp A. Kaufmann and Martin W. Huellner

    Citation: EJNMMI Physics 2018 5:27

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  30. Content type: Original research

    Positron-emission tomography (PET) simulators are frequently used for development and performance evaluation of segmentation methods or quantitative uptake metrics. To date, most PET simulation tools are based...

    Authors: Elisabeth Pfaehler, Johan R. De Jong, Rudi A. J. O. Dierckx, Floris H. P. van Velden and Ronald Boellaard

    Citation: EJNMMI Physics 2018 5:16

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  31. Content type: Original research

    Dose rate variation is a critical factor affecting radionuclide therapy (RNT) efficacy. Relatively few studies to date have investigated the dose rate effect in RNT. Therefore, the aim of this study was to ben...

    Authors: Yaser H. Gholami, Kathy P. Willowson, Nicholas J. Forwood, Rozelle Harvie, Nicholas Hardcastle, Regina Bromley, HyunJu Ryu, Samuel Yuen, Viive M. Howell, Zdenka Kuncic and Dale L. Bailey

    Citation: EJNMMI Physics 2018 5:18

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  32. Content type: Original research

    The aim of our study was to compare 90Y dosimetry obtained from PET/MRI versus PET/CT post-therapy imaging among patients with primary or metastatic hepatic tumors.

    Authors: Karin Knešaurek, Abbas Tuli, Edward Kim, Sherif Heiba and Lale Kostakoglu

    Citation: EJNMMI Physics 2018 5:23

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  33. Content type: Original research

    Radiomercury 197mHg and 197Hg, henceforth referred to as 197(m)Hg, is a promising theranostic radionuclide endowed with properties that allow diagnostic and therapeutic applications. The aim of this work was to i...

    Authors: Robert Freudenberg, Rudi Apolle, Martin Walther, Holger Hartmann and Jörg Kotzerke

    Citation: EJNMMI Physics 2018 5:15

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  34. Content type: Original research

    This inter-comparison exercise was performed to demonstrate the variability of quantitative SPECT/CT imaging for lutetium-177 (177Lu) in current clinical practice. Our aim was to assess the feasibility of using i...

    Authors: Jill Wevrett, Andrew Fenwick, James Scuffham, Lena Johansson, Jonathan Gear, Susanne Schlögl, Marcel Segbers, Katarina Sjögreen-Gleisner, Pavel Solný, Michael Lassmann, Jill Tipping and Andrew Nisbet

    Citation: EJNMMI Physics 2018 5:17

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  35. Content type: Original research

    In patients with differentiated thyroid cancer (DTC), serial 124I PET/CT imaging is, for instance, used to assess the absorbed (radiation) dose to lesions. Frequently, the lesions are located in the neck and they...

    Authors: Walter Jentzen, Jinda Phaosricharoen, Benedikt Gomez, Philipp Hetkamp, Vanessa Stebner, Ina Binse, Sonja Kinner, Ken Herrmann, Amir Sabet and James Nagarajah

    Citation: EJNMMI Physics 2018 5:13

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  36. Content type: Original research

    Recently, 177Lu-dotatate therapy for neuroendocrine tumours has received regulatory approval. Dosimetry can be used to optimize treatment on an individual basis, but there is no international consensus as to how ...

    Authors: Anna Sundlöv, Johan Gustafsson, Gustav Brolin, Nadja Mortensen, Rebecca Hermann, Peter Bernhardt, Johanna Svensson, Michael Ljungberg, Jan Tennvall and Katarina Sjögreen Gleisner

    Citation: EJNMMI Physics 2018 5:12

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  37. Content type: Original research

    Peptide receptor radionuclide therapy (PRRT) with [177Lu]-DOTA-TATE is an effective treatment of neuroendocrine tumors (NETs). After each cycle of treatment, patient dosimetry evaluates the radiation dose to the ...

    Authors: Alexandre Chicheportiche, Faozi Artoul, Arnon Schwartz, Simona Grozinsky-Glasberg, Amichay Meirovitz, David J. Gross and Jeremy Godefroy

    Citation: EJNMMI Physics 2018 5:10

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  38. Content type: Original research

    Matched attenuation maps are vital for obtaining accurate and reproducible kinetic and static parameter estimates from PET data. With increased interest in PET/CT imaging of diffuse lung diseases for assessing...

    Authors: Beverley F. Holman, Vesna Cuplov, Lynn Millner, Raymond Endozo, Toby M. Maher, Ashley M. Groves, Brian F. Hutton and Kris Thielemans

    Citation: EJNMMI Physics 2018 5:14

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  39. Content type: Original research

    SPECT quantification is important for dosimetry in targeted radionuclide therapy (TRT) and the calibration of SPECT images is a crucial stage for image quantification. The current standardized calibration prot...

    Authors: Adrien Halty, Jean-Noël Badel, Olga Kochebina and David Sarrut

    Citation: EJNMMI Physics 2018 5:11

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  40. Content type: Original research

    Camera calibration, which translates reconstructed count map into absolute activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and tomographic scans using different phantom ge...

    Authors: Wei Zhao, Pedro L. Esquinas, Xinchi Hou, Carlos F. Uribe, Marjorie Gonzalez, Jean-Mathieu Beauregard, Yuni K. Dewaraja and Anna Celler

    Citation: EJNMMI Physics 2018 5:8

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  41. Content type: Original research

    A newly introduced PET/CT scanner (Discovery Meaningful Insights—DMI, GE Healthcare) includes the silicon photomultiplier (SiPM) with time-of-flight (TOF) technology first used in the GE SIGNA PET/MRI. In this...

    Authors: Ida Sonni, Lucia Baratto, Sonya Park, Negin Hatami, Shyam Srinivas, Guido Davidzon, Sanjiv Sam Gambhir and Andrei Iagaru

    Citation: EJNMMI Physics 2018 5:9

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  42. Content type: Original research

    Yttrium-90 (90Y) radioembolization involves the intra-arterial delivery of radioactive microspheres to treat hepatic malignancies. Though this therapy involves careful pre-treatment planning and imaging, little i...

    Authors: Nichole M. Maughan, Mootaz Eldib, David Faul, Maurizio Conti, Mattijs Elschot, Karin Knešaurek, Francesca Leek, David Townsend, Frank P. DiFilippo, Kimberly Jackson, Stephan G. Nekolla, Mathias Lukas, Michael Tapner, Parag J. Parikh and Richard Laforest

    Citation: EJNMMI Physics 2018 5:7

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  43. Content type: Original research

    The performance of a prototype novel digital single-photon emission computed tomography (SPECT) camera with multiple pixelated CZT detectors and high sensitivity collimators (Digital SPECT; Valiance X12 protot...

    Authors: Elinor Goshen, Leonid Beilin, Eli Stern, Tal Kenig, Ronen Goldkorn and Simona Ben-Haim

    Citation: EJNMMI Physics 2018 5:6

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  44. Content type: Original research

    Single-photon emission computed tomography (SPECT) imaging is an important diagnostic tool for the early detection of the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease (PD) and similar neur...

    Authors: M. K. Stam, E. E. Verwer, J. Booij, S. M. Adriaanse, C. M. de Bruin and T. C. de Wit

    Citation: EJNMMI Physics 2018 5:4

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  45. Content type: Original research

    Nuclear medicine imaging of neuroendocrine tumours is performed either by SPECT/CT imaging, using 111In-octreotide or by PET/CT imaging using 68Ga-radiolabelled somatostatin analogs. These imaging techniques will...

    Authors: L. Jönsson, A. Stenvall, E. Mattsson, E. Larsson, A. Sundlöv, T. Ohlsson and C. Hindorf

    Citation: EJNMMI Physics 2018 5:5

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