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  1. Original research

    Deadtime effects in quantification of 177Lu activity for radionuclide therapy

    The aim of this study was to investigate the deadtime (DT) effects that are present in 177Lu images acquired after radionuclide therapy injection, assess differences in DT based on the full spectrum and the photo...

    Carlos F. Uribe, Pedro L. Esquinas, Marjorie Gonzalez, Wei Zhao, Jesse Tanguay and Anna Celler

    EJNMMI Physics 2018 5:2

    Published on: 11 January 2018

  2. Original research

    Fast GPU-based Monte Carlo code for SPECT/CT reconstructions generates improved 177Lu images

    Full Monte Carlo (MC)-based SPECT reconstructions have a strong potential for correcting for image degrading factors, but the reconstruction times are long. The objective of this study was to develop a highly ...

    T. Rydén, J. Heydorn Lagerlöf, J. Hemmingsson, I. Marin, J. Svensson, M. Båth, P. Gjertsson and P. Bernhardt

    EJNMMI Physics 2018 5:1

    Published on: 4 January 2018

  3. Original research

    The effect of high count rates on cardiac perfusion quantification in a simultaneous PET-MR system using a cardiac perfusion phantom

    PET-MRI is under investigation as a new strategy for quantitative myocardial perfusion imaging. Consideration is required as to the maximum scanner count rate in order to limit dead-time losses resulting from ...

    Jim O’ Doherty, Zacharias Chalampalakis, Paul Schleyer, Muhummad Sohaib Nazir, Amedeo Chiribiri and Paul K. Marsden

    EJNMMI Physics 2017 4:31

    Published on: 11 December 2017

  4. Original research

    Model selection criteria for dynamic brain PET studies

     Several criteria exist to identify the optimal model for quantification of tracer kinetics. The purpose of this study was to evaluate the correspondence in kinetic model preference identification for brain PE...

    Sandeep S. V. Golla, Sofie M. Adriaanse, Maqsood Yaqub, Albert D. Windhorst, Adriaan A. Lammertsma, Bart N. M. van Berckel and Ronald Boellaard

    EJNMMI Physics 2017 4:30

    Published on: 6 December 2017

  5. Original research

    Variations in the practice of molecular radiotherapy and implementation of dosimetry: results from a European survey

    Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availabili...

    Katarina Sjögreen Gleisner, Emiliano Spezi, Pavel Solny, Pablo Minguez Gabina, Francesco Cicone, Caroline Stokke, Carlo Chiesa, Maria Paphiti, Boudewijn Brans, Mattias Sandström, Jill Tipping, Mark Konijnenberg and Glenn Flux

    EJNMMI Physics 2017 4:28

    Published on: 4 December 2017

  6. Original research

    Comparison of machine learning and semi-quantification algorithms for (I123)FP-CIT classification: the beginning of the end for semi-quantification?

    Semi-quantification methods are well established in the clinic for assisted reporting of (I123) Ioflupane images. Arguably, these are limited diagnostic tools. Recent research has demonstrated the potential fo...

    Jonathan Christopher Taylor and John Wesley Fenner

    EJNMMI Physics 2017 4:29

    Published on: 29 November 2017

  7. Original research

    Dosimetry-based treatment planning for molecular radiotherapy: a summary of the 2017 report from the Internal Dosimetry Task Force

    The European directive on basic safety standards (Council directive 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. The directive comes into operation February 2...

    Caroline Stokke, Pablo Minguez Gabiña, Pavel Solný, Francesco Cicone, Mattias Sandström, Katarina Sjögreen Gleisner, Carlo Chiesa, Emiliano Spezi, Maria Paphiti, Mark Konijnenberg, Matt Aldridge, Jill Tipping, Michael Wissmeyer, Boudewijn Brans, Klaus Bacher, Carsten Kobe…

    EJNMMI Physics 2017 4:27

    Published on: 21 November 2017

  8. Original research

    Calculation of left ventricular volumes and ejection fraction from dynamic cardiac-gated 15O-water PET/CT: 5D-PET

    Quantitative measurement of myocardial blood flow (MBF) is of increasing interest in the clinical assessment of patients with suspected coronary artery disease (CAD). 15O-water positron emission tomography (PET) ...

    Jonny Nordström, Tanja Kero, Hendrik Johannes Harms, Charles Widström, Frank A. Flachskampf, Jens Sörensen and Mark Lubberink

    EJNMMI Physics 2017 4:26

    Published on: 14 November 2017

  9. Original research

    Predictive SIRT dosimetry based on a territorial model

    In the planning of selective internal radiation therapy (SIRT) for liver cancer treatment, one major aspect is to determine the prescribed activity and to estimate the resulting absorbed dose inside normal liv...

    Nadine Spahr, Philipp Schilling, Smita Thoduka, Nasreddin Abolmaali and Andrea Schenk

    EJNMMI Physics 2017 4:25

    Published on: 31 October 2017

  10. Original research

    Patient-specific dosimetry of 99mTc-HYNIC-Tyr3-Octreotide in children

    Technetium-99m-hydrazinonicotinamide-Tyr3-octreotide (99mTc-HYNIC-TOC) is recognized as a promising radiopharmaceutical for diagnosing neuroendocrine tumors (NETs). However, 99mTc-HYNIC-TOC dosimetry has been inv...

    Xinchi Hou, Bozena Birkenfeld, Hanna Piwowarska-Bilska and Anna Celler

    EJNMMI Physics 2017 4:24

    Published on: 13 October 2017

  11. Opinion article

    Guidelines for quality control of PET/CT scans in a multicenter clinical study

    To date, there is no published detailed checklist with parameters referencing the DICOM tag information with respect to the quality control (QC) of PET/CT scans. The aims of these guidelines are to provide the...

    Ivalina Hristova, Ronald Boellaard, Paul Galette, Lalitha K. Shankar, Yan Liu, Sigrid Stroobants, Otto S. Hoekstra and Wim J.G. Oyen

    EJNMMI Physics 2017 4:23

    Published on: 18 September 2017

  12. Original research

    Comparison of novel multi-level Otsu (MO-PET) and conventional PET segmentation methods for measuring FDG metabolic tumor volume in patients with soft tissue sarcoma

    We have previously developed a novel and highly consistent PET segmentation algorithm using a multi-level Otsu method (MO-PET). The aim of this study was to evaluate the reliability of MO-PET compared to conve...

    Inki Lee, Hyung-Jun Im, Meiyappan Solaiyappan and Steve Y. Cho

    EJNMMI Physics 2017 4:22

    Published on: 18 September 2017

  13. Original research

    Comparison of PET/CT and whole-mount histopathology sections of the human prostate: a new strategy for voxel-wise evaluation

    Implementation of PET/CT in diagnosis of primary prostate cancer (PCa) requires a profound knowledge about the tracer, preferably from a quantitative evaluation. Direct visual comparison of PET/CT slices to wh...

    F. Schiller, T. Fechter, C. Zamboglou, A. Chirindel, N. Salman, C.A. Jilg, V. Drendel, M. Werner, P.T. Meyer, A.-L. Grosu and M. Mix

    EJNMMI Physics 2017 4:21

    Published on: 17 August 2017

  14. Original research

    Design and implementation of a prototype head and neck phantom for the performance evaluation of gamma imaging systems

    A prototype anthropomorphic head and neck phantom has been designed to simulate the adult head and neck anatomy including some internal organs and tissues of interest, such as thyroid gland and sentinel lymph ...

    Mohammed S. Alqahtani, John E. Lees, Sarah L. Bugby, Piyal Samara-Ratna, Aik H. Ng and Alan C. Perkins

    EJNMMI Physics 2017 4:19

    Published on: 6 July 2017

  15. Original Research

    A CZT-based blood counter for quantitative molecular imaging

    Robust quantitative analysis in positron emission tomography (PET) and in single-photon emission computed tomography (SPECT) typically requires the time-activity curve as an input function for the pharmacokine...

    Romain Espagnet, Andrea Frezza, Jean-Pierre Martin, Louis-André Hamel, Laëtitia Lechippey, Jean-Mathieu Beauregard and Philippe Després

    EJNMMI Physics 2017 4:18

    Published on: 2 June 2017

  16. Original research

    EORTC PET response criteria are more influenced by reconstruction inconsistencies than PERCIST but both benefit from the EARL harmonization program

    This study evaluates the consistency of PET evaluation response criteria in solid tumours (PERCIST) and European Organisation for Research and Treatment of Cancer (EORTC) classification across different recons...

    Charline Lasnon, Elske Quak, Pierre-Yves Le Roux, Philippe Robin, Michael S. Hofman, David Bourhis, Jason Callahan, David S. Binns, Cédric Desmonts, Pierre-Yves Salaun, Rodney J. Hicks and Nicolas Aide

    EJNMMI Physics 2017 4:17

    Published on: 30 May 2017

  17. Original research

    Using 31P-MRI of hydroxyapatite for bone attenuation correction in PET-MRI: proof of concept in the rodent brain

    The correction of γ-photon attenuation in PET-MRI remains a critical issue, especially for bone attenuation. This problem is of great importance for brain studies due to the density of the skull. Current techn...

    Vincent Lebon, Sébastien Jan, Yoann Fontyn, Brice Tiret, Géraldine Pottier, Emilie Jaumain and Julien Valette

    EJNMMI Physics 2017 4:16

    Published on: 2 May 2017

  18. Commentary

    Saul Hertz, MD, and the birth of radionuclide therapy

    The year, 2016, marked the 75th anniversary of Dr. Saul Hertz first using radioiodine to treat a patient with thyroid disease. In November of 1936, a luncheon was held of the faculty of Harvard Medical School ...

    Frederic H. Fahey, Frederick D. Grant and James H. Thrall

    EJNMMI Physics 2017 4:15

    Published on: 27 April 2017

  19. Original research

    Minimum lesion detectability as a measure of PET system performance

    A phantom in combination with an imaging protocol was developed to measure the limit of small lesion detection on different PET systems. Seven small spheres with inner diameters ranging from 3.95 up to 15.43 m...

    Stephen Adler, Jurgen Seidel, Peter Choyke, Michael V. Knopp, Katherine Binzel, Jun Zhang, Craig Barker, Shielah Conant and Roberto Maass-Moreno

    EJNMMI Physics 2017 4:13

    Published on: 4 March 2017

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