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EJNMMI Physics
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  1. The combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) (PET-MRI) is a unique hybrid imaging modality mainly used in oncology and neurology. The MRI-based attenuation correct...

    Authors: Johanna Harries, Thies H. Jochimsen, Thomas Scholz, Tina Schlender, Henryk Barthel, Osama Sabri and Bernhard Sattler

    Citation: EJNMMI Physics 2020 7:52

    Content type: Original research

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  2. Artificial intelligence (AI) is about to transform medical imaging. The Research Consortium for Medical Image Analysis (RECOMIA), a not-for-profit organisation, has developed an online platform to facilitate c...

    Authors: Elin Trägårdh, Pablo Borrelli, Reza Kaboteh, Tony Gillberg, Johannes Ulén, Olof Enqvist and Lars Edenbrandt

    Citation: EJNMMI Physics 2020 7:51

    Content type: Original research

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  3. In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemi...

    Authors: Chang-Hoon Choi, Carina Stegmayr, Aliaksandra Shymanskaya, Wieland A. Worthoff, Nuno A. da Silva, Jörg Felder, Karl-Josef Langen and N. Jon Shah

    Citation: EJNMMI Physics 2020 7:50

    Content type: Original research

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  4. Myocardial perfusion imaging is a commonly performed SPECT protocol and hence it would be beneficial if its scan duration could be shortened. For traditional gamma cameras, two developments have separately sho...

    Authors: Martijn M. A. Dietze, Britt Kunnen, Martina Stella and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2020 7:49

    Content type: Original research

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  5. Accurate dosimetry is essential in radioembolization. To this purpose, an automatic protocol for healthy liver dosimetry based on dual isotope (DI) SPECT imaging, combining holmium-166 (166Ho)-microspheres, and t...

    Authors: M. Stella, AJAT Braat, MGEH Lam, HWAM de Jong and R. van Rooij

    Citation: EJNMMI Physics 2020 7:48

    Content type: Original research

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  6. An amendment to this paper has been published and can be accessed via the original article.

    Authors: J. E. Mackewn, J. Stirling, S. Jeljeli, S-M Gould, R. I. Johnstone, I. Merida, L. C. Pike, C. J. McGinnity, K. Beck, O. Howes, A. Hammers and P. K. Marsden

    Citation: EJNMMI Physics 2020 7:47

    Content type: Correction

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    The original article was published in EJNMMI Physics 2020 7:24

  8. It has been proposed, and preclinically demonstrated, that 161Tb is a better alternative to 177Lu for the treatment of small prostate cancer lesions due to its high emission of low-energy electrons. 161Tb also em...

    Authors: I. Marin, T. Rydèn, M. Van Essen, J. Svensson, N. Gracheva, U. Köster, J. R. Zeevaart, N. P. van der Meulen, C. Müller and P. Bernhardt

    Citation: EJNMMI Physics 2020 7:45

    Content type: Original research

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  9. In living organisms, the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conv...

    Authors: P. Moskal, D. Kisielewska, R. Y. Shopa, Z. Bura, J. Chhokar, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, R. Del Grande, B. C. Hiesmayr, B. Jasińska, K. Kacprzak…

    Citation: EJNMMI Physics 2020 7:44

    Content type: Original Research

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  11. Time-of-flight (TOF) positron emission tomography (PET) scanners can provide significant benefits by improving the noise properties of reconstructed images. In order to achieve this, the timing response of the...

    Authors: Nikos Efthimiou, Kris Thielemans, Elise Emond, Chris Cawthorne, Stephen J. Archibald and Charalampos Tsoumpas

    Citation: EJNMMI Physics 2020 7:42

    Content type: Original research

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  12. Individualized dosimetry is recommended for [177Lu]Lu-PSMA radioligand therapy (RLT) which is resource-intensive and protocols are often not optimized. Therefore, a simulation study was performed focusing on the ...

    Authors: Andreas Rinscheid, Peter Kletting, Matthias Eiber, Ambros J. Beer and Gerhard Glatting

    Citation: EJNMMI Physics 2020 7:41

    Content type: Original research

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  13. Block-sequential regularized expectation maximization (BSREM) is a fully convergent iterative image reconstruction algorithm. We hypothesize that tracers with different distribution patterns will result in dif...

    Authors: Elin Lindström, Lars Lindsjö, Anders Sundin, Jens Sörensen and Mark Lubberink

    Citation: EJNMMI Physics 2020 7:40

    Content type: Original research

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  14. The time-over-threshold (TOT) technique is being used widely due to itsimplications in developing the multi-channel readouts, mainly when fast signal processing is required. Using the TOT technique, as a measu...

    Authors: S. Sharma, J. Chhokar, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, N. Gupta-Sharma, R. Del Grande, B.C. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, H. Karimi…

    Citation: EJNMMI Physics 2020 7:39

    Content type: Original Research

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  15. Prostate cancer (PCa) represents one of the most common types of cancers facing the male population. Nowadays, to confirm PCa, systematic or multiparametric MRI-targeted transrectal or transperineal biopsies o...

    Authors: Gabriel Cañizares, Andrea Gonzalez-Montoro, Marta Freire, Efthymios Lamprou, John Barrio, Filomeno Sanchez, José M. Benlloch, Liczandro Hernandez, Laura Moliner, Luis F. Vidal, Irene Torres, Pablo Sopena, Cesar D. Vera-Donoso, Pilar Bello, Julio Barbera and Antonio J. Gonzalez

    Citation: EJNMMI Physics 2020 7:38

    Content type: Original research

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  16. Iodine-125 (125I) seeds can be used as landmarks to locate non-palpable breast lesions instead of implanting metal wires. This relatively new technique requires a nuclear probe usually used for technetium-99m (99...

    Authors: Christopher Hoog, Pierre-Malick Koulibaly, Catherine Dejean, Tom Desdoits, Olivier Humbert, Emmanuel Barranger and Jacques Darcourt

    Citation: EJNMMI Physics 2020 7:37

    Content type: Original research

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  17. Dosimetry after peptide receptor radionuclide therapy (PRRT) is increasing; however, comparing or pooling of dosimetric results can be challenging since different approaches are used. The aim of this study was...

    Authors: Daphne M. V. Huizing, Steffie M. B. Peters, Michelle W. J. Versleijen, Esther Martens, Marcel Verheij, Michiel Sinaasappel, Marcel P. M. Stokkel and Berlinda J. de Wit-van der Veen

    Citation: EJNMMI Physics 2020 7:36

    Content type: Original research

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  18. The idea of a very sensitive positron emission tomography (PET) system covering a large portion of the body of a patient already dates back to the early 1990s. In the period 2000–2010, only some prototypes wit...

    Authors: Stefaan Vandenberghe, Pawel Moskal and Joel S. Karp

    Citation: EJNMMI Physics 2020 7:35

    Content type: Review

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  19. This study investigated the impact of the size of the normal database on the classification performance of the specific binding ratio (SBR) in dopamine transporter (DAT) SPECT with [123I]FP-CIT in different setti...

    Authors: Helen Schmitz-Steinkrüger, Catharina Lange, Ivayla Apostolova, Holger Amthauer, Wencke Lehnert, Susanne Klutmann and Ralph Buchert

    Citation: EJNMMI Physics 2020 7:34

    Content type: Original research

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  20. Targeted radionuclide therapy (TRT) is gaining importance. For TRT to be also used as adjuvant therapy or for treating minimal residual disease, there is a need to increase the radiation dose to small tumours....

    Authors: Mario E. Alcocer-Ávila, Aymeric Ferreira, Michele A. Quinto, Clément Morgat, Elif Hindié and Christophe Champion

    Citation: EJNMMI Physics 2020 7:33

    Content type: Original Research

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  21. Dead time may affect the accuracy of quantitative SPECT (QPSECT), and thus of dosimetry. The aim of this study was to quantify the effect of dead time on 177Lu-QSPECT and renal dosimetry following peptide recepto...

    Authors: Alessandro Desy, Guillaume F. Bouvet, Andrea Frezza, Philippe Després and Jean-Mathieu Beauregard

    Citation: EJNMMI Physics 2020 7:32

    Content type: Short communication

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  22. Prostate-specific membrane antigen (PSMA) radiotracers such as [18F]PSMA-1007 used with positron emission tomography-computed tomography (PET-CT) is promising for initial staging and detection of recurrent diseas...

    Authors: Elin Trägårdh, David Minarik, Gustav Brolin, Ulrika Bitzén, Berit Olsson and Jenny Oddstig

    Citation: EJNMMI Physics 2020 7:31

    Content type: Original research

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  23. Quantitative imaging biomarkers are becoming usual in oncology for assessing therapy response. The harmonization of image quantitation reporting has become of utmost importance due to the multi-center trials i...

    Authors: Delphine Vallot, Elena De Ponti, Sabrina Morzenti, Anna Gramek, Anna Pieczonka, Gabriel Reynés Llompart, Jakub Siennicki, Paul Deak, Chiranjib Dutta, Jorge Uribe and Olivier Caselles

    Citation: EJNMMI Physics 2020 7:30

    Content type: Original research

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  24. Strong correlation has been demonstrated between tumor dose and response and between healthy liver dose and side effects. Individualized dosimetry is increasingly recommended in the current clinical routine. H...

    Authors: Nicolas Meyers, Alexandre Jadoul, Claire Bernard, Jean Delwaide, Anne Lamproye, Olivier Detry, Pierre Honoré, Laurent Gerard and Roland Hustinx

    Citation: EJNMMI Physics 2020 7:29

    Content type: Original research

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  25. To determine the impact of the Bayesian penalized likelihood (BPL) reconstruction algorithm in comparison to OSEM on hypoxia PET/CT images of NSCLC using 18F-MIZO and 18F-FAZA.

    Authors: Edgar Texte, Pierrick Gouel, Sébastien Thureau, Justine Lequesne, Bertrand Barres, Agathe Edet-Sanson, Pierre Decazes, Pierre Vera and Sébastien Hapdey

    Citation: EJNMMI Physics 2020 7:28

    Content type: Original research

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  26. For therapeutic applications of several isotopes (e.g., 131I, 153Sm, 177Lu) in nuclear medicine, the high activities typically applied require accurate dead time correction in early time point imaging. We present...

    Authors: Jan W. T. Heemskerk and Michel Defrise

    Citation: EJNMMI Physics 2020 7:27

    Content type: Original research

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  27. Over recent years, peptide receptor radiotherapy (PRRT) has been recognized as an effective treatment for patients with metastatic neuroendocrine tumors (NETs). Personalized dosimetry can contribute to improve...

    Authors: Nanette Freedman, Mattias Sandström, Jonathan Kuten, Natan Shtraus, Inna Ospovat, Albert Schlocker and Einat Even-Sapir

    Citation: EJNMMI Physics 2020 7:26

    Content type: Short communication

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  28. Arterial sampling in PET studies for the purposes of kinetic modeling remains an invasive, time-intensive, and expensive procedure. Alternatives to derive the blood time-activity curve (BTAC) non-invasively ar...

    Authors: Yassine Toufique, Othmane Bouhali, Pauline Negre and Jim O’ Doherty

    Citation: EJNMMI Physics 2020 7:25

    Content type: Original research

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  29. Despite the advent of clinical PET-MR imaging for routine use in 2011 and the development of several methods to address the problem of attenuation correction, some challenges remain. We have identified and inv...

    Authors: J. E. Mackewn, J. Stirling, S. Jeljeli, S-M. Gould, R. I. Johnstone, I. Merida, L. C. Pike, C. J. McGinnity, K. Beck, O. Howes, A. Hammers and P. K. Marsden

    Citation: EJNMMI Physics 2020 7:24

    Content type: Original research

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    The Correction to this article has been published in EJNMMI Physics 2020 7:47

  30. A GATE Monte Carlo model of the Philips Vereos digital photon counting PET imaging system using silicon photo-multiplier detectors was proposed. It was evaluated against experimental data in accordance with NE...

    Authors: Julien Salvadori, Joey Labour, Freddy Odille, Pierre-Yves Marie, Jean-Noël Badel, Laëtitia Imbert and David Sarrut

    Citation: EJNMMI Physics 2020 7:23

    Content type: Original Research

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  31. For multicenter clinical studies, PET/CT and SPECT/CT scanners need to be validated to ensure comparability between various scanner types and brands. This validation is usually performed using hollow phantoms ...

    Authors: Tilman Läppchen, Lorenz P. Meier, Markus Fürstner, George A. Prenosil, Thomas Krause, Axel Rominger, Bernd Klaeser and Michael Hentschel

    Citation: EJNMMI Physics 2020 7:22

    Content type: Original research

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  32. Lutetium oxyorthosilicate or lutetium yttrium oxyorthosilicate (LYSO) scintillation crystals used in most current PET scanner detectors contain 176Lu, which decays by beta emission to excited states of 176Hf acco...

    Authors: Francisco Eduardo Enríquez-Mier-y-Terán, Ana Saret Ortega-Galindo, Tirso Murrieta-Rodríguez, Mercedes Rodríguez-Villafuerte, Arnulfo Martínez-Dávalos and Héctor Alva-Sánchez

    Citation: EJNMMI Physics 2020 7:21

    Content type: Original research

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  33. Optimization of injected gallium-68 (68Ga) activity for 68Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (68Ga-PSMA PET/CT) studies is relevant for image quality, radiation...

    Authors: J. Wielaard, J. B. A. Habraken, P. Brinks, J. Lavalaye and R. Boellaard

    Citation: EJNMMI Physics 2020 7:20

    Content type: Original research

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  34. Respiratory motion in PET/CT leads to well-known image degrading effects commonly compensated using elastic motion correction approaches. Gate-to-gate motion correction techniques are promising tools for impro...

    Authors: Stefanie Pösse, Florian Büther, Dirk Mannweiler, Inki Hong, Judson Jones, Michael Schäfers and Klaus Peter Schäfers

    Citation: EJNMMI Physics 2020 7:19

    Content type: Original Research

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  35. Evaluate the physical performance of the VERITON CzT camera (Spectrum Dynamics, Caesarea, Israel) that benefits from new detection architecture enabling whole-body imaging compared to that of a conventional du...

    Authors: Cédric Desmonts, Mohammed Abdeldjalil Bouthiba, Blandine Enilorac, Catherine Nganoa, Denis Agostini and Nicolas Aide

    Citation: EJNMMI Physics 2020 7:18

    Content type: Young investigators

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  36. Currently, no consistent guidelines for CT scans used within PET/CT examinations are available. This systematic review provides an up-to-date overview of studies to answer the following questions: What are the...

    Authors: V. Bertolini, A. Palmieri, M. C. Bassi, M. Bertolini, V. Trojani, V. Piccagli, F. Fioroni, S. Cavuto, M. Guberti, A. Versari and S. Cola

    Citation: EJNMMI Physics 2020 7:17

    Content type: Review

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  37. 44Sc has been increasingly investigated as a potential alternative to 68Ga in the development of tracers for positron emission tomography (PET). The lower mean positron energy of 44Sc (0.63 MeV) compared to 68Ga ...

    Authors: Florian Rosar, Hans-Georg Buchholz, Sebastian Michels, Manuela A. Hoffmann, Markus Piel, Christopher M. Waldmann, Frank Rösch, Stefan Reuss and Mathias Schreckenberger

    Citation: EJNMMI Physics 2020 7:16

    Content type: Original research

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  38. The purpose of the EANM Dosimetry Committee Series on “Standard Operational Procedures for Dosimetry” (SOP) is to provide advice to scientists and clinicians on how to perform patient-specific absorbed dose as...

    Authors: Jonathan Gear, Carlo Chiesa, Michael Lassmann, Pablo Mínguez Gabiña, Johannes Tran-Gia, Caroline Stokke and Glenn Flux

    Citation: EJNMMI Physics 2020 7:15

    Content type: Opinion article

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  39. New digital PET scanners with improved time of flight timing and extended axial field of view such as the Siemens Biograph Vision have come on the market and are expected to replace current generation photomul...

    Authors: Britt Kunnen, Casper Beijst, Marnix G. E. H. Lam, Max A. Viergever and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2020 7:14

    Content type: Original research

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  40. Intrahepatic dosimetry is paramount to optimize radioembolization treatment accuracy using radioactive holmium-166 microspheres (166Ho). This requires a practical protocol that combines quantitative imaging of mi...

    Authors: R. van Rooij, A. J. A. T. Braat, H. W. A. M. de Jong and M. G. E. H. Lam

    Citation: EJNMMI Physics 2020 7:13

    Content type: Original research

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  41. The National Electrical Manufacturers Association’s (NEMA) NU 4-2008 standard specifies methodology for evaluating the performance of small-animal PET scanners. The standard’s goal is to enable comparison of d...

    Authors: Patrick Hallen, David Schug and Volkmar Schulz

    Citation: EJNMMI Physics 2020 7:12

    Content type: Opinion Article

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  42. Routine PET exams are increasingly performed with reduced injected activities, leading to the use of different image reconstruction parameters than the NEMA parameters, in order to prevent from any deleterious...

    Authors: Julien Salvadori, Freddy Odille, Antoine Verger, Pierre Olivier, Gilles Karcher, Pierre-Yves Marie and Laetitia Imbert

    Citation: EJNMMI Physics 2020 7:11

    Content type: Original research

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  43. Personalization of 177Lu-based radionuclide therapy requires implementation of dosimetry methods that are both accurate and practical enough for routine clinical use. Quantitative single-photon emission computed ...

    Authors: Andrea Frezza, Corentin Desport, Carlos Uribe, Wei Zhao, Anna Celler, Philippe Després and Jean-Mathieu Beauregard

    Citation: EJNMMI Physics 2020 7:10

    Content type: Original research

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  44. Quantitative SPECT imaging in targeted radionuclide therapy with lutetium-177 holds great potential for individualized treatment based on dose assessment. The establishment of dose-effect relations requires a ...

    Authors: Steffie M. B. Peters, Sebastiaan L. Meyer Viol, Niels R. van der Werf, Nick de Jong, Floris H. P. van Velden, Antoi Meeuwis, Mark W. Konijnenberg, Martin Gotthardt, Hugo W. A. M. de Jong and Marcel Segbers

    Citation: EJNMMI Physics 2020 7:9

    Content type: Original research

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  45. Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate cellular dosimetry. Therefore, we have built a refined cellular dos...

    Authors: Giulia Tamborino, Marijke De Saint-Hubert, Lara Struelens, Dayana C. Seoane, Eline A. M. Ruigrok, An Aerts, Wiggert A. van Cappellen, Marion de Jong, Mark W. Konijnenberg and Julie Nonnekens

    Citation: EJNMMI Physics 2020 7:8

    Content type: Original research

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  46. Conventional PET imaging has usually been limited to a single tracer per scan. We propose a new technique for multi-tracer PET imaging that uses dynamic imaging and multi-tracer compartment modeling including ...

    Authors: Carlos Velasco, Adriana Mota-Cobián, Jesús Mateo and Samuel España

    Citation: EJNMMI Physics 2020 7:7

    Content type: Original research

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  47. Before radioiodine therapy for Graves’ disease, the estimated thyroid-absorbed dose is calculated based on various clinical parameters. However, the actual accumulation of iodine in the thyroid during radioiod...

    Authors: Naotoshi Fujita, Yumiko Koshiba, Shinji Abe and Katsuhiko Kato

    Citation: EJNMMI Physics 2020 7:6

    Content type: Original research

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  48. After each cycle of [177Lu]-DOTA-TATE peptide receptor radionuclide therapy (PRRT) dosimetry is performed to enable precise calculation of the radiation-absorbed dose to tumors and normal organs. Absorbed doses a...

    Authors: Alexandre Chicheportiche, Simona Ben-Haim, Simona Grozinsky-Glasberg, Kira Oleinikov, Amichay Meirovitz, David J. Gross and Jeremy Godefroy

    Citation: EJNMMI Physics 2020 7:5

    Content type: Original research

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  49. This article compares the physical performance of the 4-ring digital Discovery MI (DMI) and PMT-based Discovery MI-DR (DMI-DR) PET/CT systems. Physical performance was assessed according to the NEMA NU 2-2012 ...

    Authors: Alexandre Chicheportiche, Rami Marciano and Marina Orevi

    Citation: EJNMMI Physics 2020 7:4

    Content type: Original research

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