Articles

Segmentation-guided multi-modal registration of liver images for dose estimation in SIRT

Selective internal radiation therapy (SIRT) requires a good liver registration of multi-modality images to obtain precise dose prediction and measurement. This study investigated the feasibility of liver regis...

Authors: Xikai Tang, Esmaeel Jafargholi Rangraz, Richard’s Heeren, Walter Coudyzer, Geert Maleux, Kristof Baete, Chris Verslype, Mark J. Gooding, Christophe M. Deroose and Johan Nuyts

Quantitative evaluation of PSMA PET imaging using a realistic anthropomorphic phantom and shell-less radioactive epoxy lesions

Positron emission tomography (PET) with prostate specific membrane antigen (PSMA) have shown superior performance in detecting metastatic prostate cancers. Relative to [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) PET image...

Authors: Roberto Fedrigo, Dan J. Kadrmas, Patricia E. Edem, Lauren Fougner, Ivan S. Klyuzhin, M. Peter Petric, François Bénard, Arman Rahmim and Carlos Uribe

The effect of Q.Clear reconstruction on quantification and spatial resolution of 18F-FDG PET in simultaneous PET/MR

Q.Clear is a block sequential regularized expectation maximization penalized-likelihood reconstruction algorithm for Positron Emission Tomography (PET). It has shown high potential in improving image reconstru...

Authors: Defeng Tian, Hongwei Yang, Yan Li, Bixiao Cui and Jie Lu

A population-based method to determine the time-integrated activity in molecular radiotherapy

The calculation of time-integrated activities (TIAs) for tumours and organs is required for dosimetry in molecular radiotherapy. The accuracy of the calculated TIAs is highly dependent on the chosen fit functi...

Authors: Deni Hardiansyah, Ade Riana, Peter Kletting, Nouran R. R. Zaid, Matthias Eiber, Supriyanto A. Pawiro, Ambros J. Beer and Gerhard Glatting

Artificial intelligence with deep learning in nuclear medicine and radiology

The use of deep learning in medical imaging has increased rapidly over the past few years, finding applications throughout the entire radiology pipeline, from improved scanner performance to automatic disease ...

Authors: Milan Decuyper, Jens Maebe, Roel Van Holen and Stefaan Vandenberghe

Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy

We recently reported a new absorbed dose conversion method, RAP (RAtio of Pharmacokinetics), for ²¹¹At-meta-astatobenzylguanidine (²¹¹At-MABG) using a single biodistribution measurement, the percent injected dose...

Authors: Tetsuya Sakashita, Shojiro Matsumoto, Shigeki Watanabe, Hirofumi Hanaoka, Yasuhiro Ohshima, Yoko Ikoma, Naoyuki Ukon, Ichiro Sasaki, Tatsuya Higashi, Tetsuya Higuchi, Yoshito Tsushima and Noriko S. Ishioka

Fully automated identification of brain abnormality from whole-body FDG-PET imaging using deep learning-based brain extraction and statistical parametric mapping

The whole brain is often covered in [¹⁸F]Fluorodeoxyglucose positron emission tomography ([¹⁸F]FDG-PET) in oncology patients, but the covered brain abnormality is typically screened by visual interpretation witho...

Authors: Wonseok Whi, Hongyoon Choi, Jin Chul Paeng, Gi Jeong Cheon, Keon Wook Kang and Dong Soo Lee

Practical kidney dosimetry in peptide receptor radionuclide therapy using [¹⁷⁷Lu]Lu-DOTATOC and [¹⁷⁷Lu]Lu-DOTATATE with focus on uncertainty estimates

Kidney dosimetry after peptide receptor radionuclide therapy using ¹⁷⁷Lu-labelled somatostatin analogues is a procedure with multiple steps. We present the SPECT/CT-based implementation at Aarhus University Hospi...

Authors: Peter Frøhlich Staanum, Anders Floor Frellsen, Marie Louise Olesen, Peter Iversen and Anne Kirstine Arveschoug

EANM dosimetry committee series on standard operational procedures: a unified methodology for ^99mTc-MAA pre- and ⁹⁰Y peri-therapy dosimetry in liver radioembolization with ⁹⁰Y microspheres

The aim of this standard operational procedure is to standardize the methodology employed for the evaluation of pre- and post-treatment absorbed dose calculations in ⁹⁰Y microsphere liver radioembolization. Basic...

Authors: Carlo Chiesa, Katarina Sjogreen-Gleisner, Stephan Walrand, Lidia Strigari, Glenn Flux, Jonathan Gear, Caroline Stokke, Pablo Minguez Gabina, Peter Bernhardt and Mark Konijnenberg

Fractal analysis of ¹¹C-methionine PET in patients with newly diagnosed glioma

The present study tested the possible utility of fractal analysis from l-[methyl-¹¹C]-methionine (MET) uptake in patients with newly diagnosed gliomas for differentiating glioma, especially in relation to isocitr...

Authors: Yukito Maeda, Yuka Yamamoto, Takashi Norikane, Katsuya Mitamura, Tetsuhiro Hatakeyama, Keisuke Miyake, Yoshihiro Nishiyama and Nobuyuki Kudomi

Harmonization of PET image reconstruction parameters in simultaneous PET/MRI

Simultaneous PET/MRIs vary in their quantitative PET performance due to inherent differences in the physical systems and differences in the image reconstruction implementation. This variability in quantitative...

Authors: Richard Laforest, Mehdi Khalighi, Yutaka Natsuaki, Abhejit Rajagopal, Dharshan Chandramohan, Darrin Byrd, Hongyu An, Peder Larson, Sara St. James, John J. Sunderland, Paul E. Kinahan and Thomas A. Hope

Application of dual-stream 3D convolutional neural network based on ¹⁸F-FDG PET/CT in distinguishing benign and invasive adenocarcinoma in ground-glass lung nodules

This work aims to train, validate, and test a dual-stream three-dimensional convolutional neural network (3D-CNN) based on fluorine 18 (¹⁸F)-fluorodeoxyglucose (FDG) PET/CT to distinguish benign lesions and invas...

Authors: Xiaonan Shao, Rong Niu, Xiaoliang Shao, Jianxiong Gao, Yunmei Shi, Zhenxing Jiang and Yuetao Wang

Quantitative SPECT (QSPECT) at high count rates with contemporary SPECT/CT systems

Accurate QSPECT is crucial in dosimetry-based, personalized radiopharmaceutical therapy with ¹⁷⁷Lu and other radionuclides. We compared the quantitative performance of three NaI(Tl)-crystal SPECT/CT systems equip...

Authors: Alessandro Desy, Guillaume F. Bouvet, Étienne Croteau, Nancy Lafrenière, Éric E. Turcotte, Philippe Després and Jean-Mathieu Beauregard

Image quality and quantification accuracy dependence on patient body mass in ⁸⁹Zr PET/CT imaging

This study was conducted to clarify how patient body mass affects the image quality and quantification accuracy of images obtained using ⁸⁹Zr PET/CT. ⁸⁹Zr PET/CT images from time-of-flight (TOF) PET/CT and semico...

Authors: Ukihide Tateishi, Hiromitsu Daisaki, Junichi Tsuchiya, Yuji Kojima, Keisuke Takino, Naoki Shimada and Kota Yokoyama

Standardizing SPECT/CT dosimetry following radioembolization with yttrium-90 microspheres

Authors: S. Peter Kim, Daniel Juneau, Claire Cohalan and Shirin A. Enger

Dose-reduced [¹⁸F]PSMA-1007 PET is feasible for functional imaging of the renal cortex

In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy...

Authors: Kristian Valind, Jonas Jögi, David Minarik, Gustav Brolin and Elin Trägårdh

Dual energy window imaging for optimisation of P/V ratios in VP SPECT

Ventilation–perfusion single-photon emission computed tomography (VP SPECT) plays an important role in pulmonary embolism diagnosis. Rapid results may be obtained using same-day ventilation followed by perfusi...

Authors: A. G. G. Doruyter and J. L. Holness

Performance evaluation of a PET insert for preclinical MRI in stand-alone PET and simultaneous PET–MRI modes

This study aimed to evaluate the performance of a preclinical PET insert in three configurations: as a stand-alone unit outside the MRI bore, inside the bore of a cryogen-free 3T MRI and, finally, while perfor...

Authors: Gaelle Emvalomenos, Sofie Trajanovska, Binh T. T. Pham, Peter Doughty, Jerome Burnet, Isabelle Smith, Ruslan Garipov, Marie-Claude Gregoire, Nana Sunn, John McGrath and Steven R. Meikle

Quantitative Effect of Metal Artefact Reduction on CT-based attenuation correction in FDG PET/CT in patients with hip prosthesis

Metal artefact reduction (MAR) techniques still are in limited use in positron emission tomography/computed tomography (PET/CT). This study aimed to investigate the effect of Smart MAR on quantitative PET anal...

Authors: Maarten Haemels, Delphine Vandendriessche, Jeroen De Geeter, James Velghe, Maxence Vandekerckhove and Frank De Geeter

Impacts of acquisition and reconstruction parameters on the absolute technetium quantification of the cadmium–zinc–telluride-based SPECT/CT system: a phantom study

The digital cadmium–zinc–telluride (CZT)-based SPECT system has many advantages, including better spatial and energy resolution. However, the impacts of different acquisition and reconstruction parameters on C...

Authors: Ruyi Zhang, Miao Wang, Yaqian Zhou, Shen Wang, Yiming Shen, Ning Li, Peng Wang, Jian Tan, Zhaowei Meng and Qiang Jia

Individualised dosimetry and safety of SIRT for intrahepatic cholangiocarcinoma

The aim of this study was to investigate the safety and efficacy of selective internal radiation therapy (SIRT) with ⁹⁰Y resin microspheres for the treatment of Intrahepatic Cholangiocarcinoma (ICC). A total of 2...

Authors: Kathy P. Willowson, Enid M. Eslick and Dale L. Bailey

Data-driven gated PET/CT: implications for lesion segmentation and quantitation

Data-driven gating (DDG) can improve PET quantitation and alleviate many issues with patient motion. However, misregistration between DDG-PET and CT may occur due to the distinct temporal resolutions of PET an...

Authors: M. Allan Thomas and Tinsu Pan

Simple model for estimation of absorbed dose by organs and tumors after PRRT from a single SPECT/CT study

Following each cycle of peptide receptor radionuclide therapy (PRRT), absorbed doses by tumors and normal organs are typically calculated from three quantitative single-photon emission computed tomography (SPE...

Authors: Alexandre Chicheportiche, Moshe Sason, Jeremy Godefroy, Yodphat Krausz, Mahmoud Zidan, Kira Oleinikov, Amichay Meirovitz, David J. Gross, Simona Grozinsky-Glasberg and Simona Ben-Haim

Multimodal phantoms for clinical PET/MRI

Phantoms are commonly used throughout medical imaging and medical physics for a multitude of applications, the designs of which vary between modalities and clinical or research requirements. Within positron em...

Authors: Eve Lennie, Charalampos Tsoumpas and Steven Sourbron

Evaluation of Iodine-123 and Iodine-131 SPECT activity quantification: a Monte Carlo study

The quantitative accuracy of Nuclear Medicine images, acquired for both planar and SPECT studies, is influenced by the isotope-collimator combination as well as image corrections incorporated in the iterative ...

Authors: Michaella Morphis, Johan A. van Staden, Hanlie du Raan and Michael Ljungberg

Dosimetric impact of Ac-227 in accelerator-produced Ac-225 for alpha-emitter radiopharmaceutical therapy of patients with hematological malignancies: a pharmacokinetic modeling analysis

Actinium-225 is an alpha-particle emitter under investigation for use in radiopharmaceutical therapy. To address limited supply, accelerator-produced ²²⁵Ac has been recently made available. Accelerator-produced ^2...

Authors: George Sgouros, Bin He, Nitya Ray, Dale L. Ludwig and Eric C. Frey

Correction to: Variability in lutetium-177 SPECT quantification between different state-of-the-art SPECT/CT systems

Authors: Steffie M. B. Peters, Sebastiaan L. Meyer Viol, Niels R. van der Werf, Nick de Jong, Floris H. P. van Velden, Antoi Meeuwis, Mark W. Konijnenberg, Martin Gotthardt, Hugo W. A. M. de Jong and Marcel Segbers

Optimisation of CT protocols in PET-CT across different scanner models using different automatic exposure control methods and iterative reconstruction algorithms

A significant proportion of the radiation dose from a PET-CT examination is dependent on the CT protocol, which should be optimised for clinical purposes. Matching protocols on different scanners within an ima...

Authors: Sarah-May Gould, Jane Mackewn, Sugama Chicklore, Gary J. R. Cook, Andrew Mallia and Lucy Pike

Optimization of SPECT/CT imaging protocols for quantitative and qualitative ^99mTc SPECT

The introduction of hybrid SPECT/CT devices enables quantitative imaging in SPECT, providing a methodological setup for quantitation using SPECT tracers comparable to PET/CT. We evaluated a specific quantitati...

Authors: Dennis Kupitz, Heiko Wissel, Jan Wuestemann, Stephanie Bluemel, Maciej Pech, Holger Amthauer, Michael C. Kreissl and Oliver S. Grosser

Yttrium-90 quantitative phantom study using digital photon counting PET

PET imaging of ⁹⁰Y-microsphere distribution following radioembolisation is challenging due to the count-starved statistics from the low branching ratio of e⁺/e⁻ pair production during ⁹⁰Y decay. PET systems using...

Authors: Joey Labour, Philippe Boissard, Thomas Baudier, Fouzi Khayi, David Kryza, Pascale Veyrat Durebex, Sandrine Parisse-Di Martino, Thomas Mognetti, David Sarrut and Jean-Noël Badel

A multicentre and multi-national evaluation of the accuracy of quantitative Lu-177 SPECT/CT imaging performed within the MRTDosimetry project

Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy and to predict response. Dosimetry involves several steps, the first of which is the determination of the activity of the r...

Authors: Johannes Tran-Gia, Ana M. Denis-Bacelar, Kelley M. Ferreira, Andrew P. Robinson, Nicholas Calvert, Andrew J. Fenwick, Domenico Finocchiaro, Federica Fioroni, Elisa Grassi, Warda Heetun, Stephanie J. Jewitt, Maria Kotzassarlidou, Michael Ljungberg, Daniel R. McGowan, Nathaniel Scott, James Scuffham…

Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [¹¹C]PiB amyloid imaging

Partial-volume correction (PVC) using the Geometric Transfer Matrix (GTM) method is used in positron emission tomography (PET) to compensate for the effects of spatial resolution on quantitation. We evaluate t...

Authors: Charles M. Laymon, Davneet S. Minhas, Sarah K. Royse, Howard J. Aizenstein, Ann D. Cohen, Dana L. Tudorascu and William E. Klunk

Renal ^99mTc-DMSA pharmacokinetics in pediatric patients

^99mTc-DMSA is one of the most commonly used pediatric nuclear medicine imaging agents. Nevertheless, there are no pharmacokinetic (PK) models for ^99mTc-DMSA in children, and currently available pediatric dose est...

Authors: Donika Plyku, Michael Ghaly, Ye Li, Justin L. Brown, Shannon O’Reilly, Kitiwat Khamwan, Alison B. Goodkind, Briana Sexton-Stallone, Xinhua Cao, David Zurakowski, Frederic H. Fahey, S. Ted Treves, Wesley E. Bolch, Eric C. Frey and George Sgouros

Standardisation of conventional and advanced iterative reconstruction methods for Gallium-68 multi-centre PET-CT trials

To assess the applicability of the Fluorine-18 performance specifications defined by EANM Research Ltd (EARL), in Gallium-68 multi-centre PET-CT trials using conventional (ordered subset expectation maximisati...

Authors: Georgios Krokos, Lucy C. Pike, Gary J. R. Cook and Paul K. Marsden

Internal dosimetry in F-18 FDG PET examinations based on long-time-measured organ activities using total-body PET/CT: does it make any difference from a short-time measurement?

A 2-m axial field-of-view, total-body PET/CT scanner (uEXPLORER) has been recently developed to provide total-body coverage and ultra-high sensitivity, which together, enables opportunities for in vivo time-ac...

Authors: Pengcheng Hu, Xin Lin, Weihai Zhuo, Hui Tan, Tianwu Xie, Guobing Liu, Shuguang Chen, Xin Chen, Haojun Yu, Yiqiu Zhang, Hongcheng Shi and Haikuan Liu

Optimizing reconstruction parameters for quantitative ¹²⁴I-PET in the presence of therapeutic doses of ¹³¹I

The goal of this work was to determine the quantitative accuracy and optimal reconstruction parameters for ¹²⁴I-PET imaging in the presence of therapeutic levels of ¹³¹I. In this effort, images were acquired on a...

Authors: Louise M. Fanchon, Bradley J. Beattie, Keith Pentlow, Steven M. Larson and John L. Humm

Automatic delineation and quantification of pulmonary vascular obstruction index in patients with pulmonary embolism using Perfusion SPECT-CT: a simulation study

In patients with pulmonary embolism (PE), there is a growing interest in quantifying the pulmonary vascular obtruction index (PVOI), which may be an independent risk factor for PE recurrence. Perfusion SPECT/C...

Authors: David Bourhis, Laura Wagner, Julien Rioult, Philippe Robin, Romain Le Pennec, Cécile Tromeur, Pierre Yves Salaün and Pierre Yves Le Roux

Experimental validation of absolute SPECT/CT quantification for response monitoring in patients with coronary artery disease

Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction techni...

Authors: Alina van de Burgt, Petra Dibbets-Schneider, Cornelis H. Slump, Arthur J. H. A. Scholte, Douwe E. Atsma, Lioe-Fee de Geus-Oei and Floris H. P. van Velden

Design and system evaluation of a dual-panel portable PET (DP-PET)

Integrated whole-body PET/MR technology continues to mature and is now extensively used in clinical settings. However, due to the special design architecture, integrated whole-body PET/MR comes with a few inhe...

Authors: Tianyi Zeng, Jiaxu Zheng, Xinyuan Xia, Xin Chen, Beien Wang, Shuangyue Zhang, Adam Chandler, Tuoyu Cao, Lingzhi Hu, Qun Chen and Xu Chu

Experimental phantom evaluation to identify robust positron emission tomography (PET) radiomic features

Radiomics analysis usually involves, especially in multicenter and large hospital studies, different imaging protocols for acquisition, reconstruction, and processing of data. Differences in protocols can lead...

Authors: Montserrat Carles, Tobias Fechter, Luis Martí-Bonmatí, Dimos Baltas and Michael Mix

Y-90 SIRT: evaluation of TCP variation across dosimetric models

Much progress has been made in implementing selective internal radiation therapy (SIRT) as a viable treatment option for hepatic malignancies. However, there is still much need for improved options for calcula...

Authors: Benjamin J. Van, Yuni K. Dewaraja, Mamadou L. Sangogo and Justin K. Mikell

Radiopharmacokinetic modelling and radiation dose assessment of ²²³Ra used for treatment of metastatic castration-resistant prostate cancer

Ra-223 dichloride (²²³Ra, Xofigo®) is used for treatment of patients suffering from castration-resistant metastatic prostate cancer. The objective of this work was to apply the most recent biokinetic model for ra...

Authors: Vera Höllriegl, Nina Petoussi-Henss, Kerstin Hürkamp, Juan Camilo Ocampo Ramos and Wei Bo Li

Estimation of renal perfusion based on measurement of rubidium-82 clearance by PET/CT scanning in healthy subjects

Changes in renal blood flow (RBF) may play a pathophysiological role in hypertension and kidney disease. However, RBF determination in humans has proven difficult. We aimed to confirm the feasibility of RBF es...

Authors: Stine Sundgaard Langaa, Thomas Guldager Lauridsen, Frank Holden Mose, Claire Anne Fynbo, Jørn Theil and Jesper Nørgaard Bech

Innovative procedure for measuring left ventricular ejection fraction from ¹⁸F-FDG first-pass ultra-sensitive digital PET/CT images: evaluation with an anthropomorphic heart phantom

Left ventricular ejection fraction (LVEF) is usually measured by cine-cardiac magnetic resonance imaging (MRI), planar and single-photon emission-computerized tomography (SPECT) equilibrium radionuclide angioc...

Authors: Emilie Verrecchia-Ramos, Olivier Morel, Paul Retif and Sinan Ben Mahmoud

Performance evaluation of the Q.Clear reconstruction framework versus conventional reconstruction algorithms for quantitative brain PET-MR studies

Q.Clear is a Bayesian penalized likelihood (BPL) reconstruction algorithm that presents improvements in signal-to-noise ratio (SNR) in clinical positron emission tomography (PET) scans. Brain studies in resear...

Authors: Daniela Ribeiro, William Hallett and Adriana A. S. Tavares

Comparison of different methods for post-therapeutic dosimetry in [¹⁷⁷Lu]Lu-PSMA-617 radioligand therapy

Dosimetry is of high importance for optimization of patient-individual PSMA-targeted radioligand therapy (PSMA-RLT). The aim of our study was to evaluate and compare the feasibility of different approaches of ...

Authors: Florian Rosar, Niklas Schön, Hendrik Bohnenberger, Mark Bartholomä, Tobias Stemler, Stephan Maus, Fadi Khreish, Samer Ezziddin and Andrea Schaefer-Schuler

Population-based input function for TSPO quantification and kinetic modeling with [¹¹C]-DPA-713

Quantitative positron emission tomography (PET) studies of neurodegenerative diseases typically require the measurement of arterial input functions (AIF), an invasive and risky procedure. This study aims to as...

Authors: Mercy I. Akerele, Sara A. Zein, Sneha Pandya, Anastasia Nikolopoulou, Susan A. Gauthier, Ashish Raj, Claire Henchcliffe, P. David Mozley, Nicolas A. Karakatsanis, Ajay Gupta, John Babich and Sadek A. Nehmeh

3D printing ¹⁸F radioactive phantoms for PET imaging

Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by crea...

Authors: Daniel Gillett, Daniel Marsden, Safia Ballout, Bala Attili, Nick Bird, Sarah Heard, Mark Gurnell, Iosif A. Mendichovszky and Luigi Aloj

Human biodistribution and dosimetry of [¹¹C]-UCB-J, a PET radiotracer for imaging synaptic density

[¹¹C]-UCB-J is an emerging tool for the noninvasive measurement of synaptic vesicle density in vivo. Here, we report human biodistribution and dosimetry estimates derived from sequential whole-body PET using two ...

Authors: Christopher Cawthorne, Paul Maguire, Joel Mercier, David Sciberras, Kim Serdons, Guy Bormans, Jan de Hoon, Koen Van Laere and Michel Koole

Correction to: Influence of dosimetry method on bone lesion absorbed dose estimates in PSMA therapy: application to mCRPC patients receiving Lu-177-PSMA-I&T

An amendment to this paper has been published and can be accessed via the original article.

Authors: Julia Brosch-Lenz, Carlos Uribe, Astrid Gosewisch, Lena Kaiser, Andrei Todica, Harun Ilhan, Franz Josef Gildehaus, Peter Bartenstein, Arman Rahmim, Anna Celler, Sibylle Ziegler and Guido Böning