Articles

Individualised dosimetry and safety of SIRT for intrahepatic cholangiocarcinoma

The aim of this study was to investigate the safety and efficacy of selective internal radiation therapy (SIRT) with ⁹⁰Y resin microspheres for the treatment of Intrahepatic Cholangiocarcinoma (ICC). A total of 2...

Authors: Kathy P. Willowson, Enid M. Eslick and Dale L. Bailey

Data-driven gated PET/CT: implications for lesion segmentation and quantitation

Data-driven gating (DDG) can improve PET quantitation and alleviate many issues with patient motion. However, misregistration between DDG-PET and CT may occur due to the distinct temporal resolutions of PET an...

Authors: M. Allan Thomas and Tinsu Pan

Simple model for estimation of absorbed dose by organs and tumors after PRRT from a single SPECT/CT study

Following each cycle of peptide receptor radionuclide therapy (PRRT), absorbed doses by tumors and normal organs are typically calculated from three quantitative single-photon emission computed tomography (SPE...

Authors: Alexandre Chicheportiche, Moshe Sason, Jeremy Godefroy, Yodphat Krausz, Mahmoud Zidan, Kira Oleinikov, Amichay Meirovitz, David J. Gross, Simona Grozinsky-Glasberg and Simona Ben-Haim

Multimodal phantoms for clinical PET/MRI

Phantoms are commonly used throughout medical imaging and medical physics for a multitude of applications, the designs of which vary between modalities and clinical or research requirements. Within positron em...

Authors: Eve Lennie, Charalampos Tsoumpas and Steven Sourbron

Evaluation of Iodine-123 and Iodine-131 SPECT activity quantification: a Monte Carlo study

The quantitative accuracy of Nuclear Medicine images, acquired for both planar and SPECT studies, is influenced by the isotope-collimator combination as well as image corrections incorporated in the iterative ...

Authors: Michaella Morphis, Johan A. van Staden, Hanlie du Raan and Michael Ljungberg

Dosimetric impact of Ac-227 in accelerator-produced Ac-225 for alpha-emitter radiopharmaceutical therapy of patients with hematological malignancies: a pharmacokinetic modeling analysis

Actinium-225 is an alpha-particle emitter under investigation for use in radiopharmaceutical therapy. To address limited supply, accelerator-produced ²²⁵Ac has been recently made available. Accelerator-produced ^2...

Authors: George Sgouros, Bin He, Nitya Ray, Dale L. Ludwig and Eric C. Frey

Correction to: Variability in lutetium-177 SPECT quantification between different state-of-the-art SPECT/CT systems

Authors: Steffie M. B. Peters, Sebastiaan L. Meyer Viol, Niels R. van der Werf, Nick de Jong, Floris H. P. van Velden, Antoi Meeuwis, Mark W. Konijnenberg, Martin Gotthardt, Hugo W. A. M. de Jong and Marcel Segbers

Optimisation of CT protocols in PET-CT across different scanner models using different automatic exposure control methods and iterative reconstruction algorithms

A significant proportion of the radiation dose from a PET-CT examination is dependent on the CT protocol, which should be optimised for clinical purposes. Matching protocols on different scanners within an ima...

Authors: Sarah-May Gould, Jane Mackewn, Sugama Chicklore, Gary J. R. Cook, Andrew Mallia and Lucy Pike

Optimization of SPECT/CT imaging protocols for quantitative and qualitative ^99mTc SPECT

The introduction of hybrid SPECT/CT devices enables quantitative imaging in SPECT, providing a methodological setup for quantitation using SPECT tracers comparable to PET/CT. We evaluated a specific quantitati...

Authors: Dennis Kupitz, Heiko Wissel, Jan Wuestemann, Stephanie Bluemel, Maciej Pech, Holger Amthauer, Michael C. Kreissl and Oliver S. Grosser

Yttrium-90 quantitative phantom study using digital photon counting PET

PET imaging of ⁹⁰Y-microsphere distribution following radioembolisation is challenging due to the count-starved statistics from the low branching ratio of e⁺/e⁻ pair production during ⁹⁰Y decay. PET systems using...

Authors: Joey Labour, Philippe Boissard, Thomas Baudier, Fouzi Khayi, David Kryza, Pascale Veyrat Durebex, Sandrine Parisse-Di Martino, Thomas Mognetti, David Sarrut and Jean-Noël Badel

A multicentre and multi-national evaluation of the accuracy of quantitative Lu-177 SPECT/CT imaging performed within the MRTDosimetry project

Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy and to predict response. Dosimetry involves several steps, the first of which is the determination of the activity of the r...

Authors: Johannes Tran-Gia, Ana M. Denis-Bacelar, Kelley M. Ferreira, Andrew P. Robinson, Nicholas Calvert, Andrew J. Fenwick, Domenico Finocchiaro, Federica Fioroni, Elisa Grassi, Warda Heetun, Stephanie J. Jewitt, Maria Kotzassarlidou, Michael Ljungberg, Daniel R. McGowan, Nathaniel Scott, James Scuffham…

Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [¹¹C]PiB amyloid imaging

Partial-volume correction (PVC) using the Geometric Transfer Matrix (GTM) method is used in positron emission tomography (PET) to compensate for the effects of spatial resolution on quantitation. We evaluate t...

Authors: Charles M. Laymon, Davneet S. Minhas, Sarah K. Royse, Howard J. Aizenstein, Ann D. Cohen, Dana L. Tudorascu and William E. Klunk

Renal ^99mTc-DMSA pharmacokinetics in pediatric patients

^99mTc-DMSA is one of the most commonly used pediatric nuclear medicine imaging agents. Nevertheless, there are no pharmacokinetic (PK) models for ^99mTc-DMSA in children, and currently available pediatric dose est...

Authors: Donika Plyku, Michael Ghaly, Ye Li, Justin L. Brown, Shannon O’Reilly, Kitiwat Khamwan, Alison B. Goodkind, Briana Sexton-Stallone, Xinhua Cao, David Zurakowski, Frederic H. Fahey, S. Ted Treves, Wesley E. Bolch, Eric C. Frey and George Sgouros

Standardisation of conventional and advanced iterative reconstruction methods for Gallium-68 multi-centre PET-CT trials

To assess the applicability of the Fluorine-18 performance specifications defined by EANM Research Ltd (EARL), in Gallium-68 multi-centre PET-CT trials using conventional (ordered subset expectation maximisati...

Authors: Georgios Krokos, Lucy C. Pike, Gary J. R. Cook and Paul K. Marsden

Internal dosimetry in F-18 FDG PET examinations based on long-time-measured organ activities using total-body PET/CT: does it make any difference from a short-time measurement?

A 2-m axial field-of-view, total-body PET/CT scanner (uEXPLORER) has been recently developed to provide total-body coverage and ultra-high sensitivity, which together, enables opportunities for in vivo time-ac...

Authors: Pengcheng Hu, Xin Lin, Weihai Zhuo, Hui Tan, Tianwu Xie, Guobing Liu, Shuguang Chen, Xin Chen, Haojun Yu, Yiqiu Zhang, Hongcheng Shi and Haikuan Liu

Optimizing reconstruction parameters for quantitative ¹²⁴I-PET in the presence of therapeutic doses of ¹³¹I

The goal of this work was to determine the quantitative accuracy and optimal reconstruction parameters for ¹²⁴I-PET imaging in the presence of therapeutic levels of ¹³¹I. In this effort, images were acquired on a...

Authors: Louise M. Fanchon, Bradley J. Beattie, Keith Pentlow, Steven M. Larson and John L. Humm

Automatic delineation and quantification of pulmonary vascular obstruction index in patients with pulmonary embolism using Perfusion SPECT-CT: a simulation study

In patients with pulmonary embolism (PE), there is a growing interest in quantifying the pulmonary vascular obtruction index (PVOI), which may be an independent risk factor for PE recurrence. Perfusion SPECT/C...

Authors: David Bourhis, Laura Wagner, Julien Rioult, Philippe Robin, Romain Le Pennec, Cécile Tromeur, Pierre Yves Salaün and Pierre Yves Le Roux

Experimental validation of absolute SPECT/CT quantification for response monitoring in patients with coronary artery disease

Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction techni...

Authors: Alina van de Burgt, Petra Dibbets-Schneider, Cornelis H. Slump, Arthur J. H. A. Scholte, Douwe E. Atsma, Lioe-Fee de Geus-Oei and Floris H. P. van Velden

Design and system evaluation of a dual-panel portable PET (DP-PET)

Integrated whole-body PET/MR technology continues to mature and is now extensively used in clinical settings. However, due to the special design architecture, integrated whole-body PET/MR comes with a few inhe...

Authors: Tianyi Zeng, Jiaxu Zheng, Xinyuan Xia, Xin Chen, Beien Wang, Shuangyue Zhang, Adam Chandler, Tuoyu Cao, Lingzhi Hu, Qun Chen and Xu Chu

Experimental phantom evaluation to identify robust positron emission tomography (PET) radiomic features

Radiomics analysis usually involves, especially in multicenter and large hospital studies, different imaging protocols for acquisition, reconstruction, and processing of data. Differences in protocols can lead...

Authors: Montserrat Carles, Tobias Fechter, Luis Martí-Bonmatí, Dimos Baltas and Michael Mix

Y-90 SIRT: evaluation of TCP variation across dosimetric models

Much progress has been made in implementing selective internal radiation therapy (SIRT) as a viable treatment option for hepatic malignancies. However, there is still much need for improved options for calcula...

Authors: Benjamin J. Van, Yuni K. Dewaraja, Mamadou L. Sangogo and Justin K. Mikell

Radiopharmacokinetic modelling and radiation dose assessment of ²²³Ra used for treatment of metastatic castration-resistant prostate cancer

Ra-223 dichloride (²²³Ra, Xofigo®) is used for treatment of patients suffering from castration-resistant metastatic prostate cancer. The objective of this work was to apply the most recent biokinetic model for ra...

Authors: Vera Höllriegl, Nina Petoussi-Henss, Kerstin Hürkamp, Juan Camilo Ocampo Ramos and Wei Bo Li

Estimation of renal perfusion based on measurement of rubidium-82 clearance by PET/CT scanning in healthy subjects

Changes in renal blood flow (RBF) may play a pathophysiological role in hypertension and kidney disease. However, RBF determination in humans has proven difficult. We aimed to confirm the feasibility of RBF es...

Authors: Stine Sundgaard Langaa, Thomas Guldager Lauridsen, Frank Holden Mose, Claire Anne Fynbo, Jørn Theil and Jesper Nørgaard Bech

Innovative procedure for measuring left ventricular ejection fraction from ¹⁸F-FDG first-pass ultra-sensitive digital PET/CT images: evaluation with an anthropomorphic heart phantom

Left ventricular ejection fraction (LVEF) is usually measured by cine-cardiac magnetic resonance imaging (MRI), planar and single-photon emission-computerized tomography (SPECT) equilibrium radionuclide angioc...

Authors: Emilie Verrecchia-Ramos, Olivier Morel, Paul Retif and Sinan Ben Mahmoud

Performance evaluation of the Q.Clear reconstruction framework versus conventional reconstruction algorithms for quantitative brain PET-MR studies

Q.Clear is a Bayesian penalized likelihood (BPL) reconstruction algorithm that presents improvements in signal-to-noise ratio (SNR) in clinical positron emission tomography (PET) scans. Brain studies in resear...

Authors: Daniela Ribeiro, William Hallett and Adriana A. S. Tavares

Comparison of different methods for post-therapeutic dosimetry in [¹⁷⁷Lu]Lu-PSMA-617 radioligand therapy

Dosimetry is of high importance for optimization of patient-individual PSMA-targeted radioligand therapy (PSMA-RLT). The aim of our study was to evaluate and compare the feasibility of different approaches of ...

Authors: Florian Rosar, Niklas Schön, Hendrik Bohnenberger, Mark Bartholomä, Tobias Stemler, Stephan Maus, Fadi Khreish, Samer Ezziddin and Andrea Schaefer-Schuler

Population-based input function for TSPO quantification and kinetic modeling with [¹¹C]-DPA-713

Quantitative positron emission tomography (PET) studies of neurodegenerative diseases typically require the measurement of arterial input functions (AIF), an invasive and risky procedure. This study aims to as...

Authors: Mercy I. Akerele, Sara A. Zein, Sneha Pandya, Anastasia Nikolopoulou, Susan A. Gauthier, Ashish Raj, Claire Henchcliffe, P. David Mozley, Nicolas A. Karakatsanis, Ajay Gupta, John Babich and Sadek A. Nehmeh

3D printing ¹⁸F radioactive phantoms for PET imaging

Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by crea...

Authors: Daniel Gillett, Daniel Marsden, Safia Ballout, Bala Attili, Nick Bird, Sarah Heard, Mark Gurnell, Iosif A. Mendichovszky and Luigi Aloj

Human biodistribution and dosimetry of [¹¹C]-UCB-J, a PET radiotracer for imaging synaptic density

[¹¹C]-UCB-J is an emerging tool for the noninvasive measurement of synaptic vesicle density in vivo. Here, we report human biodistribution and dosimetry estimates derived from sequential whole-body PET using two ...

Authors: Christopher Cawthorne, Paul Maguire, Joel Mercier, David Sciberras, Kim Serdons, Guy Bormans, Jan de Hoon, Koen Van Laere and Michel Koole

Correction to: Influence of dosimetry method on bone lesion absorbed dose estimates in PSMA therapy: application to mCRPC patients receiving Lu-177-PSMA-I&T

An amendment to this paper has been published and can be accessed via the original article.

Authors: Julia Brosch-Lenz, Carlos Uribe, Astrid Gosewisch, Lena Kaiser, Andrei Todica, Harun Ilhan, Franz Josef Gildehaus, Peter Bartenstein, Arman Rahmim, Anna Celler, Sibylle Ziegler and Guido Böning

The role of activity, scan duration and patient’s body mass index in the optimization of FDG imaging protocols on a TOF-PET/CT scanner

Time-of-flight (TOF) PET technology determines a reduction in the noise and improves the reconstructed image quality in low count acquisitions, such as in overweight patients, allowing a reduction of administe...

Authors: Roberta Matheoud, Naema Al-Maymani, Alessia Oldani, Gian Mauro Sacchetti, Marco Brambilla and Alessandro Carriero

Effect of quantitative values on shortened acquisition duration in brain tumor ¹¹C-methionine PET/CT

The amount of signal decreases when the acquisition duration is shortened. However, it is not clear how this affects the quantitative values. This study aims to clarify the effect of acquisition time shortenin...

Authors: Masatoshi Morimoto, Nobuyuki Kudomi, Yukito Maeda, Takuya Kobata, Akihiro Oishi, Keisuke Matsumoto, Toshihide Monden, Takanobu Iwasaki, Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto and Yoshihiro Nishiyama

Tissue dose estimation after extravasation of ¹⁷⁷Lu-DOTATATE

Extravasation of radiopharmaceuticals used for vectorized internal radiotherapy can lead to severe tissue damage (van der Pol et al., Eur J Nucl Med Mol Imaging 44:1234–1243, 2017). Clinical management of thes...

Authors: Perrine Tylski, Géraldine Pina-Jomir, Claire Bournaud-Salinas and Patrice Jalade

AI-based detection of lung lesions in [¹⁸F]FDG PET-CT from lung cancer patients

[¹⁸F]-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography (PET-CT) is a well-established modality in the work-up of patients with suspected or confirmed diagnosis of lung cancer. Recent...

Authors: Pablo Borrelli, John Ly, Reza Kaboteh, Johannes Ulén, Olof Enqvist, Elin Trägårdh and Lars Edenbrandt

Deep learning-based image quality improvement of ¹⁸F-fluorodeoxyglucose positron emission tomography: a retrospective observational study

Deep learning (DL)-based image quality improvement is a novel technique based on convolutional neural networks. The aim of this study was to compare the clinical value of ¹⁸F-fluorodeoxyglucose positron emission ...

Authors: Junichi Tsuchiya, Kota Yokoyama, Ken Yamagiwa, Ryosuke Watanabe, Koichiro Kimura, Mitsuhiro Kishino, Chung Chan, Evren Asma and Ukihide Tateishi

Evaluation of the PETsys TOFPET2 ASIC in multi-channel coincidence experiments

Aiming to measure the difference in arrival times of two coincident γ-photons with an accuracy in the order of 200ps, time-of-flight positron emission tomography systems commonly employ silicon photomultipliers (...

Authors: Vanessa Nadig, David Schug, Bjoern Weissler and Volkmar Schulz

Validation of CARE kV automated tube voltage selection for PET-CT: PET quantification and CT radiation dose reduction in phantoms

Applied tube voltage (kilovolts, kV) and tube current (milliampere seconds, mAs) affect CT radiation dose and image quality and should be optimised for the individual patient. CARE kV determines the kV and mAs...

Authors: Natalie A. Bebbington, Troels Jørgensen, Erik Dupont and Mille A. Micheelsen

Q-Bot: automatic DICOM metadata monitoring for the next level of quality management in nuclear medicine

Regular and precise inspection of the realization of the local nuclear medicine standard operation procedures (SOPs) is very complex and time-consuming, especially when large amount of patient data is obtained...

Authors: Ferenc Nagy, Aron K. Krizsan, Kornél Kukuts, Melinda Szolikova, Zsolt Hascsi, Sandor Barna, Antonietta Acs, Peter Szabo, Lajos Tron, Laszlo Balkay, Magnus Dahlbom, Mihaly Zentai, Attila Forgacs and Ildiko Garai

The effect of calibration factors and recovery coefficients on ¹⁷⁷Lu SPECT activity quantification accuracy: a Monte Carlo study

Different gamma camera calibration factor (CF) geometries have been proposed to convert SPECT data into units of activity concentration. However, no consensus has been reached on a standardised geometry. The C...

Authors: Keamogetswe Ramonaheng, Johannes A. van Staden and Hanlie du Raan

Influence of dosimetry method on bone lesion absorbed dose estimates in PSMA therapy: application to mCRPC patients receiving Lu-177-PSMA-I&T

Patients with metastatic, castration-resistant prostate cancer (mCRPC) present with an increased tumor burden in the skeleton. For these patients, Lutetium-177 (Lu-177) radioligand therapy targeting the prosta...

Authors: Julia Brosch-Lenz, Carlos Uribe, Astrid Gosewisch, Lena Kaiser, Andrei Todica, Harun Ilhan, Franz Josef Gildehaus, Peter Bartenstein, Arman Rahmim, Anna Celler, Sibylle Ziegler and Guido Böning

Artificial intelligence for reduced dose 18F-FDG PET examinations: a real-world deployment through a standardized framework and business case assessment

To determine whether artificial intelligence (AI) processed PET/CT images of reduced by one-third of 18-F-FDG activity compared to the standard injected dose, were non-inferior to native scans and if so to ass...

Authors: Katia Katsari, Daniele Penna, Vincenzo Arena, Giulia Polverari, Annarita Ianniello, Domenico Italiano, Rolando Milani, Alessandro Roncacci, Rowland O. Illing and Ettore Pelosi

Improved PET/MRI accuracy by use of static transmission source in empirically derived hardware attenuation correction

Accurate quantification of radioactivity, measured by an integrated positron emission tomography (PET) and magnetic resonance imaging (MRI) system, is still a challenge. One aspect of such a challenge is to co...

Authors: Adam Farag, R. Terry Thompson, Jonathan D. Thiessen, Frank S. Prato and Jean Théberge

Automated assessment of functional lung imaging with ⁶⁸Ga-ventilation/perfusion PET/CT using iterative histogram analysis

Functional lung mapping from Ga⁶⁸-ventilation/perfusion (V/Q) PET/CT, which has been shown to correlate with pulmonary function tests (PFTs), may be beneficial in a number of clinical applications where sparing r...

Authors: Lachlan McIntosh, Price Jackson, Nicholas Hardcastle, Mathias Bressel, Tomas Kron, Jason W. Callahan, Daniel Steinfort, Nicholas Bucknell, Michael S. Hofman and Shankar Siva

Gamma camera characterization at high holmium-166 activity in liver radioembolization

High activities of holmium-166 (¹⁶⁶Ho)–labeled microspheres are used for therapeutic radioembolization, ideally directly followed by SPECT imaging for dosimetry purposes. The resulting high-count rate potentially...

Authors: Martina Stella, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong and Rob van Rooij

Impact of segmentation and discretization on radiomic features in ⁶⁸Ga-DOTA-TOC PET/CT images of neuroendocrine tumor

To identify the impact of segmentation methods and intensity discretization on radiomic features (RFs) extraction from ⁶⁸Ga-DOTA-TOC PET images in patients with neuroendocrine tumors.

Authors: Virginia Liberini, Bruno De Santi, Osvaldo Rampado, Elena Gallio, Beatrice Dionisi, Francesco Ceci, Giulia Polverari, Philippe Thuillier, Filippo Molinari and Désirée Deandreis

Cross-validation study between the HRRT and the PET component of the SIGNA PET/MRI system with focus on neuroimaging

The Siemens high-resolution research tomograph (HRRT - a dedicated brain PET scanner) is to this day one of the highest resolution PET scanners; thus, it can serve as useful benchmark when evaluating performan...

Authors: Julia G. Mannheim, Ju-Chieh (Kevin) Cheng, Nasim Vafai, Elham Shahinfard, Carolyn English, Jessamyn McKenzie, Jing Zhang, Laura Barlow and Vesna Sossi

Head-to-head comparison of a Si-photomultiplier-based and a conventional photomultiplier-based PET-CT system

A novel generation of PET scanners based on silicon (Si)-photomultiplier (PM) technology has recently been introduced. Concurrently, there has been development of new reconstruction methods aimed at increasing...

Authors: Jenny Oddstig, Gustav Brolin, Elin Trägårdh and David Minarik

Standard MRI-based attenuation correction for PET/MRI phantoms: a novel concept using MRI-visible polymer

PET/MRI phantom studies are challenged by the need of phantom-specific attenuation templates to account for attenuation properties of the phantom material. We present a PET/MRI phantom built from MRI-visible m...

Authors: Ivo Rausch, Alejandra Valladares, Lalith Kumar Shiyam Sundar, Thomas Beyer, Marcus Hacker, Martin Meyerspeer and Ewald Unger

Theranostic SPECT reconstruction for improved resolution: application to radionuclide therapy dosimetry

SPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due to the limited spatial resolution of the gamma camera. Incorporating resolution modellin...

Authors: H. Marquis, D. Deidda, A. Gillman, K. P. Willowson, Y. Gholami, T. Hioki, E. Eslick, K. Thielemans and D. L. Bailey

Quantitative imaging of bone remodeling in patients with a unicompartmental joint unloading knee implant (ATLAS Knee System)—effect of metal artifacts on a SPECT-CT-based quantification

SPECT-CT using radiolabeled phosphonates is considered a standard for assessing bone metabolism (e.g., in patients with osteoarthritis of knee joints). However, SPECT can be influenced by metal artifacts in CT...

Authors: Oliver S. Grosser, Marcus Klutzny, Heiko Wissel, Dennis Kupitz, Michael Finger, Simone Schenke, Jan Wuestemann, Christoph H. Lohmann, Christoph Hoeschen, Maciej Pech, Christian Staerke and Michael C. Kreissl