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  1. Conventional PET imaging has usually been limited to a single tracer per scan. We propose a new technique for multi-tracer PET imaging that uses dynamic imaging and multi-tracer compartment modeling including ...

    Authors: Carlos Velasco, Adriana Mota-Cobián, Jesús Mateo and Samuel España

    Citation: EJNMMI Physics 2020 7:7

    Content type: Original research

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  2. Before radioiodine therapy for Graves’ disease, the estimated thyroid-absorbed dose is calculated based on various clinical parameters. However, the actual accumulation of iodine in the thyroid during radioiod...

    Authors: Naotoshi Fujita, Yumiko Koshiba, Shinji Abe and Katsuhiko Kato

    Citation: EJNMMI Physics 2020 7:6

    Content type: Original research

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  3. After each cycle of [177Lu]-DOTA-TATE peptide receptor radionuclide therapy (PRRT) dosimetry is performed to enable precise calculation of the radiation-absorbed dose to tumors and normal organs. Absorbed doses a...

    Authors: Alexandre Chicheportiche, Simona Ben-Haim, Simona Grozinsky-Glasberg, Kira Oleinikov, Amichay Meirovitz, David J. Gross and Jeremy Godefroy

    Citation: EJNMMI Physics 2020 7:5

    Content type: Original research

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  4. This article compares the physical performance of the 4-ring digital Discovery MI (DMI) and PMT-based Discovery MI-DR (DMI-DR) PET/CT systems. Physical performance was assessed according to the NEMA NU 2-2012 ...

    Authors: Alexandre Chicheportiche, Rami Marciano and Marina Orevi

    Citation: EJNMMI Physics 2020 7:4

    Content type: Original research

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  5. Bayesian penalized likelihood reconstruction for PET (e.g., GE Q.Clear) aims at improving convergence of lesion activity while ensuring sufficient signal-to-noise ratio (SNR). This study evaluated reconstructe...

    Authors: Julian M. Rogasch, Said Suleiman, Frank Hofheinz, Stephanie Bluemel, Mathias Lukas, Holger Amthauer and Christian Furth

    Citation: EJNMMI Physics 2020 7:2

    Content type: Original research

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  6. We assessed and compared image quality obtained with clinical 18F-FDG whole-body oncologic PET protocols used in three different, state-of-the-art digital PET/CT and two conventional PMT-based PET/CT devices.

    Authors: Silvano Gnesin, Christine Kieffer, Konstantinos Zeimpekis, Jean-Pierre Papazyan, Renaud Guignard, John O. Prior, Francis R. Verdun and Thiago V. M. Lima

    Citation: EJNMMI Physics 2020 7:1

    Content type: Original research

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  7. Recently, a Bayesian penalized likelihood (BPL) reconstruction algorithm was introduced for a commercial PET/CT with the potential to improve image quality. We compared the performance of this BPL algorithm wi...

    Authors: Joost te Riet, Sjoerd Rijnsdorp, Mark J. Roef and Albert J. Arends

    Citation: EJNMMI Physics 2019 6:32

    Content type: Original research

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  8. In ordered subsets expectation maximization (OSEM) reconstruction of electrocardiography (ECG)-gated myocardial perfusion single-photon emission computed tomography (SPECT), it is often assumed that the image ...

    Authors: Matti J. Kortelainen, Tuomas M. Koivumäki, Marko J. Vauhkonen and Mikko A. Hakulinen

    Citation: EJNMMI Physics 2019 6:30

    Content type: Original research

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  9. Absolute quantification of radiotracer distribution using SPECT/CT imaging is of great importance for dosimetry aimed at personalized radionuclide precision treatment. However, its accuracy depends on many fac...

    Authors: Steffie M. B. Peters, Niels R. van der Werf, Marcel Segbers, Floris H. P. van Velden, Roel Wierts, Koos (J.) A. K. Blokland, Mark W. Konijnenberg, Sergiy V. Lazarenko, Eric P. Visser and Martin Gotthardt

    Citation: EJNMMI Physics 2019 6:29

    Content type: Original research

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  10. Recently, updated EARL specifications (EARL2) have been developed and announced. This study aims at investigating the impact of the EARL2 specifications on the quantitative reads of clinical PET–CT studies and...

    Authors: Andres Kaalep, Coreline N. Burggraaff, Simone Pieplenbosch, Eline E. Verwer, Terez Sera, Josee Zijlstra, Otto S. Hoekstra, Daniela E. Oprea-Lager and Ronald Boellaard

    Citation: EJNMMI Physics 2019 6:28

    Content type: Original research

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  11. We aim to provide a systematic study of the impact of white matter (WM) spill-in on the calculation of standardized uptake value ratios (SUVRs) on Aβ-negative subjects, and we study the effect of including WM ...

    Authors: Francisco Javier López-González, Alexis Moscoso, Nikos Efthimiou, Anxo Fernández-Ferreiro, Manuel Piñeiro-Fiel, Stephen J. Archibald, Pablo Aguiar and Jesús Silva-Rodríguez

    Citation: EJNMMI Physics 2019 6:27

    Content type: Original research

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  12. Compartmental modelling is an established method of quantifying 18F-FDG uptake; however, only recently has it been applied to evaluate pulmonary inflammation. Implementation of compartmental models remains challe...

    Authors: Laurence D. Vass, Sarah Lee, Frederick J. Wilson, Marie Fisk, Joseph Cheriyan and Ian Wilkinson

    Citation: EJNMMI Physics 2019 6:26

    Content type: Original Research

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  13. Multi-tracer positron emission tomography (PET) imaging can be accomplished by applying multi-tracer compartment modeling. Recently, a method has been proposed in which the arterial input functions (AIFs) of t...

    Authors: Carlos Velasco, Adriana Mota-Cobián, Jesús Mateo and Samuel España

    Citation: EJNMMI Physics 2019 6:25

    Content type: Original research

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  14. Computed tomography (CT) scans are routinely performed in positron emission tomography (PET) and single photon emission computed tomography (SPECT) examinations globally, yet few surveys have been conducted to...

    Authors: Natalie A. Bebbington, Bryan T. Haddock, Henrik Bertilsson, Eero Hippeläinen, Ellen M. Husby, Virpi I. Tunninen and Marcus Söderberg

    Citation: EJNMMI Physics 2019 6:24

    Content type: Original research

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  15. The decay characteristics of radionuclides in PET studies can impact image reconstruction. 44gSc has been the topic of recent research due to potential theranostic applications and is a promising radiometal for P...

    Authors: Simon Ferguson, Hans-Sonke Jans, Melinda Wuest, Terence Riauka and Frank Wuest

    Citation: EJNMMI Physics 2019 6:23

    Content type: Original research

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  16. Q.Clear is a block sequential regularized expectation maximization (BSREM) penalized-likelihood reconstruction algorithm for PET. It tries to improve image quality by controlling noise amplification during ima...

    Authors: Paulo R. R. V. Caribé, M. Koole, Yves D’Asseler, B. Van Den Broeck and S. Vandenberghe

    Citation: EJNMMI Physics 2019 6:22

    Content type: Original research

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  17. To determine the clinically acceptable level of reduction in the injected fluorine-18 (18F)-labeled fluorodeoxyglucose (18F-FDG) dose in dedicated breast positron emission tomography (dbPET).

    Authors: Yoko Satoh, Tetsuro Sekine, Yoshie Omiya, Hiroshi Onishi and Utaroh Motosugi

    Citation: EJNMMI Physics 2019 6:21

    Content type: Original research

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  18. Volumes of usual PET phantoms are about four to sixfold that of a human liver. In order to avoid count rate saturation and handling of very high 90Y activity, reported TOF-PET phantom studies are performed using ...

    Authors: Michel Hesse and Stephan Walrand

    Citation: EJNMMI Physics 2019 6:20

    Content type: Artefact report

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  19. Performance standards for quantitative 18F-FDG PET/CT studies are provided by the EANM Research Ltd. (EARL) to enable comparability of quantitative PET in multicentre studies. Yet, such specifications are not ava...

    Authors: Daphne M. V. Huizing, Daniëlle Koopman, Jorn A. van Dalen, Martin Gotthardt, Ronald Boellaard, Terez Sera, Michiel Sinaasappel, Marcel P. M. Stokkel and Berlinda J. de Wit-van der Veen

    Citation: EJNMMI Physics 2019 6:19

    Content type: Short communication

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  20. Cerenkov Luminescence Imaging (CLI) is an emerging technology for intraoperative margin assessment. Previous research only evaluated radionuclide 18-Fluorine (18F); however, for future applications in prostate ca...

    Authors: J. olde Heuvel, B. J. de Wit-van der Veen, K. N. Vyas, D. S. Tuch, M. R. Grootendorst, M. P. M. Stokkel and C. H. Slump

    Citation: EJNMMI Physics 2019 6:17

    Content type: Original research

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  21. The technology of modern positron emission tomography (PET) systems continuously improving, and with it the possibility to detect smaller lesions. Since first introduced in 2010, the number of hybrid PET/magne...

    Authors: Silje Kjærnes Øen, Lars Birger Aasheim, Live Eikenes and Anna Maria Karlberg

    Citation: EJNMMI Physics 2019 6:16

    Content type: Original research

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  22. Software for Tomographic Image Reconstruction (STIR) is an open-source library for PET and SPECT image reconstruction, implementing iterative reconstruction as well as 2D- and 3D-filtered back projection. Quan...

    Authors: Parisa Khateri, Jannis Fischer, Werner Lustermann, Charalampos Tsoumpas and Günther Dissertori

    Citation: EJNMMI Physics 2019 6:15

    Content type: Original research

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  23. Monte Carlo-based iterative reconstruction to correct for photon scatter and collimator effects has been proven to be superior over analytical correction schemes in single-photon emission computed tomography (...

    Authors: Martijn M. A. Dietze, Woutjan Branderhorst, Britt Kunnen, Max A. Viergever and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2019 6:14

    Content type: Original research

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  24. The α-emitting radionuclide radium-223 (223Ra) is widely used for the treatment of bone metastasis in patients with castration-resistant prostate cancer. However, 223Ra decays into radon-219 (219Rn) which is a no...

    Authors: Kazuhiro Ooe, Tadashi Watabe, Takashi Kamiya, Takashi Yoshimura, Makoto Hosono, Atsushi Shinohara and Jun Hatazawa

    Citation: EJNMMI Physics 2019 6:13

    Content type: Original research

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  25. The heart-to-mediastinum (H/M) ratio is a commonly used parameter to measure cardiac I-123 metaiodobenzylguanidine (MIBG) uptake. Since the H/M ratio is substantially influenced by the collimator type, we inve...

    Authors: Joachim Brumberg, Ganna Blazhenets, Nils Schröter, Lars Frings, Wolfgang H. Jost, Constantin Lapa and Philipp T. Meyer

    Citation: EJNMMI Physics 2019 6:12

    Content type: Original research

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  26. Fully integrated PET/MR systems are being used frequently in clinical research and routine. National Electrical Manufacturers Association (NEMA) characterization of these systems is generally done with 18F which ...

    Authors: Paulo R. R. V. Caribé, M. Koole, Yves D’Asseler, Timothy W. Deller, K. Van Laere and S. Vandenberghe

    Citation: EJNMMI Physics 2019 6:11

    Content type: Original research

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  27. Squamous cell carcinoma in the head and neck region is one of the most widespread cancers with high morbidity. Classic treatment comprises the complete removal of the lymphatics together with the cancerous tis...

    Authors: Peter A. von Niederhäusern, Simon Pezold, Uri Nahum, Carlo Seppi, Guillaume Nicolas, Michael Rissi, Stephan K. Haerle and Philippe C. Cattin

    Citation: EJNMMI Physics 2019 6:10

    Content type: Original research

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  28. Gadolinium nanoparticles (Gd-NP) combined with radiotherapy are investigated for radiation dose enhancement in radiotherapy treatment. Indeed, NPs concentrated in a tumor could enhance its radiosensitization. ...

    Authors: Olga Kochebina, Adrien Halty, Jacqueline Taleb, David Kryza, Marc Janier, Alexandre Bani Sadr, Thomas Baudier, Simon Rit and David Sarrut

    Citation: EJNMMI Physics 2019 6:9

    Content type: Original research

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  29. 177Lu-DOTATATE peptide receptor radionuclide therapy is administered to patients on an inpatient and outpatient basis for the treatment of well-differentiated, metastatic neuroendocrine tumours. Following adminis...

    Authors: D. Levart, E. Kalogianni, B. Corcoran, N. Mulholland and G. Vivian

    Citation: EJNMMI Physics 2019 6:7

    Content type: Original research

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  30. Recently, the block-sequential regularized expectation maximization (BSREM) reconstruction algorithm was commercially introduced (Q.Clear, GE Healthcare, Milwaukee, WI, USA). However, the combination of noise-...

    Authors: Mimmi Bjöersdorff, Jenny Oddstig, Nina Karindotter-Borgendahl, Helén Almquist, Sophia Zackrisson, David Minarik and Elin Trägårdh

    Citation: EJNMMI Physics 2019 6:5

    Content type: Original research

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  31. Quantification is one of the key benefits of nuclear medicine imaging. Recently, driven by the demand for post radionuclide therapy imaging, quantitative SPECT has moved from relative and semiquantitative meas...

    Authors: John Dickson, James Ross and Stefan Vöö

    Citation: EJNMMI Physics 2019 6:4

    Content type: Opinion article

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  32. 68Ga-labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC ([68Ga]PSMA-11) has been increasingly used to image prostate cancer using positron emission tomography (PET)/computed tomography (CT) both during diagnosis and treatment...

    Authors: Kristina Sandgren, Lennart Johansson, Jan Axelsson, Joakim Jonsson, Mattias Ögren, Margareta Ögren, Martin Andersson, Sara Strandberg, Tufve Nyholm, Katrine Riklund and Anders Widmark

    Citation: EJNMMI Physics 2019 6:2

    Content type: Original research

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  33. PET imaging has been, and continues to be, an evolving diagnostic technology. In recent years, the modernizing digital landscape has opened new opportunities for data-driven innovation. One such facet has been...

    Authors: Adam Kesner, C. Ross Schmidtlein and Claudia Kuntner

    Citation: EJNMMI Physics 2019 6:3

    Content type: Commentary

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  34. This study aims to assess both feasibility and accuracy of renal dosimetry imaging protocols in patients receiving Lutate therapy for neuroendocrine tumours (NETs), when data acquisition over multiple days is ...

    Authors: Kathy P. Willowson, Enid Eslick, Hyunju Ryu, Aurora Poon, Elizabeth J. Bernard and Dale L. Bailey

    Citation: EJNMMI Physics 2018 5:33

    Content type: Original research

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  35. 15O-oxygen inhalation PET is unique in its ability to provide fundamental information regarding cerebral hemodynamics and energy metabolism in man. However, the use of 15O-oxygen has been limited in a clinical en...

    Authors: Satoshi Iguchi, Tetsuaki Moriguchi, Makoto Yamazaki, Yuki Hori, Kazuhiro Koshino, Kazunori Toyoda, Jarmo Teuho, Saeka Shimochi, Yusuke Terakawa, Tetsuya Fukuda, Jun C. Takahashi, Jyoji Nakagawara, Shigehiko Kanaya and Hidehiro Iida

    Citation: EJNMMI Physics 2018 5:37

    Content type: Original research

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  36. Radioiodine has been used for the treatment of benign thyroid diseases for over 70 years. However, internationally, there is no common standard for pretherapeutic dosimetry to optimally define the individual t...

    Authors: Jochen Hammes, Lutz van Heek, Melanie Hohberg, Manuel Reifegerst, Simone Stockter, Markus Dietlein, Markus Wild, Alexander Drzezga, Matthias Schmidt and Carsten Kobe

    Citation: EJNMMI Physics 2018 5:32

    Content type: Original research

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  37. The aim of this study was to evaluate the predictive power of the absorbed dose to kidneys after the first course of treatment with [177Lu]-DOTA-TATE for neuroendocrine tumors (NETs) on the cumulative kidney abso...

    Authors: Alexandre Chicheportiche, Simona Grozinsky-Glasberg, David J. Gross, Yodphat Krausz, Asher Salmon, Amichay Meirovitz, Nanette Freedman and Jeremy Godefroy

    Citation: EJNMMI Physics 2018 5:36

    Content type: Original research

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  38. The aim of this study was to compare liver and oncologic lesion standardized uptake values (SUV) obtained through two different reconstruction protocols, GE’s newest clinical lesion detection protocol (Q.Clear...

    Authors: Joke Devriese, Laurence Beels, Alex Maes, Christophe Van de Wiele and Hans Pottel

    Citation: EJNMMI Physics 2018 5:35

    Content type: Original research

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  39. Rhenium-188-labelled-Lipiodol radioembolization is a safe and cost-effective treatment for primary liver cancer. In order to determine correlations between treatment doses and patient response to therapy, accu...

    Authors: Pedro L. Esquinas, Ajit Shinto, Koramadai K. Kamaleshwaran, Jephy Joseph and Anna Celler

    Citation: EJNMMI Physics 2018 5:30

    Content type: Original research

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  40. Positron emission tomography (PET) imaging has a wide applicability in oncology, cardiology and neurology. However, a major drawback when imaging very active regions such as the bladder is the spill-in effect,...

    Authors: Mercy I. Akerele, Palak Wadhwa, Jesus Silva-Rodriguez, William Hallett and Charalampos Tsoumpas

    Citation: EJNMMI Physics 2018 5:34

    Content type: Young investigators

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  41. Generation of a SPECT scan during procedure may aid in the optimization of treatments as liver radioembolization by offering image-guided dosimetry. This, however, requires both shortened acquisition times and...

    Authors: Martijn M. A. Dietze, Sandra van der Velden, Marnix G. E. H. Lam, Max A. Viergever and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2018 5:28

    Content type: Original research

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  42. PoleStar m660 is a newly developed clinical PET/CT system with time-of-flight (TOF) capability. The aim of this study is to characterize the performance of the new system. Spatial resolution, sensitivity, scat...

    Authors: Li Huo, Nan Li, Heyu Wu, Wenjia Zhu, Haiqun Xing, Jiantao Ba, Tong Wang, Fang Li and Hui Zhang

    Citation: EJNMMI Physics 2018 5:29

    Content type: Original research

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  43. The purpose was to validate 90Y PET gradient-based tumor segmentation in phantoms and to evaluate the impact of the segmentation method on reported tumor absorbed dose (AD) and biological effective dose (BED) in

    Authors: Justin K. Mikell, Ravi K. Kaza, Peter L. Roberson, Kelly C. Younge, Ravi N. Srinivasa, Bill S. Majdalany, Kyle C. Cuneo, Dawn Owen, Theresa Devasia, Matthew J. Schipper and Yuni K. Dewaraja

    Citation: EJNMMI Physics 2018 5:31

    Content type: Original research

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