Collection on total-body PET
EJNMMI Physics volume 10, Article number: 42 (2023)
With the prompt appearance of extended axial field of view positron emission tomographs (LAFOV PET), an extensive range of prospects become possible in molecular diagnostics. An advantage using LAFOV PET is the increase of sensitivity, which can be more than 10 times higher for 1-m-long PET  and 40 times for a 2-m-long PET scanner , yet it is essential to state that these figures depend on the patient, organs of study and tracer distribution.
On the one hand, the axial extension of the scanners and their increased sensitivity offer a mixture of benefits:
Ultra-fast scanning 
Simultaneous imaging of more organs 
Scanning kinetics with wider temporal range (e.g. delayed imaging or very short frames) 
Enhanced image quality 
Scanning with appreciably lower injected radioactivity 
Enhanced support of systems biology/medicine 
Enhanced support of dosimetry and theranostics 
On the other hand, LAFOV PET scanners also brought new methodological challenges . The tremendous numbers of detectors strongly increased the complexity and data volume. It becomes more challenging to deal with large heterogeneity inside the scanner, for example, due to the oblique lines of response.
Several LAFOV PET scanners across the world have been already installed and been in use creating a wide range of exciting research .
We look forward to receiving submissions of work by researchers from all around the world.
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Shi, K., Tsoumpas, C. Collection on total-body PET. EJNMMI Phys 10, 42 (2023). https://doi.org/10.1186/s40658-023-00550-x