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  1. The calculation of time-integrated activities (TIAs) for tumours and organs is required for dosimetry in molecular radiotherapy. The accuracy of the calculated TIAs is highly dependent on the chosen fit functi...

    Authors: Deni Hardiansyah, Ade Riana, Peter Kletting, Nouran R. R. Zaid, Matthias Eiber, Supriyanto A. Pawiro, Ambros J. Beer and Gerhard Glatting
    Citation: EJNMMI Physics 2021 8:82
  2. We recently reported a new absorbed dose conversion method, RAP (RAtio of Pharmacokinetics), for 211At-meta-astatobenzylguanidine (211At-MABG) using a single biodistribution measurement, the percent injected dose...

    Authors: Tetsuya Sakashita, Shojiro Matsumoto, Shigeki Watanabe, Hirofumi Hanaoka, Yasuhiro Ohshima, Yoko Ikoma, Naoyuki Ukon, Ichiro Sasaki, Tatsuya Higashi, Tetsuya Higuchi, Yoshito Tsushima and Noriko S. Ishioka
    Citation: EJNMMI Physics 2021 8:80
  3. The whole brain is often covered in [18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) in oncology patients, but the covered brain abnormality is typically screened by visual interpretation witho...

    Authors: Wonseok Whi, Hongyoon Choi, Jin Chul Paeng, Gi Jeong Cheon, Keon Wook Kang and Dong Soo Lee
    Citation: EJNMMI Physics 2021 8:79
  4. Kidney dosimetry after peptide receptor radionuclide therapy using 177Lu-labelled somatostatin analogues is a procedure with multiple steps. We present the SPECT/CT-based implementation at Aarhus University Hospi...

    Authors: Peter Frøhlich Staanum, Anders Floor Frellsen, Marie Louise Olesen, Peter Iversen and Anne Kirstine Arveschoug
    Citation: EJNMMI Physics 2021 8:78
  5. The aim of this standard operational procedure is to standardize the methodology employed for the evaluation of pre- and post-treatment absorbed dose calculations in 90Y microsphere liver radioembolization. Basic...

    Authors: Carlo Chiesa, Katarina Sjogreen-Gleisner, Stephan Walrand, Lidia Strigari, Glenn Flux, Jonathan Gear, Caroline Stokke, Pablo Minguez Gabina, Peter Bernhardt and Mark Konijnenberg
    Citation: EJNMMI Physics 2021 8:77
  6. The present study tested the possible utility of fractal analysis from l-[methyl-11C]-methionine (MET) uptake in patients with newly diagnosed gliomas for differentiating glioma, especially in relation to isocitr...

    Authors: Yukito Maeda, Yuka Yamamoto, Takashi Norikane, Katsuya Mitamura, Tetsuhiro Hatakeyama, Keisuke Miyake, Yoshihiro Nishiyama and Nobuyuki Kudomi
    Citation: EJNMMI Physics 2021 8:76
  7. Simultaneous PET/MRIs vary in their quantitative PET performance due to inherent differences in the physical systems and differences in the image reconstruction implementation. This variability in quantitative...

    Authors: Richard Laforest, Mehdi Khalighi, Yutaka Natsuaki, Abhejit Rajagopal, Dharshan Chandramohan, Darrin Byrd, Hongyu An, Peder Larson, Sara St. James, John J. Sunderland, Paul E. Kinahan and Thomas A. Hope
    Citation: EJNMMI Physics 2021 8:75
  8. This work aims to train, validate, and test a dual-stream three-dimensional convolutional neural network (3D-CNN) based on fluorine 18 (18F)-fluorodeoxyglucose (FDG) PET/CT to distinguish benign lesions and invas...

    Authors: Xiaonan Shao, Rong Niu, Xiaoliang Shao, Jianxiong Gao, Yunmei Shi, Zhenxing Jiang and Yuetao Wang
    Citation: EJNMMI Physics 2021 8:74
  9. Accurate QSPECT is crucial in dosimetry-based, personalized radiopharmaceutical therapy with 177Lu and other radionuclides. We compared the quantitative performance of three NaI(Tl)-crystal SPECT/CT systems equip...

    Authors: Alessandro Desy, Guillaume F. Bouvet, Étienne Croteau, Nancy Lafrenière, Éric E. Turcotte, Philippe Després and Jean-Mathieu Beauregard
    Citation: EJNMMI Physics 2021 8:73
  10. This study was conducted to clarify how patient body mass affects the image quality and quantification accuracy of images obtained using 89Zr PET/CT. 89Zr PET/CT images from time-of-flight (TOF) PET/CT and semico...

    Authors: Ukihide Tateishi, Hiromitsu Daisaki, Junichi Tsuchiya, Yuji Kojima, Keisuke Takino, Naoki Shimada and Kota Yokoyama
    Citation: EJNMMI Physics 2021 8:72
  11. In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy...

    Authors: Kristian Valind, Jonas Jögi, David Minarik, Gustav Brolin and Elin Trägårdh
    Citation: EJNMMI Physics 2021 8:70
  12. This study aimed to evaluate the performance of a preclinical PET insert in three configurations: as a stand-alone unit outside the MRI bore, inside the bore of a cryogen-free 3T MRI and, finally, while perfor...

    Authors: Gaelle Emvalomenos, Sofie Trajanovska, Binh T. T. Pham, Peter Doughty, Jerome Burnet, Isabelle Smith, Ruslan Garipov, Marie-Claude Gregoire, Nana Sunn, John McGrath and Steven R. Meikle
    Citation: EJNMMI Physics 2021 8:68
  13. Metal artefact reduction (MAR) techniques still are in limited use in positron emission tomography/computed tomography (PET/CT). This study aimed to investigate the effect of Smart MAR on quantitative PET anal...

    Authors: Maarten Haemels, Delphine Vandendriessche, Jeroen De Geeter, James Velghe, Maxence Vandekerckhove and Frank De Geeter
    Citation: EJNMMI Physics 2021 8:67
  14. The digital cadmium–zinc–telluride (CZT)-based SPECT system has many advantages, including better spatial and energy resolution. However, the impacts of different acquisition and reconstruction parameters on C...

    Authors: Ruyi Zhang, Miao Wang, Yaqian Zhou, Shen Wang, Yiming Shen, Ning Li, Peng Wang, Jian Tan, Zhaowei Meng and Qiang Jia
    Citation: EJNMMI Physics 2021 8:66
  15. Following each cycle of peptide receptor radionuclide therapy (PRRT), absorbed doses by tumors and normal organs are typically calculated from three quantitative single-photon emission computed tomography (SPE...

    Authors: Alexandre Chicheportiche, Moshe Sason, Jeremy Godefroy, Yodphat Krausz, Mahmoud Zidan, Kira Oleinikov, Amichay Meirovitz, David J. Gross, Simona Grozinsky-Glasberg and Simona Ben-Haim
    Citation: EJNMMI Physics 2021 8:63
  16. Phantoms are commonly used throughout medical imaging and medical physics for a multitude of applications, the designs of which vary between modalities and clinical or research requirements. Within positron em...

    Authors: Eve Lennie, Charalampos Tsoumpas and Steven Sourbron
    Citation: EJNMMI Physics 2021 8:62
  17. The quantitative accuracy of Nuclear Medicine images, acquired for both planar and SPECT studies, is influenced by the isotope-collimator combination as well as image corrections incorporated in the iterative ...

    Authors: Michaella Morphis, Johan A. van Staden, Hanlie du Raan and Michael Ljungberg
    Citation: EJNMMI Physics 2021 8:61
  18. Actinium-225 is an alpha-particle emitter under investigation for use in radiopharmaceutical therapy. To address limited supply, accelerator-produced 225Ac has been recently made available. Accelerator-produced 2...

    Authors: George Sgouros, Bin He, Nitya Ray, Dale L. Ludwig and Eric C. Frey
    Citation: EJNMMI Physics 2021 8:60
  19. Authors: Steffie M. B. Peters, Sebastiaan L. Meyer Viol, Niels R. van der Werf, Nick de Jong, Floris H. P. van Velden, Antoi Meeuwis, Mark W. Konijnenberg, Martin Gotthardt, Hugo W. A. M. de Jong and Marcel Segbers
    Citation: EJNMMI Physics 2021 8:59

    The original article was published in EJNMMI Physics 2020 7:9

  20. A significant proportion of the radiation dose from a PET-CT examination is dependent on the CT protocol, which should be optimised for clinical purposes. Matching protocols on different scanners within an ima...

    Authors: Sarah-May Gould, Jane Mackewn, Sugama Chicklore, Gary J. R. Cook, Andrew Mallia and Lucy Pike
    Citation: EJNMMI Physics 2021 8:58
  21. The introduction of hybrid SPECT/CT devices enables quantitative imaging in SPECT, providing a methodological setup for quantitation using SPECT tracers comparable to PET/CT. We evaluated a specific quantitati...

    Authors: Dennis Kupitz, Heiko Wissel, Jan Wuestemann, Stephanie Bluemel, Maciej Pech, Holger Amthauer, Michael C. Kreissl and Oliver S. Grosser
    Citation: EJNMMI Physics 2021 8:57
  22. PET imaging of 90Y-microsphere distribution following radioembolisation is challenging due to the count-starved statistics from the low branching ratio of e+/e pair production during 90Y decay. PET systems using...

    Authors: Joey Labour, Philippe Boissard, Thomas Baudier, Fouzi Khayi, David Kryza, Pascale Veyrat Durebex, Sandrine Parisse-Di Martino, Thomas Mognetti, David Sarrut and Jean-Noël Badel
    Citation: EJNMMI Physics 2021 8:56
  23. Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy and to predict response. Dosimetry involves several steps, the first of which is the determination of the activity of the r...

    Authors: Johannes Tran-Gia, Ana M. Denis-Bacelar, Kelley M. Ferreira, Andrew P. Robinson, Nicholas Calvert, Andrew J. Fenwick, Domenico Finocchiaro, Federica Fioroni, Elisa Grassi, Warda Heetun, Stephanie J. Jewitt, Maria Kotzassarlidou, Michael Ljungberg, Daniel R. McGowan, Nathaniel Scott, James Scuffham…
    Citation: EJNMMI Physics 2021 8:55
  24. Partial-volume correction (PVC) using the Geometric Transfer Matrix (GTM) method is used in positron emission tomography (PET) to compensate for the effects of spatial resolution on quantitation. We evaluate t...

    Authors: Charles M. Laymon, Davneet S. Minhas, Sarah K. Royse, Howard J. Aizenstein, Ann D. Cohen, Dana L. Tudorascu and William E. Klunk
    Citation: EJNMMI Physics 2021 8:54
  25. 99mTc-DMSA is one of the most commonly used pediatric nuclear medicine imaging agents. Nevertheless, there are no pharmacokinetic (PK) models for 99mTc-DMSA in children, and currently available pediatric dose est...

    Authors: Donika Plyku, Michael Ghaly, Ye Li, Justin L. Brown, Shannon O’Reilly, Kitiwat Khamwan, Alison B. Goodkind, Briana Sexton-Stallone, Xinhua Cao, David Zurakowski, Frederic H. Fahey, S. Ted Treves, Wesley E. Bolch, Eric C. Frey and George Sgouros
    Citation: EJNMMI Physics 2021 8:53
  26. To assess the applicability of the Fluorine-18 performance specifications defined by EANM Research Ltd (EARL), in Gallium-68 multi-centre PET-CT trials using conventional (ordered subset expectation maximisati...

    Authors: Georgios Krokos, Lucy C. Pike, Gary J. R. Cook and Paul K. Marsden
    Citation: EJNMMI Physics 2021 8:52
  27. A 2-m axial field-of-view, total-body PET/CT scanner (uEXPLORER) has been recently developed to provide total-body coverage and ultra-high sensitivity, which together, enables opportunities for in vivo time-ac...

    Authors: Pengcheng Hu, Xin Lin, Weihai Zhuo, Hui Tan, Tianwu Xie, Guobing Liu, Shuguang Chen, Xin Chen, Haojun Yu, Yiqiu Zhang, Hongcheng Shi and Haikuan Liu
    Citation: EJNMMI Physics 2021 8:51
  28. The goal of this work was to determine the quantitative accuracy and optimal reconstruction parameters for 124I-PET imaging in the presence of therapeutic levels of 131I. In this effort, images were acquired on a...

    Authors: Louise M. Fanchon, Bradley J. Beattie, Keith Pentlow, Steven M. Larson and John L. Humm
    Citation: EJNMMI Physics 2021 8:50
  29. In patients with pulmonary embolism (PE), there is a growing interest in quantifying the pulmonary vascular obtruction index (PVOI), which may be an independent risk factor for PE recurrence. Perfusion SPECT/C...

    Authors: David Bourhis, Laura Wagner, Julien Rioult, Philippe Robin, Romain Le Pennec, Cécile Tromeur, Pierre Yves Salaün and Pierre Yves Le Roux
    Citation: EJNMMI Physics 2021 8:49
  30. Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction techni...

    Authors: Alina van de Burgt, Petra Dibbets-Schneider, Cornelis H. Slump, Arthur J. H. A. Scholte, Douwe E. Atsma, Lioe-Fee de Geus-Oei and Floris H. P. van Velden
    Citation: EJNMMI Physics 2021 8:48
  31. Integrated whole-body PET/MR technology continues to mature and is now extensively used in clinical settings. However, due to the special design architecture, integrated whole-body PET/MR comes with a few inhe...

    Authors: Tianyi Zeng, Jiaxu Zheng, Xinyuan Xia, Xin Chen, Beien Wang, Shuangyue Zhang, Adam Chandler, Tuoyu Cao, Lingzhi Hu, Qun Chen and Xu Chu
    Citation: EJNMMI Physics 2021 8:47
  32. Radiomics analysis usually involves, especially in multicenter and large hospital studies, different imaging protocols for acquisition, reconstruction, and processing of data. Differences in protocols can lead...

    Authors: Montserrat Carles, Tobias Fechter, Luis Martí-Bonmatí, Dimos Baltas and Michael Mix
    Citation: EJNMMI Physics 2021 8:46
  33. Much progress has been made in implementing selective internal radiation therapy (SIRT) as a viable treatment option for hepatic malignancies. However, there is still much need for improved options for calcula...

    Authors: Benjamin J. Van, Yuni K. Dewaraja, Mamadou L. Sangogo and Justin K. Mikell
    Citation: EJNMMI Physics 2021 8:45
  34. Ra-223 dichloride (223Ra, Xofigo®) is used for treatment of patients suffering from castration-resistant metastatic prostate cancer. The objective of this work was to apply the most recent biokinetic model for ra...

    Authors: Vera Höllriegl, Nina Petoussi-Henss, Kerstin Hürkamp, Juan Camilo Ocampo Ramos and Wei Bo Li
    Citation: EJNMMI Physics 2021 8:44
  35. Changes in renal blood flow (RBF) may play a pathophysiological role in hypertension and kidney disease. However, RBF determination in humans has proven difficult. We aimed to confirm the feasibility of RBF es...

    Authors: Stine Sundgaard Langaa, Thomas Guldager Lauridsen, Frank Holden Mose, Claire Anne Fynbo, Jørn Theil and Jesper Nørgaard Bech
    Citation: EJNMMI Physics 2021 8:43
  36. Left ventricular ejection fraction (LVEF) is usually measured by cine-cardiac magnetic resonance imaging (MRI), planar and single-photon emission-computerized tomography (SPECT) equilibrium radionuclide angioc...

    Authors: Emilie Verrecchia-Ramos, Olivier Morel, Paul Retif and Sinan Ben Mahmoud
    Citation: EJNMMI Physics 2021 8:42
  37. Q.Clear is a Bayesian penalized likelihood (BPL) reconstruction algorithm that presents improvements in signal-to-noise ratio (SNR) in clinical positron emission tomography (PET) scans. Brain studies in resear...

    Authors: Daniela Ribeiro, William Hallett and Adriana A. S. Tavares
    Citation: EJNMMI Physics 2021 8:41
  38. Dosimetry is of high importance for optimization of patient-individual PSMA-targeted radioligand therapy (PSMA-RLT). The aim of our study was to evaluate and compare the feasibility of different approaches of ...

    Authors: Florian Rosar, Niklas Schön, Hendrik Bohnenberger, Mark Bartholomä, Tobias Stemler, Stephan Maus, Fadi Khreish, Samer Ezziddin and Andrea Schaefer-Schuler
    Citation: EJNMMI Physics 2021 8:40
  39. Quantitative positron emission tomography (PET) studies of neurodegenerative diseases typically require the measurement of arterial input functions (AIF), an invasive and risky procedure. This study aims to as...

    Authors: Mercy I. Akerele, Sara A. Zein, Sneha Pandya, Anastasia Nikolopoulou, Susan A. Gauthier, Ashish Raj, Claire Henchcliffe, P. David Mozley, Nicolas A. Karakatsanis, Ajay Gupta, John Babich and Sadek A. Nehmeh
    Citation: EJNMMI Physics 2021 8:39
  40. Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by crea...

    Authors: Daniel Gillett, Daniel Marsden, Safia Ballout, Bala Attili, Nick Bird, Sarah Heard, Mark Gurnell, Iosif A. Mendichovszky and Luigi Aloj
    Citation: EJNMMI Physics 2021 8:38
  41. [11C]-UCB-J is an emerging tool for the noninvasive measurement of synaptic vesicle density in vivo. Here, we report human biodistribution and dosimetry estimates derived from sequential whole-body PET using two ...

    Authors: Christopher Cawthorne, Paul Maguire, Joel Mercier, David Sciberras, Kim Serdons, Guy Bormans, Jan de Hoon, Koen Van Laere and Michel Koole
    Citation: EJNMMI Physics 2021 8:37
  42. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Julia Brosch-Lenz, Carlos Uribe, Astrid Gosewisch, Lena Kaiser, Andrei Todica, Harun Ilhan, Franz Josef Gildehaus, Peter Bartenstein, Arman Rahmim, Anna Celler, Sibylle Ziegler and Guido Böning
    Citation: EJNMMI Physics 2021 8:36

    The original article was published in EJNMMI Physics 2021 8:26

  43. Time-of-flight (TOF) PET technology determines a reduction in the noise and improves the reconstructed image quality in low count acquisitions, such as in overweight patients, allowing a reduction of administe...

    Authors: Roberta Matheoud, Naema Al-Maymani, Alessia Oldani, Gian Mauro Sacchetti, Marco Brambilla and Alessandro Carriero
    Citation: EJNMMI Physics 2021 8:35
  44. The amount of signal decreases when the acquisition duration is shortened. However, it is not clear how this affects the quantitative values. This study aims to clarify the effect of acquisition time shortenin...

    Authors: Masatoshi Morimoto, Nobuyuki Kudomi, Yukito Maeda, Takuya Kobata, Akihiro Oishi, Keisuke Matsumoto, Toshihide Monden, Takanobu Iwasaki, Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto and Yoshihiro Nishiyama
    Citation: EJNMMI Physics 2021 8:34
  45. Extravasation of radiopharmaceuticals used for vectorized internal radiotherapy can lead to severe tissue damage (van der Pol et al., Eur J Nucl Med Mol Imaging 44:1234–1243, 2017). Clinical management of thes...

    Authors: Perrine Tylski, Géraldine Pina-Jomir, Claire Bournaud-Salinas and Patrice Jalade
    Citation: EJNMMI Physics 2021 8:33