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EJNMMI Physics
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  1. Myocardial perfusion imaging (MPI) using positron emission tomography (PET) tracers is an essential tool in investigating diseases and treatment responses in cardiology. 82Rubidium (82Rb)-PET imaging is advantage...

    Authors: Malte Jensen, Simon Bentsen, Andreas Clemmensen, Jacob Kildevang Jensen, Johanne Madsen, Jonas Rossing, Anna Laier, Philip Hasbak, Andreas Kjaer and Rasmus Sejersten Ripa
    Citation: EJNMMI Physics 2022 9:51
    Content type: Original research Published on:

  2. Partial volume correction with anatomical magnetic resonance (MR) images (MR-PVC) is useful for accurately quantifying tracer uptake on brain positron emission tomography (PET) images. However, MR segmentation...

    Authors: Keisuke Matsubara, Masanobu Ibaraki and Toshibumi Kinoshita
    Citation: EJNMMI Physics 2022 9:50
    Content type: Original research Published on:

  3. The prediction of response is one of the major challenges in radiation-based therapies. Although the selection of accurate linear–quadratic model parameters is essential for the estimation of radiation respons...

    Authors: Yaser H. Gholami, Kathy P. Willowson and Dale L. Bailey
    Citation: EJNMMI Physics 2022 9:49
    Content type: Original research Published on:

  4. In recent years, a lot of effort has been put in the enhancement of medical imaging using artificial intelligence. However, limited patient data in combination with the unavailability of a ground truth often p...

    Authors: Julian Leube, Johan Gustafsson, Michael Lassmann, Maikol Salas-Ramirez and Johannes Tran-Gia
    Citation: EJNMMI Physics 2022 9:47
    Content type: Original research Published on:

  5. The development of new targeted alpha therapies motivates improving alpha particle dosimetry. For alpha particles, microscopic targets must be considered to estimate dosimetric quantities that can predict the ...

    Authors: Emma Mellhammar, Magnus Dahlbom, Oskar Vilhelmsson-Timmermand and Sven-Erik Strand
    Citation: EJNMMI Physics 2022 9:46
    Content type: Original research Published on:

  6. The present study aimed to explore the boundary of acquisition time and propose an optimized acquisition time range for total-body positron emission tomography (PET)/computed tomography (CT) oncological imagin...

    Authors: Yibo He, Yushen Gu, Haojun Yu, Bing Wu, Siyang Wang, Hui Tan, Yanyan Cao, Shuguang Chen, Xiuli Sui, Yiqiu Zhang and Hongcheng Shi
    Citation: EJNMMI Physics 2022 9:45
    Content type: Original research Published on:

  7. To evaluate if satisfactory post-therapeutic image-based dosimetry can be achieved for Lu-177-DOTATATE treatments using a reduced number of image acquisitions to improve patient comfort and reduce economical c...

    Authors: Oscar Ardenfors, Joachim N. Nilsson, Daniel Thor and Cecilia Hindorf
    Citation: EJNMMI Physics 2022 9:44
    Content type: Original research Published on:

  9. The SAFIR prototype insert is a preclinical Positron Emission Tomography (PET) scanner built to acquire dynamic images simultaneously with a 7 T Bruker Magnetic Resonance Imaging (MRI) scanner. The insert is d...

    Authors: Parisa Khateri, Werner Lustermann, Christian Ritzer, Charalampos Tsoumpas and Günther Dissertori
    Citation: EJNMMI Physics 2022 9:42
    Content type: Original research Published on:

  12. 211At, a promising alpha-particle-emitting radionuclide, can easily volatilize and contaminate the environment. To safely manage this unique alpha-particle-emitting radionuclide, we investigated the permeability ...

    Authors: Kazunobu Ohnuki, Mitsuyoshi Yoshimoto, Hiromitsu Haba, Shino Manabe, Hiroki Takashima, Masahiro Yasunaga, Yasumasa Takenaka and Hirofumi Fujii
    Citation: EJNMMI Physics 2022 9:39
    Content type: Short communication Published on:

  13. Organs-on-Chips (OOCs), microdevices mimicking in vivo organs, find growing applications in disease modeling and drug discovery. With the increasing number of uses comes a strong demand for imaging capabilitie...

    Authors: Christoph Clement, Gabriele Birindelli, Marco Pizzichemi, Fiammetta Pagano, Marianna Kruithof-De Julio, Sibylle Ziegler, Axel Rominger, Etiennette Auffray and Kuangyu Shi
    Citation: EJNMMI Physics 2022 9:38
    Content type: Original research Published on:

  14. The number of SPECT/CT time-points is important for accurate patient dose estimation in peptide receptor radionuclide therapy. However, it may be limited by the patient’s health and logistical reasons. Here,  ...

    Authors: Laure Vergnaud, Anne-Laure Giraudet, Aurélie Moreau, Julien Salvadori, Alessio Imperiale, Thomas Baudier, Jean-Noël Badel and David Sarrut
    Citation: EJNMMI Physics 2022 9:37
    Content type: Original research Published on:

  15. PET/CT image quality is directly influenced by the F-18-FDG injected activity. The higher the injected activity, the less noise in the reconstructed images but the more radioactive staff exposition. A new FDA ...

    Authors: Gerald Bonardel, Axel Dupont, Pierre Decazes, Mathieu Queneau, Romain Modzelewski, Jeremy Coulot, Nicolas Le Calvez and Sébastien Hapdey
    Citation: EJNMMI Physics 2022 9:36
    Content type: Original research Published on:

  16. Semiconductor gamma-camera systems based on cadmium zinc telluride (CZT) detectors present new challenges due to an energy-response that includes effects of low-energy tailing. In particular, such energy tails...

    Authors: Daniel Roth, Erik Larsson, Michael Ljungberg and Katarina Sjögreen Gleisner
    Citation: EJNMMI Physics 2022 9:35
    Content type: Original research Published on:

  17. Anthropomorphic torso phantoms, including a cardiac insert, are frequently used to investigate the imaging performance of SPECT and PET systems. These phantom solutions are generally featuring a simple anatomi...

    Authors: Janos Kiss, Laszlo Balkay, Kornel Kukuts, Marton Miko, Attila Forgacs, Gyorgy Trencsenyi and Aron K. Krizsan
    Citation: EJNMMI Physics 2022 9:34
    Content type: Original research Published on:

  18. Given the recent and rapid development of peptide receptor radionuclide therapy (PRRT), increasing emphasis should be placed on the early identification and quantification of therapeutic radiopharmaceutical (t...

    Authors: Christophe Mazzara, Julien Salvadori, Florian Ritzenthaler, Simon Martin, Clémence Porot and Alessio Imperiale
    Citation: EJNMMI Physics 2022 9:33
    Content type: Original research Published on:

  19. Neuronal damage and synapse loss in the spinal cord (SC) have been implicated in spinal cord injury (SCI) and neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS). Current standards of diagn...

    Authors: Samantha Rossano, Takuya Toyonaga, Jason Bini, Nabeel Nabulsi, Jim Ropchan, Zhengxin Cai, Yiyun Huang and Richard E. Carson
    Citation: EJNMMI Physics 2022 9:32
    Content type: Original research Published on:

  20. Absolute myocardial perfusion imaging (MPI) is beneficial in the diagnosis and prognosis of patients with suspected or known coronary artery disease. However, validation and standardization of perfusion estima...

    Authors: Marije E. Kamphuis, Henny Kuipers, Jacqueline Verschoor, Johannes C. G. van Hespen, Marcel J. W. Greuter, Riemer H. J. A. Slart and Cornelis H. Slump
    Citation: EJNMMI Physics 2022 9:31
    Content type: Original research Published on:

  21. Partition modeling allows personalized activity calculation for holmium-166 (166Ho) radioembolization. However, it requires the definition of tumor and non-tumorous liver, by segmentation and registration of a se...

    Authors: Martina Stella, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong and Rob van Rooij
    Citation: EJNMMI Physics 2022 9:30
    Content type: Original research Published on:

  22. Most current whole-body positron emission tomography (PET) scanners use detectors with high timing resolution to measure the time-of-flight of two 511 keV photons, improving the signal-to-noise ratio of PET im...

    Authors: Zheng Liu, Ming Niu, Zhonghua Kuang, Ning Ren, San Wu, Longhan Cong, Xiaohui Wang, Ziru Sang, Crispin Williams and Yongfeng Yang
    Citation: EJNMMI Physics 2022 9:29
    Content type: Original research Published on:

  23. To develop a model of the internal vasculature of the adult liver and demonstrate its application to the differentiation of radiopharmaceutical decay sites within liver parenchyma from those within organ blood.

    Authors: Camilo M. Correa-Alfonso, Julia D. Withrow, Sean J. Domal, Shu Xing, Jungwook Shin, Clemens Grassberger, Harald Paganetti and Wesley E. Bolch
    Citation: EJNMMI Physics 2022 9:28
    Content type: Original research Published on:

  24. There has been an ongoing need to compare and combine the results of new PET imaging studies conducted with [11C]raclopride with older data. This typically means harmonizing data across different scanners. Previo...

    Authors: Jocelyn Hoye, Takuya Toyonaga, Yasmin Zakiniaeiz, Gelsina Stanley, Michelle Hampson and Evan D. Morris
    Citation: EJNMMI Physics 2022 9:27
    Content type: Short communication Published on:

  25. Our aim was to determine sets of reconstruction parameters for the Biograph Vision Quadra (Siemens Healthineers) PET/CT system that result in quantitative images compliant with the European Association of Nucl...

    Authors: George A. Prenosil, Michael Hentschel, Thilo Weitzel, Hasan Sari, Kuangyu Shi, Ali Afshar-Oromieh and Axel Rominger
    Citation: EJNMMI Physics 2022 9:26
    Content type: Original research Published on:

  26. Selective internal radiation therapy with Yttrium-90 microspheres is an effective therapy for liver cancer and liver metastases. Yttrium-90 is mainly a high-energy beta particle emitter. These beta particles e...

    Authors: Daniel Deidda, Ana M. Denis-Bacelar, Andrew J. Fenwick, Kelley M. Ferreira, Warda Heetun, Brian F. Hutton, Andrew P. Robinson, James Scuffham and Kris Thielemans
    Citation: EJNMMI Physics 2022 9:25
    Content type: Original research Published on:

  27. Recent reports personalizing the administered activity (AA) of each cycle of peptide receptor radionuclide therapy based on the predicted absorbed dose (AD) to the kidneys (dose-limiting organ) have been promi...

    Authors: Javian C. Malcolm, Nadia Falzone, Jennifer E. Gains, Matthew D. Aldridge, David Mirando, Boon Q. Lee, Mark N. Gaze and Katherine A. Vallis
    Citation: EJNMMI Physics 2022 9:24
    Content type: Original research Published on:

  28. To investigate the influence of small voxel Bayesian penalized likelihood (SVB) reconstruction on small lesion detection compared to ordered subset expectation maximization (OSEM) reconstruction using a clinic...

    Authors: Lei Xu, Ru-Shuai Li, Run-Ze Wu, Rui Yang, Qin-Qin You, Xiao-Chen Yao, Hui-Fang Xie, Yang Lv, Yun Dong, Feng Wang and Qing-Le Meng
    Citation: EJNMMI Physics 2022 9:23
    Content type: Original research Published on:

  29. A Vereos PET/CT device was adapted to be compatible with the experimentation in large animals within BSL-3 environment. The aim of this study was to investigate the impact of this modification on the performan...

    Authors: Nidhal Kahlaoui, Thibaut Naninck, Roger Le Grand and Catherine Chapon
    Citation: EJNMMI Physics 2022 9:22
    Content type: Original research Published on:

  30. To perform precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model and to compare extracted dose metrics to those produced from conventional PE...

    Authors: E. Courtney Henry, Matthew Strugari, George Mawko, Kimberly Brewer, David Liu, Andrew C. Gordon, Jeffrey N. Bryan, Charles Maitz, Robert Abraham, S. Cheenu Kappadath and Alasdair Syme
    Citation: EJNMMI Physics 2022 9:21
    Content type: Original research Published on:

  31. Quantitative whole-body PET/MRI relies on accurate patient-specific MRI-based attenuation correction (AC) of PET, which is a non-trivial challenge, especially for the anatomically complex head and neck region....

    Authors: Anders B. Olin, Adam E. Hansen, Jacob H. Rasmussen, Björn Jakoby, Anne K. Berthelsen, Claes N. Ladefoged, Andreas Kjær, Barbara M. Fischer and Flemming L. Andersen
    Citation: EJNMMI Physics 2022 9:20
    Content type: Original research Published on:

  32. 161Tb draws an increasing interest in nuclear medicine for therapeutic applications. More than 99% of the emitted gamma and X-rays of 161Tb have an energy below 100 keV. Consequently, precise activity measurement...

    Authors: Frédéric Juget, Zeynep Talip, Youcef Nedjadi, M. Teresa Durán, Pascal V. Grundler, Jan Rijn Zeevaart, Nicholas P. van der Meulen and Claude Bailat
    Citation: EJNMMI Physics 2022 9:19
    Content type: Original research Published on:

  34. The purpose of this study was to investigate the image quality and diagnostic performance of different reconstructions over a wide range of patient body mass indices (BMIs) obtained by total-body PET/CT with u...

    Authors: Xiuli Sui, Hui Tan, Haojun Yu, Jie Xiao, Chi Qi, Yanyan Cao, Shuguang Chen, Yiqiu Zhang, Pengcheng Hu and Hongcheng Shi
    Citation: EJNMMI Physics 2022 9:17
    Content type: Original research Published on:

  35. Low photon count in 89Zr-Immuno-PET results in images with a low signal-to-noise ratio (SNR). Since PET radiomics are sensitive to noise, this study focuses on the impact of noise on radiomic features from 89Zr-I...

    Authors: Ananthi Somasundaram, David Vállez García, Elisabeth Pfaehler, Yvonne W. S. Jauw, Josée M. Zijlstra, Guus A. M. S. van Dongen, Willemien C. Menke-van der Houven van Oordt, Marc C. Huisman, Elisabeth G. E. de Vries and Ronald Boellaard
    Citation: EJNMMI Physics 2022 9:16
    Content type: Original research Published on:

  36. Due to comparatively long measurement times in simultaneous positron emission tomography and magnetic resonance (PET/MR) imaging, patient movement during the measurement can be challenging. This leads to artif...

    Authors: Eric Einspänner, Thies H. Jochimsen, Johanna Harries, Andreas Melzer, Michael Unger, Richard Brown, Kris Thielemans, Osama Sabri and Bernhard Sattler
    Citation: EJNMMI Physics 2022 9:15
    Content type: Original research Published on:

  38. In order to acquire accurate drug pharmacokinetic information, which is required for tissue dosimetry, micro-SPECT must be quantitative to allow for an accurate assessment of radioligand activity in the releva...

    Authors: Clarita Saldarriaga Vargas, Lara Struelens, Matthias D’Huyvetter, Vicky Caveliers and Peter Covens
    Citation: EJNMMI Physics 2022 9:13
    Content type: Original research Published on:

  39. Whole-body bone scintigraphy is a clinically useful non-invasive and highly sensitive imaging method enabling detection of metabolic changes at an early stage of disease, often earlier than with conventional r...

    Authors: Agnetha Gustafsson, Eva Örndahl, David Minarik, Kerstin Cederholm, Sophia Frantz, Jessica Hagerman, Lena Johansson, Johan Fredén Lindqvist and Cathrine Jonsson
    Citation: EJNMMI Physics 2022 9:12
    Content type: Original research Published on:

  40. The free-breathing T1-weighted 3D Stack of Stars GRE (StarVIBE) MR sequence potentially reduces artifacts in chest MRI. The purpose of this study was to evaluate StarVIBE for the detection of pulmonary nodules...

    Authors: Nils Martin Bruckmann, Julian Kirchner, Janna Morawitz, Lale Umutlu, Wolfgang P. Fendler, Ken Herrmann, Ann-Kathrin Bittner, Oliver Hoffmann, Tanja Fehm, Maike E. Lindemann, Christian Buchbender, Gerald Antoch and Lino M. Sawicki
    Citation: EJNMMI Physics 2022 9:11
    Content type: Original research Published on:

  41. Non-human primates (NHP) are critical in biomedical research to better understand the pathophysiology of diseases and develop new therapies. Based on its translational and longitudinal abilities along with its...

    Authors: Frédéric Boisson, Sophie Serriere, Liji Cao, Sylvie Bodard, Alessandro Pilleri, Lionel Thomas, Giancarlo Sportelli, Johnny Vercouillie, Patrick Emond, Clovis Tauber, Nicola Belcari, Jean-Luc Lefaucheur, David Brasse and Laurent Galineau
    Citation: EJNMMI Physics 2022 9:10
    Content type: Original research Published on:

  42. Multicentre clinical trials evaluating the role of 18F-Fluoroethyl-l-tyrosine (18F-FET) PET as a diagnostic biomarker in glioma management have highlighted a need for standardised methods of data analysis. 18F-FE...

    Authors: Caterina Brighi, Simon Puttick, Shenpeng Li, Paul Keall, Katherine Neville, David Waddington, Pierrick Bourgeat, Ashley Gillman and Michael Fay
    Citation: EJNMMI Physics 2022 9:9
    Content type: Original research Published on:

  43. The aim of the study was to assess the accuracy of quantitative SPECT/CT imaging in a clinical setting and to compare test results from two nuclear medicine departments.

    Authors: Hanna Piwowarska-Bilska, Aleksandra Supińska and Bożena Birkenfeld
    Citation: EJNMMI Physics 2022 9:8
    Content type: Original research Published on:

  44. This study aimed to investigate the impact of a deep learning (DL)-based denoising method on the image quality and lesion detectability of 18F-FDG positron emission tomography (PET) images.

    Authors: Yan Xing, Wenli Qiao, Taisong Wang, Ying Wang, Chenwei Li, Yang Lv, Chen Xi, Shu Liao, Zheng Qian and Jinhua Zhao
    Citation: EJNMMI Physics 2022 9:7
    Content type: Original research Published on:

  45. Metabolic positron emission tomography/computed tomography (PET/CT) parameters describing tumour activity contain valuable prognostic information, but to perform the measurements manually leads to both intra- ...

    Authors: Pablo Borrelli, José Luis Loaiza Góngora, Reza Kaboteh, Johannes Ulén, Olof Enqvist, Elin Trägårdh and Lars Edenbrandt
    Citation: EJNMMI Physics 2022 9:6
    Content type: Original research Published on:

  47. Current 18F-NaF assessments of aortic valve microcalcification using 18F-NaF PET/CT are based on evaluations of end-diastolic or cardiac motion-corrected (ECG-MC) images, which are affected by both patient and re...

    Authors: Martin Lyngby Lassen, Evangelos Tzolos, Daniele Massera, Sebastien Cadet, Rong Bing, Jacek Kwiecinski, Damini Dey, Daniel S. Berman, Marc R. Dweck, David E. Newby and Piotr J. Slomka
    Citation: EJNMMI Physics 2022 9:4
    Content type: Original research Published on:

  48. Selective internal radiation therapy (SIRT) requires a good liver registration of multi-modality images to obtain precise dose prediction and measurement. This study investigated the feasibility of liver regis...

    Authors: Xikai Tang, Esmaeel Jafargholi Rangraz, Richard’s Heeren, Walter Coudyzer, Geert Maleux, Kristof Baete, Chris Verslype, Mark J. Gooding, Christophe M. Deroose and Johan Nuyts
    Citation: EJNMMI Physics 2022 9:3
    Content type: Original research Published on:

  49. Positron emission tomography (PET) with prostate specific membrane antigen (PSMA) have shown superior performance in detecting metastatic prostate cancers. Relative to [18F]fluorodeoxyglucose ([18F]FDG) PET image...

    Authors: Roberto Fedrigo, Dan J. Kadrmas, Patricia E. Edem, Lauren Fougner, Ivan S. Klyuzhin, M. Peter Petric, François Bénard, Arman Rahmim and Carlos Uribe
    Citation: EJNMMI Physics 2022 9:2
    Content type: Original research Published on:

  50. Q.Clear is a block sequential regularized expectation maximization penalized-likelihood reconstruction algorithm for Positron Emission Tomography (PET). It has shown high potential in improving image reconstru...

    Authors: Defeng Tian, Hongwei Yang, Yan Li, Bixiao Cui and Jie Lu
    Citation: EJNMMI Physics 2022 9:1
    Content type: Original research Published on:
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