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EJNMMI Physics
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  1. Dead time may affect the accuracy of quantitative SPECT (QPSECT), and thus of dosimetry. The aim of this study was to quantify the effect of dead time on 177Lu-QSPECT and renal dosimetry following peptide recepto...

    Authors: Alessandro Desy, Guillaume F. Bouvet, Andrea Frezza, Philippe Després and Jean-Mathieu Beauregard

    Citation: EJNMMI Physics 2020 7:32

    Content type: Short communication

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  2. Prostate-specific membrane antigen (PSMA) radiotracers such as [18F]PSMA-1007 used with positron emission tomography-computed tomography (PET-CT) is promising for initial staging and detection of recurrent diseas...

    Authors: Elin Trägårdh, David Minarik, Gustav Brolin, Ulrika Bitzén, Berit Olsson and Jenny Oddstig

    Citation: EJNMMI Physics 2020 7:31

    Content type: Original research

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  3. Quantitative imaging biomarkers are becoming usual in oncology for assessing therapy response. The harmonization of image quantitation reporting has become of utmost importance due to the multi-center trials i...

    Authors: Delphine Vallot, Elena De Ponti, Sabrina Morzenti, Anna Gramek, Anna Pieczonka, Gabriel Reynés Llompart, Jakub Siennicki, Paul Deak, Chiranjib Dutta, Jorge Uribe and Olivier Caselles

    Citation: EJNMMI Physics 2020 7:30

    Content type: Original research

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  4. Strong correlation has been demonstrated between tumor dose and response and between healthy liver dose and side effects. Individualized dosimetry is increasingly recommended in the current clinical routine. H...

    Authors: Nicolas Meyers, Alexandre Jadoul, Claire Bernard, Jean Delwaide, Anne Lamproye, Olivier Detry, Pierre Honoré, Laurent Gerard and Roland Hustinx

    Citation: EJNMMI Physics 2020 7:29

    Content type: Original research

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  5. To determine the impact of the Bayesian penalized likelihood (BPL) reconstruction algorithm in comparison to OSEM on hypoxia PET/CT images of NSCLC using 18F-MIZO and 18F-FAZA.

    Authors: Edgar Texte, Pierrick Gouel, Sébastien Thureau, Justine Lequesne, Bertrand Barres, Agathe Edet-Sanson, Pierre Decazes, Pierre Vera and Sébastien Hapdey

    Citation: EJNMMI Physics 2020 7:28

    Content type: Original research

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  6. For therapeutic applications of several isotopes (e.g., 131I, 153Sm, 177Lu) in nuclear medicine, the high activities typically applied require accurate dead time correction in early time point imaging. We present...

    Authors: Jan W. T. Heemskerk and Michel Defrise

    Citation: EJNMMI Physics 2020 7:27

    Content type: Original research

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  7. Over recent years, peptide receptor radiotherapy (PRRT) has been recognized as an effective treatment for patients with metastatic neuroendocrine tumors (NETs). Personalized dosimetry can contribute to improve...

    Authors: Nanette Freedman, Mattias Sandström, Jonathan Kuten, Natan Shtraus, Inna Ospovat, Albert Schlocker and Einat Even-Sapir

    Citation: EJNMMI Physics 2020 7:26

    Content type: Short communication

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  8. Arterial sampling in PET studies for the purposes of kinetic modeling remains an invasive, time-intensive, and expensive procedure. Alternatives to derive the blood time-activity curve (BTAC) non-invasively ar...

    Authors: Yassine Toufique, Othmane Bouhali, Pauline Negre and Jim O’ Doherty

    Citation: EJNMMI Physics 2020 7:25

    Content type: Original research

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  9. Despite the advent of clinical PET-MR imaging for routine use in 2011 and the development of several methods to address the problem of attenuation correction, some challenges remain. We have identified and inv...

    Authors: J. E. Mackewn, J. Stirling, S. Jeljeli, S-M. Gould, R. I. Johnstone, I. Merida, L. C. Pike, C. J. McGinnity, K. Beck, O. Howes, A. Hammers and P. K. Marsden

    Citation: EJNMMI Physics 2020 7:24

    Content type: Original research

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    The Correction to this article has been published in EJNMMI Physics 2020 7:47

  10. A GATE Monte Carlo model of the Philips Vereos digital photon counting PET imaging system using silicon photo-multiplier detectors was proposed. It was evaluated against experimental data in accordance with NE...

    Authors: Julien Salvadori, Joey Labour, Freddy Odille, Pierre-Yves Marie, Jean-Noël Badel, Laëtitia Imbert and David Sarrut

    Citation: EJNMMI Physics 2020 7:23

    Content type: Original Research

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  11. For multicenter clinical studies, PET/CT and SPECT/CT scanners need to be validated to ensure comparability between various scanner types and brands. This validation is usually performed using hollow phantoms ...

    Authors: Tilman Läppchen, Lorenz P. Meier, Markus Fürstner, George A. Prenosil, Thomas Krause, Axel Rominger, Bernd Klaeser and Michael Hentschel

    Citation: EJNMMI Physics 2020 7:22

    Content type: Original research

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  12. Lutetium oxyorthosilicate or lutetium yttrium oxyorthosilicate (LYSO) scintillation crystals used in most current PET scanner detectors contain 176Lu, which decays by beta emission to excited states of 176Hf acco...

    Authors: Francisco Eduardo Enríquez-Mier-y-Terán, Ana Saret Ortega-Galindo, Tirso Murrieta-Rodríguez, Mercedes Rodríguez-Villafuerte, Arnulfo Martínez-Dávalos and Héctor Alva-Sánchez

    Citation: EJNMMI Physics 2020 7:21

    Content type: Original research

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  13. Optimization of injected gallium-68 (68Ga) activity for 68Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (68Ga-PSMA PET/CT) studies is relevant for image quality, radiation...

    Authors: J. Wielaard, J. B. A. Habraken, P. Brinks, J. Lavalaye and R. Boellaard

    Citation: EJNMMI Physics 2020 7:20

    Content type: Original research

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  14. Respiratory motion in PET/CT leads to well-known image degrading effects commonly compensated using elastic motion correction approaches. Gate-to-gate motion correction techniques are promising tools for impro...

    Authors: Stefanie Pösse, Florian Büther, Dirk Mannweiler, Inki Hong, Judson Jones, Michael Schäfers and Klaus Peter Schäfers

    Citation: EJNMMI Physics 2020 7:19

    Content type: Original Research

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  15. Evaluate the physical performance of the VERITON CzT camera (Spectrum Dynamics, Caesarea, Israel) that benefits from new detection architecture enabling whole-body imaging compared to that of a conventional du...

    Authors: Cédric Desmonts, Mohammed Abdeldjalil Bouthiba, Blandine Enilorac, Catherine Nganoa, Denis Agostini and Nicolas Aide

    Citation: EJNMMI Physics 2020 7:18

    Content type: Young investigators

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  16. Currently, no consistent guidelines for CT scans used within PET/CT examinations are available. This systematic review provides an up-to-date overview of studies to answer the following questions: What are the...

    Authors: V. Bertolini, A. Palmieri, M. C. Bassi, M. Bertolini, V. Trojani, V. Piccagli, F. Fioroni, S. Cavuto, M. Guberti, A. Versari and S. Cola

    Citation: EJNMMI Physics 2020 7:17

    Content type: Review

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  17. 44Sc has been increasingly investigated as a potential alternative to 68Ga in the development of tracers for positron emission tomography (PET). The lower mean positron energy of 44Sc (0.63 MeV) compared to 68Ga ...

    Authors: Florian Rosar, Hans-Georg Buchholz, Sebastian Michels, Manuela A. Hoffmann, Markus Piel, Christopher M. Waldmann, Frank Rösch, Stefan Reuss and Mathias Schreckenberger

    Citation: EJNMMI Physics 2020 7:16

    Content type: Original research

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  18. The purpose of the EANM Dosimetry Committee Series on “Standard Operational Procedures for Dosimetry” (SOP) is to provide advice to scientists and clinicians on how to perform patient-specific absorbed dose as...

    Authors: Jonathan Gear, Carlo Chiesa, Michael Lassmann, Pablo Mínguez Gabiña, Johannes Tran-Gia, Caroline Stokke and Glenn Flux

    Citation: EJNMMI Physics 2020 7:15

    Content type: Opinion article

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  19. New digital PET scanners with improved time of flight timing and extended axial field of view such as the Siemens Biograph Vision have come on the market and are expected to replace current generation photomul...

    Authors: Britt Kunnen, Casper Beijst, Marnix G. E. H. Lam, Max A. Viergever and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2020 7:14

    Content type: Original research

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  20. Intrahepatic dosimetry is paramount to optimize radioembolization treatment accuracy using radioactive holmium-166 microspheres (166Ho). This requires a practical protocol that combines quantitative imaging of mi...

    Authors: R. van Rooij, A. J. A. T. Braat, H. W. A. M. de Jong and M. G. E. H. Lam

    Citation: EJNMMI Physics 2020 7:13

    Content type: Original research

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  21. The National Electrical Manufacturers Association’s (NEMA) NU 4-2008 standard specifies methodology for evaluating the performance of small-animal PET scanners. The standard’s goal is to enable comparison of d...

    Authors: Patrick Hallen, David Schug and Volkmar Schulz

    Citation: EJNMMI Physics 2020 7:12

    Content type: Opinion Article

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  22. Routine PET exams are increasingly performed with reduced injected activities, leading to the use of different image reconstruction parameters than the NEMA parameters, in order to prevent from any deleterious...

    Authors: Julien Salvadori, Freddy Odille, Antoine Verger, Pierre Olivier, Gilles Karcher, Pierre-Yves Marie and Laetitia Imbert

    Citation: EJNMMI Physics 2020 7:11

    Content type: Original research

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  23. Personalization of 177Lu-based radionuclide therapy requires implementation of dosimetry methods that are both accurate and practical enough for routine clinical use. Quantitative single-photon emission computed ...

    Authors: Andrea Frezza, Corentin Desport, Carlos Uribe, Wei Zhao, Anna Celler, Philippe Després and Jean-Mathieu Beauregard

    Citation: EJNMMI Physics 2020 7:10

    Content type: Original research

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  24. Quantitative SPECT imaging in targeted radionuclide therapy with lutetium-177 holds great potential for individualized treatment based on dose assessment. The establishment of dose-effect relations requires a ...

    Authors: Steffie M. B. Peters, Sebastiaan L. Meyer Viol, Niels R. van der Werf, Nick de Jong, Floris H. P. van Velden, Antoi Meeuwis, Mark W. Konijnenberg, Martin Gotthardt, Hugo W. A. M. de Jong and Marcel Segbers

    Citation: EJNMMI Physics 2020 7:9

    Content type: Original research

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  25. Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate cellular dosimetry. Therefore, we have built a refined cellular dos...

    Authors: Giulia Tamborino, Marijke De Saint-Hubert, Lara Struelens, Dayana C. Seoane, Eline A. M. Ruigrok, An Aerts, Wiggert A. van Cappellen, Marion de Jong, Mark W. Konijnenberg and Julie Nonnekens

    Citation: EJNMMI Physics 2020 7:8

    Content type: Original research

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  26. Conventional PET imaging has usually been limited to a single tracer per scan. We propose a new technique for multi-tracer PET imaging that uses dynamic imaging and multi-tracer compartment modeling including ...

    Authors: Carlos Velasco, Adriana Mota-Cobián, Jesús Mateo and Samuel España

    Citation: EJNMMI Physics 2020 7:7

    Content type: Original research

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  27. Before radioiodine therapy for Graves’ disease, the estimated thyroid-absorbed dose is calculated based on various clinical parameters. However, the actual accumulation of iodine in the thyroid during radioiod...

    Authors: Naotoshi Fujita, Yumiko Koshiba, Shinji Abe and Katsuhiko Kato

    Citation: EJNMMI Physics 2020 7:6

    Content type: Original research

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  28. After each cycle of [177Lu]-DOTA-TATE peptide receptor radionuclide therapy (PRRT) dosimetry is performed to enable precise calculation of the radiation-absorbed dose to tumors and normal organs. Absorbed doses a...

    Authors: Alexandre Chicheportiche, Simona Ben-Haim, Simona Grozinsky-Glasberg, Kira Oleinikov, Amichay Meirovitz, David J. Gross and Jeremy Godefroy

    Citation: EJNMMI Physics 2020 7:5

    Content type: Original research

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  29. This article compares the physical performance of the 4-ring digital Discovery MI (DMI) and PMT-based Discovery MI-DR (DMI-DR) PET/CT systems. Physical performance was assessed according to the NEMA NU 2-2012 ...

    Authors: Alexandre Chicheportiche, Rami Marciano and Marina Orevi

    Citation: EJNMMI Physics 2020 7:4

    Content type: Original research

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  31. Bayesian penalized likelihood reconstruction for PET (e.g., GE Q.Clear) aims at improving convergence of lesion activity while ensuring sufficient signal-to-noise ratio (SNR). This study evaluated reconstructe...

    Authors: Julian M. Rogasch, Said Suleiman, Frank Hofheinz, Stephanie Bluemel, Mathias Lukas, Holger Amthauer and Christian Furth

    Citation: EJNMMI Physics 2020 7:2

    Content type: Original research

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  32. We assessed and compared image quality obtained with clinical 18F-FDG whole-body oncologic PET protocols used in three different, state-of-the-art digital PET/CT and two conventional PMT-based PET/CT devices.

    Authors: Silvano Gnesin, Christine Kieffer, Konstantinos Zeimpekis, Jean-Pierre Papazyan, Renaud Guignard, John O. Prior, Francis R. Verdun and Thiago V. M. Lima

    Citation: EJNMMI Physics 2020 7:1

    Content type: Original research

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  33. Recently, a Bayesian penalized likelihood (BPL) reconstruction algorithm was introduced for a commercial PET/CT with the potential to improve image quality. We compared the performance of this BPL algorithm wi...

    Authors: Joost te Riet, Sjoerd Rijnsdorp, Mark J. Roef and Albert J. Arends

    Citation: EJNMMI Physics 2019 6:32

    Content type: Original research

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  35. In ordered subsets expectation maximization (OSEM) reconstruction of electrocardiography (ECG)-gated myocardial perfusion single-photon emission computed tomography (SPECT), it is often assumed that the image ...

    Authors: Matti J. Kortelainen, Tuomas M. Koivumäki, Marko J. Vauhkonen and Mikko A. Hakulinen

    Citation: EJNMMI Physics 2019 6:30

    Content type: Original research

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  36. Absolute quantification of radiotracer distribution using SPECT/CT imaging is of great importance for dosimetry aimed at personalized radionuclide precision treatment. However, its accuracy depends on many fac...

    Authors: Steffie M. B. Peters, Niels R. van der Werf, Marcel Segbers, Floris H. P. van Velden, Roel Wierts, Koos (J.) A. K. Blokland, Mark W. Konijnenberg, Sergiy V. Lazarenko, Eric P. Visser and Martin Gotthardt

    Citation: EJNMMI Physics 2019 6:29

    Content type: Original research

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  37. Recently, updated EARL specifications (EARL2) have been developed and announced. This study aims at investigating the impact of the EARL2 specifications on the quantitative reads of clinical PET–CT studies and...

    Authors: Andres Kaalep, Coreline N. Burggraaff, Simone Pieplenbosch, Eline E. Verwer, Terez Sera, Josee Zijlstra, Otto S. Hoekstra, Daniela E. Oprea-Lager and Ronald Boellaard

    Citation: EJNMMI Physics 2019 6:28

    Content type: Original research

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  38. We aim to provide a systematic study of the impact of white matter (WM) spill-in on the calculation of standardized uptake value ratios (SUVRs) on Aβ-negative subjects, and we study the effect of including WM ...

    Authors: Francisco Javier López-González, Alexis Moscoso, Nikos Efthimiou, Anxo Fernández-Ferreiro, Manuel Piñeiro-Fiel, Stephen J. Archibald, Pablo Aguiar and Jesús Silva-Rodríguez

    Citation: EJNMMI Physics 2019 6:27

    Content type: Original research

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  39. Compartmental modelling is an established method of quantifying 18F-FDG uptake; however, only recently has it been applied to evaluate pulmonary inflammation. Implementation of compartmental models remains challe...

    Authors: Laurence D. Vass, Sarah Lee, Frederick J. Wilson, Marie Fisk, Joseph Cheriyan and Ian Wilkinson

    Citation: EJNMMI Physics 2019 6:26

    Content type: Original Research

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  40. Multi-tracer positron emission tomography (PET) imaging can be accomplished by applying multi-tracer compartment modeling. Recently, a method has been proposed in which the arterial input functions (AIFs) of t...

    Authors: Carlos Velasco, Adriana Mota-Cobián, Jesús Mateo and Samuel España

    Citation: EJNMMI Physics 2019 6:25

    Content type: Original research

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  41. Computed tomography (CT) scans are routinely performed in positron emission tomography (PET) and single photon emission computed tomography (SPECT) examinations globally, yet few surveys have been conducted to...

    Authors: Natalie A. Bebbington, Bryan T. Haddock, Henrik Bertilsson, Eero Hippeläinen, Ellen M. Husby, Virpi I. Tunninen and Marcus Söderberg

    Citation: EJNMMI Physics 2019 6:24

    Content type: Original research

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  42. The decay characteristics of radionuclides in PET studies can impact image reconstruction. 44gSc has been the topic of recent research due to potential theranostic applications and is a promising radiometal for P...

    Authors: Simon Ferguson, Hans-Sonke Jans, Melinda Wuest, Terence Riauka and Frank Wuest

    Citation: EJNMMI Physics 2019 6:23

    Content type: Original research

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  43. Q.Clear is a block sequential regularized expectation maximization (BSREM) penalized-likelihood reconstruction algorithm for PET. It tries to improve image quality by controlling noise amplification during ima...

    Authors: Paulo R. R. V. Caribé, M. Koole, Yves D’Asseler, B. Van Den Broeck and S. Vandenberghe

    Citation: EJNMMI Physics 2019 6:22

    Content type: Original research

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  44. To determine the clinically acceptable level of reduction in the injected fluorine-18 (18F)-labeled fluorodeoxyglucose (18F-FDG) dose in dedicated breast positron emission tomography (dbPET).

    Authors: Yoko Satoh, Tetsuro Sekine, Yoshie Omiya, Hiroshi Onishi and Utaroh Motosugi

    Citation: EJNMMI Physics 2019 6:21

    Content type: Original research

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  45. Volumes of usual PET phantoms are about four to sixfold that of a human liver. In order to avoid count rate saturation and handling of very high 90Y activity, reported TOF-PET phantom studies are performed using ...

    Authors: Michel Hesse and Stephan Walrand

    Citation: EJNMMI Physics 2019 6:20

    Content type: Artefact report

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  46. Performance standards for quantitative 18F-FDG PET/CT studies are provided by the EANM Research Ltd. (EARL) to enable comparability of quantitative PET in multicentre studies. Yet, such specifications are not ava...

    Authors: Daphne M. V. Huizing, Daniëlle Koopman, Jorn A. van Dalen, Martin Gotthardt, Ronald Boellaard, Terez Sera, Michiel Sinaasappel, Marcel P. M. Stokkel and Berlinda J. de Wit-van der Veen

    Citation: EJNMMI Physics 2019 6:19

    Content type: Short communication

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  48. Cerenkov Luminescence Imaging (CLI) is an emerging technology for intraoperative margin assessment. Previous research only evaluated radionuclide 18-Fluorine (18F); however, for future applications in prostate ca...

    Authors: J. olde Heuvel, B. J. de Wit-van der Veen, K. N. Vyas, D. S. Tuch, M. R. Grootendorst, M. P. M. Stokkel and C. H. Slump

    Citation: EJNMMI Physics 2019 6:17

    Content type: Original research

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  49. The technology of modern positron emission tomography (PET) systems continuously improving, and with it the possibility to detect smaller lesions. Since first introduced in 2010, the number of hybrid PET/magne...

    Authors: Silje Kjærnes Øen, Lars Birger Aasheim, Live Eikenes and Anna Maria Karlberg

    Citation: EJNMMI Physics 2019 6:16

    Content type: Original research

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  50. Monte Carlo-based iterative reconstruction to correct for photon scatter and collimator effects has been proven to be superior over analytical correction schemes in single-photon emission computed tomography (...

    Authors: Martijn M. A. Dietze, Woutjan Branderhorst, Britt Kunnen, Max A. Viergever and Hugo W. A. M. de Jong

    Citation: EJNMMI Physics 2019 6:14

    Content type: Original research

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