Articles

Biodistribution, pharmacokinetics, and organ-level dosimetry for ¹⁸⁸Re-AHDD-Lipiodol radioembolization based on quantitative post-treatment SPECT/CT scans

Rhenium-188-labelled-Lipiodol radioembolization is a safe and cost-effective treatment for primary liver cancer. In order to determine correlations between treatment doses and patient response to therapy, accu...

Authors: Pedro L. Esquinas, Ajit Shinto, Koramadai K. Kamaleshwaran, Jephy Joseph and Anna Celler

Validation of the physiological background correction method for the suppression of the spill-in effect near highly radioactive regions in positron emission tomography

Positron emission tomography (PET) imaging has a wide applicability in oncology, cardiology and neurology. However, a major drawback when imaging very active regions such as the bladder is the spill-in effect,...

Authors: Mercy I. Akerele, Palak Wadhwa, Jesus Silva-Rodriguez, William Hallett and Charalampos Tsoumpas

Fast quantitative reconstruction with focusing collimators for liver SPECT

Generation of a SPECT scan during procedure may aid in the optimization of treatments as liver radioembolization by offering image-guided dosimetry. This, however, requires both shortened acquisition times and...

Authors: Martijn M. A. Dietze, Sandra van der Velden, Marnix G. E. H. Lam, Max A. Viergever and Hugo W. A. M. de Jong

Performance evaluation of a new high-sensitivity time-of-flight clinical PET/CT system

PoleStar m660 is a newly developed clinical PET/CT system with time-of-flight (TOF) capability. The aim of this study is to characterize the performance of the new system. Spatial resolution, sensitivity, scat...

Authors: Li Huo, Nan Li, Heyu Wu, Wenjia Zhu, Haiqun Xing, Jiantao Ba, Tong Wang, Fang Li and Hui Zhang

Impact of ⁹⁰Y PET gradient-based tumor segmentation on voxel-level dosimetry in liver radioembolization

The purpose was to validate ⁹⁰Y PET gradient-based tumor segmentation in phantoms and to evaluate the impact of the segmentation method on reported tumor absorbed dose (AD) and biological effective dose (BED) in

Authors: Justin K. Mikell, Ravi K. Kaza, Peter L. Roberson, Kelly C. Younge, Ravi N. Srinivasa, Bill S. Majdalany, Kyle C. Cuneo, Dawn Owen, Theresa Devasia, Matthew J. Schipper and Yuni K. Dewaraja

Feasibility of PET/CT system performance harmonisation for quantitative multicentre ⁸⁹Zr studies

The aim of this study was to investigate the variability in quantitative performance and feasibility of quantitative harmonisation in ⁸⁹Zr PET/CT imaging.

Authors: Andres Kaalep, Marc Huisman, Terez Sera, Danielle Vugts and Ronald Boellaard

A deep learning approach for ¹⁸F-FDG PET attenuation correction

To develop and evaluate the feasibility of a data-driven deep learning approach (deepAC) for positron-emission tomography (PET) image attenuation correction without anatomical imaging. A PET attenuation correc...

Authors: Fang Liu, Hyungseok Jang, Richard Kijowski, Gengyan Zhao, Tyler Bradshaw and Alan B. McMillan

The physics of radioembolization

Radioembolization is an established treatment for chemoresistant and unresectable liver cancers. Currently, treatment planning is often based on semi-empirical methods, which yield acceptable toxicity profiles...

Authors: Remco Bastiaannet, S. Cheenu Kappadath, Britt Kunnen, Arthur J. A. T. Braat, Marnix G. E. H. Lam and Hugo W. A. M. de Jong

Evaluation of zero-echo-time attenuation correction for integrated PET/MR brain imaging—comparison to head atlas and ⁶⁸Ge-transmission-based attenuation correction

MRI does not offer a direct method to obtain attenuation correction maps as its predecessors (stand-alone PET and PET/CT), and bone visualisation is particularly challenging. Recently, zero-echo-time (ZTE) was...

Authors: João M. Sousa, Lieuwe Appel, Mathias Engström, Stergios Papadimitriou, Dag Nyholm, Elna-Marie Larsson, Håkan Ahlström and Mark Lubberink

Accuracy and reproducibility of simplified QSPECT dosimetry for personalized ¹⁷⁷Lu-octreotate PRRT

Routine dosimetry is essential for personalized ¹⁷⁷Lu-octreotate peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs), but practical and robust dosimetry methods are needed for wide clinic...

Authors: Michela Del Prete, Frédéric Arsenault, Nassim Saighi, Wei Zhao, François-Alexandre Buteau, Anna Celler and Jean-Mathieu Beauregard

Validation of gallbladder absorbed radiation dose reduction simulation: human dosimetry of [¹⁸F]fluortriopride

[¹⁸F]Fluortriopride (FTP) was developed as a dopamine D3-selective radiotracer, thought to be important to neurobiological reward pathways and implicated in drug addiction, Parkinson’s disease, and schizophrenia....

Authors: Robert K. Doot, Jacob G. Dubroff, Joshua S. Scheuermann, Kyle J. Labban, Jenny Cai, Chia-Ju Hsieh, Shihong Li, Hsiaoju Lee, Erin K. Schubert, Catherine Hou, Regan Sheffer, Alexander Schmitz, Kuiying Xu and Robert H. Mach

Impact of a Bayesian penalized likelihood reconstruction algorithm on image quality in novel digital PET/CT: clinical implications for the assessment of lung tumors

The aim of this study was to evaluate and compare PET image reconstruction algorithms on novel digital silicon photomultiplier PET/CT in patients with newly diagnosed and histopathologically confirmed lung can...

Authors: Michael Messerli, Paul Stolzmann, Michèle Egger-Sigg, Josephine Trinckauf, Stefano D’Aguanno, Irene A. Burger, Gustav K. von Schulthess, Philipp A. Kaufmann and Martin W. Huellner

SMART (SiMulAtion and ReconsTruction) PET: an efficient PET simulation-reconstruction tool

Positron-emission tomography (PET) simulators are frequently used for development and performance evaluation of segmentation methods or quantitative uptake metrics. To date, most PET simulation tools are based...

Authors: Elisabeth Pfaehler, Johan R. De Jong, Rudi A. J. O. Dierckx, Floris H. P. van Velden and Ronald Boellaard

Comparison of radiobiological parameters for ⁹⁰Y radionuclide therapy (RNT) and external beam radiotherapy (EBRT) in vitro

Dose rate variation is a critical factor affecting radionuclide therapy (RNT) efficacy. Relatively few studies to date have investigated the dose rate effect in RNT. Therefore, the aim of this study was to ben...

Authors: Yaser H. Gholami, Kathy P. Willowson, Nicholas J. Forwood, Rozelle Harvie, Nicholas Hardcastle, Regina Bromley, HyunJu Ryu, Samuel Yuen, Viive M. Howell, Zdenka Kuncic and Dale L. Bailey

Comparison of PET/CT and PET/MR imaging and dosimetry of yttrium-90 (⁹⁰Y) in patients with unresectable hepatic tumors who have received intra-arterial radioembolization therapy with ⁹⁰Y microspheres

The aim of our study was to compare ⁹⁰Y dosimetry obtained from PET/MRI versus PET/CT post-therapy imaging among patients with primary or metastatic hepatic tumors.

Authors: Karin Knešaurek, Abbas Tuli, Edward Kim, Sherif Heiba and Lale Kostakoglu

Molecular imaging using the theranostic agent ^197(m)Hg: phantom measurements and Monte Carlo simulations

Radiomercury ^197mHg and ¹⁹⁷Hg, henceforth referred to as ^197(m)Hg, is a promising theranostic radionuclide endowed with properties that allow diagnostic and therapeutic applications. The aim of this work was to i...

Authors: Robert Freudenberg, Rudi Apolle, Martin Walther, Holger Hartmann and Jörg Kotzerke

Inter-comparison of quantitative imaging of lutetium-177 (¹⁷⁷Lu) in European hospitals

This inter-comparison exercise was performed to demonstrate the variability of quantitative SPECT/CT imaging for lutetium-177 (¹⁷⁷Lu) in current clinical practice. Our aim was to assess the feasibility of using i...

Authors: Jill Wevrett, Andrew Fenwick, James Scuffham, Lena Johansson, Jonathan Gear, Susanne Schlögl, Marcel Segbers, Katarina Sjögreen-Gleisner, Pavel Solný, Michael Lassmann, Jill Tipping and Andrew Nisbet

Quantitative performance of ¹²⁴I PET/MR of neck lesions in thyroid cancer patients using ¹²⁴I PET/CT as reference

In patients with differentiated thyroid cancer (DTC), serial ¹²⁴I PET/CT imaging is, for instance, used to assess the absorbed (radiation) dose to lesions. Frequently, the lesions are located in the neck and they...

Authors: Walter Jentzen, Jinda Phaosricharoen, Benedikt Gomez, Philipp Hetkamp, Vanessa Stebner, Ina Binse, Sonja Kinner, Ken Herrmann, Amir Sabet and James Nagarajah

Feasibility of simplifying renal dosimetry in ¹⁷⁷Lu peptide receptor radionuclide therapy

Recently, ¹⁷⁷Lu-dotatate therapy for neuroendocrine tumours has received regulatory approval. Dosimetry can be used to optimize treatment on an individual basis, but there is no international consensus as to how ...

Authors: Anna Sundlöv, Johan Gustafsson, Gustav Brolin, Nadja Mortensen, Rebecca Hermann, Peter Bernhardt, Johanna Svensson, Michael Ljungberg, Jan Tennvall and Katarina Sjögreen Gleisner

Abstracts of the Total Body PET conference 2018

Authors:

Reducing the number of CTs performed to monitor personalized dosimetry during peptide receptor radionuclide therapy (PRRT)

Peptide receptor radionuclide therapy (PRRT) with [¹⁷⁷Lu]-DOTA-TATE is an effective treatment of neuroendocrine tumors (NETs). After each cycle of treatment, patient dosimetry evaluates the radiation dose to the ...

Authors: Alexandre Chicheportiche, Faozi Artoul, Arnon Schwartz, Simona Grozinsky-Glasberg, Amichay Meirovitz, David J. Gross and Jeremy Godefroy

Improved quantitation and reproducibility in multi-PET/CT lung studies by combining CT information

Matched attenuation maps are vital for obtaining accurate and reproducible kinetic and static parameter estimates from PET data. With increased interest in PET/CT imaging of diffuse lung diseases for assessing...

Authors: Beverley F. Holman, Vesna Cuplov, Lynn Millner, Raymond Endozo, Toby M. Maher, Ashley M. Groves, Brian F. Hutton and Kris Thielemans

Image-based SPECT calibration based on the evaluation of the Fraction of Activity in the Field of View

SPECT quantification is important for dosimetry in targeted radionuclide therapy (TRT) and the calibration of SPECT images is a crucial stage for image quantification. The current standardized calibration prot...

Authors: Adrien Halty, Jean-Noël Badel, Olga Kochebina and David Sarrut

Determination of gamma camera calibration factors for quantitation of therapeutic radioisotopes

Camera calibration, which translates reconstructed count map into absolute activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and tomographic scans using different phantom ge...

Authors: Wei Zhao, Pedro L. Esquinas, Xinchi Hou, Carlos F. Uribe, Marjorie Gonzalez, Jean-Mathieu Beauregard, Yuni K. Dewaraja and Anna Celler

Initial experience with a SiPM-based PET/CT scanner: influence of acquisition time on image quality

A newly introduced PET/CT scanner (Discovery Meaningful Insights—DMI, GE Healthcare) includes the silicon photomultiplier (SiPM) with time-of-flight (TOF) technology first used in the GE SIGNA PET/MRI. In this...

Authors: Ida Sonni, Lucia Baratto, Sonya Park, Negin Hatami, Shyam Srinivas, Guido Davidzon, Sanjiv Sam Gambhir and Andrei Iagaru

Multi institutional quantitative phantom study of yttrium-90 PET in PET/MRI: the MR-QUEST study

Yttrium-90 (⁹⁰Y) radioembolization involves the intra-arterial delivery of radioactive microspheres to treat hepatic malignancies. Though this therapy involves careful pre-treatment planning and imaging, little i...

Authors: Nichole M. Maughan, Mootaz Eldib, David Faul, Maurizio Conti, Mattijs Elschot, Karin Knešaurek, Francesca Leek, David Townsend, Frank P. DiFilippo, Kimberly Jackson, Stephan G. Nekolla, Mathias Lukas, Michael Tapner, Parag J. Parikh and Richard Laforest

Feasibility study of a novel general purpose CZT-based digital SPECT camera: initial clinical results

The performance of a prototype novel digital single-photon emission computed tomography (SPECT) camera with multiple pixelated CZT detectors and high sensitivity collimators (Digital SPECT; Valiance X12 protot...

Authors: Elinor Goshen, Leonid Beilin, Eli Stern, Tal Kenig, Ronen Goldkorn and Simona Ben-Haim

Performance evaluation of a novel brain-dedicated SPECT system

Single-photon emission computed tomography (SPECT) imaging is an important diagnostic tool for the early detection of the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease (PD) and similar neur...

Authors: M. K. Stam, E. E. Verwer, J. Booij, S. M. Adriaanse, C. M. de Bruin and T. C. de Wit

Quantitative analysis of phantom studies of ¹¹¹In and ⁶⁸Ga imaging of neuroendocrine tumours

Nuclear medicine imaging of neuroendocrine tumours is performed either by SPECT/CT imaging, using ¹¹¹In-octreotide or by PET/CT imaging using ⁶⁸Ga-radiolabelled somatostatin analogs. These imaging techniques will...

Authors: L. Jönsson, A. Stenvall, E. Mattsson, E. Larsson, A. Sundlöv, T. Ohlsson and C. Hindorf

MR-based motion correction for cardiac PET parametric imaging: a simulation study

Both cardiac and respiratory motions bias the kinetic parameters measured by dynamic PET. The aim of this study was to perform a realistic positron emission tomography-magnetic resonance (PET-MR) simulation st...

Authors: Rong Guo, Yoann Petibon, Yixin Ma, Georges El Fakhri, Kui Ying and Jinsong Ouyang

Deadtime effects in quantification of ¹⁷⁷Lu activity for radionuclide therapy

The aim of this study was to investigate the deadtime (DT) effects that are present in ¹⁷⁷Lu images acquired after radionuclide therapy injection, assess differences in DT based on the full spectrum and the photo...

Authors: Carlos F. Uribe, Pedro L. Esquinas, Marjorie Gonzalez, Wei Zhao, Jesse Tanguay and Anna Celler

Fast GPU-based Monte Carlo code for SPECT/CT reconstructions generates improved ¹⁷⁷Lu images

Full Monte Carlo (MC)-based SPECT reconstructions have a strong potential for correcting for image degrading factors, but the reconstruction times are long. The objective of this study was to develop a highly ...

Authors: T. Rydén, J. Heydorn Lagerlöf, J. Hemmingsson, I. Marin, J. Svensson, M. Båth, P. Gjertsson and P. Bernhardt

Monte Carlo-based quantitative pinhole SPECT reconstruction using a ray-tracing back-projector

Monte Carlo simulations provide accurate models of nuclear medicine imaging systems as they can properly account for the full physics of photon transport. The accuracy of the model included in the maximum-like...

Authors: Mikael Peterson, Johan Gustafsson and Michael Ljungberg

The effect of high count rates on cardiac perfusion quantification in a simultaneous PET-MR system using a cardiac perfusion phantom

PET-MRI is under investigation as a new strategy for quantitative myocardial perfusion imaging. Consideration is required as to the maximum scanner count rate in order to limit dead-time losses resulting from ...

Authors: Jim O’ Doherty, Zacharias Chalampalakis, Paul Schleyer, Muhummad Sohaib Nazir, Amedeo Chiribiri and Paul K. Marsden

Model selection criteria for dynamic brain PET studies

 Several criteria exist to identify the optimal model for quantification of tracer kinetics. The purpose of this study was to evaluate the correspondence in kinetic model preference identification for brain PE...

Authors: Sandeep S. V. Golla, Sofie M. Adriaanse, Maqsood Yaqub, Albert D. Windhorst, Adriaan A. Lammertsma, Bart N. M. van Berckel and Ronald Boellaard

Variations in the practice of molecular radiotherapy and implementation of dosimetry: results from a European survey

Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availabili...

Authors: Katarina Sjögreen Gleisner, Emiliano Spezi, Pavel Solny, Pablo Minguez Gabina, Francesco Cicone, Caroline Stokke, Carlo Chiesa, Maria Paphiti, Boudewijn Brans, Mattias Sandström, Jill Tipping, Mark Konijnenberg and Glenn Flux

Comparison of machine learning and semi-quantification algorithms for (I123)FP-CIT classification: the beginning of the end for semi-quantification?

Semi-quantification methods are well established in the clinic for assisted reporting of (I123) Ioflupane images. Arguably, these are limited diagnostic tools. Recent research has demonstrated the potential fo...

Authors: Jonathan Christopher Taylor and John Wesley Fenner

Dosimetry-based treatment planning for molecular radiotherapy: a summary of the 2017 report from the Internal Dosimetry Task Force

The European directive on basic safety standards (Council directive 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. The directive comes into operation February 2...

Authors: Caroline Stokke, Pablo Minguez Gabiña, Pavel Solný, Francesco Cicone, Mattias Sandström, Katarina Sjögreen Gleisner, Carlo Chiesa, Emiliano Spezi, Maria Paphiti, Mark Konijnenberg, Matt Aldridge, Jill Tipping, Michael Wissmeyer, Boudewijn Brans, Klaus Bacher, Carsten Kobe…

Calculation of left ventricular volumes and ejection fraction from dynamic cardiac-gated ¹⁵O-water PET/CT: 5D-PET

Quantitative measurement of myocardial blood flow (MBF) is of increasing interest in the clinical assessment of patients with suspected coronary artery disease (CAD). ¹⁵O-water positron emission tomography (PET) ...

Authors: Jonny Nordström, Tanja Kero, Hendrik Johannes Harms, Charles Widström, Frank A. Flachskampf, Jens Sörensen and Mark Lubberink

Predictive SIRT dosimetry based on a territorial model

In the planning of selective internal radiation therapy (SIRT) for liver cancer treatment, one major aspect is to determine the prescribed activity and to estimate the resulting absorbed dose inside normal liv...

Authors: Nadine Spahr, Philipp Schilling, Smita Thoduka, Nasreddin Abolmaali and Andrea Schenk

Patient-specific dosimetry of ^99mTc-HYNIC-Tyr³-Octreotide in children

Technetium-99m-hydrazinonicotinamide-Tyr³-octreotide (^99mTc-HYNIC-TOC) is recognized as a promising radiopharmaceutical for diagnosing neuroendocrine tumors (NETs). However, ^99mTc-HYNIC-TOC dosimetry has been inv...

Authors: Xinchi Hou, Bozena Birkenfeld, Hanna Piwowarska-Bilska and Anna Celler

Guidelines for quality control of PET/CT scans in a multicenter clinical study

To date, there is no published detailed checklist with parameters referencing the DICOM tag information with respect to the quality control (QC) of PET/CT scans. The aims of these guidelines are to provide the...

Authors: Ivalina Hristova, Ronald Boellaard, Paul Galette, Lalitha K. Shankar, Yan Liu, Sigrid Stroobants, Otto S. Hoekstra and Wim J.G. Oyen

Comparison of novel multi-level Otsu (MO-PET) and conventional PET segmentation methods for measuring FDG metabolic tumor volume in patients with soft tissue sarcoma

We have previously developed a novel and highly consistent PET segmentation algorithm using a multi-level Otsu method (MO-PET). The aim of this study was to evaluate the reliability of MO-PET compared to conve...

Authors: Inki Lee, Hyung-Jun Im, Meiyappan Solaiyappan and Steve Y. Cho

Comparison of PET/CT and whole-mount histopathology sections of the human prostate: a new strategy for voxel-wise evaluation

Implementation of PET/CT in diagnosis of primary prostate cancer (PCa) requires a profound knowledge about the tracer, preferably from a quantitative evaluation. Direct visual comparison of PET/CT slices to wh...

Authors: F. Schiller, T. Fechter, C. Zamboglou, A. Chirindel, N. Salman, C.A. Jilg, V. Drendel, M. Werner, P.T. Meyer, A.-L. Grosu and M. Mix

Ejection fraction in myocardial perfusion imaging assessed with a dynamic phantom: comparison between IQ-SPECT and LEHR

Developments in single photon emission tomography instrumentation and reconstruction methods present a potential for decreasing acquisition times. One of such recent options for myocardial perfusion imaging (M...

Authors: Eero Hippeläinen, Teemu Mäkelä, Touko Kaasalainen and Erna Kaleva

Design and implementation of a prototype head and neck phantom for the performance evaluation of gamma imaging systems

A prototype anthropomorphic head and neck phantom has been designed to simulate the adult head and neck anatomy including some internal organs and tissues of interest, such as thyroid gland and sentinel lymph ...

Authors: Mohammed S. Alqahtani, John E. Lees, Sarah L. Bugby, Piyal Samara-Ratna, Aik H. Ng and Alan C. Perkins

A CZT-based blood counter for quantitative molecular imaging

Robust quantitative analysis in positron emission tomography (PET) and in single-photon emission computed tomography (SPECT) typically requires the time-activity curve as an input function for the pharmacokine...

Authors: Romain Espagnet, Andrea Frezza, Jean-Pierre Martin, Louis-André Hamel, Laëtitia Lechippey, Jean-Mathieu Beauregard and Philippe Després

EORTC PET response criteria are more influenced by reconstruction inconsistencies than PERCIST but both benefit from the EARL harmonization program

This study evaluates the consistency of PET evaluation response criteria in solid tumours (PERCIST) and European Organisation for Research and Treatment of Cancer (EORTC) classification across different recons...

Authors: Charline Lasnon, Elske Quak, Pierre-Yves Le Roux, Philippe Robin, Michael S. Hofman, David Bourhis, Jason Callahan, David S. Binns, Cédric Desmonts, Pierre-Yves Salaun, Rodney J. Hicks and Nicolas Aide

Using ³¹P-MRI of hydroxyapatite for bone attenuation correction in PET-MRI: proof of concept in the rodent brain

The correction of γ-photon attenuation in PET-MRI remains a critical issue, especially for bone attenuation. This problem is of great importance for brain studies due to the density of the skull. Current techn...

Authors: Vincent Lebon, Sébastien Jan, Yoann Fontyn, Brice Tiret, Géraldine Pottier, Emilie Jaumain and Julien Valette

Saul Hertz, MD, and the birth of radionuclide therapy

The year, 2016, marked the 75th anniversary of Dr. Saul Hertz first using radioiodine to treat a patient with thyroid disease. In November of 1936, a luncheon was held of the faculty of Harvard Medical School ...

Authors: Frederic H. Fahey, Frederick D. Grant and James H. Thrall