Articles

Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance

Small-animal imaging has become an important technique for the development of new radiotracers, drugs and therapies. Many laboratories have now a combination of different small-animal imaging systems, which ar...

Authors: Christian Vanhove, Jens P. Bankstahl, Stefanie D. Krämer, Eric Visser, Nicola Belcari and Stefaan Vandenberghe

Erratum to: Compatibility of metal additive manufactured tungsten collimator for SPECT/MRI integration

Authors: Amine M. Samoudi, Karen Van Audenhaege, Gunter Vermeeren, Luc Martens, Roel Van Holen and Wout Joseph

Erratum to: Determination of position and shape of flexible MRI surface coils using the Microsoft Kinect for attenuation correction in PET/MRI

Authors: Lynn J. Frohwein, Mirco Heß, Florian Büther and Klaus P. Schäfers

Erratum to: Analysis and reduction of eddy current effects induced by tesseral end zonal gradient coils in different collimator geometries for SPECT/MRI integration

Authors: Amine M. Samoudi, Karen Van Audenhaege, Gunter Vermeeren, Emmeric Tanghe, Luc Martens, Roel Van Holen and Wout Joseph

Erratum to: Establishment of an open database of realistic simulated data for evaluation of partial volume correction techniques in brain PET/MR

Authors: Ana Mota, Vesna Cuplov, Ivana Drobnjak, John Dickson, Julien Bert, Ninon Burgos, Jorge Cardoso, Marc Modat, Sebastien Ourselin, Jonathan Schott, Kjell Erlandsson, Brian Hutton and Kris Thielemans

Performance evaluation of the Biograph mCT Flow PET/CT system according to the NEMA NU2-2012 standard

The purpose of the study is to evaluate the physical performance of a Biograph mCT Flow 64-4R PET/CT system (Siemens Healthcare, Germany) and to compare clinical image quality in step-and-shoot (SS) and contin...

Authors: Ivo Rausch, Jacobo Cal-González, David Dapra, Hans Jürgen Gallowitsch, Peter Lind, Thomas Beyer and Gregory Minear

Automatic extraction of forward stroke volume using dynamic PET/CT: a dual-tracer and dual-scanner validation in patients with heart valve disease

The aim of this study was to develop and validate an automated method for extracting forward stroke volume (FSV) using indicator dilution theory directly from dynamic positron emission tomography (PET) studies...

Authors: Hendrik Johannes Harms, Lars Poulsen Tolbod, Nils Henrik Stubkjær Hansson, Tanja Kero, Lovisa Holm Orndahl, Won Yong Kim, Tomas Bjerner, Kirsten Bouchelouche, Henrik Wiggers, Jørgen Frøkiær and Jens Sörensen

Method dependence, observer variability and kidney volumes in radiation dosimetry of ¹⁷⁷Lu-DOTATATE therapy in patients with neuroendocrine tumours

Radionuclide therapy can be individualized by performing dosimetry. To determine absorbed organ doses in ¹⁷⁷Lu-DOTATATE therapy, three methods based on activity concentrations are currently in use: the small volu...

Authors: Mattias Sandström, Ezgi Ilan, Anna Karlberg, Silvia Johansson, Nanette Freedman and Ulrike Garske-Román

Erratum to: Motion correction in simultaneous PET/MR brain imaging using sparsely sampled MR navigators: a clinically feasible tool

Authors: Sune H. Keller, Casper Hansen, Christian Hansen, Flemming L. Andersen, Claes Ladefoged, Claus Svarer, Andreas Kjær, Liselotte Højgaard, Ian Law, Otto M. Henriksen and Adam E. Hansen

Erratum to: Effective dose to adult patients from 338 radiopharmaceuticals estimated using ICRP biokinetic data, ICRP/ICRU computational reference phantoms and ICRP 2007 tissue weighting factors

Authors: Martin Andersson

Correcting for respiratory motion in liver PET/MRI: preliminary evaluation of the utility of bellows and navigated hepatobiliary phase imaging

The purpose of this study was to evaluate the utility of bellows-based respiratory compensation and navigated hepatobiliary phase imaging to correct for respiratory motion in the setting of dedicated liver PET...

Authors: Thomas A. Hope, Emily F. Verdin, Emily K. Bergsland, Michael A. Ohliger, Carlos U. Corvera and Eric K. Nakakura

In vivo quantification of ¹⁷⁷Lu with planar whole-body and SPECT/CT gamma camera imaging

Advances in gamma camera technology and the emergence of a number of new theranostic radiopharmaceutical pairings have re-awakened interest in in vivo quantification with single-photon-emitting radionuclides. ...

Authors: Dale L. Bailey, Thomas M. Hennessy, Kathy P. Willowson, E. Courtney Henry, David L.H. Chan, Alireza Aslani and Paul J. Roach

A method for comparing intra-tumoural radioactivity uptake heterogeneity in preclinical positron emission tomography studies

Non-uniformity influences the interpretation of nuclear medicine based images and consequently their use in treatment planning and monitoring. However, no standardised method for evaluating and ranking heterog...

Authors: Jonas Grafström, Hanna-Stina Ahlzén and Sharon Stone-Elander

NEMA image quality phantom measurements and attenuation correction in integrated PET/MR hybrid imaging

In integrated PET/MR hybrid imaging the evaluation of PET performance characteristics according to the NEMA standard NU 2–2007 is challenging because of incomplete MR-based attenuation correction (AC) for phan...

Authors: Susanne Ziegler, Bjoern W. Jakoby, Harald Braun, Daniel H. Paulus and Harald H. Quick

Reliability and advantages of using non-uniform Chang’s attenuation correction method using a CT-based attenuation coefficient map in ^99mTc-GSA SPECT/CT hepatic imaging

Generally, attenuation correction is made by incorporating a linear attenuation coefficient, which is based on the attenuation coefficient map (mu-map) created from a computed tomography scan, into the ordered...

Authors: Yuya Nakamura, Seiji Tomiguchi and Masayuki Tanaka

Comparing voxel-based absorbed dosimetry methods in tumors, liver, lung, and at the liver-lung interface for ⁹⁰Y microsphere selective internal radiation therapy

To assess differences between four different voxel-based dosimetry methods (VBDM) for tumor, liver, and lung absorbed doses following ⁹⁰Y microsphere selective internal radiation therapy (SIRT) based on ⁹⁰Y brems...

Authors: Justin K Mikell, Armeen Mahvash, Wendy Siman, Firas Mourtada and S Cheenu Kappadath

Impact of image-based motion correction on dopamine D3/D2 receptor occupancy—comparison of groupwise and frame-by-frame registration approaches

Image registration algorithms are frequently used to align the reconstructed brain PET frames to remove subject head motion. However, in occupancy studies, this is a challenging task where competitive binding ...

Authors: Jieqing Jiao, Graham E. Searle, Julia A. Schnabel and Roger N. Gunn

Motion correction in simultaneous PET/MR brain imaging using sparsely sampled MR navigators: a clinically feasible tool

We present a study performing motion correction (MC) of PET using MR navigators sampled between other protocolled MR sequences during simultaneous PET/MR brain scanning with the purpose of evaluating its clini...

Authors: Sune H Keller, Casper Hansen, Christian Hansen, Flemming L Andersen, Claes Ladefoged, Claus Svarer, Andreas Kjær, Liselotte Højgaard, Ian Law, Otto M Henriksen and Adam E Hansen

A novel phantom technique for evaluating the performance of PET auto-segmentation methods in delineating heterogeneous and irregular lesions

Positron Emission Tomography (PET)-based automatic segmentation (PET-AS) methods can improve tumour delineation for radiotherapy treatment planning, particularly for Head and Neck (H&N) cancer. Thorough valida...

Authors: B Berthon, C Marshall, R Holmes and E Spezi

Applicability of emission-based attenuation map for rapid CBF, OEF, and CMRO₂ measurements using gaseous ¹⁵O-labeled compounds

Cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO₂) images have facilitated understanding of the pathophysiological basis of cerebrovascular disorders. Such ...

Authors: Yukito Maeda, Nobuyuki Kudomi, Yasuhiro Sasakawa, Toshihide Monden, Koji Kato, Yuka Yamamoto, Nobuyuki Kawai and Yoshihiro Nishiyama

Performance evaluation of two SiPMs arrays coupled to pixelated scintillations for PET/MR applications

Authors: Maria Georgiou, Tomasz Szczesniak, Martyna Grodzicka, Eleftherios Fysikopoulos and George Loudos

Preliminary evaluation of MRI-derived input function for quantitative measurement of glucose metabolism in an integrated PET-MRI

Authors: Udunna Anazodo, Matthew Kewin, Elizabeth Finger, Jonathan Thiessen, Jennifer Hadway, John Butler, William Pavlosky, Frank Prato, Terry Thompson and Keith St Lawrence

Clinical evaluation of PET image quality as a function of acquisition time in a new TOF-PET/MR compared to TOF-PET/CT - initial results

Authors: Konstantinos Zeimpekis, Martin Huellner, Felipe De Galiza Barbosa, Edwin Ter Voert, Helen Davison, Gaspar Delso and Patrick Veit-Haibach

Comparison of different tube-of-response (TOR) models for resolution recovery in PET image reconstruction for the Philips Ingenuity TF PET/MR

Authors: Alexandr Lougovski, Frank Hofheinz and Jorg Van Den Hoff

Ultra fast, accurate PET image reconstruction for the Siemens hybrid MR/BrainPET scanner using raw LOR data

Authors: Juergen Scheins, Christoph Lerche and Jon Shah

Evaluation of large-area, low-noise, arrays of SiPMs

Authors: Antonio Gonzalez, Albert Talens Aguilar, Hernandez Hernandez, Pablo Conde, Filomeno Sanchez Martinez and José María Benlloch Baviera

Quantitative impact of Dixon μmap variability in dual-time-point brain PET/MR

Authors: Kimberly Jackson, Rachel Bartlett, Kent Friedman, Timothy Shepherd, Thomas Koesters, Jose Teruel, Mathias Fenchel, Gerardo Hermosillova-Valadez, David Faul and Fernando Boada

Multi-modality image reconstruction for dual-head small-animal PET

Authors: Chang-Han Huang and Cheng-Ying Chou

Development of an MR-compatible DOI-PET detector module

Authors: Qingyang Wei, Shi Wang, Tianpeng Xu, Yunpeng Gao, Yaqiang Liu and Tianyu Ma

Resolution improvement of brain PET images using prior information from MRI: clinical application on refractory epilepsy

Authors: Jesus Silva-Rodríguez, Charalampos Tsoumpas, Pablo Aguiar, Julia Cortes and Jesus Lopez Urdaneta

Impact of atlas-CT-based bone anatomy compensation on MR-based attenuation correction for brain PET imaging in a time-of-flight PET/MRI system: A direct comparison to a patient-CT-based approach

Authors: Jaewon Yang, Yiqiang Jian, Michel Tohme, Spencer Behr, Daniel Vigneron, Sharmila Majumdar and Youngho Seo

Simultaneous reconstruction of attenuation and activity in ToF PET/MRI with additional transmission data

Authors: Ester D’Hoe, Pieter Mollet, Ekaterina Mikhaylova, Michel Defrise and Stefaan Vandenberghe

Pseudo-CT generation in brain MR-PET attenuation correction: comparison of several multi-atlas methods

Authors: Ines Merida, Nicolas Costes, Rolf Heckemann and Alexander Hammers

Development of compact DOI-measurable PET detectors for simultaneous PET/MR Imaging

Authors: Yiping Shao, Xishan Sun and Kai Lou

Simultaneous acquisition of dynamic PET-MRI: arterial input function using DSC-MRI and [18F]-FET

Authors: Liliana Caldeira, Seong Dae Yun, Nuno da Silva, Christian Filss, Juergen Scheins, Lutz Telmann, Hans Herzog and Jon Shah

Simultaneous functional imaging using fPET and fMRI

Authors: Marjorie Villien

CT synthesis in the head & neck region for PET/MR attenuation correction: an iterative multi-atlas approach

Authors: Ninon Burgos, M Jorge Cardoso, Marc Modat, Shonit Punwani, David Atkinson, Simon R Arridge, Brian F Hutton and Sébastien Ourselin

Automatic derivation of an MR-PET image-based input function for quantification of 18F-FET

Authors: Nuno Andre da Silva, Liliana Caldeira, Hans Herzog, Lutz Tellmann, Christian Filss, Karl-Josef Langen and Jon Shah

Whole-body simultaneous time-of-flight PET-MRI: early experience with clinical studies

Authors: Ryogo Minamimoto, Andrei Iagaru, Mehran Jamali, Amir Barkodhodari, Dawn Holley, Shreyas Vasanawala and Greg Zaharchuk

Improved parameter-estimation with combined PET-MRI kinetic modelling

Authors: Kjell Erlandsson, Maria Liljeroth, David Atkinson, Simon Arridge, Sebastien Ourselin and Brian Hutton

Image artifacts from MR-based attenuation correction in dedicated PET/MR breast coil for PET/MR mammography

Authors: Ihnho Cho, Eunjung Kong and Kyunga Chun

PET/MR: improvement of the UTE μ-maps using modified MLAA

Authors: Didier Benoit, Claes Ladefoged, Ahmadreza Rezaei, Sune Keller, Flemming Andersen, Liselotte Hojgaard, Adam Espe Hansen, Soren Holm and Johan Nuyts

Geometric optimization of an ultralow-dose high-resolution pediatric PET scanner based on monolithic scintillators with dSiPM readout

Authors: Ekaterina Mikhaylova, Valerio Tabacchini, Giacomo Borghi, Pieter Mollet, Ester D‘Hoe, Dennis R Schaart and Stefaan Vandenberghe

A single-mode data acquisition architecture for PET/MRI

Authors: Giancarlo Sportelli, Nicola Belcari, Maria Giuseppina Bisogni, Niccolo Camarlinghi, Emanuele Zaccaro and Alberto Del Guerra

Dynamic brain PET/MR using TOF reconstruction

Authors: Mohammad Mehdi Khalighi, Gaspar Delso, Michel Tohme, Andrei Iagaru and Greg Zaharchuk

Initial reconstruction results from a simulated adaptive small animal C shaped PET/MR insert

Authors: Nikos Efthimiou, Theodora Kostou, Panagiotis Papadimitroulas, Tsoumpas Charalampos and George Loudos

Development of a PET Insert for simultaneously small animal PET/MRI

Authors: Yingjie Wang, Zhiming Zhang, Daowu Li, Shuangquan Liu, Peilin Wang, Baotong Feng, Pei Chai and Long Wei

Successful demonstration of simultaneous PET/MR Imaging with a RF-penetrable PET insert

Authors: Brian Lee, Alexander Grant, Chen-Ming Chang, Gary Glover and Craig Levin

Initial in vitro and in vivo assessment of Au@DTDTPA-RGD nanoparticles for Gd-MRI and 68Ga-PET dual modality imaging

Authors: Charalmpos Tsoukalas, Gautier Laurent, Gloria Jiménez Sánchez, Theodoros Tsotakos, Rana Bazzi, Dimitris Stellas, Constantinos Anagnostopoulos, Lia Moulopoulos, Vasilis Koutoulidis, Maria Paravatou-Petsotas, Stavros Xanthopoulos, Stephane Roux and Penelope Bouziotis

First results from a high-resolution small animal PET insert for PET/MRI imaging

Authors: Andrew Goertzen, Greg Stortz, Jonathan Thiessen, Daryl Bishop, Muhammad Salman Khan, Piotr Kozlowski, Fabrice Retiere, Graham Schellenberg, Vesna Sossi and Christopher Thompson