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EJNMMI Physics
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  1. The Siemens high-resolution research tomograph (HRRT - a dedicated brain PET scanner) is to this day one of the highest resolution PET scanners; thus, it can serve as useful benchmark when evaluating performan...

    Authors: Julia G. Mannheim, Ju-Chieh (Kevin) Cheng, Nasim Vafai, Elham Shahinfard, Carolyn English, Jessamyn McKenzie, Jing Zhang, Laura Barlow and Vesna Sossi
    Citation: EJNMMI Physics 2021 8:20
    Content type: Original research Published on:

  2. A novel generation of PET scanners based on silicon (Si)-photomultiplier (PM) technology has recently been introduced. Concurrently, there has been development of new reconstruction methods aimed at increasing...

    Authors: Jenny Oddstig, Gustav Brolin, Elin Trägårdh and David Minarik
    Citation: EJNMMI Physics 2021 8:19
    Content type: Original research Published on:

  3. PET/MRI phantom studies are challenged by the need of phantom-specific attenuation templates to account for attenuation properties of the phantom material. We present a PET/MRI phantom built from MRI-visible m...

    Authors: Ivo Rausch, Alejandra Valladares, Lalith Kumar Shiyam Sundar, Thomas Beyer, Marcus Hacker, Martin Meyerspeer and Ewald Unger
    Citation: EJNMMI Physics 2021 8:18
    Content type: Original research Published on:

  4. To systematically evaluate the consistency of various standardized uptake value (SUV) lean body mass (LBM) normalization methods in a clinical positron emission tomography/magnetic resonance imaging (PET/MR) s...

    Authors: Jun Zhao, Qiaoyi Xue, Xing Chen, Zhiwen You, Zhe Wang, Jianmin Yuan, Hui Liu and Lingzhi Hu
    Citation: EJNMMI Physics 2021 8:17
    Content type: Original research Published on:

  5. SPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due to the limited spatial resolution of the gamma camera. Incorporating resolution modellin...

    Authors: H. Marquis, D. Deidda, A. Gillman, K. P. Willowson, Y. Gholami, T. Hioki, E. Eslick, K. Thielemans and D. L. Bailey
    Citation: EJNMMI Physics 2021 8:16
    Content type: Original research Published on:

  6. SPECT-CT using radiolabeled phosphonates is considered a standard for assessing bone metabolism (e.g., in patients with osteoarthritis of knee joints). However, SPECT can be influenced by metal artifacts in CT...

    Authors: Oliver S. Grosser, Marcus Klutzny, Heiko Wissel, Dennis Kupitz, Michael Finger, Simone Schenke, Jan Wuestemann, Christoph H. Lohmann, Christoph Hoeschen, Maciej Pech, Christian Staerke and Michael C. Kreissl
    Citation: EJNMMI Physics 2021 8:15
    Content type: Original research Published on:

  7. In recurrent differentiated thyroid cancer patients, detectability in 124I PET is limited for lesions with low radioiodine uptake. We assess the improvements in lesion detectability and image quality between thre...

    Authors: David Kersting, Walter Jentzen, Miriam Sraieb, Pedro Fragoso Costa, Maurizio Conti, Lale Umutlu, Gerald Antoch, Michael Nader, Ken Herrmann, Wolfgang Peter Fendler, Christoph Rischpler and Manuel Weber
    Citation: EJNMMI Physics 2021 8:14
    Content type: Original research Published on:

  8. Image quality and quantitative accuracy of positron emission tomography (PET) depend on several factors such as uptake time, scanner characteristics and image reconstruction methods. Ordered subset expectation...

    Authors: Alexandre Chicheportiche, Elinor Goshen, Jeremy Godefroy, Simona Grozinsky-Glasberg, Kira Oleinikov, Amichay Meirovitz, David J. Gross and Simona Ben-Haim
    Citation: EJNMMI Physics 2021 8:13
    Content type: Original research Published on:

  9. Standardized uptake value (SUV) normalized by lean body mass ([LBM] SUL) is recommended as metric by PERCIST 1.0. The James predictive equation (PE) is a frequently used formula for LBM estimation, but may cau...

    Authors: Jingjie Shang, Zhiqiang Tan, Yong Cheng, Yongjin Tang, Bin Guo, Jian Gong, Xueying Ling, Lu Wang and Hao Xu
    Citation: EJNMMI Physics 2021 8:12
    Content type: Original research Published on:

  10. Whole-body Patlak images can be obtained from an acquisition of first 6 min of dynamic imaging over the heart to obtain the arterial input function (IF), followed by multiple whole-body sweeps up to 60 min pi....

    Authors: Joyce van Sluis, Maqsood Yaqub, Adrienne H. Brouwers, Rudi A. J. O. Dierckx, Walter Noordzij and Ronald Boellaard
    Citation: EJNMMI Physics 2021 8:11
    Content type: Short communication Published on:

  11. The SwiftScan solution (General Electric Healthcare) combines a new low-energy high-resolution sensitivity collimator and a tomographic step-and-shoot continuous (SSC) mode acquisition. The purpose of this study ...

    Authors: Valentin Picone, Nikolaos Makris, Fanny Boutevin, Sarah Roy, Margot Playe and Michael Soussan
    Citation: EJNMMI Physics 2021 8:10
    Content type: Original research Published on:

  12. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hugo Levillain, Manuela Burghelea, Ivan Duran Derijckere, Thomas Guiot, Akos Gulyban, Bruno Vanderlinden, Michael Vouche, Patrick Flamen and Nick Reynaert
    Citation: EJNMMI Physics 2021 8:9
    Content type: Correction Published on:

    The original article was published in EJNMMI Physics 2020 7:75

  13. The study aimed to establish a 68Ga-FAPI-04 kinetic model in hepatic lesions, to determine the potential role of kinetic parameters in the differentiation of hepatocellular carcinoma (HCC) from non-HCC lesions.

    Authors: Barbara Katharina Geist, Haiqun Xing, Jingnan Wang, Ximin Shi, Haitao Zhao, Marcus Hacker, Xinting Sang, Li Huo and Xiang Li
    Citation: EJNMMI Physics 2021 8:8
    Content type: Short communication Published on:

  14. Respiratory motion compromises image quality in myocardial perfusion (MP) single-photon emission computed tomography (SPECT) imaging and may affect analysis of left ventricular (LV) functional parameters, incl...

    Authors: Matti J Kortelainen, Tuomas M Koivumäki, Marko J Vauhkonen and Mikko A Hakulinen
    Citation: EJNMMI Physics 2021 8:7
    Content type: Original research Published on:

  15. The aim of this study was to evaluate the use of a Bayesian penalized likelihood reconstruction algorithm (Q.Clear) for 89Zr-immunoPET image reconstruction and its potential to improve image quality and reduce th...

    Authors: Julian Kirchner, Joseph A. O’Donoghue, Anton S. Becker and Gary A. Ulaner
    Citation: EJNMMI Physics 2021 8:6
    Content type: Original research Published on:

  16. Using phantoms and clinical studies in prone hanging breast imaging, we assessed the image quality of a commercially available dedicated breast PET (dbPET) at the detector’s edge, where mammary glands near the...

    Authors: Yoko Satoh, Utaroh Motosugi, Masamichi Imai, Yoshie Omiya and Hiroshi Onishi
    Citation: EJNMMI Physics 2021 8:5
    Content type: Original research Published on:

  17. An individual dosimetry system is essential for the evaluation of precise doses in nuclear medicine. The purpose of this study was to develop a system for calculating not only absorbed doses but also EQDX(α/β) fr...

    Authors: Tatsuhiko Sato, Takuya Furuta, Yuwei Liu, Sadahiro Naka, Shushi Nagamori, Yoshikatsu Kanai and Tadashi Watabe
    Citation: EJNMMI Physics 2021 8:4
    Content type: Original research Published on:

  18. 99mTc-PYP scintigraphy provides differential diagnosis of ATTR cardiomyopathy (ATTR-CM) from light chain cardiac amyloidosis and other myocardial disorders without biopsy. This study was aimed to assess the diagn...

    Authors: Chao Ren, Jingyun Ren, Zhuang Tian, Yanrong Du, Zhixin Hao, Zongyao Zhang, Wei Fang, Fang Li, Shuyang Zhang, Bailing Hsu and Li Huo
    Citation: EJNMMI Physics 2021 8:3
    Content type: Original research Published on:

  20. Digital PET involving silicon photomultipliers (SiPM) provides an enhanced time-of-flight (TOF) resolution as compared with photomultiplier (PMT)-based PET, but also a better prevention of the count-related ri...

    Authors: Julien Salvadori, Freddy Odille, Gilles Karcher, Pierre-Yves Marie and Laetitia Imbert
    Citation: EJNMMI Physics 2021 8:1
    Content type: Original research Published on:

  21. A valid photon attenuation correction (AC) method is instrumental for obtaining quantitatively correct PET images. Integrated PET/MR systems provide no direct information on attenuation, and novel methods for ...

    Authors: João M. Sousa, Lieuwe Appel, Inés Merida, Rolf A. Heckemann, Nicolas Costes, Mathias Engström, Stergios Papadimitriou, Dag Nyholm, Håkan Ahlström, Alexander Hammers and Mark Lubberink
    Citation: EJNMMI Physics 2020 7:77
    Content type: Original research Published on:

  22. For pediatric lymphoma, quantitative FDG PET/CT imaging features such as metabolic tumor volume (MTV) are important for prognosis and risk stratification strategies. However, feature extraction is difficult an...

    Authors: Amy J. Weisman, Jihyun Kim, Inki Lee, Kathleen M. McCarten, Sandy Kessel, Cindy L. Schwartz, Kara M. Kelly, Robert Jeraj, Steve Y. Cho and Tyler J. Bradshaw
    Citation: EJNMMI Physics 2020 7:76
    Content type: Original research Published on:

  23. The relationship between the mean absorbed dose delivered to the tumour and the outcome in liver metastases from colorectal cancer patients treated with radioembolization has already been presented in several ...

    Authors: Hugo Levillain, Manuela Burghelea, Ivan Duran Derijckere, Thomas Guiot, Akos Gulyban, Bruno Vanderlinden, Michael Vouche, Patrick Flamen and Nick Reynaert
    Citation: EJNMMI Physics 2020 7:75
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Physics 2021 8:9

  24. To evaluate whether lesion radiomics features and absorbed dose metrics extracted from post-therapy 90Y PET can be integrated to better predict outcomes in microsphere radioembolization of liver malignancies

    Authors: Lise Wei, Can Cui, Jiarui Xu, Ravi Kaza, Issam El Naqa and Yuni K. Dewaraja
    Citation: EJNMMI Physics 2020 7:74
    Content type: Original research Published on:

  25. Fractionated peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE is increasingly applied as an effective treatment for patients with disseminated neuroendocrine tumors. In parallel to dose planning b...

    Authors: Mattias Sandström, Nanette Freedman, Katarzyna Fröss-Baron, Tanweera Kahn and Anders Sundin
    Citation: EJNMMI Physics 2020 7:73
    Content type: Original research Published on:

  26. Prior radioembolization, a simulation using 99mTc-macroaggregated albumin as 90Y-microspheres surrogate is performed. Gamma scintigraphy images (planar, SPECT, or SPECT-CT) are acquired to evaluate intrahepatic 9...

    Authors: Verónica Morán, Elena Prieto, Lidia Sancho, Macarena Rodríguez-Fraile, Leticia Soria, Arantxa Zubiria and Josep M. Martí-Climent
    Citation: EJNMMI Physics 2020 7:72
    Content type: Original research Published on:

  28. Silicon photomultiplier-positron emission tomography (SiPM-PET) has better sensitivity, spatial resolution, and timing resolution than photomultiplier tube (PMT)-PET. The present study aimed to clarify the adv...

    Authors: Kei Wagatsuma, Muneyuki Sakata, Kenji Ishibashi, Akira Hirayama, Hirofumi Kawakami, Kenta Miwa, Yukihisa Suzuki and Kenji Ishii
    Citation: EJNMMI Physics 2020 7:70
    Content type: Original research Published on:

  29. Personalized molecular radiotherapy based on theragnostics requires accurate quantification of the amount of radiopharmaceutical activity administered to patients both in diagnostic and therapeutic application...

    Authors: Clarita Saldarriaga Vargas, Matthias Bauwens, Ivo N. A. Pooters, Stefaan Pommé, Steffie M. B. Peters, Marcel Segbers, Walter Jentzen, Andreas Vogg, Floris H. P. van Velden, Sebastiaan L. Meyer Viol, Martin Gotthardt, Felix M. Mottaghy, Joachim E. Wildberger, Peter Covens and Roel Wierts
    Citation: EJNMMI Physics 2020 7:69
    Content type: Original research Published on:

  30. Attenuation correction of PET/MRI is a remaining problem for whole-body PET/MRI. The statistical decomposition algorithm (SDA) is a probabilistic atlas-based method that calculates synthetic CTs from T2-weight...

    Authors: Elin Wallstén, Jan Axelsson, Joakim Jonsson, Camilla Thellenberg Karlsson, Tufve Nyholm and Anne Larsson
    Citation: EJNMMI Physics 2020 7:68
    Content type: Original research Published on:

  31. Arterial blood sampling is the gold standard method to obtain the arterial input function (AIF) for quantification of whole body (WB) dynamic 18F-FDG PET imaging. However, this procedure is invasive and not typic...

    Authors: Mika Naganawa, Jean-Dominique Gallezot, Vijay Shah, Tim Mulnix, Colin Young, Mark Dias, Ming-Kai Chen, Anne M. Smith and Richard E. Carson
    Citation: EJNMMI Physics 2020 7:67
    Content type: Original research Published on:

  32. Halo artifacts from urinary catheters can occur due to inaccurate scatter correction, and the artifacts affect the tumor visibility in 18F-FDG PET/CT images. We investigated the incidence rate and the mechanisms ...

    Authors: Keiichi Magota, Naoto Numata, Daiki Shinyama, Junya Katahata, Yamato Munakata, Piotr J. Maniawski, Kentaro Kobayashi, Osamu Manabe, Kenji Hirata, Ukihide Tateishi, Kohsuke Kudo and Tohru Shiga
    Citation: EJNMMI Physics 2020 7:66
    Content type: Original research Published on:

  33. The aim of this study was to compare brain perfusion SPECT obtained from a 360° CZT and a conventional Anger camera.

    Authors: Manon Bordonne, Mohammad B. Chawki, Pierre-Yves Marie, Timothée Zaragori, Véronique Roch, Rachel Grignon, Laetitia Imbert and Antoine Verger
    Citation: EJNMMI Physics 2020 7:65
    Content type: Original research Published on:

  34. Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These syst...

    Authors: Jan V. Hoffmann, Jan P. Janssen, Takayuki Kanno, Takayuki Shibutani, Masahisa Onoguchi, Constantin Lapa, Jan-Peter Grunz, Andreas K. Buck and Takahiro Higuchi
    Citation: EJNMMI Physics 2020 7:64
    Content type: Original research Published on:

  35. Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly igno...

    Authors: Domenico Finocchiaro, Jonathan I. Gear, Federica Fioroni, Glenn D. Flux, Iain Murray, Gastone Castellani, Annibale Versari, Mauro Iori and Elisa Grassi
    Citation: EJNMMI Physics 2020 7:63
    Content type: Original research Published on:

  36. The CT of PET CT provides diagnostic information, anatomic localisation and attenuation correction (AC). When only AC is required, very lose dose CT is desirable. CT iterative reconstruction (IR) improves imag...

    Authors: Ivan Ho Shon, Christopher Reece, Thomas Hennessy, Megan Horsfield and Bruce McBride
    Citation: EJNMMI Physics 2020 7:62
    Content type: Original research Published on:

  37. Differentiated thyroid cancer has been treated with radioiodine for almost 80 years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresol...

    Authors: Jan Taprogge, Francesca Leek, Tino Schurrat, Johannes Tran-Gia, Delphine Vallot, Manuel Bardiès, Uta Eberlein, Michael Lassmann, Susanne Schlögl, Alex Vergara Gil and Glenn D. Flux
    Citation: EJNMMI Physics 2020 7:61
    Content type: Original research Published on:

  38. This article presents a new perspective on the development of inorganic scintillator-based fiber dosimeters (IOSFDs) for medical radiotherapy dosimetry (RTD) focusing on real-time in vivo dosimetry. The scinti...

    Authors: Liang Ding, Qiong Wu, Qun Wang, Yamei Li, Richard M. Perks and Liang Zhao
    Citation: EJNMMI Physics 2020 7:60
    Content type: Review Published on:

  39. Quantitative evaluation of amyloid positron emission tomography (PET) with standardized uptake value ratio (SUVR) plays a key role in clinical studies of Alzheimer’s disease (AD). We have proposed a PET-only (...

    Authors: Yuma Tsubaki, Go Akamatsu, Natsumi Shimokawa, Suguru Katsube, Aya Takashima and Masayuki Sasaki
    Citation: EJNMMI Physics 2020 7:59
    Content type: Young investigators Published on:

  40. 211At is one of the ideal nuclides for targeted radionuclide therapies (TRTs). Meta-[211At]astatobenzylguanidine (211At-MABG) has been proposed for the treatment of pheochromocytoma. To effectively use these radi...

    Authors: Naoyuki Ukon, Songji Zhao, Kohshin Washiyama, Noboru Oriuchi, Chengbo Tan, Saki Shimoyama, Miho Aoki, Hitoshi Kubo, Kazuhiro Takahashi and Hiroshi Ito
    Citation: EJNMMI Physics 2020 7:58
    Content type: Original research Published on:

  41. Novel partial volume correction (PVC) algorithms have been validated by assuming ideal conditions of image processing; however, in real clinical PET studies, the input datasets include error sources which caus...

    Authors: Senri Oyama, Ayumu Hosoi, Masanobu Ibaraki, Colm J. McGinnity, Keisuke Matsubara, Shoichi Watanuki, Hiroshi Watabe, Manabu Tashiro and Miho Shidahara
    Citation: EJNMMI Physics 2020 7:57
    Content type: Original research Published on:

  42. The Bayesian penalized likelihood (BPL) algorithm Q.Clear (GE Healthcare) allows fully convergent iterative reconstruction that results in better image quality and quantitative accuracy, while limiting image n...

    Authors: Tokiya Yoshii, Kenta Miwa, Masashi Yamaguchi, Kai Shimada, Kei Wagatsuma, Tensho Yamao, Yuto Kamitaka, Seiya Hiratsuka, Rinya Kobayashi, Hajime Ichikawa, Noriaki Miyaji, Tsuyoshi Miyazaki and Kenji Ishii
    Citation: EJNMMI Physics 2020 7:56
    Content type: Original research Published on:

  43. The purpose of this work was to propose an approach based on noise measurement to adapt present clinical acquisition and reconstruction parameters adapted to a PMT-based system (Biograph mCT) to a SiPM-based s...

    Authors: Thomas Carlier, Ludovic Ferrer, Maurizio Conti, Caroline Bodet-Milin, Caroline Rousseau, Yanic Bercier, Bernard Bendriem and Françoise Kraeber-Bodéré
    Citation: EJNMMI Physics 2020 7:55
    Content type: Original research Published on:

  44. In this study, we investigate the impact of increased PET acquisition time per bed position on lesion detectability, standard uptake value, and image noise in 68Ga-PSMA-11 PET/MRI scans.

    Authors: Vishnu Murthy, Raven L. Smith, Dora H. Tao, Courtney A. Lawhn-Heath, Dave E. Korenchan, Peder E. Z. Larson, Robert R. Flavell and Thomas A. Hope
    Citation: EJNMMI Physics 2020 7:54
    Content type: Original research Published on:

  46. The combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) (PET-MRI) is a unique hybrid imaging modality mainly used in oncology and neurology. The MRI-based attenuation correct...

    Authors: Johanna Harries, Thies H. Jochimsen, Thomas Scholz, Tina Schlender, Henryk Barthel, Osama Sabri and Bernhard Sattler
    Citation: EJNMMI Physics 2020 7:52
    Content type: Original research Published on:

  47. Artificial intelligence (AI) is about to transform medical imaging. The Research Consortium for Medical Image Analysis (RECOMIA), a not-for-profit organisation, has developed an online platform to facilitate c...

    Authors: Elin Trägårdh, Pablo Borrelli, Reza Kaboteh, Tony Gillberg, Johannes Ulén, Olof Enqvist and Lars Edenbrandt
    Citation: EJNMMI Physics 2020 7:51
    Content type: Original research Published on:

  48. In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemi...

    Authors: Chang-Hoon Choi, Carina Stegmayr, Aliaksandra Shymanskaya, Wieland A. Worthoff, Nuno A. da Silva, Jörg Felder, Karl-Josef Langen and N. Jon Shah
    Citation: EJNMMI Physics 2020 7:50
    Content type: Original research Published on:

  49. Myocardial perfusion imaging is a commonly performed SPECT protocol and hence it would be beneficial if its scan duration could be shortened. For traditional gamma cameras, two developments have separately sho...

    Authors: Martijn M. A. Dietze, Britt Kunnen, Martina Stella and Hugo W. A. M. de Jong
    Citation: EJNMMI Physics 2020 7:49
    Content type: Original research Published on:

  50. An amendment to this paper has been published and can be accessed via the original article.

    Authors: J. E. Mackewn, J. Stirling, S. Jeljeli, S-M Gould, R. I. Johnstone, I. Merida, L. C. Pike, C. J. McGinnity, K. Beck, O. Howes, A. Hammers and P. K. Marsden
    Citation: EJNMMI Physics 2020 7:47
    Content type: Correction Published on:

    The original article was published in EJNMMI Physics 2020 7:24

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