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  1. CT-based attenuation correction (CT-AC) plays a major role in accurate activity quantification by SPECT/CT imaging. However, the effect of kilovoltage peak (kVp) and quality-reference mAs (QRM) on the attenuat...

    Authors: Maikol Salas-Ramirez, Julian Leube, Michael Lassmann and Johannes Tran-Gia
    Citation: EJNMMI Physics 2024 11:21
  2. In literature are reported different analytical methods (AM) to choose the proper fit model and to fit data of the time-activity curve (TAC). On the other hand, Machine Learning algorithms (ML) are increasingl...

    Authors: Davide Ciucci, Bartolomeo Cassano, Salvatore Donatiello, Federica Martire, Antonio Napolitano, Claudia Polito, Elena Solfaroli Camillocci, Gianluca Cervino, Ludovica Pungitore, Claudio Altini, Maria Felicia Villani, Milena Pizzoferro, Maria Carmen Garganese and Vittorio Cannatà
    Citation: EJNMMI Physics 2024 11:19
  3. Terbium-161 (161Tb)-based radionuclide therapy poses an alternative to current Lutetium-177 (177Lu) approaches with the additional benefit of secondary Auger and conversion electron emissions capable of deliverin...

    Authors: Lachlan McIntosh, Price Jackson, Brittany Emmerson, James P. Buteau, Ramin Alipour, Grace Kong and Michael S. Hofman
    Citation: EJNMMI Physics 2024 11:18
  4. Conventional PET/CT imaging reconstruction is typically performed using voxel size of 3.0–4.0 mm in three axes. It is hypothesized that a smaller voxel sizes could improve the accuracy of small lesion detectio...

    Authors: Chi Qi, Xiuli Sui, Haojun Yu, Siyang Wang, Yan Hu, Hongyan Sun, Xinlan Yang, Yihan Wang, Yun Zhou and Hongcheng Shi
    Citation: EJNMMI Physics 2024 11:17
  5. PET scans using zirconium-89 labelled monoclonal antibodies (89Zr-mAbs), known as 89Zr-immuno-PET, are made to measure uptake in tumour and organ tissue. Uptake is related to the supply of 89Zr-mAbs in the blood....

    Authors: Jessica E. Wijngaarden, Amina Ahbari, Johanna E. E. Pouw, Henri N. J. M. Greuter, Idris Bahce, Gerben J. C. Zwezerijnen, Daniëlle J. Vugts, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt and Marc C. Huisman
    Citation: EJNMMI Physics 2024 11:16
  6. In peptide receptor radionuclide therapy (PRRT), accurate quantification of kidney activity on post-treatment SPECT images paves the way for patient-specific treatment. Due to the limited spatial resolution of...

    Authors: Julien Salvadori, Oreste Allegrini, Thomas Opsommer, Josefina Carullo, David Sarrut, Clemence Porot, Florian Ritzenthaler, Philippe Meyer and Izzie-Jacques Namer
    Citation: EJNMMI Physics 2024 11:15
  7. Peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE has shown efficacy in patients with metastatic neuroendocrine tumours (NETs). Personalised dosimetry is crucial to optimise treatment outcomes...

    Authors: Sejin Ha, Yong-il Kim, Jungsu S. Oh, Changhoon Yoo, Baek-Yeol Ryoo and Jin-Sook Ryu
    Citation: EJNMMI Physics 2024 11:14
  8. We propose a comprehensive evaluation of a Discovery MI 4-ring (DMI) model, using a Monte Carlo simulator (GATE) and a clinical reconstruction software package (PET toolbox). The following performance characte...

    Authors: Antoine Merlet, Benoît Presles, Kuan-Hao Su, Julien Salvadori, Farzam Sayah, Hanieh Jozi, Alexandre Cochet and Jean-Marc Vrigneaud
    Citation: EJNMMI Physics 2024 11:13
  9. Pharmacokinetic positron emission tomography (PET) studies rely on the measurement of the arterial input function (AIF), which represents the time-activity curve of the radiotracer concentration in the blood p...

    Authors: Sara de Scals, Luis Mario Fraile, José Manuel Udías, Laura Martínez Cortés, Marta Oteo, Miguel Ángel Morcillo, José Luis Carreras-Delgado, María Nieves Cabrera-Martín and Samuel España
    Citation: EJNMMI Physics 2024 11:12
  10. Quantification of the cerebral metabolic rate of glucose (CMRGlu) by dynamic [18F]FDG PET requires invasive arterial sampling. Alternatives to using an arterial input function (AIF) include the simultaneous estim...

    Authors: Lucas Narciso, Graham Deller, Praveen Dassanayake, Linshan Liu, Samara Pinto, Udunna Anazodo, Andrea Soddu and Keith St Lawrence
    Citation: EJNMMI Physics 2024 11:11
  11. Positron emission tomography–magnetic resonance (PET-MR) attenuation correction is challenging because the MR signal does not represent tissue density and conventional MR sequences cannot image bone. A novel z...

    Authors: Jonathan J. Wyatt, Sandeep Kaushik, Cristina Cozzini, Rachel A. Pearson, George Petrides, Florian Wiesinger, Hazel M. McCallum and Ross J. Maxwell
    Citation: EJNMMI Physics 2024 11:10
  12. Performance assessment of positron emission tomography (PET) scanners is crucial to guide clinical practice with efficiency. We have already introduced and experimentally evaluated a simulation method allowing...

    Authors: Quentin Maronnier, Nesrine Robaine, Léonor Chaltiel, Lawrence O. Dierickx, Thibaut Cassou-Mounat, Marie Terroir, Lavinia Vija, Delphine Vallot, Séverine Brillouet, Chloé Lamesa, Thomas Filleron, Olivier Caselles and Frédéric Courbon
    Citation: EJNMMI Physics 2024 11:9
  13. A 3D printing grid-based method was developed to construct anthropomorphic phantoms with non-uniform activity distributions, to be used for evaluation of quantitative SPECT images. The aims were to characteriz...

    Authors: Lovisa Jessen, Johan Gustafsson, Michael Ljungberg, Selma Curkic-Kapidzic, Muris Imsirovic and Katarina Sjögreen-Gleisner
    Citation: EJNMMI Physics 2024 11:8
  14. To improve the PET image quality by a deep progressive learning (DPL) reconstruction algorithm and evaluate the DPL performance in lesion quantification.

    Authors: Hongxing Yang, Shihao Chen, Ming Qi, Wen Chen, Qing Kong, Jianping Zhang and Shaoli Song
    Citation: EJNMMI Physics 2024 11:7
  15. The Otsu method and the Chan–Vese model are two methods proven to perform well in determining volumes of different organs and specific tissue fractions. This study aimed to compare the performance of the two m...

    Authors: Jonas Högberg, Christoffer Andersén, Tobias Rydén and Jakob H. Lagerlöf
    Citation: EJNMMI Physics 2024 11:6
  16. Due to spatial resolution limitations, conventional NaI-SPECT typically overestimates the left ventricular (LV) ejection fraction (EF) in patients with small LV volumes. The purpose of this study was to explor...

    Authors: Yan Huang, Han Zhang, Xueping Hu, Shanshan Qin, Fan Hu, Yuchen Li, Haidong Cai, Kuangyu Shi and Fei Yu
    Citation: EJNMMI Physics 2024 11:5
  17. To investigate the optimal threshold for measuring thyroid volume in patients with Grave's hyperthyroidism (GH) by SPECT/CT.

    Authors: Chengpeng Gong, Yajing Zhang, Fei Feng, Mengmeng Hu, Kun Li, Rundong Pi, Hua Shu, Rongmei Tang, Xiaoli Wang, Shilin Tan, Fan Hu and Jia Hu
    Citation: EJNMMI Physics 2024 11:4
  18. Positron emission tomography (PET) using 124I-mIBG has been established for imaging and pretherapeutic dosimetry. Here, we report the first systematic analysis of the biodistribution and radiation dosimetry of 12...

    Authors: Alexandros Moraitis, Walter Jentzen, Gloria Reiter, Jochen Schmitz, Thorsten Dirk Pöppel, Manuel Weber, Ken Herrmann, Wolfgang Peter Fendler, Pedro Fragoso Costa, Andreas Bockisch and David Kersting
    Citation: EJNMMI Physics 2024 11:3
  19. In image processing for activity quantification, the end goal is to produce a metric that is independent of the measurement geometry. Photon attenuation needs to be accounted for and can be accomplished utiliz...

    Authors: Daniel Roth, Erik Larsson, Joanna Strand, Michael Ljungberg and Katarina Sjögreen Gleisner
    Citation: EJNMMI Physics 2024 11:2
  20. This study aims to decrease the scan time and enhance image quality in pediatric total-body PET imaging by utilizing multimodal artificial intelligence techniques.

    Authors: Qiyang Zhang, Yingying Hu, Chao Zhou, Yumo Zhao, Na Zhang, Yun Zhou, Yongfeng Yang, Hairong Zheng, Wei Fan, Dong Liang and Zhanli Hu
    Citation: EJNMMI Physics 2024 11:1
  21. 90Y SPECT-based dosimetry following radioembolization (RE) in liver malignancies is challenging due to the inherent scatter and the poor spatial resolution of bremsstrahlung SPECT. This study explores a deep-l...

    Authors: Yixuan Jia, Zongyu Li, Azadeh Akhavanallaf, Jeffrey A. Fessler and Yuni K. Dewaraja
    Citation: EJNMMI Physics 2023 10:82
  22. Drug occupancy studies with positron emission tomography imaging are used routinely in early phase drug development trials. Recently, our group introduced the Lassen Plot Filter, an extended version of the sta...

    Authors: Alaaddin Ibrahimy, Jocelyn Hoye, Hao Wu, Bart de Laat, Su Jin Kim, David L. Wilson and Evan D. Morris
    Citation: EJNMMI Physics 2023 10:80
  23. The aim was to investigate the feasibility of a shortened dynamic whole-body (dWB) FDG-PET/CT protocol and Patlak imaging using a population-based input function (PBIF), instead of an image-derived input funct...

    Authors: Mathieu Pavoine, Philippe Thuillier, Nicolas Karakatsanis, Delphine Legoupil, Karim Amrane, Romain Floch, Romain Le Pennec, Pierre-Yves Salaün, Ronan Abgral and David Bourhis
    Citation: EJNMMI Physics 2023 10:79
  24. Kinetic modeling in positron emission tomography (PET) requires measurement of the tracer plasma activity in the absence of a suitable reference region. To avoid invasive blood sampling, the use of an image de...

    Authors: Alan Miranda, Daniele Bertoglio, Steven Staelens and Jeroen Verhaeghe
    Citation: EJNMMI Physics 2023 10:78
  25. Over the past five years, ultrafast high-frequency (HF) readout concepts have advanced the timing performance of silicon photomultipliers (SiPMs). The shown impact in time-of-flight (TOF) techniques can furthe...

    Authors: Vanessa Nadig, Matthias Hornisch, Jakob Oehm, Katrin Herweg, Volkmar Schulz and Stefan Gundacker
    Citation: EJNMMI Physics 2023 10:76
  26. Although a new generation of tomographs with a longer axial field-of-view called total-body PET have been developed, they are not widely utilized due to their high cost compared to conventional scanners. The n...

    Authors: Meysam Dadgar, Jens Maebe, Maya Abi Akl, Boris Vervenne and Stefaan Vandenberghe
    Citation: EJNMMI Physics 2023 10:75
  27. Authors: E. Courtney Henry, Matthew Strugari, George Mawko, Kimberly Brewer, David Liu, Andrew C. Gordon, Jeffrey N. Bryan, Charles Maitz, James J. Karnia, Robert Abraham, S. Cheenu Kappadath and Alasdair Syme
    Citation: EJNMMI Physics 2023 10:74

    The original article was published in EJNMMI Physics 2022 9:21

  28. Commissioning, calibration, and quality control procedures for nuclear medicine imaging systems are typically performed using hollow containers filled with radionuclide solutions. This leads to multiple source...

    Authors: Johannes Tran-Gia, Ana M. Denis-Bacelar, Kelley M. Ferreira, Andrew P. Robinson, Christophe Bobin, Lara M. Bonney, Nicholas Calvert, Sean M. Collins, Andrew J. Fenwick, Domenico Finocchiaro, Federica Fioroni, Katerina Giannopoulou, Elisa Grassi, Warda Heetun, Stephanie J. Jewitt, Maria Kotzasarlidou…
    Citation: EJNMMI Physics 2023 10:73
  29. Full quantification of Positron Emission Tomography (PET) requires an arterial input function (AIF) for measurement of certain targets, or using particular radiotracers, or for the quantification of specific o...

    Authors: Granville J. Matheson, Liner Ge, Mengyu Zhang, Bingyu Sun, Yuqi Tu, Francesca Zanderigo, Anton Forsberg Morèn and R. Todd Ogden
    Citation: EJNMMI Physics 2023 10:72
  30. The use of lutetium-177 (177Lu)-based radiopharmaceuticals in peptide receptor nuclear therapy is increasing, but so is the number of nuclear medicine workers exposed to higher levels of radiation. In recent year...

    Authors: Mercedes Riveira-Martin, Lara Struelens, José Muñoz Iglesias, Werner Schoonjans, Olga Tabuenca, José Manuel Nogueiras, Francisco Javier Salvador Gómez and Antonio López Medina
    Citation: EJNMMI Physics 2023 10:70
  31. Image harmonization has been proposed to minimize heterogeneity in brain PET scans acquired in multi-center studies. However, standard validated methods and software tools are lacking. Here, we assessed the pe...

    Authors: Mahnaz Shekari, Eline E. Verwer, Maqsood Yaqub, Marcel Daamen, Christopher Buckley, Giovanni B. Frisoni, Pieter Jelle Visser, Gill Farrar, Frederik Barkhof, Juan Domingo Gispert and Ronald Boellaard
    Citation: EJNMMI Physics 2023 10:68
  32. Dynamic positron emission tomography (PET) images are useful in clinical practice because they can be used to calculate the metabolic parameters (Ki) of tissues using graphical methods (such as Patlak plots). Ki ...

    Authors: Ganglin Liang, Jinpeng Zhou, Zixiang Chen, Liwen Wan, Xieraili Wumener, Yarong Zhang, Dong Liang, Ying Liang and Zhanli Hu
    Citation: EJNMMI Physics 2023 10:67
  33. Ultra-low-dose (ULD) computed tomography (CT) scans should be used when CT is performed only for attenuation correction (AC) of positron emission tomography (PET) data. A tin filter can be used in addition to ...

    Authors: Natalie Anne Bebbington, Kenneth Boye Christensen, Lone Lange Østergård and Paw Christian Holdgaard
    Citation: EJNMMI Physics 2023 10:66
  34. Q.Clear, a Bayesian penalized likelihood reconstruction algorithm, has shown high potential in improving quantitation accuracy in PET systems. The Q.Clear algorithm controls noise during the iterative reconstr...

    Authors: Elisabeth Kirkeby Lysvik, Lars Tore Gyland Mikalsen, Mona-Elisabeth Rootwelt-Revheim, Kyrre Eeg Emblem and Trine Hjørnevik
    Citation: EJNMMI Physics 2023 10:65
  35. Dosimetry after radiopharmaceutical therapy with 177Lu (177Lu-RPT) relies on quantitative SPECT/CT imaging, for which suitable reconstruction protocols are required. In this study, we characterized for the first ...

    Authors: Rachele Danieli, Martina Stella, Julian Leube, Johannes Tran-Gia, Clementine Marin, Carlos F. Uribe, Bruno Vanderlinden, Nick Reynaert, Patrick Flamen and Hugo Levillain
    Citation: EJNMMI Physics 2023 10:64
  36. The Q.Clear algorithm is a fully convergent iterative image reconstruction technique. We hypothesize that different PET/CT scanners with distinct crystal properties will require different optimal settings for ...

    Authors: Fatemeh Sadeghi, Peyman Sheikhzadeh, Saeed Farzanehfar, Pardis Ghafarian, Yalda Moafpurian and Mohammadreza Ay
    Citation: EJNMMI Physics 2023 10:63
  37. Alongside the benefits of Total-Body imaging modalities, such as higher sensitivity, single-bed position, low dose imaging, etc., their final construction cost prevents worldwide utilization. The main aim of t...

    Authors: M. Dadgar, S. Parzych, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, K. Dulski, K. Elyan, A. Gajos, B. C. Hiesmayr, Ł. Kapłon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemien…
    Citation: EJNMMI Physics 2023 10:62
  38. Monte Carlo (MC) simulations are used in nuclear medicine imaging as they provide unparalleled insight into processes that are not directly experimentally measurable, such as scatter and attenuation in an acqu...

    Authors: Sophia Pells, David M. Cullen, Daniel Deidda, Ana M. Denis-Bacelar, Andrew Fenwick, Kelley M. Ferreira, David Hamilton, Warda Heetun, Peter Julyan, George Needham, Ben Pietras, Emlyn Price, James Scuffham, Jill Tipping and Andrew P. Robinson
    Citation: EJNMMI Physics 2023 10:60
  39. Dynamic PET is an essential tool in oncology due to its ability to visualize and quantify radiotracer uptake, which has the potential to improve imaging quality. However, image noise caused by a low photon cou...

    Authors: Lin Xin, Weihai Zhuo, Haikuan Liu and Tianwu Xie
    Citation: EJNMMI Physics 2023 10:59
  40. Lung lobar ventilation and perfusion (V/Q) quantification is generally obtained by generating planar scintigraphy images and then imposing three equally sized regions of interest on the data of each lung. This...

    Authors: Emilie Verrecchia-Ramos, Olivier Morel, Merwan Ginet, Paul Retif and Sinan Ben Mahmoud
    Citation: EJNMMI Physics 2023 10:57
  41. Current guidelines of the radioiodine uptake (RAIU) test allow the use of different equipment, isotopes, activity and region-of-interest (ROI). We evaluated presence and extent of these differences in clinical...

    Authors: Jurgen E. M. Mourik, Mark Derks, Erik T. te Beek and Marc R. J. ten Broek
    Citation: EJNMMI Physics 2023 10:55
  42. Total-body PET imaging with ultra-high sensitivity makes high-temporal-resolution framing protocols possible for the first time, which allows to capture rapid tracer dynamic changes. However, whether protocols...

    Authors: Qing Ye, Hao Zeng, Yizhang Zhao, Weiguang Zhang, Yun Dong, Wei Fan and Yihuan Lu
    Citation: EJNMMI Physics 2023 10:54