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EJNMMI Physics
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  1. EQ.PET is a software package that overcomes the reconstruction-dependent variation of standard uptake values (SUV). In this study, we validated the use of EQ.PET for harmonizing SUVs between different positron...

    Authors: Yufei Song, Xiangxi Meng, Zhen Cao, Wei Zhao, Yan Zhang, Rui Guo, Xin Zhou, Zhi Yang and Nan Li
    Citation: EJNMMI Physics 2023 10:19
    Content type: Original research Published on:

  4. SimPET-L and SimPET-XL have recently been introduced with increased transaxial fields of view (FOV) compared with their predecessors (SimPET™ and SimPET-X), enabling whole-body positron emission tomography (PE...

    Authors: Minjee Seo, Guen Bae Ko, Kyeong Yun Kim, Jeong-Whan Son, Jung Woo Byun, Yun-Sang Lee, Kyeong Min Kim, Jang Woo Park, Kipom Kim, Taekwan Lee and Jae Sung Lee
    Citation: EJNMMI Physics 2023 10:16
    Content type: Original research Published on:

  5. Quantitative positron emission tomography (PET) scans of the brain typically require arterial blood sampling but this is complicated and logistically challenging. One solution to remove the need for arterial b...

    Authors: Peter Young, Lieuwe Appel, Andreas Tolf, Savvas Kosmidis, Joachim Burman, Anna Rieckmann, Michael Schöll and Mark Lubberink
    Citation: EJNMMI Physics 2023 10:15
    Content type: Original research Published on:

  6. Highly sensitive digital total-body PET/CT scanners (uEXPLORER) have great potential for clinical applications and fundamental research. Given their increasing sensitivity, low-dose scanning or snapshot imagin...

    Authors: Yanchao Huang, Meng Wang, Li Jiang, Lijuan Wang, Li Chen, Qiaoyu Wang, Jiatai Feng, Jingyi Wang, Wanbang Xu, Hubing Wu and Yanjiang Han
    Citation: EJNMMI Physics 2023 10:14
    Content type: Original research Published on:

  8. This project aims to develop and evaluate a method for accurately determining time-integrated activities (TIAs) in single-time-point (STP) dosimetry for molecular radiotherapy. It performs a model selection (M...

    Authors: Deni Hardiansyah, Ade Riana, Ambros J. Beer and Gerhard Glatting
    Citation: EJNMMI Physics 2023 10:12
    Content type: Original research Published on:

  9. 177Lu-PSMA therapy has been successfully used to prolong the survival of patients with metastatic castration-resistant prostate cancer. Patient-specific dosimetry based on serial quantitative SPECT/CT imaging can...

    Authors: Sandra Resch, Sarah Takayama Fouladgar, Mathias Zacherl, Gabriel T. Sheikh, Grigory Liubchenko, Mikhail Rumiantcev, Lena M. Unterrainer, Vera Wenter, Peter Bartenstein, Sibylle I. Ziegler, Harun Ilhan, Leonie Beyer, Guido Böning and Astrid Delker
    Citation: EJNMMI Physics 2023 10:11
    Content type: Original research Published on:

  10. The aim was to review available biokinetic data, collect own experimental data, and propose an updated compartmental model for 2-[18F]FDG in the frame of the revision of the ICRP report on dose coefficients for r...

    Authors: Alexandra Kamp, Martin Andersson, Sigrid Leide-Svegborn, Dietmar Noβke, Sören Mattsson and Augusto Giussani
    Citation: EJNMMI Physics 2023 10:10
    Content type: Original research Published on:

  11. Myocardial perfusion SPECT (MPS) images often suffer from artefacts caused by low-count statistics. Poor-quality images can lead to misinterpretations of perfusion defects. Deep learning (DL)-based methods hav...

    Authors: Antti Sohlberg, Tuija Kangasmaa, Chris Constable and Antti Tikkakoski
    Citation: EJNMMI Physics 2023 10:9
    Content type: Original research Published on:

  12. In selective internal radiation therapy, 99mTc SPECT images are used to optimize patient treatment planning, but they are affected by respiratory motion. In this study, we evaluated on patient data the dosimetric...

    Authors: Laure Vergnaud, Antoine Robert, Thomas Baudier, Sandrine Parisse-Di Martino, Philippe Boissard, Simon Rit, Jean-Noël Badel and David Sarrut
    Citation: EJNMMI Physics 2023 10:8
    Content type: Original research Published on:

  13. Advances in hepatic radioembolization are based on a selective approach with radical intent and the use of multicompartment dosimetric analysis. The objective of this study is to assess the utility of voxel-ba...

    Authors: Javier Orcajo Rincón, Amanda Rotger Regi, Ana Matilla Peña, Laura Reguera Berenguer, Manuel González Leyte, Laura Carrión Martín, Jaime Atance García De La Santa, Miguel Echenagusia Boyra, Cristina González Ruiz, Arturo Colón Rodríguez and Juan Carlos Alonso Farto
    Citation: EJNMMI Physics 2023 10:7
    Content type: Original Research Published on:

  14. Deep learning (DL) has a growing popularity and is a well-established method of artificial intelligence for data processing, especially for images and videos. Its applications in nuclear medicine are broad and...

    Authors: Ioannis D. Apostolopoulos, Nikolaos I. Papandrianos, Anna Feleki, Serafeim Moustakidis and Elpiniki I. Papageorgiou
    Citation: EJNMMI Physics 2023 10:6
    Content type: Review Published on:

  15. Conventional calibration of the gamma camera consists of the calculation of calibration factors (CFs) (ratio of counts/cc and true concentration activity) as the function of the volume of interest (VOI). Howev...

    Authors: Stanislav Raskin, Dan Gamliel, David Abookasis, Simona Ben-Haim and Alexandre Chicheportiche
    Citation: EJNMMI Physics 2023 10:5
    Content type: Original research Published on:

  16. The Bayesian penalized likelihood PET reconstruction (BPL) algorithm, Q.Clear (GE Healthcare), has recently been clinically applied to clinical image reconstruction. The BPL includes a relative difference pena...

    Authors: Kenta Miwa, Tokiya Yoshii, Kei Wagatsuma, Shogo Nezu, Yuto Kamitaka, Tensho Yamao, Rinya Kobayashi, Shohei Fukuda, Yu Yakushiji, Noriaki Miyaji and Kenji Ishii
    Citation: EJNMMI Physics 2023 10:4
    Content type: Original research Published on:

  17. A strategy for management of radioactive waste associated with 177Lu-dotatate (Lutathera®) treatments was established in our institution, based on predicted storage times of 3–5 years extrapolated from the result...

    Authors: Sylviane Prevot, Inna Dygaï-Cochet, Jean-Marc Riedinger, Jean-Marc Vrigneaud, Myriam Quermonne, Matthieu Gallet and Alexandre Cochet
    Citation: EJNMMI Physics 2023 10:3
    Content type: Short communication Published on:

  19. To investigate the feasibility of ultra-low-dose CT (ULDCT) reconstructed with the artificial intelligence iterative reconstruction (AIIR) algorithm in total-body PET/CT imaging.

    Authors: Yan Hu, Zhe Zheng, Haojun Yu, Jingyi Wang, Xinlan Yang and Hongcheng Shi
    Citation: EJNMMI Physics 2023 10:1
    Content type: Original Research Published on:

  20. Molecular imaging of the dopamine transporters (DAT) provides valuable information about neurodegenerative diseases, such as Parkinson’s. This study assessed the accuracy and precision of DAT-SPECT quantificat...

    Authors: Leonardo Alexandre-Santos, Ana Carolina Trevisan, Felipe Arriva Pitella, Vitor Tumas, Jose Henrique Silvah, Mery Kato, Eder Rezende de Moraes and Lauro Wichert-Ana
    Citation: EJNMMI Physics 2022 9:91
    Content type: Original research Published on:

  21. The aim was to quantify inter- and intra-observer variability in manually delineated hepatocellular carcinoma (HCC) lesion contours and the resulting impact on radioembolization (RE) dosimetry.

    Authors: Elise C. Covert, Kellen Fitzpatrick, Justin Mikell, Ravi K. Kaza, John D. Millet, Daniel Barkmeier, Joseph Gemmete, Jared Christensen, Matthew J. Schipper and Yuni K. Dewaraja
    Citation: EJNMMI Physics 2022 9:90
    Content type: Original research Published on:

  22. 18F-FDG PET is often utilized to determine BNCT selection due to the limited availability of 18F-BPA PET, which is performed by synthesizing 18F into the boron drug used for BNCT, although the uptake mechanisms b...

    Authors: Tetsu Nakaichi, Satoshi Nakamura, Kimiteru Ito, Kana Takahashi, Mihiro Takemori, Tairo Kashihara, Kouji Kunito, Naoya Murakami, Kotaro Iijima, Takahito Chiba, Hiroki Nakayama, Shohei Mikasa, Teiji Nishio, Hiroyuki Okamoto, Jun Itami, Hiroaki Kurihara…
    Citation: EJNMMI Physics 2022 9:89
    Content type: Original research Published on:

  23. This study evaluated the physical performance of a positron emission tomography (PET) system dedicated to the head and breast according to the National Electrical Manufacturers Association (NEMA) NU2-2012 stan...

    Authors: Daisuke Morimoto-Ishikawa, Kohei Hanaoka, Shota Watanabe, Takahiro Yamada, Yoshiyuki Yamakawa, Suzuka Minagawa, Shiho Takenouchi, Atsushi Ohtani, Tetsuro Mizuta, Hayato Kaida and Kazunari Ishii
    Citation: EJNMMI Physics 2022 9:88
    Content type: Original Research Published on:

  24. Recently, total-body PET/CT systems with an extended axial field-of-view (aFOV) became commercially available which allow acquiring physiologic information of multiple organs simultaneously. However, the nomin...

    Authors: Ivo Rausch, Julia G. Mannheim, Jürgen Kupferschläger, Christian la Fougère and Fabian P. Schmidt
    Citation: EJNMMI Physics 2022 9:87
    Content type: Original research Published on:

  25. Accurate quantification of radioactivity in a source of interest relies on accurate registration between SPECT and anatomical images, and appropriate correction of partial volume effects (PVEs). For small volu...

    Authors: Lily Carnegie-Peake, Jan Taprogge, Iain Murray, Glenn D. Flux and Jonathan Gear
    Citation: EJNMMI Physics 2022 9:86
    Content type: Original Research Published on:

  26. We evaluated the effects of acquisition time, energy window width, and matrix size on the image quality, quantitation, and diagnostic performance of whole-body 99mTc-HMDP SPECT/CT in the primary metastasis stagin...

    Authors: Samuli Arvola, Marko Seppänen, Kirsi L. Timonen, Pentti Rautio, Otto Ettala, Mikael Anttinen, Peter J. Boström and Tommi Noponen
    Citation: EJNMMI Physics 2022 9:85
    Content type: Original research Published on:

  27. COVID-19 infection, especially in cases with pneumonia, is associated with a high rate of pulmonary embolism (PE). In patients with contraindications for CT pulmonary angiography (CTPA) or non-diagnostic CTPA,...

    Authors: Sonia Baeza, Debora Gil, Ignasi Garcia-Olivé, Maite Salcedo-Pujantell, Jordi Deportós, Carles Sanchez, Guillermo Torres, Gloria Moragas and Antoni Rosell
    Citation: EJNMMI Physics 2022 9:84
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Physics 2023 10:13

  28. The purpose of the present study was to elucidate the correlation between standardized uptake value (SUV) and volume-based parameters measured by quantitative [99mTc]Tc-methylene diphosphonate (MDP) single photon...

    Authors: Kenichi Tanaka, Takashi Norikane, Katsuya Mitamura, Yuka Yamamoto, Yukito Maeda, Kengo Fujimoto, Yasukage Takami, Mariko Ishimura, Hanae Arai-Okuda, Yoichiro Tohi, Nobuyuki Kudomi, Mikio Sugimoto and Yoshihiro Nishiyama
    Citation: EJNMMI Physics 2022 9:83
    Content type: Short communication Published on:

  30. To establish a proof-of-concept study using a phantom model to allow the fusion of preoperative single-photon emission computed tomography (SPECT) combined with computed tomography (CT), also known as SPECT/CT...

    Authors: Lise Lecointre, Juan Verde, Fabrice Hubele, Julien Salvadori, Laurent Goffin, Chérif Akladios and Benoît Gallix
    Citation: EJNMMI Physics 2022 9:81
    Content type: Short communication Published on:

  31. Patient’s breathing affects the quality of chest images acquired with positron emission tomography/computed tomography (PET/CT) studies. Movement correction is required to optimize PET quantification in clinic...

    Authors: Andrea Martinez-Movilla, Michael Mix, Irene Torres-Espallardo, Elena Teijeiro, Pilar Bello, Dimos Baltas, Luis Martí-Bonmatí and Montserrat Carles
    Citation: EJNMMI Physics 2022 9:80
    Content type: Original research Published on:

  32. We aimed to investigate the effect and significance of the rotation method with variable-angle anterior probe corrected for the depth of two kidneys on the determination of glomerular filtration rate (GFR) in ...

    Authors: Hua Wei, Ke Han, Jiaojiao Wu, Guang Hu, Zhifang Wu, Hongliang Wang, Xiaoshan Guo, Yansong Hou, Rui Wang and Sijin Li
    Citation: EJNMMI Physics 2022 9:79
    Content type: Original research Published on:

  36. Since it was first approved in Europe in 2016, the gallium-68 (68Ga) radiopharmaceutical [68Ga]Ga-DOTA-TOC has been widely used for imaging of somatostatin receptor (SSTR) positive tumours using positron emission...

    Authors: Mercedes Riveira-Martin, Lara Struelens, Werner Schoonjans, Isaac Sánchez-Díaz, Jose Muñoz Iglesias, Óscar Ferreira Dávila, Francisco Javier Salvador Gómez, Manuel Salgado Fernández and Antonio López Medina
    Citation: EJNMMI Physics 2022 9:75
    Content type: Young investigators Published on:

  37. Excellent performance characteristics of the Vision Quadra PET/CT, e.g. a substantial increase in sensitivity, allow for precise measurements of image-derived input functions (IDIF) and tissue time activity cu...

    Authors: Joyce van Sluis, Johannes H. van Snick, Adrienne H. Brouwers, Walter Noordzij, Rudi A. J. O. Dierckx, Ronald J. H. Borra, Adriaan A. Lammertsma, Andor W. J. M. Glaudemans, Riemer H. J. A. Slart, Maqsood Yaqub, Charalampos Tsoumpas and Ronald Boellaard
    Citation: EJNMMI Physics 2022 9:74
    Content type: Original research Published on:

  38. The 2018 BNMS Glomerular Filtration Rate (GFR) guidelines recommend a single-sample technique with the sampling time dictated by the expected renal function, but this is not known with any accuracy before the ...

    Authors: Helena McMeekin, Sam Townrow, Mark Barnfield, Andy Bradley, Ben Fongenie, Daniel R. McGowan, Matthew Memmott, Charlotte A. Porter, Fred Wickham, Nick Vennart and Maria Burniston
    Citation: EJNMMI Physics 2022 9:73
    Content type: Original research Published on:

  39. An open-source, extensible medical viewing platform is described, called the TriDFusion image viewer (3DF). The 3DF addresses many broad unmet needs in nuclear medicine research; it provides a viewer with seve...

    Authors: Daniel Lafontaine, C. Ross Schmidtlein, Assen Kirov, Ryan P. Reddy, Simone Krebs, Heiko Schöder and John L. Humm
    Citation: EJNMMI Physics 2022 9:72
    Content type: Commentary Published on:

  41. PET/MRI is an attractive imaging modality due to the complementary nature of MRI and PET. Obtaining high quality small animal PET/MRI results is key for the translation of novel PET/MRI agents and techniques t...

    Authors: Alyssa C. Pollard, Jorge de la Cerda, F. William Schuler, Charles V. Kingsley, Seth T. Gammon and Mark D. Pagel
    Citation: EJNMMI Physics 2022 9:70
    Content type: Original research Published on:

  42. To confirm the performance of the first hemispherical positron emission tomography (PET) for the brain (Vrain) that we developed to visualise the small nuclei in the deep brain area, we compared 18F-fluorodeoxygl...

    Authors: Miwako Takahashi, Go Akamatsu, Yuma Iwao, Hideaki Tashima, Eiji Yoshida and Taiga Yamaya
    Citation: EJNMMI Physics 2022 9:69
    Content type: Original research Published on:

  43. Performance assessment of positron emission tomography (PET) scanners is crucial to guide clinical practice with efficiency. Even though clinical data are the final target, their use to characterize systems re...

    Authors: Quentin Maronnier, Frédéric Courbon and Olivier Caselles
    Citation: EJNMMI Physics 2022 9:68
    Content type: Original research Published on:

  44. The aim of this study is to elucidate the difference in absorbed dose (Dabs) patterns in radiopharmaceutical therapies between alpha emitters (225Ac) and beta emitters (177Lu) when targeting cancer-associated fib...

    Authors: Jonathan Tranel, Stig Palm, Stephen A. Graves, Felix Y. Feng and Thomas A. Hope
    Citation: EJNMMI Physics 2022 9:67
    Content type: Original research Published on:

  45. [18F] FDG PET-CT has an important role in the initial staging of lung cancer; however, accurate differentiation between activity in malignant and benign intrathoracic lymph nodes on PET-CT scans can be challengin...

    Authors: Sara S. A. Laros, Dennis Dieckens, Stephan P. Blazis and Johannes A. van der Heide
    Citation: EJNMMI Physics 2022 9:66
    Content type: Original research Published on:

  46. Based on theoretical and preclinical results, terbium-161 may be a valid alternative to lutetium-177 and yttrium-90 in radionuclide therapies. The large low-energy electron emission from terbium-161 is a favor...

    Authors: Jens Hemmingsson, Johanna Svensson, Nicholas P. van der Meulen, Cristina Müller and Peter Bernhardt
    Citation: EJNMMI Physics 2022 9:65
    Content type: Original research Published on:

  47. The clinical utility of radiomics is hampered by a high correlation between the large number of features analysed which may result in the “bouncing beta” phenomenon which could in part explain why in a similar...

    Authors: DeLeu Anne-Leen, Sathekge Machaba, Maes Alex, De Spiegeleer Bart, Beels Laurence, Sathekge Mike, Pottel Hans and Christophe Van de Wiele
    Citation: EJNMMI Physics 2022 9:64
    Content type: Original research Published on:

  48. Efforts have been made both to avoid invasive blood sampling and to shorten the scan duration for dynamic positron emission tomography (PET) imaging. A total-body scanner, such as the uEXPLORER PET/CT, can rel...

    Authors: Zhenguo Wang, Yaping Wu, Xiaochen Li, Yan Bai, Hongzhao Chen, Jie Ding, Chushu Shen, Zhanli Hu, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang, Yun Zhou, Meiyun Wang and Tao Sun
    Citation: EJNMMI Physics 2022 9:63
    Content type: Original research Published on:

  49. The total-body positron emission tomography (PET) scanner provides an unprecedented opportunity to scan the whole body simultaneously, thanks to its long axial field of view and ultrahigh temporal resolution. ...

    Authors: Tao Sun, Yaping Wu, Wei Wei, Fangfang Fu, Nan Meng, Hongzhao Chen, Xiaochen Li, Yan Bai, Zhenguo Wang, Jie Ding, Debin Hu, Chaojie Chen, Zhanli Hu, Dong Liang, Xin Liu, Hairong Zheng…
    Citation: EJNMMI Physics 2022 9:62
    Content type: Original research Published on:

  50. Radiotracer extravasations, caused largely by faulty tracer injections, can occur in up to 23% of 18F-fluorodeoxyglucose (FDG) PET/CT scans and negatively impact radiological review and tracer quantification. Con...

    Authors: Steve Perrin, Jackson W. Kiser, Josh Knowland and Spencer L. Bowen
    Citation: EJNMMI Physics 2022 9:61
    Content type: Original research Published on:
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