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EJNMMI Physics
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  1. Dynamic PET is an essential tool in oncology due to its ability to visualize and quantify radiotracer uptake, which has the potential to improve imaging quality. However, image noise caused by a low photon cou...

    Authors: Lin Xin, Weihai Zhuo, Haikuan Liu and Tianwu Xie
    Citation: EJNMMI Physics 2023 10:59
    Content type: Original research Published on:

  3. Lung lobar ventilation and perfusion (V/Q) quantification is generally obtained by generating planar scintigraphy images and then imposing three equally sized regions of interest on the data of each lung. This...

    Authors: Emilie Verrecchia-Ramos, Olivier Morel, Merwan Ginet, Paul Retif and Sinan Ben Mahmoud
    Citation: EJNMMI Physics 2023 10:57
    Content type: Original research Published on:

  4. Current guidelines of the radioiodine uptake (RAIU) test allow the use of different equipment, isotopes, activity and region-of-interest (ROI). We evaluated presence and extent of these differences in clinical...

    Authors: Jurgen E. M. Mourik, Mark Derks, Erik T. te Beek and Marc R. J. ten Broek
    Citation: EJNMMI Physics 2023 10:55
    Content type: Original research Published on:

  5. Total-body PET imaging with ultra-high sensitivity makes high-temporal-resolution framing protocols possible for the first time, which allows to capture rapid tracer dynamic changes. However, whether protocols...

    Authors: Qing Ye, Hao Zeng, Yizhang Zhao, Weiguang Zhang, Yun Dong, Wei Fan and Yihuan Lu
    Citation: EJNMMI Physics 2023 10:54
    Content type: Original research Published on:

  6. Over recent years, [225Ac]Ac-PSMA and [177Lu]Lu-PSMA radiopharmaceutical therapy have evolved as a promising treatment option for advanced prostate cancer. Especially for alpha particle emitter treatments, there ...

    Authors: Mikhail Rumiantcev, Wei Bo Li, Simon Lindner, Grigory Liubchenko, Sandra Resch, Peter Bartenstein, Sibylle I. Ziegler, Guido Böning and Astrid Delker
    Citation: EJNMMI Physics 2023 10:53
    Content type: Original research Published on:

  7. Despite being thirteen years since the installation of the first PET-MR system, the scanners constitute a very small proportion of the total hybrid PET systems installed. This is in stark contrast to the rapid...

    Authors: Georgios Krokos, Jane MacKewn, Joel Dunn and Paul Marsden
    Citation: EJNMMI Physics 2023 10:52
    Content type: Review Published on:

  8. Conventional clinical PET scanners typically have an axial field of view (AFOV) of 15–30 cm, resulting in limited coverage and relatively low photon detection efficiency. Taking advantage of the development of...

    Authors: Huiran Hu, Yanchao Huang, Hongyan Sun, Kemin Zhou, Li Jiang, Jinmei Zhong, Li Chen, Lijuan Wang, Yanjiang Han and Hubing Wu
    Citation: EJNMMI Physics 2023 10:51
    Content type: Original research Published on:

  9. As for any other nuclear medicine treatment, patients treated with [177Lu]Lu-DOTA-TATE should be given some radiation protection recommendations after being discharged to limit the dose received by family members...

    Authors: Teresa Monserrat Fuertes, Borja Santos Zorrozua, Emilia Rodeño Ortiz de Zarate, Miguel Ángel Peinado Montes, Carmen Vigil Díaz and Pablo Mínguez Gabiña
    Citation: EJNMMI Physics 2023 10:50
    Content type: Original research Published on:

  10. The use of CT images for attenuation correction of myocardial perfusion imaging with single photon emission computer tomography (SPECT) increases diagnostic confidence. However, acquiring a CT image registered...

    Authors: Tamino Huxohl, Gopesh Patel, Reinhard Zabel and Wolfgang Burchert
    Citation: EJNMMI Physics 2023 10:49
    Content type: Original research Published on:

  11. Prediction of [177Lu]Lu-HA-DOTATATE kidney and tumor uptake based on diagnostic [68Ga]Ga-HA-DOTATATE imaging would be a crucial step for precision dosing of [177Lu]Lu-HA-DOTATATE. In this study, the population ph...

    Authors: Hinke Siebinga, Berlinda J. de Wit-van der Veen, Jos H. Beijnen, Marcel P. M. Stokkel, Thomas P. C. Dorlo, Alwin D. R. Huitema and Jeroen J. M. A. Hendrikx
    Citation: EJNMMI Physics 2023 10:48
    Content type: Original research Published on:

  12. 212Pb is a promising radionuclide for targeted alpha therapy. Here, the feasibility of visualising the tumour uptake and biodistribution of 212Pb-NG001 in mice with a clinical SPECT/CT scanner was investigated.

    Authors: Monika Kvassheim, Anna Julie Kjøl Tornes, Asta Juzeniene, Caroline Stokke and Mona-Elisabeth R. Revheim
    Citation: EJNMMI Physics 2023 10:47
    Content type: Short communication Published on:

  13. Radiopharmaceutical therapy (RPT) with alpha-emitting radionuclides has shown great promise in treating metastatic cancers. The successive emission of four alpha particles in the 225Ac decay chain leads to highly...

    Authors: Helena Koniar, Cassandra Miller, Arman Rahmim, Paul Schaffer and Carlos Uribe
    Citation: EJNMMI Physics 2023 10:46
    Content type: Original research Published on:

  14. The main objective of this study was to evaluate the ability of a large field Cadmium Zinc Telluride (CZT) camera to estimate thyroid uptake (TU) on single photon emission computed tomography (SPECT) images wi...

    Authors: Benjamin Serrano, Régis Amblard, Tiffany Beaumont, Florent Hugonnet, Matthieu Dietz, Frédéric Berthier, Nicolas Garnier, Rémy Villeneuve, Valérie Nataf, François Mocquot, Christopher Montemagno, Marc Faraggi and Benoît Paulmier
    Citation: EJNMMI Physics 2023 10:45
    Content type: Original research Published on:

  15. Estimation of brain amyloid accumulation is valuable for evaluation of patients with cognitive impairment in both research and clinical routine. The development of high throughput and accurate strategies for t...

    Authors: Claes Nøhr Ladefoged, Lasse Anderberg, Karine Madsen, Otto Mølby Henriksen, Steen Gregers Hasselbalch, Flemming Littrup Andersen, Liselotte Højgaard and Ian Law
    Citation: EJNMMI Physics 2023 10:44
    Content type: Original research Published on:

  16. Positron emission tomography (PET) requires a high signal-to-noise ratio (SNR) to improve image quality, with time-of-flight (TOF) being an effective way to boost the SNR. However, the scanner sensitivity and ...

    Authors: Konstantin Weindel, Vanessa Nadig, Katrin Herweg, Volkmar Schulz and Stefan Gundacker
    Citation: EJNMMI Physics 2023 10:43
    Content type: Original research Published on:

  21. This study evaluated, as a snapshot, the variability in quantification and image quality (IQ) of the clinically utilized PET [18F]FDG whole-body protocols in Finland using a NEMA/IEC IQ phantom permanently filled...

    Authors: O. Sipilä, J. Liukkonen, H.-L. Halme, T. Tolvanen, A. Sohlberg, M. Hakulinen, A.-L. Manninen, K. Tahvanainen, V. Tunninen, T. Ollikainen, T. Kangasmaa, A. Kangasmäki and J. Vuorela
    Citation: EJNMMI Physics 2023 10:38
    Content type: Original research Published on:

  22. In light of the milestones achieved in PET design so far, further sensitivity improvements aim to optimise factors such as the dose, throughput, and detection of small lesions. While several longer axial field...

    Authors: Maya Abi-Akl, Meysam Dadgar, Yassine Toufique, Othmane Bouhali and Stefaan Vandenberghe
    Citation: EJNMMI Physics 2023 10:37
    Content type: Original research Published on:

  23. Early cancer detection is crucial for patients’ survival. The image quality in 111In-octreotide SPECT imaging could be improved by using Monte Carlo (MC)-based reconstruction. The aim of this observational study ...

    Authors: Emma Wikberg, Martijn van Essen, Tobias Rydén, Johanna Svensson, Peter Gjertsson and Peter Bernhardt
    Citation: EJNMMI Physics 2023 10:36
    Content type: Original research Published on:

  24. The Cubresa Spark is a novel benchtop silicon-photomultiplier (SiPM)-based preclinical SPECT system. SiPMs in SPECT significantly improve resolution and reduce detector size compared to preclinical cameras wit...

    Authors: Matthew E. Strugari, Drew R. DeBay, Steven D. Beyea and Kimberly D. Brewer
    Citation: EJNMMI Physics 2023 10:35
    Content type: Original research Published on:

  25. Image optimization is a key step in clinical nuclear medicine, and phantoms play an essential role in this process. However, most phantoms do not accurately reflect the complexity of human anatomy, and this pr...

    Authors: Daniel Gillett, Daniel Marsden, Rosy Crawford, Safia Ballout, James MacFarlane, Merel van der Meulen, Bethany Gillett, Nick Bird, Sarah Heard, Andrew S. Powlson, Thomas Santarius, Richard Mannion, Angelos Kolias, Ines Harper, Iosif A. Mendichovszky, Luigi Aloj…
    Citation: EJNMMI Physics 2023 10:34
    Content type: Original research Published on:

  26. Total-body PET scanners with axial field of views (FOVs) longer than 1 m enable new applications to study multiple organs (e.g., the brain-gut-axis) simultaneously. As the spatial resolution and the associated...

    Authors: Julia G. Mannheim, Ivo Rausch, Maurizio Conti, Christian la Fougère and Fabian P. Schmidt
    Citation: EJNMMI Physics 2023 10:33
    Content type: Original research Published on:

  27. While diagnostic reference levels (DRLs) are well-established for the radiopharmaceutical part, published DRLs for the CT component of positron emission tomography/computed tomography (PET/CT) and single photo...

    Authors: Gwenny Verfaillie, Caro Franck, An De Crop, Laurence Beels, Yves D’Asseler and Klaus Bacher
    Citation: EJNMMI Physics 2023 10:32
    Content type: Review Published on:

  28. 18F-FDG PET/CT imaging allows to study oncological patients and their relative diagnosis through the standardised uptake value (SUV) evaluation. During radiopharmaceutical injection, an extravasation event may o....

    Authors: Mauro Iori, Elisa Grassi, Lorenzo Piergallini, Greta Meglioli, Andrea Botti, Giada Sceni, Noemi Cucurachi, Laura Verzellesi, Domenico Finocchiaro, Annibale Versari, Beatrice Fraboni and Federica Fioroni
    Citation: EJNMMI Physics 2023 10:31
    Content type: Original research Published on:

  29. Nuclear medicine imaging modalities like computed tomography (CT), single photon emission CT (SPECT) and positron emission tomography (PET) are employed in the field of theranostics to estimate and plan the do...

    Authors: Daniel Deidda, Ana M. Denis-Bacelar, Andrew J. Fenwick, Kelley M. Ferreira, Warda Heetun, Brian F. Hutton, Daniel R. McGowan, Andrew P. Robinson, James Scuffham, Kris Thielemans and Robert Twyman
    Citation: EJNMMI Physics 2023 10:30
    Content type: Original research Published on:

  30. In this retrospective study, we compared the maximum standardized uptake values (SUVmax) of parathyroid lesions and the target-to-background ratio (TBR) of parathyroid lesions to thyroid tissue in early-phase ...

    Authors: Yuhua Wang, Ye Liu, Na Li, Kang Xu and Wanchun Zhang
    Citation: EJNMMI Physics 2023 10:29
    Content type: Original research Published on:

  31. The Jagiellonian Positron Emission Tomograph is the 3-layer prototype of the first scanner based on plastic scintillators, consisting of 192 half-metre-long strips with readouts at both ends. Compared to cryst...

    Authors: S. Sharma, J. Baran, N. Chug, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, K. Eliyan, A. Gajos, N. Gupta-Sharma, B. C. Hiesmayr, K. Kacprzak, Ł. Kapłon, K. Klimaszewski, P. Konieczka, G. Korcyl…
    Citation: EJNMMI Physics 2023 10:28
    Content type: Original research Published on:

  32. Monte Carlo (MC) simulation in Nuclear Medicine is a powerful tool for modeling many physical phenomena which are difficult to track or measure directly. MC simulation in SPECT/CT imaging is particularly suita...

    Authors: Giovanni Di Domenico, Simona Di Biaso, Lorenzo Longo, Alessandro Turra, Eugenia Tonini, MariaConcetta Longo, Licia Uccelli and Mirco Bartolomei
    Citation: EJNMMI Physics 2023 10:27
    Content type: Original research Published on:

  34. The specific binding ratio (SBR) of 123I-FP-CIT in the putamen is widely used to support the interpretation of dopamine transporter (DAT) SPECT. Automatic methods for computation of the putamen SBR often include ...

    Authors: Ivayla Apostolova, Tassilo Schiebler, Catharina Lange, Franziska Lara Mathies, Wencke Lehnert, Susanne Klutmann and Ralph Buchert
    Citation: EJNMMI Physics 2023 10:25
    Content type: Original research Published on:

  35. In this study we evaluated the imaging capabilities of a novel Multi-pinhole collimator (MPH-Cardiac) specially designed for nuclear cardiology imaging on a Triple-NaI-detector based SPECT/CT system.

    Authors: Aron K. Krizsan, Kornel Kukuts, Walid Al-Muhanna, Zoltan Szoboszlai, Laszlo Balazs, Balazs Szabo, Janos Kiss, Stephan Nekolla, Sandor Barna, Ildiko Garai, Tamas Bukki and Attila Forgacs
    Citation: EJNMMI Physics 2023 10:24
    Content type: Original research Published on:

  36. Patient radioprotection in myocardial perfusion imaging (MPI)-SPECT is important but difficult to optimize. The aim of this study was to adjust injected activity according to patient size—weight or BMI—by usin...

    Authors: Emilie Verrecchia-Ramos, Olivier Morel, Valérie Beauchat, Sylvie Denet, Abdourahamane Djibo Sidikou, Merwan Ginet, Estelle Pfletschinger, Luminita Teodor, Maud Trombowsky, Jeany Verdier, Christelle Vère, Paul Retif and Sinan Ben Mahmoud
    Citation: EJNMMI Physics 2023 10:23
    Content type: Short communication Published on:

  37. Cardiac myxoma (CM), the most common cardiac tumor in adults, accounts for 50–75% of benign cardiac tumors. The diagnosis of CM is often elusive, especially in young stroke survivors and transthoracic echocard...

    Authors: Paweł Moskal, Ewelina Kubicz, Grzegorz Grudzień, Eryk Czerwiński, Kamil Dulski, Bartosz Leszczyński, Szymon Niedźwiecki and Ewa Ł. Stępień
    Citation: EJNMMI Physics 2023 10:22
    Content type: Original research Published on:

  38. Recent studies have shown that the right ventricular (RV) quantitative analysis in myocardial perfusion imaging (MPI) SPECT can be beneficial in the diagnosis of many cardiopulmonary diseases. This study propo...

    Authors: Seyed Mohammad Entezarmahdi, Reza Faghihi, Mehran Yazdi, Negar Shahamiri, Parham Geramifar and Mahdi Haghighatafshar
    Citation: EJNMMI Physics 2023 10:21
    Content type: Original research Published on:

  39. Quantitative thyroid single-photon emission computed tomography/computed tomography (SPECT/CT) requires computed tomography (CT)-based attenuation correction and manual thyroid segmentation on CT for %thyroid ...

    Authors: Kyounghyoun Kwon, Donghwi Hwang, Dongkyu Oh, Ji Hye Kim, Jihyung Yoo, Jae Sung Lee and Won Woo Lee
    Citation: EJNMMI Physics 2023 10:20
    Content type: Original research Published on:

  40. EQ.PET is a software package that overcomes the reconstruction-dependent variation of standard uptake values (SUV). In this study, we validated the use of EQ.PET for harmonizing SUVs between different positron...

    Authors: Yufei Song, Xiangxi Meng, Zhen Cao, Wei Zhao, Yan Zhang, Rui Guo, Xin Zhou, Zhi Yang and Nan Li
    Citation: EJNMMI Physics 2023 10:19
    Content type: Original research Published on:

  43. SimPET-L and SimPET-XL have recently been introduced with increased transaxial fields of view (FOV) compared with their predecessors (SimPET™ and SimPET-X), enabling whole-body positron emission tomography (PE...

    Authors: Minjee Seo, Guen Bae Ko, Kyeong Yun Kim, Jeong-Whan Son, Jung Woo Byun, Yun-Sang Lee, Kyeong Min Kim, Jang Woo Park, Kipom Kim, Taekwan Lee and Jae Sung Lee
    Citation: EJNMMI Physics 2023 10:16
    Content type: Original research Published on:

  44. Quantitative positron emission tomography (PET) scans of the brain typically require arterial blood sampling but this is complicated and logistically challenging. One solution to remove the need for arterial b...

    Authors: Peter Young, Lieuwe Appel, Andreas Tolf, Savvas Kosmidis, Joachim Burman, Anna Rieckmann, Michael Schöll and Mark Lubberink
    Citation: EJNMMI Physics 2023 10:15
    Content type: Original research Published on:

  45. Highly sensitive digital total-body PET/CT scanners (uEXPLORER) have great potential for clinical applications and fundamental research. Given their increasing sensitivity, low-dose scanning or snapshot imagin...

    Authors: Yanchao Huang, Meng Wang, Li Jiang, Lijuan Wang, Li Chen, Qiaoyu Wang, Jiatai Feng, Jingyi Wang, Wanbang Xu, Hubing Wu and Yanjiang Han
    Citation: EJNMMI Physics 2023 10:14
    Content type: Original research Published on:

  47. This project aims to develop and evaluate a method for accurately determining time-integrated activities (TIAs) in single-time-point (STP) dosimetry for molecular radiotherapy. It performs a model selection (M...

    Authors: Deni Hardiansyah, Ade Riana, Ambros J. Beer and Gerhard Glatting
    Citation: EJNMMI Physics 2023 10:12
    Content type: Original research Published on:

  48. 177Lu-PSMA therapy has been successfully used to prolong the survival of patients with metastatic castration-resistant prostate cancer. Patient-specific dosimetry based on serial quantitative SPECT/CT imaging can...

    Authors: Sandra Resch, Sarah Takayama Fouladgar, Mathias Zacherl, Gabriel T. Sheikh, Grigory Liubchenko, Mikhail Rumiantcev, Lena M. Unterrainer, Vera Wenter, Peter Bartenstein, Sibylle I. Ziegler, Harun Ilhan, Leonie Beyer, Guido Böning and Astrid Delker
    Citation: EJNMMI Physics 2023 10:11
    Content type: Original research Published on:

  49. The aim was to review available biokinetic data, collect own experimental data, and propose an updated compartmental model for 2-[18F]FDG in the frame of the revision of the ICRP report on dose coefficients for r...

    Authors: Alexandra Kamp, Martin Andersson, Sigrid Leide-Svegborn, Dietmar Noβke, Sören Mattsson and Augusto Giussani
    Citation: EJNMMI Physics 2023 10:10
    Content type: Original research Published on:

  50. Myocardial perfusion SPECT (MPS) images often suffer from artefacts caused by low-count statistics. Poor-quality images can lead to misinterpretations of perfusion defects. Deep learning (DL)-based methods hav...

    Authors: Antti Sohlberg, Tuija Kangasmaa, Chris Constable and Antti Tikkakoski
    Citation: EJNMMI Physics 2023 10:9
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Physics 2023 10:26

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