Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, et al. Imaging synaptic density in the living human brain. Sci Transl Med. 2016;8(348):348ra96.
Article
Google Scholar
Bajjalieh SM, Frantz GD, Weimann JM, McConnell SK, Scheller RH. Differential expression of synaptic vesicle protein 2 (SV2) isoforms. J Neurosci. 1994;14(9):5223–35. https://doi.org/10.1523/JNEUROSCI.14-09-05223.1994.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bajjalieh SM, Peterson K, Shinghal R, Scheller RH. SV2, a brain synaptic vesicle protein homologous to bacterial transporters. Science. 1992;257(5074):1271–3. https://doi.org/10.1126/science.1519064.
Article
CAS
PubMed
Google Scholar
Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci U S A. 2004;101(26):9861–6. https://doi.org/10.1073/pnas.0308208101.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nowack A, Malarkey EB, Yao J, Bleckert A, Hill J, Bajjalieh SM. Levetiracetam reverses synaptic deficits produced by overexpression of SV2A. PLoS One. 2011;6(12):e29560. https://doi.org/10.1371/journal.pone.0029560.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mercier J, Provins L, Valade A. Discovery and development of SV2A PET tracers: potential for imaging synaptic density and clinical applications. Drug Discov Today Technol. 2017;25:45–52. https://doi.org/10.1016/j.ddtec.2017.11.003.
Article
PubMed
Google Scholar
Cai Z, Li S, Matuskey D, Nabulsi N, Huang Y. PET imaging of synaptic density: a new tool for investigation of neuropsychiatric diseases. Neurosci Lett. 2019;691:44–50. https://doi.org/10.1016/j.neulet.2018.07.038.
Article
CAS
PubMed
Google Scholar
Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, et al. Kinetic evaluation and test-retest reproducibility of [(11)C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans. J Cereb Blood Flow Metab. 2018;38(11):2041–52. https://doi.org/10.1177/0271678X17724947.
Article
CAS
PubMed
Google Scholar
Koole M, van Aalst J, Devrome M, Mertens N, Serdons K, Lacroix B, et al. Quantifying SV2A density and drug occupancy in the human brain using [(11)C]UCB-J PET imaging and subcortical white matter as reference tissue. Eur J Nucl Med Mol Imaging. 2019;46(2):396–406. https://doi.org/10.1007/s00259-018-4119-8.
Article
CAS
PubMed
Google Scholar
Bini J, Holden D, Fontaine K, Mulnix T, Lu Y, Matuskey D, et al. Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand (11)C-UCB-J. EJNMMI Res. 2020;10(1):83. https://doi.org/10.1186/s13550-020-00670-w.
Article
CAS
PubMed
PubMed Central
Google Scholar
Stabin MG, Siegel JA. RADAR dose estimate report: a compendium of radiopharmaceutical dose estimates based on OLINDA/EXM version 2.0. J Nucl Med. 2018;59(1):154–60. https://doi.org/10.2967/jnumed.117.196261.
Article
PubMed
Google Scholar
Bolch WE, Eckerman KF, Sgouros G, Thomas SR. MIRD pamphlet no. 21: a generalized schema for radiopharmaceutical dosimetry--standardization of nomenclature. J Nucl Med. 2009;50(3):477–84. https://doi.org/10.2967/jnumed.108.056036.
Article
CAS
PubMed
Google Scholar
ICRP. Publication 30, part 1, 1979. Ann ICRP. 1979;2(3-4P1):1–4.
Google Scholar
International Commission on Radiological P. Human alimentary tract model for radiological protection. ICRP publication 100. A report of the international commission on radiological protection. Ann ICRP. 2006;36(1-2):25–327 iii.
Article
Google Scholar
Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, et al. Assessing synaptic density in Alzheimer disease with synaptic vesicle glycoprotein 2A positron emission tomographic imaging. JAMA Neurol. 2018;75(10):1215–24. https://doi.org/10.1001/jamaneurol.2018.1836.
Article
PubMed
PubMed Central
Google Scholar
Finnema SJ, Rossano S, Naganawa M, Henry S, Gao H, Pracitto R, et al. A single-center, open-label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers. Epilepsia. 2019;60(5):958–67. https://doi.org/10.1111/epi.14701.
Article
CAS
PubMed
PubMed Central
Google Scholar
Finnema SJ, Toyonaga T, Detyniecki K, Chen MK, Dias M, Wang Q, et al. Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: a [(11) C]UCB-J positron emission tomography study. Epilepsia. 2020;61(10):2183–93. https://doi.org/10.1111/epi.16653.
Article
CAS
PubMed
Google Scholar
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, et al. Lower synaptic density is associated with depression severity and network alterations. Nat Commun. 2019;10(1):1529. https://doi.org/10.1038/s41467-019-09562-7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mansur A, Rabiner EA, Comley RA, Lewis Y, Middleton LT, Huiban M, et al. Characterization of 3 PET tracers for quantification of mitochondrial and synaptic function in healthy human brain: (18)F-BCPP-EF, (11)C-SA-4503, and (11)C-UCB-J. J Nucl Med. 2020;61(1):96–103. https://doi.org/10.2967/jnumed.119.228080.
Article
CAS
PubMed
Google Scholar
Matuskey D, Tinaz S, Wilcox KC, Naganawa M, Toyonaga T, Dias M, et al. Synaptic changes in Parkinson disease assessed with in vivo imaging. Ann Neurol. 2020;87(3):329–38. https://doi.org/10.1002/ana.25682.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mecca AP, Chen MK, O’Dell RS, Naganawa M, Toyonaga T, Godek TA, et al. In vivo measurement of widespread synaptic loss in Alzheimer’s disease with SV2A PET. Alzheimers Dement. 2020;16(7):974–82. https://doi.org/10.1002/alz.12097.
Article
PubMed
PubMed Central
Google Scholar
Mertens N, Maguire RP, Serdons K, Lacroix B, Mercier J, Sciberras D, et al. Validation of parametric methods for [(11)C]UCB-J PET imaging using subcortical white matter as reference tissue. Mol Imaging Biol. 2020;22(2):444–52. https://doi.org/10.1007/s11307-019-01387-6.
Article
CAS
PubMed
Google Scholar
Naganawa M, Gallezot JD, Finnema S, Matuskey D, Mecca AP, Nabulsi NB, et al. Simplified quantification of (11)C-UCB-J PET evaluated in a large human cohort. J Nucl Med. 2021;62(3):418–21.
Nicastro N, Holland N, Savulich G, Carter SF, Mak E, Hong YT, et al. (11)C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies. Eur J Hybrid Imaging. 2020;4(1):25.
Article
Google Scholar
O’Dell RS, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, et al. Association of Abeta deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [(11)C]UCB-J. Alzheimers Res Ther. 2021;13(1):11. https://doi.org/10.1186/s13195-020-00742-y.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rossano S, Toyonaga T, Finnema SJ, Naganawa M, Lu Y, Nabulsi N, et al. Assessment of a white matter reference region for (11)C-UCB-J PET quantification. J Cereb Blood Flow Metab. 2020;40(9):1890–901. https://doi.org/10.1177/0271678X19879230.
Article
CAS
PubMed
Google Scholar
Smart K, Liu H, Matuskey D, Chen MK, Torres K, Nabulsi N, et al. Binding of the synaptic vesicle radiotracer [(11)C]UCB-J is unchanged during functional brain activation using a visual stimulation task. J Cereb Blood Flow Metab. 2021;41(5):1067–79.
van der Aart J, Hallett WA, Rabiner EA, Passchier J, Comley RA. Radiation dose estimates for carbon-11-labelled PET tracers. Nucl Med Biol. 2012;39(2):305–14. https://doi.org/10.1016/j.nucmedbio.2011.08.005.
Article
CAS
PubMed
Google Scholar
Nabulsi NB, Mercier J, Holden D, Carre S, Najafzadeh S, Vandergeten MC, et al. Synthesis and preclinical evaluation of 11C-UCB-J as a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the brain. J Nucl Med. 2016;57(5):777–84. https://doi.org/10.2967/jnumed.115.168179.
Article
CAS
PubMed
Google Scholar
Hall C, Lueshen E, Mosat A, Linninger AA. Interspecies scaling in pharmacokinetics: a novel whole-body physiologically based modeling framework to discover drug biodistribution mechanisms in vivo. J Pharm Sci. 2012;101(3):1221–41. https://doi.org/10.1002/jps.22811.
Article
CAS
PubMed
Google Scholar
Petrulli JR, Hansen SB, Abourbeh G, Yaqub M, Bahce I, Holden D, et al. A multi species evaluation of the radiation dosimetry of [(11)C]erlotinib, the radiolabeled analog of a clinically utilized tyrosine kinase inhibitor. Nucl Med Biol. 2017;47:56–61. https://doi.org/10.1016/j.nucmedbio.2016.12.009.
Article
CAS
PubMed
PubMed Central
Google Scholar
Milicevic Sephton S, Miklovicz T, Russell JJ, Doke A, Li L, Boros I, et al. Automated radiosynthesis of [(11) C]UCB-J for imaging synaptic density by positron emission tomography. J Labelled Comp Radiopharm. 2020;63(3):151–8. https://doi.org/10.1002/jlcr.3828.
Article
CAS
PubMed
PubMed Central
Google Scholar
Stabin MG, Siegel JA, Xu XG. SNMMI RADARCot. RADAR develops new generation of dosimetry phantoms. J Nucl Med. 2018;59(5):11N.
CAS
PubMed
Google Scholar
Gnesin S, Cicone F, Mitsakis P, Van der Gucht A, Baechler S, Miralbell R, et al. First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist (68)Ga-NODAGA-MJ9. EJNMMI Res. 2018;8(1):108. https://doi.org/10.1186/s13550-018-0462-9.
Article
PubMed
PubMed Central
Google Scholar
Melendez-Alafort L, Ferro-Flores G, De Nardo L, Bello M, Paiusco M, Negri A, et al. Internal radiation dose assessment of radiopharmaceuticals prepared with cyclotron-produced (99m) Tc. Med Phys. 2019;46(3):1437–46. https://doi.org/10.1002/mp.13393.
Article
CAS
PubMed
Google Scholar
Zanotti-Fregonara P, Innis RB. Suggested pathway to assess radiation safety of 11C-labeled PET tracers for first-in-human studies. Eur J Nucl Med Mol Imaging. 2012;39(3):544–7. https://doi.org/10.1007/s00259-011-2005-8.
Article
PubMed
Google Scholar
Radiation protection 99: Guidance on medical exposures in medical and biomedical research 1998 [cited 2020 24/11/2020]. Available from: https://ec.europa.eu/energy/sites/ener/files/documents/099_en.pdf.