Skip to main content

Table 4 Absorbed dose coefficients for [11C]-UCB-J determined from three healthy subjects using OLINDA/EXM 2.1, compared to OLINDA/EXM 1.1

From: Human biodistribution and dosimetry of [11C]-UCB-J, a PET radiotracer for imaging synaptic density

Target organ Absorbed dose coefficients (mSv/MBq)  
Adult female Adult female Adult male Average % Difference
Adrenals 4.99E−03 4.84E−03 4.13E−03 4.52E−03 ± 0.56 55%
Brain 1.93E−02 1.56E−02 1.13E−02 14.38E−02± 4.35 −6%
Breasts 1.56E−03 1.65E−03   1.61E−03 ± 0.06 10%
Esophagus 2.63E−03 2.62E−03 2.36E−03 2.49E−03 ± 0.19 n/a
Eyes 2.93E−03 2.73E−03 1.87E−03 2.35E−03 ± 0.68 n/a
Gallbladder wall 1.28E−02 4.19E−03 7.95E−03 8.22E−03 ± 0.39 9%
Left colon 3.62E−03 3.18E−03 3.82E−03 3.61E−03 ± 0.30 14%
Small intestine 2.67E−02 1.82E−02 2.46E−02 23.53E−02 ± 1.52 26%
Stomach wall 9.32E−03 5.58E−03 6.76E−03 7.11E−03 ± 0.49 8%
Right colon 8.63E−03 6.52E−03 9.06E−03 8.32E−03 ± 1.05 8%
Rectum 3.96E−03 3.48E−03 2.62E−03 3.17E−03 ± 0.78 n/a
Heart wall 5.33E−03 4.97E−03 5.82E−03 5.49E−03 ± 0.47 0%
Kidneys 1.60E−02 1.68E−02 7.33E−03 11.87E−02 ± 6.41 1%
Liver 1.58E−02 1.54E−02 1.35E−02 14.55E−02 ± 1.49 4%
Lungs 4.09E−03 3.85E−03 3.80E−03 3.89E−03 ± 0.12 −8%
Ovaries 3.33E−03 3.02E−03   3.18E−03 ± 0.22 68%
Pancreas 4.66E−03 4.16E−03 3.89E−03 4.15E−03 ± 0.37 17%
Prostate    2.50E−03 2.50 n/a
Salivary glands 2.64E−03 2.52E−03 2.00E−03 2.29E−03 ± 0. 41 n/a
Red marrow 4.81E−03 4.55E−03 3.67E−03 4.18E−03 ± 0.71 6%
Osteogenic cells 3.40E−03 3.23E−03 2.88E−03 3.10E−03 ± 0.31 −23%
Spleen 5.23E−03 5.34E−03 2.80E−03 4.04E−03 ± 1.76 18%
Testes 0.00E+00 0.00E+00 1.38E−03 1.38E−03 −3%
Thymus 2.10E−03 2.17E−03 1.86E−03 2.00E−03 ± 0.19 16%
Thyroid 1.74E−03 1.83E−03 1.57E−03 1.68E−03 ± 0.15 7%
Urinary bladder wall 3.12E−02 2.34E−02 1.61E−02 21.70E−02 ± 7.92 −7%
Uterus 4.56E−03 3.88E−03 0.00E+00 4.22E−03 ± 0.48 12%
Total body 3.45E−03 3.20E−03 2.39E−03 2.86E−03 ± 0.66 −1%
Effective dose coefficient (mSv/MBq) (ICRP 103) 6.24E−03 5.07E−03 4.50E−03 5.08E−03 ± 0.82 −6%