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Table 3 Absorbed dose coefficients for [11C]-UCB-J determined from three healthy subjects using OLINDA/EXM 1.1 compared to literature values

From: Human biodistribution and dosimetry of [11C]-UCB-J, a PET radiotracer for imaging synaptic density

Target organ

Absorbed dose coefficients (mSv/MBq)

 

Adult female

Adult female

Adult male

Average

Average [10]

% Difference

Adrenals

3.26E−03

3.28E−03

2.57E−03

2.92E−03 ± 0.50

3.34E−03

−12%

Brain

2.09E−02

1.69E−02

1.17E−02

15.30E−03 ± 5.09

1.85E−02

−17%

Breasts

1.56E−03

1.66E−03

1.32E−03

1.47E−03 ± 0.21

1.75E−03

−16%

Gallbladder wall

1.20E−02

4.14E−03

6.95E−03

7.51E−03 ± 0.79

1.22E−02

−38%

LLI wall

3.62E−03

3.13E−03

2.95E−03

3.16E−03 ± 0.30

2.20E−02

−86%

Small intestine

2.08E−02

1.43E−02

1.97E−02

18.63E−03 ± 1.52

2.83E−03

558%

Stomach wall

8.82E−03

5.27E−03

6.16E−03

6.60E−03 ± 0.63

6.83E−03

−3%

ULI wall

8.55E−03

6.35E−03

7.96E−03

7.71E−03 ± 0.36

2.83E−03

173%

Heart wall

5.53E−03

5.19E−03

5.62E−03

5.49E−03 ± 0.18

4.44E−03

24%

Kidneys

1.57E−02

1.67E−02

7.29E−03

11.75E−03 ± 6.30

1.01E−02

16%

Liver

1.56E−02

1.52E−02

1.27E−02

14.05E−02 ± 1.91

1.98E−02

−29%

Lungs

4.50E−03

4.25E−03

4.09E−03

4.23E−03 ± 0.20

5.24E−03

−19%

Muscle

2.09E−03

2.09E−03

1.70E−03

1.90E−03 ± 0.28

2.11E−03

−10%

Ovaries

4.05E−03

3.46E−03

3.31E−03

3.53E−03 ± 0.32

3.50E−03

1%

Pancreas

3.43E−03

3.23E−03

2.72E−03

3.03E−03 ± 0.43

3.37E−03

−10%

Red marrow

4.21E−03

3.96E−03

3.77E−03

3.93E−03 ± 0.22

2.22E−03

77%

Osteogenic cells

4.69E−03

4.63E−03

3.42E−03

4.04E−03 ± 0.88

3.11E−03

30%

Skin

1.53E−03

1.59E−03

1.25E−03

1.41E−03 ± 0.22

1.64E−03

−14%

Spleen

4.35E−03

4.57E−03

2.40E−03

3.43E−03 ± 1.46

4.60E−03

−25%

Testes

  

1.43E−03

1.43E−03

2.16E−03

−34%

Thymus

1.82E−03

1.95E−03

1.55E−03

1.72E−03 ± 0.24

2.06E−03

−16%

Thyroid

1.59E−03

1.71E−03

1.49E−03

1.57E−03 ± 0.11

1.87E−03

−16%

Urinary bladder wall

3.50E−02

2.62E−02

1.59E−02

23.25E−02 ± 4.84

2.21E−02

5%

Uterus

4.43E−03

3.76E−03

3.41E−03

3.75E−03 ± 0.48

3.21E−03

17%

Total body

3.33E03

3.15E03

2.56E03

2.90E−03 ± 0.48

3.12E−03

−7%

Effective dose coefficient (mSv/MBq) (ICRP 60)

6.53E03

5.35E03

4.91E03

5.43E−03 ± 0.73

7.59E−03

−28%