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Table 3 Absorbed dose coefficients for [11C]-UCB-J determined from three healthy subjects using OLINDA/EXM 1.1 compared to literature values

From: Human biodistribution and dosimetry of [11C]-UCB-J, a PET radiotracer for imaging synaptic density

Target organ Absorbed dose coefficients (mSv/MBq)  
Adult female Adult female Adult male Average Average [10] % Difference
Adrenals 3.26E−03 3.28E−03 2.57E−03 2.92E−03 ± 0.50 3.34E−03 −12%
Brain 2.09E−02 1.69E−02 1.17E−02 15.30E−03 ± 5.09 1.85E−02 −17%
Breasts 1.56E−03 1.66E−03 1.32E−03 1.47E−03 ± 0.21 1.75E−03 −16%
Gallbladder wall 1.20E−02 4.14E−03 6.95E−03 7.51E−03 ± 0.79 1.22E−02 −38%
LLI wall 3.62E−03 3.13E−03 2.95E−03 3.16E−03 ± 0.30 2.20E−02 −86%
Small intestine 2.08E−02 1.43E−02 1.97E−02 18.63E−03 ± 1.52 2.83E−03 558%
Stomach wall 8.82E−03 5.27E−03 6.16E−03 6.60E−03 ± 0.63 6.83E−03 −3%
ULI wall 8.55E−03 6.35E−03 7.96E−03 7.71E−03 ± 0.36 2.83E−03 173%
Heart wall 5.53E−03 5.19E−03 5.62E−03 5.49E−03 ± 0.18 4.44E−03 24%
Kidneys 1.57E−02 1.67E−02 7.29E−03 11.75E−03 ± 6.30 1.01E−02 16%
Liver 1.56E−02 1.52E−02 1.27E−02 14.05E−02 ± 1.91 1.98E−02 −29%
Lungs 4.50E−03 4.25E−03 4.09E−03 4.23E−03 ± 0.20 5.24E−03 −19%
Muscle 2.09E−03 2.09E−03 1.70E−03 1.90E−03 ± 0.28 2.11E−03 −10%
Ovaries 4.05E−03 3.46E−03 3.31E−03 3.53E−03 ± 0.32 3.50E−03 1%
Pancreas 3.43E−03 3.23E−03 2.72E−03 3.03E−03 ± 0.43 3.37E−03 −10%
Red marrow 4.21E−03 3.96E−03 3.77E−03 3.93E−03 ± 0.22 2.22E−03 77%
Osteogenic cells 4.69E−03 4.63E−03 3.42E−03 4.04E−03 ± 0.88 3.11E−03 30%
Skin 1.53E−03 1.59E−03 1.25E−03 1.41E−03 ± 0.22 1.64E−03 −14%
Spleen 4.35E−03 4.57E−03 2.40E−03 3.43E−03 ± 1.46 4.60E−03 −25%
Testes    1.43E−03 1.43E−03 2.16E−03 −34%
Thymus 1.82E−03 1.95E−03 1.55E−03 1.72E−03 ± 0.24 2.06E−03 −16%
Thyroid 1.59E−03 1.71E−03 1.49E−03 1.57E−03 ± 0.11 1.87E−03 −16%
Urinary bladder wall 3.50E−02 2.62E−02 1.59E−02 23.25E−02 ± 4.84 2.21E−02 5%
Uterus 4.43E−03 3.76E−03 3.41E−03 3.75E−03 ± 0.48 3.21E−03 17%
Total body 3.33E03 3.15E03 2.56E03 2.90E−03 ± 0.48 3.12E−03 −7%
Effective dose coefficient (mSv/MBq) (ICRP 60) 6.53E03 5.35E03 4.91E03 5.43E−03 ± 0.73 7.59E−03 −28%