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EJNMMI Physics
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  2. The purpose of the present study was to elucidate the correlation between standardized uptake value (SUV) and volume-based parameters measured by quantitative [99mTc]Tc-methylene diphosphonate (MDP) single photon...

    Authors: Kenichi Tanaka, Takashi Norikane, Katsuya Mitamura, Yuka Yamamoto, Yukito Maeda, Kengo Fujimoto, Yasukage Takami, Mariko Ishimura, Hanae Arai-Okuda, Yoichiro Tohi, Nobuyuki Kudomi, Mikio Sugimoto and Yoshihiro Nishiyama
    Citation: EJNMMI Physics 2022 9:83
    Content type: Short communication Published on:

  3. The aim of this study is to elucidate the difference in absorbed dose (Dabs) patterns in radiopharmaceutical therapies between alpha emitters (225Ac) and beta emitters (177Lu) when targeting cancer-associated fib...

    Authors: Jonathan Tranel, Stig Palm, Stephen A. Graves, Felix Y. Feng and Thomas A. Hope
    Citation: EJNMMI Physics 2022 9:67
    Content type: Original research Published on:

  5. The goal of this prospective study was to estimate the absorbed (radiation) doses to salivary glands in radioiodine therapy of thyroid cancer under chewing-gum stimulation using 124I positron emission tomography ...

    Authors: Walter Jentzen, Marion Richter, James Nagarajah, Thorsten Dirk Poeppel, Wolfgang Brandau, Colin Dawes, Andreas Bockisch and Ina Binse
    Citation: EJNMMI Physics 2014 1:100
    Content type: Original research Published on:

  6. Ultra-low-dose (ULD) computed tomography (CT) scans should be used when CT is performed only for attenuation correction (AC) of positron emission tomography (PET) data. A tin filter can be used in addition to ...

    Authors: Natalie Anne Bebbington, Kenneth Boye Christensen, Lone Lange Østergård and Paw Christian Holdgaard
    Citation: EJNMMI Physics 2023 10:66
    Content type: Original research Published on:

  7. The amount of signal decreases when the acquisition duration is shortened. However, it is not clear how this affects the quantitative values. This study aims to clarify the effect of acquisition time shortenin...

    Authors: Masatoshi Morimoto, Nobuyuki Kudomi, Yukito Maeda, Takuya Kobata, Akihiro Oishi, Keisuke Matsumoto, Toshihide Monden, Takanobu Iwasaki, Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto and Yoshihiro Nishiyama
    Citation: EJNMMI Physics 2021 8:34
    Content type: Original research Published on:

  8. Prostate-specific membrane antigen (PSMA) radiotracers such as [18F]PSMA-1007 used with positron emission tomography-computed tomography (PET-CT) is promising for initial staging and detection of recurrent diseas...

    Authors: Elin Trägårdh, David Minarik, Gustav Brolin, Ulrika Bitzén, Berit Olsson and Jenny Oddstig
    Citation: EJNMMI Physics 2020 7:31
    Content type: Original research Published on:

  9. There has been an ongoing need to compare and combine the results of new PET imaging studies conducted with [11C]raclopride with older data. This typically means harmonizing data across different scanners. Previo...

    Authors: Jocelyn Hoye, Takuya Toyonaga, Yasmin Zakiniaeiz, Gelsina Stanley, Michelle Hampson and Evan D. Morris
    Citation: EJNMMI Physics 2022 9:27
    Content type: Short communication Published on:

  10. Non-human primates (NHP) are critical in biomedical research to better understand the pathophysiology of diseases and develop new therapies. Based on its translational and longitudinal abilities along with its...

    Authors: Frédéric Boisson, Sophie Serriere, Liji Cao, Sylvie Bodard, Alessandro Pilleri, Lionel Thomas, Giancarlo Sportelli, Johnny Vercouillie, Patrick Emond, Clovis Tauber, Nicola Belcari, Jean-Luc Lefaucheur, David Brasse and Laurent Galineau
    Citation: EJNMMI Physics 2022 9:10
    Content type: Original research Published on:

  11. Due to spatial resolution limitations, conventional NaI-SPECT typically overestimates the left ventricular (LV) ejection fraction (EF) in patients with small LV volumes. The purpose of this study was to explor...

    Authors: Yan Huang, Han Zhang, Xueping Hu, Shanshan Qin, Fan Hu, Yuchen Li, Haidong Cai, Kuangyu Shi and Fei Yu
    Citation: EJNMMI Physics 2024 11:5
    Content type: Original research Published on:

  12. We aimed to investigate the effect and significance of the rotation method with variable-angle anterior probe corrected for the depth of two kidneys on the determination of glomerular filtration rate (GFR) in ...

    Authors: Hua Wei, Ke Han, Jiaojiao Wu, Guang Hu, Zhifang Wu, Hongliang Wang, Xiaoshan Guo, Yansong Hou, Rui Wang and Sijin Li
    Citation: EJNMMI Physics 2022 9:79
    Content type: Original research Published on:

  13. In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy...

    Authors: Kristian Valind, Jonas Jögi, David Minarik, Gustav Brolin and Elin Trägårdh
    Citation: EJNMMI Physics 2021 8:70
    Content type: Original research Published on:

  14. In literature are reported different analytical methods (AM) to choose the proper fit model and to fit data of the time-activity curve (TAC). On the other hand, Machine Learning algorithms (ML) are increasingl...

    Authors: Davide Ciucci, Bartolomeo Cassano, Salvatore Donatiello, Federica Martire, Antonio Napolitano, Claudia Polito, Elena Solfaroli Camillocci, Gianluca Cervino, Ludovica Pungitore, Claudio Altini, Maria Felicia Villani, Milena Pizzoferro, Maria Carmen Garganese and Vittorio Cannatà
    Citation: EJNMMI Physics 2024 11:19
    Content type: Original research Published on:

  15. Accurate QSPECT is crucial in dosimetry-based, personalized radiopharmaceutical therapy with 177Lu and other radionuclides. We compared the quantitative performance of three NaI(Tl)-crystal SPECT/CT systems equip...

    Authors: Alessandro Desy, Guillaume F. Bouvet, Étienne Croteau, Nancy Lafrenière, Éric E. Turcotte, Philippe Després and Jean-Mathieu Beauregard
    Citation: EJNMMI Physics 2021 8:73
    Content type: Short communication Published on:

  16. Quantitative evaluation of amyloid positron emission tomography (PET) with standardized uptake value ratio (SUVR) plays a key role in clinical studies of Alzheimer’s disease (AD). We have proposed a PET-only (...

    Authors: Yuma Tsubaki, Go Akamatsu, Natsumi Shimokawa, Suguru Katsube, Aya Takashima and Masayuki Sasaki
    Citation: EJNMMI Physics 2020 7:59
    Content type: Young investigators Published on:

  19. 211At, a promising alpha-particle-emitting radionuclide, can easily volatilize and contaminate the environment. To safely manage this unique alpha-particle-emitting radionuclide, we investigated the permeability ...

    Authors: Kazunobu Ohnuki, Mitsuyoshi Yoshimoto, Hiromitsu Haba, Shino Manabe, Hiroki Takashima, Masahiro Yasunaga, Yasumasa Takenaka and Hirofumi Fujii
    Citation: EJNMMI Physics 2022 9:39
    Content type: Short communication Published on:

  20. Terbium-161 (161Tb)-based radionuclide therapy poses an alternative to current Lutetium-177 (177Lu) approaches with the additional benefit of secondary Auger and conversion electron emissions capable of deliverin...

    Authors: Lachlan McIntosh, Price Jackson, Brittany Emmerson, James P. Buteau, Ramin Alipour, Grace Kong and Michael S. Hofman
    Citation: EJNMMI Physics 2024 11:18
    Content type: Original research Published on:

  21. Dead time may affect the accuracy of quantitative SPECT (QPSECT), and thus of dosimetry. The aim of this study was to quantify the effect of dead time on 177Lu-QSPECT and renal dosimetry following peptide recepto...

    Authors: Alessandro Desy, Guillaume F. Bouvet, Andrea Frezza, Philippe Després and Jean-Mathieu Beauregard
    Citation: EJNMMI Physics 2020 7:32
    Content type: Short communication Published on:

  22. Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction techni...

    Authors: Alina van de Burgt, Petra Dibbets-Schneider, Cornelis H. Slump, Arthur J. H. A. Scholte, Douwe E. Atsma, Lioe-Fee de Geus-Oei and Floris H. P. van Velden
    Citation: EJNMMI Physics 2021 8:48
    Content type: Original research Published on:

  23. Accurate dosimetry is essential in radioembolization. To this purpose, an automatic protocol for healthy liver dosimetry based on dual isotope (DI) SPECT imaging, combining holmium-166 (166Ho)-microspheres, and t...

    Authors: M. Stella, AJAT Braat, MGEH Lam, HWAM de Jong and R. van Rooij
    Citation: EJNMMI Physics 2020 7:48
    Content type: Original research Published on:

  25. Attenuation correction of PET/MRI is a remaining problem for whole-body PET/MRI. The statistical decomposition algorithm (SDA) is a probabilistic atlas-based method that calculates synthetic CTs from T2-weight...

    Authors: Elin Wallstén, Jan Axelsson, Joakim Jonsson, Camilla Thellenberg Karlsson, Tufve Nyholm and Anne Larsson
    Citation: EJNMMI Physics 2020 7:68
    Content type: Original research Published on:

  26. Magnetic resonance (MR)-based attenuation correction is a critical component of integrated positron emission tomography (PET)/MR scanners. It is generally achieved by segmenting MR images into tissue classes w...

    Authors: Gaspar Delso, Konstantinos Zeimpekis, Michael Carl, Florian Wiesinger, Martin Hüllner and Patrick Veit-Haibach
    Citation: EJNMMI Physics 2014 1:7
    Content type: Original research Published on:

  27. Optimization of injected gallium-68 (68Ga) activity for 68Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (68Ga-PSMA PET/CT) studies is relevant for image quality, radiation...

    Authors: J. Wielaard, J. B. A. Habraken, P. Brinks, J. Lavalaye and R. Boellaard
    Citation: EJNMMI Physics 2020 7:20
    Content type: Original research Published on:

  28. EQ.PET is a software package that overcomes the reconstruction-dependent variation of standard uptake values (SUV). In this study, we validated the use of EQ.PET for harmonizing SUVs between different positron...

    Authors: Yufei Song, Xiangxi Meng, Zhen Cao, Wei Zhao, Yan Zhang, Rui Guo, Xin Zhou, Zhi Yang and Nan Li
    Citation: EJNMMI Physics 2023 10:19
    Content type: Original research Published on:

  29. The whole brain is often covered in [18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) in oncology patients, but the covered brain abnormality is typically screened by visual interpretation witho...

    Authors: Wonseok Whi, Hongyoon Choi, Jin Chul Paeng, Gi Jeong Cheon, Keon Wook Kang and Dong Soo Lee
    Citation: EJNMMI Physics 2021 8:79
    Content type: Original research Published on:

  30. Patient radioprotection in myocardial perfusion imaging (MPI)-SPECT is important but difficult to optimize. The aim of this study was to adjust injected activity according to patient size—weight or BMI—by usin...

    Authors: Emilie Verrecchia-Ramos, Olivier Morel, Valérie Beauchat, Sylvie Denet, Abdourahamane Djibo Sidikou, Merwan Ginet, Estelle Pfletschinger, Luminita Teodor, Maud Trombowsky, Jeany Verdier, Christelle Vère, Paul Retif and Sinan Ben Mahmoud
    Citation: EJNMMI Physics 2023 10:23
    Content type: Short communication Published on:

  31. The study aimed to establish a 68Ga-FAPI-04 kinetic model in hepatic lesions, to determine the potential role of kinetic parameters in the differentiation of hepatocellular carcinoma (HCC) from non-HCC lesions.

    Authors: Barbara Katharina Geist, Haiqun Xing, Jingnan Wang, Ximin Shi, Haitao Zhao, Marcus Hacker, Xinting Sang, Li Huo and Xiang Li
    Citation: EJNMMI Physics 2021 8:8
    Content type: Short communication Published on:

  32. A Vereos PET/CT device was adapted to be compatible with the experimentation in large animals within BSL-3 environment. The aim of this study was to investigate the impact of this modification on the performan...

    Authors: Nidhal Kahlaoui, Thibaut Naninck, Roger Le Grand and Catherine Chapon
    Citation: EJNMMI Physics 2022 9:22
    Content type: Original research Published on:

  33. Standardized uptake value (SUV) normalized by lean body mass ([LBM] SUL) is recommended as metric by PERCIST 1.0. The James predictive equation (PE) is a frequently used formula for LBM estimation, but may cau...

    Authors: Jingjie Shang, Zhiqiang Tan, Yong Cheng, Yongjin Tang, Bin Guo, Jian Gong, Xueying Ling, Lu Wang and Hao Xu
    Citation: EJNMMI Physics 2021 8:12
    Content type: Original research Published on:

  35. The purpose of this study is to describe a clinical relation of noise equivalent count rate (NECR) - an objective measurement of positron emission tomography (PET) systems - measured in a large number of patie...

    Authors: Marcelo A Queiroz, Scott D Wollenweber, Gustav von Schulthess, Gaspar Delso and Patrick Veit-Haibach
    Citation: EJNMMI Physics 2014 1:103
    Content type: Original research Published on:

  36. 212Pb is a promising radionuclide for targeted alpha therapy. Here, the feasibility of visualising the tumour uptake and biodistribution of 212Pb-NG001 in mice with a clinical SPECT/CT scanner was investigated.

    Authors: Monika Kvassheim, Anna Julie Kjøl Tornes, Asta Juzeniene, Caroline Stokke and Mona-Elisabeth R. Revheim
    Citation: EJNMMI Physics 2023 10:47
    Content type: Short communication Published on:

  37. A strategy for management of radioactive waste associated with 177Lu-dotatate (Lutathera®) treatments was established in our institution, based on predicted storage times of 3–5 years extrapolated from the result...

    Authors: Sylviane Prevot, Inna Dygaï-Cochet, Jean-Marc Riedinger, Jean-Marc Vrigneaud, Myriam Quermonne, Matthieu Gallet and Alexandre Cochet
    Citation: EJNMMI Physics 2023 10:3
    Content type: Short communication Published on:

  38. [11C]-UCB-J is an emerging tool for the noninvasive measurement of synaptic vesicle density in vivo. Here, we report human biodistribution and dosimetry estimates derived from sequential whole-body PET using two ...

    Authors: Christopher Cawthorne, Paul Maguire, Joel Mercier, David Sciberras, Kim Serdons, Guy Bormans, Jan de Hoon, Koen Van Laere and Michel Koole
    Citation: EJNMMI Physics 2021 8:37
    Content type: Short communication Published on:

  39. To confirm the performance of the first hemispherical positron emission tomography (PET) for the brain (Vrain) that we developed to visualise the small nuclei in the deep brain area, we compared 18F-fluorodeoxygl...

    Authors: Miwako Takahashi, Go Akamatsu, Yuma Iwao, Hideaki Tashima, Eiji Yoshida and Taiga Yamaya
    Citation: EJNMMI Physics 2022 9:69
    Content type: Original research Published on:

  40. In this study, we investigate the impact of increased PET acquisition time per bed position on lesion detectability, standard uptake value, and image noise in 68Ga-PSMA-11 PET/MRI scans.

    Authors: Vishnu Murthy, Raven L. Smith, Dora H. Tao, Courtney A. Lawhn-Heath, Dave E. Korenchan, Peder E. Z. Larson, Robert R. Flavell and Thomas A. Hope
    Citation: EJNMMI Physics 2020 7:54
    Content type: Original research Published on:

  41. PET scans using zirconium-89 labelled monoclonal antibodies (89Zr-mAbs), known as 89Zr-immuno-PET, are made to measure uptake in tumour and organ tissue. Uptake is related to the supply of 89Zr-mAbs in the blood....

    Authors: Jessica E. Wijngaarden, Amina Ahbari, Johanna E. E. Pouw, Henri N. J. M. Greuter, Idris Bahce, Gerben J. C. Zwezerijnen, Daniëlle J. Vugts, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt and Marc C. Huisman
    Citation: EJNMMI Physics 2024 11:16
    Content type: Original research Published on:

  42. This study aimed to evaluate the feasibility of 11C-CFT PET brain imaging in Parkinson’s Disease using a total-body PET/CT scanner and explore the optimal scan duration to guide the clinical practice.

    Authors: Xiaolin Sun, Xiaoyue Tan, Qing Zhang, Shanzhen He, Siyun Wang, Yongrong Zhou, Qi Huang and Lei Jiang
    Citation: EJNMMI Physics 2024 11:40
    Content type: Original research Published on:

  43. In this retrospective study, we compared the maximum standardized uptake values (SUVmax) of parathyroid lesions and the target-to-background ratio (TBR) of parathyroid lesions to thyroid tissue in early-phase ...

    Authors: Yuhua Wang, Ye Liu, Na Li, Kang Xu and Wanchun Zhang
    Citation: EJNMMI Physics 2023 10:29
    Content type: Original research Published on:

  44. For pediatric lymphoma, quantitative FDG PET/CT imaging features such as metabolic tumor volume (MTV) are important for prognosis and risk stratification strategies. However, feature extraction is difficult an...

    Authors: Amy J. Weisman, Jihyun Kim, Inki Lee, Kathleen M. McCarten, Sandy Kessel, Cindy L. Schwartz, Kara M. Kelly, Robert Jeraj, Steve Y. Cho and Tyler J. Bradshaw
    Citation: EJNMMI Physics 2020 7:76
    Content type: Original research Published on:

  45. The current MR-based attenuation correction (AC) used in combined PET/MR systems computes a Dixon attenuation map (MR-ACDixon) based on fat and water images derived from in- and opposed-phase MRI. We observed an ...

    Authors: Claes Nøhr Ladefoged, Adam Espe Hansen, Sune Høgild Keller, Søren Holm, Ian Law, Thomas Beyer, Liselotte Højgaard, Andreas Kjær and Flemming Littrup Andersen
    Citation: EJNMMI Physics 2014 1:101
    Content type: Original research Published on:

  46. High activities of holmium-166 (166Ho)–labeled microspheres are used for therapeutic radioembolization, ideally directly followed by SPECT imaging for dosimetry purposes. The resulting high-count rate potentially...

    Authors: Martina Stella, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong and Rob van Rooij
    Citation: EJNMMI Physics 2021 8:22
    Content type: Original research Published on:

  47. Quantitative imaging biomarkers are becoming usual in oncology for assessing therapy response. The harmonization of image quantitation reporting has become of utmost importance due to the multi-center trials i...

    Authors: Delphine Vallot, Elena De Ponti, Sabrina Morzenti, Anna Gramek, Anna Pieczonka, Gabriel Reynés Llompart, Jakub Siennicki, Paul Deak, Chiranjib Dutta, Jorge Uribe and Olivier Caselles
    Citation: EJNMMI Physics 2020 7:30
    Content type: Original research Published on:

  48. Targeted radionuclide therapy (TRT) is gaining importance. For TRT to be also used as adjuvant therapy or for treating minimal residual disease, there is a need to increase the radiation dose to small tumours....

    Authors: Mario E. Alcocer-Ávila, Aymeric Ferreira, Michele A. Quinto, Clément Morgat, Elif Hindié and Christophe Champion
    Citation: EJNMMI Physics 2020 7:33
    Content type: Original Research Published on:

  49. Respiratory motion in PET/CT leads to well-known image degrading effects commonly compensated using elastic motion correction approaches. Gate-to-gate motion correction techniques are promising tools for impro...

    Authors: Stefanie Pösse, Florian Büther, Dirk Mannweiler, Inki Hong, Judson Jones, Michael Schäfers and Klaus Peter Schäfers
    Citation: EJNMMI Physics 2020 7:19
    Content type: Original Research Published on:

  50. To investigate the feasibility of ultra-low-dose CT (ULDCT) reconstructed with the artificial intelligence iterative reconstruction (AIIR) algorithm in total-body PET/CT imaging.

    Authors: Yan Hu, Zhe Zheng, Haojun Yu, Jingyi Wang, Xinlan Yang and Hongcheng Shi
    Citation: EJNMMI Physics 2023 10:1
    Content type: Original Research Published on:
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