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EJNMMI Physics
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  1. Silicon photomultiplier-positron emission tomography (SiPM-PET) has better sensitivity, spatial resolution, and timing resolution than photomultiplier tube (PMT)-PET. The present study aimed to clarify the adv...

    Authors: Kei Wagatsuma, Muneyuki Sakata, Kenji Ishibashi, Akira Hirayama, Hirofumi Kawakami, Kenta Miwa, Yukihisa Suzuki and Kenji Ishii
    Citation: EJNMMI Physics 2020 7:70
    Content type: Original research Published on:

  2. Personalized molecular radiotherapy based on theragnostics requires accurate quantification of the amount of radiopharmaceutical activity administered to patients both in diagnostic and therapeutic application...

    Authors: Clarita Saldarriaga Vargas, Matthias Bauwens, Ivo N. A. Pooters, Stefaan Pommé, Steffie M. B. Peters, Marcel Segbers, Walter Jentzen, Andreas Vogg, Floris H. P. van Velden, Sebastiaan L. Meyer Viol, Martin Gotthardt, Felix M. Mottaghy, Joachim E. Wildberger, Peter Covens and Roel Wierts
    Citation: EJNMMI Physics 2020 7:69
    Content type: Original research Published on:

  3. Arterial blood sampling is the gold standard method to obtain the arterial input function (AIF) for quantification of whole body (WB) dynamic 18F-FDG PET imaging. However, this procedure is invasive and not typic...

    Authors: Mika Naganawa, Jean-Dominique Gallezot, Vijay Shah, Tim Mulnix, Colin Young, Mark Dias, Ming-Kai Chen, Anne M. Smith and Richard E. Carson
    Citation: EJNMMI Physics 2020 7:67
    Content type: Original research Published on:

  4. Halo artifacts from urinary catheters can occur due to inaccurate scatter correction, and the artifacts affect the tumor visibility in 18F-FDG PET/CT images. We investigated the incidence rate and the mechanisms ...

    Authors: Keiichi Magota, Naoto Numata, Daiki Shinyama, Junya Katahata, Yamato Munakata, Piotr J. Maniawski, Kentaro Kobayashi, Osamu Manabe, Kenji Hirata, Ukihide Tateishi, Kohsuke Kudo and Tohru Shiga
    Citation: EJNMMI Physics 2020 7:66
    Content type: Original research Published on:

  5. The aim of this study was to compare brain perfusion SPECT obtained from a 360° CZT and a conventional Anger camera.

    Authors: Manon Bordonne, Mohammad B. Chawki, Pierre-Yves Marie, Timothée Zaragori, Véronique Roch, Rachel Grignon, Laetitia Imbert and Antoine Verger
    Citation: EJNMMI Physics 2020 7:65
    Content type: Original research Published on:

  6. Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These syst...

    Authors: Jan V. Hoffmann, Jan P. Janssen, Takayuki Kanno, Takayuki Shibutani, Masahisa Onoguchi, Constantin Lapa, Jan-Peter Grunz, Andreas K. Buck and Takahiro Higuchi
    Citation: EJNMMI Physics 2020 7:64
    Content type: Original research Published on:

  7. Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly igno...

    Authors: Domenico Finocchiaro, Jonathan I. Gear, Federica Fioroni, Glenn D. Flux, Iain Murray, Gastone Castellani, Annibale Versari, Mauro Iori and Elisa Grassi
    Citation: EJNMMI Physics 2020 7:63
    Content type: Original research Published on:

  8. The CT of PET CT provides diagnostic information, anatomic localisation and attenuation correction (AC). When only AC is required, very lose dose CT is desirable. CT iterative reconstruction (IR) improves imag...

    Authors: Ivan Ho Shon, Christopher Reece, Thomas Hennessy, Megan Horsfield and Bruce McBride
    Citation: EJNMMI Physics 2020 7:62
    Content type: Original research Published on:

  9. Differentiated thyroid cancer has been treated with radioiodine for almost 80 years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresol...

    Authors: Jan Taprogge, Francesca Leek, Tino Schurrat, Johannes Tran-Gia, Delphine Vallot, Manuel Bardiès, Uta Eberlein, Michael Lassmann, Susanne Schlögl, Alex Vergara Gil and Glenn D. Flux
    Citation: EJNMMI Physics 2020 7:61
    Content type: Original research Published on:

  10. This article presents a new perspective on the development of inorganic scintillator-based fiber dosimeters (IOSFDs) for medical radiotherapy dosimetry (RTD) focusing on real-time in vivo dosimetry. The scinti...

    Authors: Liang Ding, Qiong Wu, Qun Wang, Yamei Li, Richard M. Perks and Liang Zhao
    Citation: EJNMMI Physics 2020 7:60
    Content type: Review Published on:

  11. Quantitative evaluation of amyloid positron emission tomography (PET) with standardized uptake value ratio (SUVR) plays a key role in clinical studies of Alzheimer’s disease (AD). We have proposed a PET-only (...

    Authors: Yuma Tsubaki, Go Akamatsu, Natsumi Shimokawa, Suguru Katsube, Aya Takashima and Masayuki Sasaki
    Citation: EJNMMI Physics 2020 7:59
    Content type: Young investigators Published on:

  12. 211At is one of the ideal nuclides for targeted radionuclide therapies (TRTs). Meta-[211At]astatobenzylguanidine (211At-MABG) has been proposed for the treatment of pheochromocytoma. To effectively use these radi...

    Authors: Naoyuki Ukon, Songji Zhao, Kohshin Washiyama, Noboru Oriuchi, Chengbo Tan, Saki Shimoyama, Miho Aoki, Hitoshi Kubo, Kazuhiro Takahashi and Hiroshi Ito
    Citation: EJNMMI Physics 2020 7:58
    Content type: Original research Published on:

  13. Novel partial volume correction (PVC) algorithms have been validated by assuming ideal conditions of image processing; however, in real clinical PET studies, the input datasets include error sources which caus...

    Authors: Senri Oyama, Ayumu Hosoi, Masanobu Ibaraki, Colm J. McGinnity, Keisuke Matsubara, Shoichi Watanuki, Hiroshi Watabe, Manabu Tashiro and Miho Shidahara
    Citation: EJNMMI Physics 2020 7:57
    Content type: Original research Published on:

  14. The Bayesian penalized likelihood (BPL) algorithm Q.Clear (GE Healthcare) allows fully convergent iterative reconstruction that results in better image quality and quantitative accuracy, while limiting image n...

    Authors: Tokiya Yoshii, Kenta Miwa, Masashi Yamaguchi, Kai Shimada, Kei Wagatsuma, Tensho Yamao, Yuto Kamitaka, Seiya Hiratsuka, Rinya Kobayashi, Hajime Ichikawa, Noriaki Miyaji, Tsuyoshi Miyazaki and Kenji Ishii
    Citation: EJNMMI Physics 2020 7:56
    Content type: Original research Published on:

  15. The purpose of this work was to propose an approach based on noise measurement to adapt present clinical acquisition and reconstruction parameters adapted to a PMT-based system (Biograph mCT) to a SiPM-based s...

    Authors: Thomas Carlier, Ludovic Ferrer, Maurizio Conti, Caroline Bodet-Milin, Caroline Rousseau, Yanic Bercier, Bernard Bendriem and Françoise Kraeber-Bodéré
    Citation: EJNMMI Physics 2020 7:55
    Content type: Original research Published on:

  16. In this study, we investigate the impact of increased PET acquisition time per bed position on lesion detectability, standard uptake value, and image noise in 68Ga-PSMA-11 PET/MRI scans.

    Authors: Vishnu Murthy, Raven L. Smith, Dora H. Tao, Courtney A. Lawhn-Heath, Dave E. Korenchan, Peder E. Z. Larson, Robert R. Flavell and Thomas A. Hope
    Citation: EJNMMI Physics 2020 7:54
    Content type: Original research Published on:

  18. The combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) (PET-MRI) is a unique hybrid imaging modality mainly used in oncology and neurology. The MRI-based attenuation correct...

    Authors: Johanna Harries, Thies H. Jochimsen, Thomas Scholz, Tina Schlender, Henryk Barthel, Osama Sabri and Bernhard Sattler
    Citation: EJNMMI Physics 2020 7:52
    Content type: Original research Published on:

  19. Artificial intelligence (AI) is about to transform medical imaging. The Research Consortium for Medical Image Analysis (RECOMIA), a not-for-profit organisation, has developed an online platform to facilitate c...

    Authors: Elin Trägårdh, Pablo Borrelli, Reza Kaboteh, Tony Gillberg, Johannes Ulén, Olof Enqvist and Lars Edenbrandt
    Citation: EJNMMI Physics 2020 7:51
    Content type: Original research Published on:

  20. In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemi...

    Authors: Chang-Hoon Choi, Carina Stegmayr, Aliaksandra Shymanskaya, Wieland A. Worthoff, Nuno A. da Silva, Jörg Felder, Karl-Josef Langen and N. Jon Shah
    Citation: EJNMMI Physics 2020 7:50
    Content type: Original research Published on:

  21. Myocardial perfusion imaging is a commonly performed SPECT protocol and hence it would be beneficial if its scan duration could be shortened. For traditional gamma cameras, two developments have separately sho...

    Authors: Martijn M. A. Dietze, Britt Kunnen, Martina Stella and Hugo W. A. M. de Jong
    Citation: EJNMMI Physics 2020 7:49
    Content type: Original research Published on:

  22. Accurate dosimetry is essential in radioembolization. To this purpose, an automatic protocol for healthy liver dosimetry based on dual isotope (DI) SPECT imaging, combining holmium-166 (166Ho)-microspheres, and t...

    Authors: M. Stella, AJAT Braat, MGEH Lam, HWAM de Jong and R. van Rooij
    Citation: EJNMMI Physics 2020 7:48
    Content type: Original research Published on:

  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: J. E. Mackewn, J. Stirling, S. Jeljeli, S-M Gould, R. I. Johnstone, I. Merida, L. C. Pike, C. J. McGinnity, K. Beck, O. Howes, A. Hammers and P. K. Marsden
    Citation: EJNMMI Physics 2020 7:47
    Content type: Correction Published on:

    The original article was published in EJNMMI Physics 2020 7:24

  25. It has been proposed, and preclinically demonstrated, that 161Tb is a better alternative to 177Lu for the treatment of small prostate cancer lesions due to its high emission of low-energy electrons. 161Tb also em...

    Authors: I. Marin, T. Rydèn, M. Van Essen, J. Svensson, N. Gracheva, U. Köster, J. R. Zeevaart, N. P. van der Meulen, C. Müller and P. Bernhardt
    Citation: EJNMMI Physics 2020 7:45
    Content type: Original research Published on:

  26. In living organisms, the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conv...

    Authors: P. Moskal, D. Kisielewska, R. Y. Shopa, Z. Bura, J. Chhokar, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, R. Del Grande, B. C. Hiesmayr, B. Jasińska, K. Kacprzak…
    Citation: EJNMMI Physics 2020 7:44
    Content type: Original Research Published on:

  28. Time-of-flight (TOF) positron emission tomography (PET) scanners can provide significant benefits by improving the noise properties of reconstructed images. In order to achieve this, the timing response of the...

    Authors: Nikos Efthimiou, Kris Thielemans, Elise Emond, Chris Cawthorne, Stephen J. Archibald and Charalampos Tsoumpas
    Citation: EJNMMI Physics 2020 7:42
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Physics 2022 9:14

  29. Individualized dosimetry is recommended for [177Lu]Lu-PSMA radioligand therapy (RLT) which is resource-intensive and protocols are often not optimized. Therefore, a simulation study was performed focusing on the ...

    Authors: Andreas Rinscheid, Peter Kletting, Matthias Eiber, Ambros J. Beer and Gerhard Glatting
    Citation: EJNMMI Physics 2020 7:41
    Content type: Original research Published on:

  30. Block-sequential regularized expectation maximization (BSREM) is a fully convergent iterative image reconstruction algorithm. We hypothesize that tracers with different distribution patterns will result in dif...

    Authors: Elin Lindström, Lars Lindsjö, Anders Sundin, Jens Sörensen and Mark Lubberink
    Citation: EJNMMI Physics 2020 7:40
    Content type: Original research Published on:

  31. The time-over-threshold (TOT) technique is being used widely due to itsimplications in developing the multi-channel readouts, mainly when fast signal processing is required. Using the TOT technique, as a measu...

    Authors: S. Sharma, J. Chhokar, C. Curceanu, E. Czerwiński, M. Dadgar, K. Dulski, J. Gajewski, A. Gajos, M. Gorgol, N. Gupta-Sharma, R. Del Grande, B.C. Hiesmayr, B. Jasińska, K. Kacprzak, Ł. Kapłon, H. Karimi…
    Citation: EJNMMI Physics 2020 7:39
    Content type: Original Research Published on:

  32. Prostate cancer (PCa) represents one of the most common types of cancers facing the male population. Nowadays, to confirm PCa, systematic or multiparametric MRI-targeted transrectal or transperineal biopsies o...

    Authors: Gabriel Cañizares, Andrea Gonzalez-Montoro, Marta Freire, Efthymios Lamprou, John Barrio, Filomeno Sanchez, José M. Benlloch, Liczandro Hernandez, Laura Moliner, Luis F. Vidal, Irene Torres, Pablo Sopena, Cesar D. Vera-Donoso, Pilar Bello, Julio Barbera and Antonio J. Gonzalez
    Citation: EJNMMI Physics 2020 7:38
    Content type: Original research Published on:

  33. Iodine-125 (125I) seeds can be used as landmarks to locate non-palpable breast lesions instead of implanting metal wires. This relatively new technique requires a nuclear probe usually used for technetium-99m (99...

    Authors: Christopher Hoog, Pierre-Malick Koulibaly, Catherine Dejean, Tom Desdoits, Olivier Humbert, Emmanuel Barranger and Jacques Darcourt
    Citation: EJNMMI Physics 2020 7:37
    Content type: Original research Published on:

  34. Dosimetry after peptide receptor radionuclide therapy (PRRT) is increasing; however, comparing or pooling of dosimetric results can be challenging since different approaches are used. The aim of this study was...

    Authors: Daphne M. V. Huizing, Steffie M. B. Peters, Michelle W. J. Versleijen, Esther Martens, Marcel Verheij, Michiel Sinaasappel, Marcel P. M. Stokkel and Berlinda J. de Wit-van der Veen
    Citation: EJNMMI Physics 2020 7:36
    Content type: Original research Published on:

  35. The idea of a very sensitive positron emission tomography (PET) system covering a large portion of the body of a patient already dates back to the early 1990s. In the period 2000–2010, only some prototypes wit...

    Authors: Stefaan Vandenberghe, Pawel Moskal and Joel S. Karp
    Citation: EJNMMI Physics 2020 7:35
    Content type: Review Published on:

  36. This study investigated the impact of the size of the normal database on the classification performance of the specific binding ratio (SBR) in dopamine transporter (DAT) SPECT with [123I]FP-CIT in different setti...

    Authors: Helen Schmitz-Steinkrüger, Catharina Lange, Ivayla Apostolova, Holger Amthauer, Wencke Lehnert, Susanne Klutmann and Ralph Buchert
    Citation: EJNMMI Physics 2020 7:34
    Content type: Original research Published on:

  37. Targeted radionuclide therapy (TRT) is gaining importance. For TRT to be also used as adjuvant therapy or for treating minimal residual disease, there is a need to increase the radiation dose to small tumours....

    Authors: Mario E. Alcocer-Ávila, Aymeric Ferreira, Michele A. Quinto, Clément Morgat, Elif Hindié and Christophe Champion
    Citation: EJNMMI Physics 2020 7:33
    Content type: Original Research Published on:

  38. Dead time may affect the accuracy of quantitative SPECT (QPSECT), and thus of dosimetry. The aim of this study was to quantify the effect of dead time on 177Lu-QSPECT and renal dosimetry following peptide recepto...

    Authors: Alessandro Desy, Guillaume F. Bouvet, Andrea Frezza, Philippe Després and Jean-Mathieu Beauregard
    Citation: EJNMMI Physics 2020 7:32
    Content type: Short communication Published on:

  39. Prostate-specific membrane antigen (PSMA) radiotracers such as [18F]PSMA-1007 used with positron emission tomography-computed tomography (PET-CT) is promising for initial staging and detection of recurrent diseas...

    Authors: Elin Trägårdh, David Minarik, Gustav Brolin, Ulrika Bitzén, Berit Olsson and Jenny Oddstig
    Citation: EJNMMI Physics 2020 7:31
    Content type: Original research Published on:

  40. Quantitative imaging biomarkers are becoming usual in oncology for assessing therapy response. The harmonization of image quantitation reporting has become of utmost importance due to the multi-center trials i...

    Authors: Delphine Vallot, Elena De Ponti, Sabrina Morzenti, Anna Gramek, Anna Pieczonka, Gabriel Reynés Llompart, Jakub Siennicki, Paul Deak, Chiranjib Dutta, Jorge Uribe and Olivier Caselles
    Citation: EJNMMI Physics 2020 7:30
    Content type: Original research Published on:

  41. Strong correlation has been demonstrated between tumor dose and response and between healthy liver dose and side effects. Individualized dosimetry is increasingly recommended in the current clinical routine. H...

    Authors: Nicolas Meyers, Alexandre Jadoul, Claire Bernard, Jean Delwaide, Anne Lamproye, Olivier Detry, Pierre Honoré, Laurent Gerard and Roland Hustinx
    Citation: EJNMMI Physics 2020 7:29
    Content type: Original research Published on:

  42. To determine the impact of the Bayesian penalized likelihood (BPL) reconstruction algorithm in comparison to OSEM on hypoxia PET/CT images of NSCLC using 18F-MIZO and 18F-FAZA.

    Authors: Edgar Texte, Pierrick Gouel, Sébastien Thureau, Justine Lequesne, Bertrand Barres, Agathe Edet-Sanson, Pierre Decazes, Pierre Vera and Sébastien Hapdey
    Citation: EJNMMI Physics 2020 7:28
    Content type: Original research Published on:

  43. For therapeutic applications of several isotopes (e.g., 131I, 153Sm, 177Lu) in nuclear medicine, the high activities typically applied require accurate dead time correction in early time point imaging. We present...

    Authors: Jan W. T. Heemskerk and Michel Defrise
    Citation: EJNMMI Physics 2020 7:27
    Content type: Original research Published on:

  44. Over recent years, peptide receptor radiotherapy (PRRT) has been recognized as an effective treatment for patients with metastatic neuroendocrine tumors (NETs). Personalized dosimetry can contribute to improve...

    Authors: Nanette Freedman, Mattias Sandström, Jonathan Kuten, Natan Shtraus, Inna Ospovat, Albert Schlocker and Einat Even-Sapir
    Citation: EJNMMI Physics 2020 7:26
    Content type: Short communication Published on:

  45. Arterial sampling in PET studies for the purposes of kinetic modeling remains an invasive, time-intensive, and expensive procedure. Alternatives to derive the blood time-activity curve (BTAC) non-invasively ar...

    Authors: Yassine Toufique, Othmane Bouhali, Pauline Negre and Jim O’ Doherty
    Citation: EJNMMI Physics 2020 7:25
    Content type: Original research Published on:

  46. Despite the advent of clinical PET-MR imaging for routine use in 2011 and the development of several methods to address the problem of attenuation correction, some challenges remain. We have identified and inv...

    Authors: J. E. Mackewn, J. Stirling, S. Jeljeli, S-M. Gould, R. I. Johnstone, I. Merida, L. C. Pike, C. J. McGinnity, K. Beck, O. Howes, A. Hammers and P. K. Marsden
    Citation: EJNMMI Physics 2020 7:24
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Physics 2020 7:47

  47. A GATE Monte Carlo model of the Philips Vereos digital photon counting PET imaging system using silicon photo-multiplier detectors was proposed. It was evaluated against experimental data in accordance with NE...

    Authors: Julien Salvadori, Joey Labour, Freddy Odille, Pierre-Yves Marie, Jean-Noël Badel, Laëtitia Imbert and David Sarrut
    Citation: EJNMMI Physics 2020 7:23
    Content type: Original Research Published on:

  48. For multicenter clinical studies, PET/CT and SPECT/CT scanners need to be validated to ensure comparability between various scanner types and brands. This validation is usually performed using hollow phantoms ...

    Authors: Tilman Läppchen, Lorenz P. Meier, Markus Fürstner, George A. Prenosil, Thomas Krause, Axel Rominger, Bernd Klaeser and Michael Hentschel
    Citation: EJNMMI Physics 2020 7:22
    Content type: Original research Published on:

  49. Lutetium oxyorthosilicate or lutetium yttrium oxyorthosilicate (LYSO) scintillation crystals used in most current PET scanner detectors contain 176Lu, which decays by beta emission to excited states of 176Hf acco...

    Authors: Francisco Eduardo Enríquez-Mier-y-Terán, Ana Saret Ortega-Galindo, Tirso Murrieta-Rodríguez, Mercedes Rodríguez-Villafuerte, Arnulfo Martínez-Dávalos and Héctor Alva-Sánchez
    Citation: EJNMMI Physics 2020 7:21
    Content type: Original research Published on:

  50. Optimization of injected gallium-68 (68Ga) activity for 68Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (68Ga-PSMA PET/CT) studies is relevant for image quality, radiation...

    Authors: J. Wielaard, J. B. A. Habraken, P. Brinks, J. Lavalaye and R. Boellaard
    Citation: EJNMMI Physics 2020 7:20
    Content type: Original research Published on:
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