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  1. [18F]-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography (PET-CT) is a well-established modality in the work-up of patients with suspected or confirmed diagnosis of lung cancer. Recent...

    Authors: Pablo Borrelli, John Ly, Reza Kaboteh, Johannes Ulén, Olof Enqvist, Elin Trägårdh and Lars Edenbrandt
    Citation: EJNMMI Physics 2021 8:32
  2. Deep learning (DL)-based image quality improvement is a novel technique based on convolutional neural networks. The aim of this study was to compare the clinical value of 18F-fluorodeoxyglucose positron emission ...

    Authors: Junichi Tsuchiya, Kota Yokoyama, Ken Yamagiwa, Ryosuke Watanabe, Koichiro Kimura, Mitsuhiro Kishino, Chung Chan, Evren Asma and Ukihide Tateishi
    Citation: EJNMMI Physics 2021 8:31
  3. Applied tube voltage (kilovolts, kV) and tube current (milliampere seconds, mAs) affect CT radiation dose and image quality and should be optimised for the individual patient. CARE kV determines the kV and mAs...

    Authors: Natalie A. Bebbington, Troels Jørgensen, Erik Dupont and Mille A. Micheelsen
    Citation: EJNMMI Physics 2021 8:29
  4. Regular and precise inspection of the realization of the local nuclear medicine standard operation procedures (SOPs) is very complex and time-consuming, especially when large amount of patient data is obtained...

    Authors: Ferenc Nagy, Aron K. Krizsan, Kornél Kukuts, Melinda Szolikova, Zsolt Hascsi, Sandor Barna, Antonietta Acs, Peter Szabo, Lajos Tron, Laszlo Balkay, Magnus Dahlbom, Mihaly Zentai, Attila Forgacs and Ildiko Garai
    Citation: EJNMMI Physics 2021 8:28
  5. Different gamma camera calibration factor (CF) geometries have been proposed to convert SPECT data into units of activity concentration. However, no consensus has been reached on a standardised geometry. The C...

    Authors: Keamogetswe Ramonaheng, Johannes A. van Staden and Hanlie du Raan
    Citation: EJNMMI Physics 2021 8:27
  6. Patients with metastatic, castration-resistant prostate cancer (mCRPC) present with an increased tumor burden in the skeleton. For these patients, Lutetium-177 (Lu-177) radioligand therapy targeting the prosta...

    Authors: Julia Brosch-Lenz, Carlos Uribe, Astrid Gosewisch, Lena Kaiser, Andrei Todica, Harun Ilhan, Franz Josef Gildehaus, Peter Bartenstein, Arman Rahmim, Anna Celler, Sibylle Ziegler and Guido Böning
    Citation: EJNMMI Physics 2021 8:26

    The Correction to this article has been published in EJNMMI Physics 2021 8:36

  7. To determine whether artificial intelligence (AI) processed PET/CT images of reduced by one-third of 18-F-FDG activity compared to the standard injected dose, were non-inferior to native scans and if so to ass...

    Authors: Katia Katsari, Daniele Penna, Vincenzo Arena, Giulia Polverari, Annarita Ianniello, Domenico Italiano, Rolando Milani, Alessandro Roncacci, Rowland O. Illing and Ettore Pelosi
    Citation: EJNMMI Physics 2021 8:25
  8. Accurate quantification of radioactivity, measured by an integrated positron emission tomography (PET) and magnetic resonance imaging (MRI) system, is still a challenge. One aspect of such a challenge is to co...

    Authors: Adam Farag, R. Terry Thompson, Jonathan D. Thiessen, Frank S. Prato and Jean Théberge
    Citation: EJNMMI Physics 2021 8:24
  9. Functional lung mapping from Ga68-ventilation/perfusion (V/Q) PET/CT, which has been shown to correlate with pulmonary function tests (PFTs), may be beneficial in a number of clinical applications where sparing r...

    Authors: Lachlan McIntosh, Price Jackson, Nicholas Hardcastle, Mathias Bressel, Tomas Kron, Jason W. Callahan, Daniel Steinfort, Nicholas Bucknell, Michael S. Hofman and Shankar Siva
    Citation: EJNMMI Physics 2021 8:23
  10. High activities of holmium-166 (166Ho)–labeled microspheres are used for therapeutic radioembolization, ideally directly followed by SPECT imaging for dosimetry purposes. The resulting high-count rate potentially...

    Authors: Martina Stella, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong and Rob van Rooij
    Citation: EJNMMI Physics 2021 8:22
  11. To identify the impact of segmentation methods and intensity discretization on radiomic features (RFs) extraction from 68Ga-DOTA-TOC PET images in patients with neuroendocrine tumors.

    Authors: Virginia Liberini, Bruno De Santi, Osvaldo Rampado, Elena Gallio, Beatrice Dionisi, Francesco Ceci, Giulia Polverari, Philippe Thuillier, Filippo Molinari and Désirée Deandreis
    Citation: EJNMMI Physics 2021 8:21
  12. The Siemens high-resolution research tomograph (HRRT - a dedicated brain PET scanner) is to this day one of the highest resolution PET scanners; thus, it can serve as useful benchmark when evaluating performan...

    Authors: Julia G. Mannheim, Ju-Chieh (Kevin) Cheng, Nasim Vafai, Elham Shahinfard, Carolyn English, Jessamyn McKenzie, Jing Zhang, Laura Barlow and Vesna Sossi
    Citation: EJNMMI Physics 2021 8:20
  13. A novel generation of PET scanners based on silicon (Si)-photomultiplier (PM) technology has recently been introduced. Concurrently, there has been development of new reconstruction methods aimed at increasing...

    Authors: Jenny Oddstig, Gustav Brolin, Elin Trägårdh and David Minarik
    Citation: EJNMMI Physics 2021 8:19
  14. PET/MRI phantom studies are challenged by the need of phantom-specific attenuation templates to account for attenuation properties of the phantom material. We present a PET/MRI phantom built from MRI-visible m...

    Authors: Ivo Rausch, Alejandra Valladares, Lalith Kumar Shiyam Sundar, Thomas Beyer, Marcus Hacker, Martin Meyerspeer and Ewald Unger
    Citation: EJNMMI Physics 2021 8:18
  15. To systematically evaluate the consistency of various standardized uptake value (SUV) lean body mass (LBM) normalization methods in a clinical positron emission tomography/magnetic resonance imaging (PET/MR) s...

    Authors: Jun Zhao, Qiaoyi Xue, Xing Chen, Zhiwen You, Zhe Wang, Jianmin Yuan, Hui Liu and Lingzhi Hu
    Citation: EJNMMI Physics 2021 8:17
  16. SPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due to the limited spatial resolution of the gamma camera. Incorporating resolution modellin...

    Authors: H. Marquis, D. Deidda, A. Gillman, K. P. Willowson, Y. Gholami, T. Hioki, E. Eslick, K. Thielemans and D. L. Bailey
    Citation: EJNMMI Physics 2021 8:16
  17. SPECT-CT using radiolabeled phosphonates is considered a standard for assessing bone metabolism (e.g., in patients with osteoarthritis of knee joints). However, SPECT can be influenced by metal artifacts in CT...

    Authors: Oliver S. Grosser, Marcus Klutzny, Heiko Wissel, Dennis Kupitz, Michael Finger, Simone Schenke, Jan Wuestemann, Christoph H. Lohmann, Christoph Hoeschen, Maciej Pech, Christian Staerke and Michael C. Kreissl
    Citation: EJNMMI Physics 2021 8:15
  18. In recurrent differentiated thyroid cancer patients, detectability in 124I PET is limited for lesions with low radioiodine uptake. We assess the improvements in lesion detectability and image quality between thre...

    Authors: David Kersting, Walter Jentzen, Miriam Sraieb, Pedro Fragoso Costa, Maurizio Conti, Lale Umutlu, Gerald Antoch, Michael Nader, Ken Herrmann, Wolfgang Peter Fendler, Christoph Rischpler and Manuel Weber
    Citation: EJNMMI Physics 2021 8:14
  19. Image quality and quantitative accuracy of positron emission tomography (PET) depend on several factors such as uptake time, scanner characteristics and image reconstruction methods. Ordered subset expectation...

    Authors: Alexandre Chicheportiche, Elinor Goshen, Jeremy Godefroy, Simona Grozinsky-Glasberg, Kira Oleinikov, Amichay Meirovitz, David J. Gross and Simona Ben-Haim
    Citation: EJNMMI Physics 2021 8:13
  20. Standardized uptake value (SUV) normalized by lean body mass ([LBM] SUL) is recommended as metric by PERCIST 1.0. The James predictive equation (PE) is a frequently used formula for LBM estimation, but may cau...

    Authors: Jingjie Shang, Zhiqiang Tan, Yong Cheng, Yongjin Tang, Bin Guo, Jian Gong, Xueying Ling, Lu Wang and Hao Xu
    Citation: EJNMMI Physics 2021 8:12
  21. Whole-body Patlak images can be obtained from an acquisition of first 6 min of dynamic imaging over the heart to obtain the arterial input function (IF), followed by multiple whole-body sweeps up to 60 min pi....

    Authors: Joyce van Sluis, Maqsood Yaqub, Adrienne H. Brouwers, Rudi A. J. O. Dierckx, Walter Noordzij and Ronald Boellaard
    Citation: EJNMMI Physics 2021 8:11
  22. The SwiftScan solution (General Electric Healthcare) combines a new low-energy high-resolution sensitivity collimator and a tomographic step-and-shoot continuous (SSC) mode acquisition. The purpose of this study ...

    Authors: Valentin Picone, Nikolaos Makris, Fanny Boutevin, Sarah Roy, Margot Playe and Michael Soussan
    Citation: EJNMMI Physics 2021 8:10
  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hugo Levillain, Manuela Burghelea, Ivan Duran Derijckere, Thomas Guiot, Akos Gulyban, Bruno Vanderlinden, Michael Vouche, Patrick Flamen and Nick Reynaert
    Citation: EJNMMI Physics 2021 8:9

    The original article was published in EJNMMI Physics 2020 7:75

  24. The study aimed to establish a 68Ga-FAPI-04 kinetic model in hepatic lesions, to determine the potential role of kinetic parameters in the differentiation of hepatocellular carcinoma (HCC) from non-HCC lesions.

    Authors: Barbara Katharina Geist, Haiqun Xing, Jingnan Wang, Ximin Shi, Haitao Zhao, Marcus Hacker, Xinting Sang, Li Huo and Xiang Li
    Citation: EJNMMI Physics 2021 8:8
  25. Respiratory motion compromises image quality in myocardial perfusion (MP) single-photon emission computed tomography (SPECT) imaging and may affect analysis of left ventricular (LV) functional parameters, incl...

    Authors: Matti J Kortelainen, Tuomas M Koivumäki, Marko J Vauhkonen and Mikko A Hakulinen
    Citation: EJNMMI Physics 2021 8:7
  26. The aim of this study was to evaluate the use of a Bayesian penalized likelihood reconstruction algorithm (Q.Clear) for 89Zr-immunoPET image reconstruction and its potential to improve image quality and reduce th...

    Authors: Julian Kirchner, Joseph A. O’Donoghue, Anton S. Becker and Gary A. Ulaner
    Citation: EJNMMI Physics 2021 8:6
  27. Using phantoms and clinical studies in prone hanging breast imaging, we assessed the image quality of a commercially available dedicated breast PET (dbPET) at the detector’s edge, where mammary glands near the...

    Authors: Yoko Satoh, Utaroh Motosugi, Masamichi Imai, Yoshie Omiya and Hiroshi Onishi
    Citation: EJNMMI Physics 2021 8:5
  28. An individual dosimetry system is essential for the evaluation of precise doses in nuclear medicine. The purpose of this study was to develop a system for calculating not only absorbed doses but also EQDX(α/β) fr...

    Authors: Tatsuhiko Sato, Takuya Furuta, Yuwei Liu, Sadahiro Naka, Shushi Nagamori, Yoshikatsu Kanai and Tadashi Watabe
    Citation: EJNMMI Physics 2021 8:4
  29. 99mTc-PYP scintigraphy provides differential diagnosis of ATTR cardiomyopathy (ATTR-CM) from light chain cardiac amyloidosis and other myocardial disorders without biopsy. This study was aimed to assess the diagn...

    Authors: Chao Ren, Jingyun Ren, Zhuang Tian, Yanrong Du, Zhixin Hao, Zongyao Zhang, Wei Fang, Fang Li, Shuyang Zhang, Bailing Hsu and Li Huo
    Citation: EJNMMI Physics 2021 8:3
  30. Digital PET involving silicon photomultipliers (SiPM) provides an enhanced time-of-flight (TOF) resolution as compared with photomultiplier (PMT)-based PET, but also a better prevention of the count-related ri...

    Authors: Julien Salvadori, Freddy Odille, Gilles Karcher, Pierre-Yves Marie and Laetitia Imbert
    Citation: EJNMMI Physics 2021 8:1
  31. A valid photon attenuation correction (AC) method is instrumental for obtaining quantitatively correct PET images. Integrated PET/MR systems provide no direct information on attenuation, and novel methods for ...

    Authors: João M. Sousa, Lieuwe Appel, Inés Merida, Rolf A. Heckemann, Nicolas Costes, Mathias Engström, Stergios Papadimitriou, Dag Nyholm, Håkan Ahlström, Alexander Hammers and Mark Lubberink
    Citation: EJNMMI Physics 2020 7:77
  32. For pediatric lymphoma, quantitative FDG PET/CT imaging features such as metabolic tumor volume (MTV) are important for prognosis and risk stratification strategies. However, feature extraction is difficult an...

    Authors: Amy J. Weisman, Jihyun Kim, Inki Lee, Kathleen M. McCarten, Sandy Kessel, Cindy L. Schwartz, Kara M. Kelly, Robert Jeraj, Steve Y. Cho and Tyler J. Bradshaw
    Citation: EJNMMI Physics 2020 7:76
  33. The relationship between the mean absorbed dose delivered to the tumour and the outcome in liver metastases from colorectal cancer patients treated with radioembolization has already been presented in several ...

    Authors: Hugo Levillain, Manuela Burghelea, Ivan Duran Derijckere, Thomas Guiot, Akos Gulyban, Bruno Vanderlinden, Michael Vouche, Patrick Flamen and Nick Reynaert
    Citation: EJNMMI Physics 2020 7:75

    The Correction to this article has been published in EJNMMI Physics 2021 8:9

  34. To evaluate whether lesion radiomics features and absorbed dose metrics extracted from post-therapy 90Y PET can be integrated to better predict outcomes in microsphere radioembolization of liver malignancies

    Authors: Lise Wei, Can Cui, Jiarui Xu, Ravi Kaza, Issam El Naqa and Yuni K. Dewaraja
    Citation: EJNMMI Physics 2020 7:74
  35. Fractionated peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE is increasingly applied as an effective treatment for patients with disseminated neuroendocrine tumors. In parallel to dose planning b...

    Authors: Mattias Sandström, Nanette Freedman, Katarzyna Fröss-Baron, Tanweera Kahn and Anders Sundin
    Citation: EJNMMI Physics 2020 7:73
  36. Prior radioembolization, a simulation using 99mTc-macroaggregated albumin as 90Y-microspheres surrogate is performed. Gamma scintigraphy images (planar, SPECT, or SPECT-CT) are acquired to evaluate intrahepatic 9...

    Authors: Verónica Morán, Elena Prieto, Lidia Sancho, Macarena Rodríguez-Fraile, Leticia Soria, Arantxa Zubiria and Josep M. Martí-Climent
    Citation: EJNMMI Physics 2020 7:72
  37. Silicon photomultiplier-positron emission tomography (SiPM-PET) has better sensitivity, spatial resolution, and timing resolution than photomultiplier tube (PMT)-PET. The present study aimed to clarify the adv...

    Authors: Kei Wagatsuma, Muneyuki Sakata, Kenji Ishibashi, Akira Hirayama, Hirofumi Kawakami, Kenta Miwa, Yukihisa Suzuki and Kenji Ishii
    Citation: EJNMMI Physics 2020 7:70
  38. Personalized molecular radiotherapy based on theragnostics requires accurate quantification of the amount of radiopharmaceutical activity administered to patients both in diagnostic and therapeutic application...

    Authors: Clarita Saldarriaga Vargas, Matthias Bauwens, Ivo N. A. Pooters, Stefaan Pommé, Steffie M. B. Peters, Marcel Segbers, Walter Jentzen, Andreas Vogg, Floris H. P. van Velden, Sebastiaan L. Meyer Viol, Martin Gotthardt, Felix M. Mottaghy, Joachim E. Wildberger, Peter Covens and Roel Wierts
    Citation: EJNMMI Physics 2020 7:69
  39. Attenuation correction of PET/MRI is a remaining problem for whole-body PET/MRI. The statistical decomposition algorithm (SDA) is a probabilistic atlas-based method that calculates synthetic CTs from T2-weight...

    Authors: Elin Wallstén, Jan Axelsson, Joakim Jonsson, Camilla Thellenberg Karlsson, Tufve Nyholm and Anne Larsson
    Citation: EJNMMI Physics 2020 7:68
  40. Arterial blood sampling is the gold standard method to obtain the arterial input function (AIF) for quantification of whole body (WB) dynamic 18F-FDG PET imaging. However, this procedure is invasive and not typic...

    Authors: Mika Naganawa, Jean-Dominique Gallezot, Vijay Shah, Tim Mulnix, Colin Young, Mark Dias, Ming-Kai Chen, Anne M. Smith and Richard E. Carson
    Citation: EJNMMI Physics 2020 7:67
  41. Halo artifacts from urinary catheters can occur due to inaccurate scatter correction, and the artifacts affect the tumor visibility in 18F-FDG PET/CT images. We investigated the incidence rate and the mechanisms ...

    Authors: Keiichi Magota, Naoto Numata, Daiki Shinyama, Junya Katahata, Yamato Munakata, Piotr J. Maniawski, Kentaro Kobayashi, Osamu Manabe, Kenji Hirata, Ukihide Tateishi, Kohsuke Kudo and Tohru Shiga
    Citation: EJNMMI Physics 2020 7:66
  42. The aim of this study was to compare brain perfusion SPECT obtained from a 360° CZT and a conventional Anger camera.

    Authors: Manon Bordonne, Mohammad B. Chawki, Pierre-Yves Marie, Timothée Zaragori, Véronique Roch, Rachel Grignon, Laetitia Imbert and Antoine Verger
    Citation: EJNMMI Physics 2020 7:65
  43. Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These syst...

    Authors: Jan V. Hoffmann, Jan P. Janssen, Takayuki Kanno, Takayuki Shibutani, Masahisa Onoguchi, Constantin Lapa, Jan-Peter Grunz, Andreas K. Buck and Takahiro Higuchi
    Citation: EJNMMI Physics 2020 7:64
  44. Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly igno...

    Authors: Domenico Finocchiaro, Jonathan I. Gear, Federica Fioroni, Glenn D. Flux, Iain Murray, Gastone Castellani, Annibale Versari, Mauro Iori and Elisa Grassi
    Citation: EJNMMI Physics 2020 7:63
  45. The CT of PET CT provides diagnostic information, anatomic localisation and attenuation correction (AC). When only AC is required, very lose dose CT is desirable. CT iterative reconstruction (IR) improves imag...

    Authors: Ivan Ho Shon, Christopher Reece, Thomas Hennessy, Megan Horsfield and Bruce McBride
    Citation: EJNMMI Physics 2020 7:62
  46. Differentiated thyroid cancer has been treated with radioiodine for almost 80 years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresol...

    Authors: Jan Taprogge, Francesca Leek, Tino Schurrat, Johannes Tran-Gia, Delphine Vallot, Manuel Bardiès, Uta Eberlein, Michael Lassmann, Susanne Schlögl, Alex Vergara Gil and Glenn D. Flux
    Citation: EJNMMI Physics 2020 7:61
  47. This article presents a new perspective on the development of inorganic scintillator-based fiber dosimeters (IOSFDs) for medical radiotherapy dosimetry (RTD) focusing on real-time in vivo dosimetry. The scinti...

    Authors: Liang Ding, Qiong Wu, Qun Wang, Yamei Li, Richard M. Perks and Liang Zhao
    Citation: EJNMMI Physics 2020 7:60