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EJNMMI Physics
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  1. Absolute quantification of radiotracer distribution using SPECT/CT imaging is of great importance for dosimetry aimed at personalized radionuclide precision treatment. However, its accuracy depends on many fac...

    Authors: Steffie M. B. Peters, Niels R. van der Werf, Marcel Segbers, Floris H. P. van Velden, Roel Wierts, Koos (J.) A. K. Blokland, Mark W. Konijnenberg, Sergiy V. Lazarenko, Eric P. Visser and Martin Gotthardt
    Citation: EJNMMI Physics 2019 6:29
    Content type: Original research Published on:

  2. Recently, updated EARL specifications (EARL2) have been developed and announced. This study aims at investigating the impact of the EARL2 specifications on the quantitative reads of clinical PET–CT studies and...

    Authors: Andres Kaalep, Coreline N. Burggraaff, Simone Pieplenbosch, Eline E. Verwer, Terez Sera, Josee Zijlstra, Otto S. Hoekstra, Daniela E. Oprea-Lager and Ronald Boellaard
    Citation: EJNMMI Physics 2019 6:28
    Content type: Original research Published on:

  3. We aim to provide a systematic study of the impact of white matter (WM) spill-in on the calculation of standardized uptake value ratios (SUVRs) on Aβ-negative subjects, and we study the effect of including WM ...

    Authors: Francisco Javier López-González, Alexis Moscoso, Nikos Efthimiou, Anxo Fernández-Ferreiro, Manuel Piñeiro-Fiel, Stephen J. Archibald, Pablo Aguiar and Jesús Silva-Rodríguez
    Citation: EJNMMI Physics 2019 6:27
    Content type: Original research Published on:

  4. Compartmental modelling is an established method of quantifying 18F-FDG uptake; however, only recently has it been applied to evaluate pulmonary inflammation. Implementation of compartmental models remains challe...

    Authors: Laurence D. Vass, Sarah Lee, Frederick J. Wilson, Marie Fisk, Joseph Cheriyan and Ian Wilkinson
    Citation: EJNMMI Physics 2019 6:26
    Content type: Original Research Published on:

  5. Multi-tracer positron emission tomography (PET) imaging can be accomplished by applying multi-tracer compartment modeling. Recently, a method has been proposed in which the arterial input functions (AIFs) of t...

    Authors: Carlos Velasco, Adriana Mota-Cobián, Jesús Mateo and Samuel España
    Citation: EJNMMI Physics 2019 6:25
    Content type: Original research Published on:

  6. Computed tomography (CT) scans are routinely performed in positron emission tomography (PET) and single photon emission computed tomography (SPECT) examinations globally, yet few surveys have been conducted to...

    Authors: Natalie A. Bebbington, Bryan T. Haddock, Henrik Bertilsson, Eero Hippeläinen, Ellen M. Husby, Virpi I. Tunninen and Marcus Söderberg
    Citation: EJNMMI Physics 2019 6:24
    Content type: Original research Published on:

  7. The decay characteristics of radionuclides in PET studies can impact image reconstruction. 44gSc has been the topic of recent research due to potential theranostic applications and is a promising radiometal for P...

    Authors: Simon Ferguson, Hans-Sonke Jans, Melinda Wuest, Terence Riauka and Frank Wuest
    Citation: EJNMMI Physics 2019 6:23
    Content type: Original research Published on:

  8. Q.Clear is a block sequential regularized expectation maximization (BSREM) penalized-likelihood reconstruction algorithm for PET. It tries to improve image quality by controlling noise amplification during ima...

    Authors: Paulo R. R. V. Caribé, M. Koole, Yves D’Asseler, B. Van Den Broeck and S. Vandenberghe
    Citation: EJNMMI Physics 2019 6:22
    Content type: Original research Published on:

  9. To determine the clinically acceptable level of reduction in the injected fluorine-18 (18F)-labeled fluorodeoxyglucose (18F-FDG) dose in dedicated breast positron emission tomography (dbPET).

    Authors: Yoko Satoh, Tetsuro Sekine, Yoshie Omiya, Hiroshi Onishi and Utaroh Motosugi
    Citation: EJNMMI Physics 2019 6:21
    Content type: Original research Published on:

  10. Volumes of usual PET phantoms are about four to sixfold that of a human liver. In order to avoid count rate saturation and handling of very high 90Y activity, reported TOF-PET phantom studies are performed using ...

    Authors: Michel Hesse and Stephan Walrand
    Citation: EJNMMI Physics 2019 6:20
    Content type: Artefact report Published on:

  11. Performance standards for quantitative 18F-FDG PET/CT studies are provided by the EANM Research Ltd. (EARL) to enable comparability of quantitative PET in multicentre studies. Yet, such specifications are not ava...

    Authors: Daphne M. V. Huizing, Daniëlle Koopman, Jorn A. van Dalen, Martin Gotthardt, Ronald Boellaard, Terez Sera, Michiel Sinaasappel, Marcel P. M. Stokkel and Berlinda J. de Wit-van der Veen
    Citation: EJNMMI Physics 2019 6:19
    Content type: Short communication Published on:

  13. Cerenkov Luminescence Imaging (CLI) is an emerging technology for intraoperative margin assessment. Previous research only evaluated radionuclide 18-Fluorine (18F); however, for future applications in prostate ca...

    Authors: J. olde Heuvel, B. J. de Wit-van der Veen, K. N. Vyas, D. S. Tuch, M. R. Grootendorst, M. P. M. Stokkel and C. H. Slump
    Citation: EJNMMI Physics 2019 6:17
    Content type: Original research Published on:

  14. The technology of modern positron emission tomography (PET) systems continuously improving, and with it the possibility to detect smaller lesions. Since first introduced in 2010, the number of hybrid PET/magne...

    Authors: Silje Kjærnes Øen, Lars Birger Aasheim, Live Eikenes and Anna Maria Karlberg
    Citation: EJNMMI Physics 2019 6:16
    Content type: Original research Published on:

  15. Software for Tomographic Image Reconstruction (STIR) is an open-source library for PET and SPECT image reconstruction, implementing iterative reconstruction as well as 2D- and 3D-filtered back projection. Quan...

    Authors: Parisa Khateri, Jannis Fischer, Werner Lustermann, Charalampos Tsoumpas and Günther Dissertori
    Citation: EJNMMI Physics 2019 6:15
    Content type: Original research Published on:

  16. Monte Carlo-based iterative reconstruction to correct for photon scatter and collimator effects has been proven to be superior over analytical correction schemes in single-photon emission computed tomography (...

    Authors: Martijn M. A. Dietze, Woutjan Branderhorst, Britt Kunnen, Max A. Viergever and Hugo W. A. M. de Jong
    Citation: EJNMMI Physics 2019 6:14
    Content type: Original research Published on:

  17. The α-emitting radionuclide radium-223 (223Ra) is widely used for the treatment of bone metastasis in patients with castration-resistant prostate cancer. However, 223Ra decays into radon-219 (219Rn) which is a no...

    Authors: Kazuhiro Ooe, Tadashi Watabe, Takashi Kamiya, Takashi Yoshimura, Makoto Hosono, Atsushi Shinohara and Jun Hatazawa
    Citation: EJNMMI Physics 2019 6:13
    Content type: Original research Published on:

  18. The heart-to-mediastinum (H/M) ratio is a commonly used parameter to measure cardiac I-123 metaiodobenzylguanidine (MIBG) uptake. Since the H/M ratio is substantially influenced by the collimator type, we inve...

    Authors: Joachim Brumberg, Ganna Blazhenets, Nils Schröter, Lars Frings, Wolfgang H. Jost, Constantin Lapa and Philipp T. Meyer
    Citation: EJNMMI Physics 2019 6:12
    Content type: Original research Published on:

  19. Fully integrated PET/MR systems are being used frequently in clinical research and routine. National Electrical Manufacturers Association (NEMA) characterization of these systems is generally done with 18F which ...

    Authors: Paulo R. R. V. Caribé, M. Koole, Yves D’Asseler, Timothy W. Deller, K. Van Laere and S. Vandenberghe
    Citation: EJNMMI Physics 2019 6:11
    Content type: Original research Published on:

  20. Squamous cell carcinoma in the head and neck region is one of the most widespread cancers with high morbidity. Classic treatment comprises the complete removal of the lymphatics together with the cancerous tis...

    Authors: Peter A. von Niederhäusern, Simon Pezold, Uri Nahum, Carlo Seppi, Guillaume Nicolas, Michael Rissi, Stephan K. Haerle and Philippe C. Cattin
    Citation: EJNMMI Physics 2019 6:10
    Content type: Original research Published on:

  21. Gadolinium nanoparticles (Gd-NP) combined with radiotherapy are investigated for radiation dose enhancement in radiotherapy treatment. Indeed, NPs concentrated in a tumor could enhance its radiosensitization. ...

    Authors: Olga Kochebina, Adrien Halty, Jacqueline Taleb, David Kryza, Marc Janier, Alexandre Bani Sadr, Thomas Baudier, Simon Rit and David Sarrut
    Citation: EJNMMI Physics 2019 6:9
    Content type: Original research Published on:

  23. 177Lu-DOTATATE peptide receptor radionuclide therapy is administered to patients on an inpatient and outpatient basis for the treatment of well-differentiated, metastatic neuroendocrine tumours. Following adminis...

    Authors: D. Levart, E. Kalogianni, B. Corcoran, N. Mulholland and G. Vivian
    Citation: EJNMMI Physics 2019 6:7
    Content type: Original research Published on:

  25. Recently, the block-sequential regularized expectation maximization (BSREM) reconstruction algorithm was commercially introduced (Q.Clear, GE Healthcare, Milwaukee, WI, USA). However, the combination of noise-...

    Authors: Mimmi Bjöersdorff, Jenny Oddstig, Nina Karindotter-Borgendahl, Helén Almquist, Sophia Zackrisson, David Minarik and Elin Trägårdh
    Citation: EJNMMI Physics 2019 6:5
    Content type: Original research Published on:

  26. Quantification is one of the key benefits of nuclear medicine imaging. Recently, driven by the demand for post radionuclide therapy imaging, quantitative SPECT has moved from relative and semiquantitative meas...

    Authors: John Dickson, James Ross and Stefan Vöö
    Citation: EJNMMI Physics 2019 6:4
    Content type: Opinion article Published on:

  27. 68Ga-labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC ([68Ga]PSMA-11) has been increasingly used to image prostate cancer using positron emission tomography (PET)/computed tomography (CT) both during diagnosis and treatment...

    Authors: Kristina Sandgren, Lennart Johansson, Jan Axelsson, Joakim Jonsson, Mattias Ögren, Margareta Ögren, Martin Andersson, Sara Strandberg, Tufve Nyholm, Katrine Riklund and Anders Widmark
    Citation: EJNMMI Physics 2019 6:2
    Content type: Original research Published on:

  28. PET imaging has been, and continues to be, an evolving diagnostic technology. In recent years, the modernizing digital landscape has opened new opportunities for data-driven innovation. One such facet has been...

    Authors: Adam Kesner, C. Ross Schmidtlein and Claudia Kuntner
    Citation: EJNMMI Physics 2019 6:3
    Content type: Commentary Published on:

  30. This study aims to assess both feasibility and accuracy of renal dosimetry imaging protocols in patients receiving Lutate therapy for neuroendocrine tumours (NETs), when data acquisition over multiple days is ...

    Authors: Kathy P. Willowson, Enid Eslick, Hyunju Ryu, Aurora Poon, Elizabeth J. Bernard and Dale L. Bailey
    Citation: EJNMMI Physics 2018 5:33
    Content type: Original research Published on:

  31. 15O-oxygen inhalation PET is unique in its ability to provide fundamental information regarding cerebral hemodynamics and energy metabolism in man. However, the use of 15O-oxygen has been limited in a clinical en...

    Authors: Satoshi Iguchi, Tetsuaki Moriguchi, Makoto Yamazaki, Yuki Hori, Kazuhiro Koshino, Kazunori Toyoda, Jarmo Teuho, Saeka Shimochi, Yusuke Terakawa, Tetsuya Fukuda, Jun C. Takahashi, Jyoji Nakagawara, Shigehiko Kanaya and Hidehiro Iida
    Citation: EJNMMI Physics 2018 5:37
    Content type: Original research Published on:

  32. Radioiodine has been used for the treatment of benign thyroid diseases for over 70 years. However, internationally, there is no common standard for pretherapeutic dosimetry to optimally define the individual t...

    Authors: Jochen Hammes, Lutz van Heek, Melanie Hohberg, Manuel Reifegerst, Simone Stockter, Markus Dietlein, Markus Wild, Alexander Drzezga, Matthias Schmidt and Carsten Kobe
    Citation: EJNMMI Physics 2018 5:32
    Content type: Original research Published on:

  33. The aim of this study was to evaluate the predictive power of the absorbed dose to kidneys after the first course of treatment with [177Lu]-DOTA-TATE for neuroendocrine tumors (NETs) on the cumulative kidney abso...

    Authors: Alexandre Chicheportiche, Simona Grozinsky-Glasberg, David J. Gross, Yodphat Krausz, Asher Salmon, Amichay Meirovitz, Nanette Freedman and Jeremy Godefroy
    Citation: EJNMMI Physics 2018 5:36
    Content type: Original research Published on:

  34. The aim of this study was to compare liver and oncologic lesion standardized uptake values (SUV) obtained through two different reconstruction protocols, GE’s newest clinical lesion detection protocol (Q.Clear...

    Authors: Joke Devriese, Laurence Beels, Alex Maes, Christophe Van de Wiele and Hans Pottel
    Citation: EJNMMI Physics 2018 5:35
    Content type: Original research Published on:

  35. Rhenium-188-labelled-Lipiodol radioembolization is a safe and cost-effective treatment for primary liver cancer. In order to determine correlations between treatment doses and patient response to therapy, accu...

    Authors: Pedro L. Esquinas, Ajit Shinto, Koramadai K. Kamaleshwaran, Jephy Joseph and Anna Celler
    Citation: EJNMMI Physics 2018 5:30
    Content type: Original research Published on:

  36. Positron emission tomography (PET) imaging has a wide applicability in oncology, cardiology and neurology. However, a major drawback when imaging very active regions such as the bladder is the spill-in effect,...

    Authors: Mercy I. Akerele, Palak Wadhwa, Jesus Silva-Rodriguez, William Hallett and Charalampos Tsoumpas
    Citation: EJNMMI Physics 2018 5:34
    Content type: Young investigators Published on:

  37. Generation of a SPECT scan during procedure may aid in the optimization of treatments as liver radioembolization by offering image-guided dosimetry. This, however, requires both shortened acquisition times and...

    Authors: Martijn M. A. Dietze, Sandra van der Velden, Marnix G. E. H. Lam, Max A. Viergever and Hugo W. A. M. de Jong
    Citation: EJNMMI Physics 2018 5:28
    Content type: Original research Published on:

  38. PoleStar m660 is a newly developed clinical PET/CT system with time-of-flight (TOF) capability. The aim of this study is to characterize the performance of the new system. Spatial resolution, sensitivity, scat...

    Authors: Li Huo, Nan Li, Heyu Wu, Wenjia Zhu, Haiqun Xing, Jiantao Ba, Tong Wang, Fang Li and Hui Zhang
    Citation: EJNMMI Physics 2018 5:29
    Content type: Original research Published on:

  39. The purpose was to validate 90Y PET gradient-based tumor segmentation in phantoms and to evaluate the impact of the segmentation method on reported tumor absorbed dose (AD) and biological effective dose (BED) in

    Authors: Justin K. Mikell, Ravi K. Kaza, Peter L. Roberson, Kelly C. Younge, Ravi N. Srinivasa, Bill S. Majdalany, Kyle C. Cuneo, Dawn Owen, Theresa Devasia, Matthew J. Schipper and Yuni K. Dewaraja
    Citation: EJNMMI Physics 2018 5:31
    Content type: Original research Published on:

  41. To develop and evaluate the feasibility of a data-driven deep learning approach (deepAC) for positron-emission tomography (PET) image attenuation correction without anatomical imaging. A PET attenuation correc...

    Authors: Fang Liu, Hyungseok Jang, Richard Kijowski, Gengyan Zhao, Tyler Bradshaw and Alan B. McMillan
    Citation: EJNMMI Physics 2018 5:24
    Content type: Original research Published on:

  42. Radioembolization is an established treatment for chemoresistant and unresectable liver cancers. Currently, treatment planning is often based on semi-empirical methods, which yield acceptable toxicity profiles...

    Authors: Remco Bastiaannet, S. Cheenu Kappadath, Britt Kunnen, Arthur J. A. T. Braat, Marnix G. E. H. Lam and Hugo W. A. M. de Jong
    Citation: EJNMMI Physics 2018 5:22
    Content type: Review Published on:

  43. MRI does not offer a direct method to obtain attenuation correction maps as its predecessors (stand-alone PET and PET/CT), and bone visualisation is particularly challenging. Recently, zero-echo-time (ZTE) was...

    Authors: João M. Sousa, Lieuwe Appel, Mathias Engström, Stergios Papadimitriou, Dag Nyholm, Elna-Marie Larsson, Håkan Ahlström and Mark Lubberink
    Citation: EJNMMI Physics 2018 5:20
    Content type: Original research Published on:

  44. Routine dosimetry is essential for personalized 177Lu-octreotate peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs), but practical and robust dosimetry methods are needed for wide clinic...

    Authors: Michela Del Prete, Frédéric Arsenault, Nassim Saighi, Wei Zhao, François-Alexandre Buteau, Anna Celler and Jean-Mathieu Beauregard
    Citation: EJNMMI Physics 2018 5:25
    Content type: Original research Published on:

  45. [18F]Fluortriopride (FTP) was developed as a dopamine D3-selective radiotracer, thought to be important to neurobiological reward pathways and implicated in drug addiction, Parkinson’s disease, and schizophrenia....

    Authors: Robert K. Doot, Jacob G. Dubroff, Joshua S. Scheuermann, Kyle J. Labban, Jenny Cai, Chia-Ju Hsieh, Shihong Li, Hsiaoju Lee, Erin K. Schubert, Catherine Hou, Regan Sheffer, Alexander Schmitz, Kuiying Xu and Robert H. Mach
    Citation: EJNMMI Physics 2018 5:21
    Content type: Original research Published on:

  46. The aim of this study was to evaluate and compare PET image reconstruction algorithms on novel digital silicon photomultiplier PET/CT in patients with newly diagnosed and histopathologically confirmed lung can...

    Authors: Michael Messerli, Paul Stolzmann, Michèle Egger-Sigg, Josephine Trinckauf, Stefano D’Aguanno, Irene A. Burger, Gustav K. von Schulthess, Philipp A. Kaufmann and Martin W. Huellner
    Citation: EJNMMI Physics 2018 5:27
    Content type: Original research Published on:

  47. Positron-emission tomography (PET) simulators are frequently used for development and performance evaluation of segmentation methods or quantitative uptake metrics. To date, most PET simulation tools are based...

    Authors: Elisabeth Pfaehler, Johan R. De Jong, Rudi A. J. O. Dierckx, Floris H. P. van Velden and Ronald Boellaard
    Citation: EJNMMI Physics 2018 5:16
    Content type: Original research Published on:

  48. Dose rate variation is a critical factor affecting radionuclide therapy (RNT) efficacy. Relatively few studies to date have investigated the dose rate effect in RNT. Therefore, the aim of this study was to ben...

    Authors: Yaser H. Gholami, Kathy P. Willowson, Nicholas J. Forwood, Rozelle Harvie, Nicholas Hardcastle, Regina Bromley, HyunJu Ryu, Samuel Yuen, Viive M. Howell, Zdenka Kuncic and Dale L. Bailey
    Citation: EJNMMI Physics 2018 5:18
    Content type: Original research Published on:

  49. The aim of our study was to compare 90Y dosimetry obtained from PET/MRI versus PET/CT post-therapy imaging among patients with primary or metastatic hepatic tumors.

    Authors: Karin Knešaurek, Abbas Tuli, Edward Kim, Sherif Heiba and Lale Kostakoglu
    Citation: EJNMMI Physics 2018 5:23
    Content type: Original research Published on:

  50. Radiomercury 197mHg and 197Hg, henceforth referred to as 197(m)Hg, is a promising theranostic radionuclide endowed with properties that allow diagnostic and therapeutic applications. The aim of this work was to i...

    Authors: Robert Freudenberg, Rudi Apolle, Martin Walther, Holger Hartmann and Jörg Kotzerke
    Citation: EJNMMI Physics 2018 5:15
    Content type: Original research Published on:
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