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  1. Original Research

    A CZT-based blood counter for quantitative molecular imaging

    Robust quantitative analysis in positron emission tomography (PET) and in single-photon emission computed tomography (SPECT) typically requires the time-activity curve as an input function for the pharmacokine...

    Romain Espagnet, Andrea Frezza, Jean-Pierre Martin, Louis-André Hamel, Laëtitia Lechippey, Jean-Mathieu Beauregard and Philippe Després

    EJNMMI Physics 2017 4:18

    Published on: 2 June 2017

  2. Original research

    EORTC PET response criteria are more influenced by reconstruction inconsistencies than PERCIST but both benefit from the EARL harmonization program

    This study evaluates the consistency of PET evaluation response criteria in solid tumours (PERCIST) and European Organisation for Research and Treatment of Cancer (EORTC) classification across different recons...

    Charline Lasnon, Elske Quak, Pierre-Yves Le Roux, Philippe Robin, Michael S. Hofman, David Bourhis, Jason Callahan, David S. Binns, Cédric Desmonts, Pierre-Yves Salaun, Rodney J. Hicks and Nicolas Aide

    EJNMMI Physics 2017 4:17

    Published on: 30 May 2017

  3. Original research

    Using 31P-MRI of hydroxyapatite for bone attenuation correction in PET-MRI: proof of concept in the rodent brain

    The correction of γ-photon attenuation in PET-MRI remains a critical issue, especially for bone attenuation. This problem is of great importance for brain studies due to the density of the skull. Current techn...

    Vincent Lebon, Sébastien Jan, Yoann Fontyn, Brice Tiret, Géraldine Pottier, Emilie Jaumain and Julien Valette

    EJNMMI Physics 2017 4:16

    Published on: 2 May 2017

  4. Commentary

    Saul Hertz, MD, and the birth of radionuclide therapy

    The year, 2016, marked the 75th anniversary of Dr. Saul Hertz first using radioiodine to treat a patient with thyroid disease. In November of 1936, a luncheon was held of the faculty of Harvard Medical School ...

    Frederic H. Fahey, Frederick D. Grant and James H. Thrall

    EJNMMI Physics 2017 4:15

    Published on: 27 April 2017

  5. Original research

    Minimum lesion detectability as a measure of PET system performance

    A phantom in combination with an imaging protocol was developed to measure the limit of small lesion detection on different PET systems. Seven small spheres with inner diameters ranging from 3.95 up to 15.43 m...

    Stephen Adler, Jurgen Seidel, Peter Choyke, Michael V. Knopp, Katherine Binzel, Jun Zhang, Craig Barker, Shielah Conant and Roberto Maass-Moreno

    EJNMMI Physics 2017 4:13

    Published on: 4 March 2017

  6. Original research

    Depth of interaction determination in monolithic scintillator with double side SiPM readout

    Monolithic scintillators read out by arrays of photodetectors represent a promising solution to obtain high spatial resolution and the depth of interaction (DOI) of the annihilation photon. We have recently in...

    Matteo Morrocchi, Giovanni Ambrosi, Maria Giuseppina Bisogni, Filippo Bosi, Marco Boretto, Piergiorgio Cerello, Maria Ionica, Ben Liu, Francesco Pennazio, Maria Antonietta Piliero, Giovanni Pirrone, Vasile Postolache, Richard Wheadon and Alberto Del Guerra

    EJNMMI Physics 2017 4:11

    Published on: 16 February 2017

  7. Short communication

    Digital PET compliance to EARL accreditation specifications

    Our aim was to evaluate if a recently introduced TOF PET system with digital photon counting technology (Philips Healthcare), potentially providing an improved image quality over analogue systems, can fulfil E...

    Daniëlle Koopman, Maureen Groot Koerkamp, Pieter L. Jager, Hester Arkies, Siert Knollema, Cornelis H. Slump, Pedro G. Sanches and Jorn A. van Dalen

    EJNMMI Physics 2017 4:9

    Published on: 31 January 2017

  8. Original research

    [123I]FP-CIT ENC-DAT normal database: the impact of the reconstruction and quantification methods

    [123I]FP-CIT is a well-established radiotracer for the diagnosis of dopaminergic degenerative disorders. The European Normal Control Database of DaTSCAN (ENC-DAT) of healthy controls has provided age and gender-s...

    Livia Tossici-Bolt, John C. Dickson, Terez Sera, Jan Booij, Susanne Asenbaun-Nan, Maria C. Bagnara, Thierry Vander Borght, Cathrine Jonsson, Robin de Nijs, Swen Hesse, Pierre M. Koulibaly, Umit O. Akdemir, Michel Koole, Klaus Tatsch and Andrea Varrone

    EJNMMI Physics 2017 4:8

    Published on: 28 January 2017

  9. Original research

    Accuracy and precision assessment for activity quantification in individualized dosimetry of 177Lu-DOTATATE therapy

    In order to obtain a reliable 177Lu-DOTATATE therapy dosimetry, it is crucial to acquire accurate and precise activity measurements with the radionuclide calibrator, the SPECT/CT camera, and the NaI(Tl) well coun...

    Gwennaëlle Marin, Bruno Vanderlinden, Ioannis Karfis, Thomas Guiot, Zena Wimana, Patrick Flamen and Stefaan Vandenberghe

    EJNMMI Physics 2017 4:7

    Published on: 26 January 2017

  10. Original Research

    3D absorbed dose distribution estimated by Monte Carlo simulation in radionuclide therapy with a monoclonal antibody targeting synovial sarcoma

    Radiolabeled OTSA101, a monoclonal antibody targeting synovial sarcoma (SS) developed by OncoTherapy Science, was used to treat relapsing SS metastases following a theranostic procedure: in case of significant 11...

    David Sarrut, Jean-Noël Badel, Adrien Halty, Gwenaelle Garin, David Perol, Philippe Cassier, Jean-Yves Blay, David Kryza and Anne-Laure Giraudet

    EJNMMI Physics 2017 4:6

    Published on: 18 January 2017

  11. Short communication

    An experimental phantom study of the effect of gadolinium-based MR contrast agents on PET attenuation coefficients and PET quantification in PET-MR imaging: application to cardiac studies

    Simultaneous cardiac perfusion studies are an increasing trend in PET-MR imaging. During dynamic PET imaging, the introduction of gadolinium-based MR contrast agents (GBCA) at high concentrations during a dual...

    Jim O’ Doherty and Paul Schleyer

    EJNMMI Physics 2017 4:4

    Published on: 13 January 2017

  12. Original research

    Accuracy of 177Lu activity quantification in SPECT imaging: a phantom study

    The aim of the study is to assess accuracy of activity quantification of 177Lu studies performed according to recommendations provided by the committee on Medical Internal Radiation Dose (MIRD) pamphlets 23 and 2...

    Carlos F. Uribe, Pedro L. Esquinas, Jesse Tanguay, Marjorie Gonzalez, Emilie Gaudin, Jean-Mathieu Beauregard and Anna Celler

    EJNMMI Physics 2017 4:2

    Published on: 7 January 2017

  13. Original research

    Quantitative myocardial blood flow imaging with integrated time-of-flight PET-MR

    The use of integrated PET-MR offers new opportunities for comprehensive assessment of cardiac morphology and function. However, little is known on the quantitative accuracy of cardiac PET imaging with integrat...

    Tanja Kero, Jonny Nordström, Hendrik J. Harms, Jens Sörensen, Håkan Ahlström and Mark Lubberink

    EJNMMI Physics 2017 4:1

    Published on: 6 January 2017

  14. Original research

    A gamma-distribution convolution model of 99mTc-MIBI thyroid time-activity curves

    The convolution approach to thyroid time-activity curve (TAC) data fitting with a gamma distribution convolution (GDC) TAC model following bolus intravenous injection is presented and applied to 99mTc-MIBI data. ...

    Carl A. Wesolowski, Surajith N. Wanasundara, Michal J. Wesolowski, Belkis Erbas and Paul S. Babyn

    EJNMMI Physics 2016 3:31

    Published on: 16 December 2016

  15. Original research

    Pharmacokinetic modeling of a novel hypoxia PET tracer [18F]HX4 in patients with non-small cell lung cancer

    [18F]HX4 is a promising new PET tracer developed to identify hypoxic areas in tumor tissue. This study analyzes [18F]HX4 kinetics and assesses the performance of simplified methods for quantification of [18F]HX4 ...

    E. E. Verwer, C. M. L. Zegers, W. van Elmpt, R. Wierts, A. D. Windhorst, F. M. Mottaghy, P. Lambin and R. Boellaard

    EJNMMI Physics 2016 3:30

    Published on: 12 December 2016

  16. Original Research

    A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin

    Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nea...

    Wietske Woliner-van der Weg, Laura N. Deden, Antoi P. W. Meeuwis, Maaike Koenrades, Laura H. C. Peeters, Henny Kuipers, Geert Jan Laanstra, Martin Gotthardt, Cornelis H. Slump and Eric P. Visser

    EJNMMI Physics 2016 3:29

    Published on: 7 December 2016

  17. Original research

    Estimation of activity of administered 18F-fluorodeoxyglucose by measurement of the dose equivalent rate on the right temporal region of the head

    Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) is now a routine procedure for the management of cancer patients. Intravenous administration of FDG is sometimes halted due to troubles. In suc...

    Kenta Sakaguchi, Makoto Hosono, Tomomi Imamura, Naomi Takahara, Misa Hayashi, Yuko Yakushiji, Kazunari Ishii, Tatsuro Uto and Takamichi Murakami

    EJNMMI Physics 2016 3:28

    Published on: 14 November 2016

  18. Original research

    Left ventricular function assessment using 123I/99mTc dual-isotope acquisition with two semi-conductor cadmium–zinc–telluride (CZT) cameras: a gated cardiac phantom study

    The impact of increased energy resolution of cadmium–zinc–telluride (CZT) cameras on the assessment of left ventricular function under dual-isotope conditions (99mTc and 123I) remains unknown.

    Tanguy Blaire, Alban Bailliez, Fayçal Ben Bouallegue, Dimitri Bellevre, Denis Agostini and Alain Manrique

    EJNMMI Physics 2016 3:27

    Published on: 11 November 2016

  19. Original article

    Evaluation of spatial dependence of point spread function-based PET reconstruction using a traceable point-like 22Na source

    The point spread function (PSF) of positron emission tomography (PET) depends on the position across the field of view (FOV). Reconstruction based on PSF improves spatial resolution and quantitative accuracy. ...

    Taisuke Murata, Kenta Miwa, Noriaki Miyaji, Kei Wagatsuma, Tomoyuki Hasegawa, Keiichi Oda, Takuro Umeda, Takashi Iimori, Yoshitada Masuda, Takashi Terauchi and Mitsuru Koizumi

    EJNMMI Physics 2016 3:26

    Published on: 26 October 2016

  20. Original research

    Radiation dosimetry of the α4β2 nicotinic receptor ligand (+)-[18F]flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results

    Both enantiomers of [18F]flubatine are new radioligands for neuroimaging of α4β2 nicotinic acetylcholine receptors with positron emission tomography (PET) exhibiting promising pharmacokinetics which makes them at...

    Mathias Kranz, Bernhard Sattler, Solveig Tiepolt, Stephan Wilke, Winnie Deuther-Conrad, Cornelius K. Donat, Steffen Fischer, Marianne Patt, Andreas Schildan, Jörg Patt, René Smits, Alexander Hoepping, Jörg Steinbach, Osama Sabri and Peter Brust

    EJNMMI Physics 2016 3:25

    Published on: 21 October 2016

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