Tumor response prediction in 90Y radioembolization with PET-based radiomics features and absorbed dose metrics

EJNMMI Physics

Table 1 Summary of statistical analysis for volume, the 15 robust radiomics features, and absorbed dose with Bonferroni correction

	Features	Spearman correlation with absorbed dose	p value for dose correlation	Spearman correlation with OR	p value for OR	C-index for progression	Hazard ratio for progression	p value for progression
	Volume	− 0.262	0.007	− 0.215	0.028	0.565	0.282	0.417
Global	Sphericity	0.061	0.539	0.142	0.148	0.590	0.728	0.313
GLCM	Correlation	− 0.340	3.882e−4	− 0.216	0.027	0.438	1.019	0.950
GLRLM	GLN	− 0.362	1.45e−4	− 0.269	0.006	0.600	0.297	0.323
GLRLM	RLN	− 0.252	0.010	− 0.236	0.015	0.639	0.213	0.201
GLSZM	LZE	− 0.482	1.989e−7	− 0.333	0.0005	0.562	0.415	0.629
	GLN	− 0.078	0.427	− 0.121	0.218	0.734	0.326	0.088
	ZSN	− 0.057	0.565	− 0.081	0.412	0.752	0.358	0.063
	ZP	0.483	1.828e−7	0.341	0.0004	0.491	0.804	0.502
	LZLGE	− 0.548	1.485e−9	− 0.317	0.001	0.460	0.872	0.760
	LZHGE	− 0.293	0.002	− 0.300	0.002	0.676	0.006	0.348
	GLV	0.467	5.104e−7	0.320	0.0009	0.549	0.491	0.136
NGTDM	Coarseness	0.379	6.789e−5	0.285	0.003	0.601	1.027	0.930
	Busyness	− 0.509	2.862e−8	− 0.307	0.001	0.482	0.522	0.585
	Complexity	0.324	7.596e−4	0.244	0.012	0.609	1.124	0.657
	Strength	0.245	0.012	0.284	0.003	0.669	1.110	0.321
DOSE	Mean absorbed dose	NA	NA	0.345	0.0003	0.819	0.121	0.005