Impact of point spread function modelling and time of flight on FDG uptake measurements in lung lesions using alternative filtering strategies

EJNMMI Physics

Table 4 Relative uptake differences for matched voxel COV

Uptake		TOF	HD	UHD
SUV_max	Mean% change	+8.8%	+32%	+49%
	95% CI	−7.2% to +25%	+7.8% to +55%	+1.0% to +97%
	n > 25% change	4/74	50/74	63/74
SUV_peak	Mean% change	+6.9%	+17%	+27%
	95% CI	−5.7% to +20%	+5.3% to +29%	+1.6% to +51%
	n > 30% change	1/74	1/74	25/74
TLG-40	Mean% change	+1.9%	−8.4%	−7.5%
	95% CI	−16% to +20%	−29% to +12%	−37% to +22%

Mean percentage changes and 95% confidence intervals of the three uptake measures relative to OSEM reconstruction. Also shown are the number of lesions with a greater than 25% and 30% increase in SUV_max and SUV_peak, respectively. Data in the table are from images using post-filters to match image voxel COV.