Combining MRI with PET for partial volume correction improves image-derived input functions in mice
© Evans et al; licensee Springer 2014
Published: 29 July 2014
Kinetic modelling in PET requires the arterial input function (AIF), defined as the time-activity curve (TAC) in plasma. This measure is challenging to obtain in mice due to low blood volumes, resulting in a reliance on image-based methods for AIF derivation. We present a comparison of PET- and MR-based region-of-interest (ROI) analysis to obtain image-derived AIFs from the left ventricle (LV) of a mouse model. ROI-based partial volume correction (PVC) was performed to improve quantification.
Glucose metabolism K i (ml/min/cm3), Mean ± SD
0.03 ± 0.01
0.03 ± 0.01
0.4 ± 0.3
0.6 ± 0.2*
0.03 ± 0.01
0.03 ± 0.02
0.2 ± 0.3
0.2 ± 0.2*
GTM-based PVC gives best results in mice when ROIs are based on MRI data, due to its high-resolution and excellent soft-tissue contrast.
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