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Towards authentically labelled bi-modal PET(SPECT)/MR-probes

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Application of radiolabelled, existing MRI probes using a suitable reporter group for multimodal PET(SPECT)/MRI imaging is limited due to the required alteration of the molecular structure and thus changing their in vivo properties. Radiolabelling of existing MRI contrast agents with PET(SPECT) isotopes of paramagnetic elements offers a simple way to address this issue. Therefore, new routes to the production of SPECT/PET-radionuclides 147,149Gd and 52gMn were examined which can be applied for n.c.a. labelling of Gd(III) and Mn(II) MRI contrast agents. Additionally, Mn(II)-based complexes stable for in vivo application are to be synthesized.

Reaction cross sections and experimental thick target yields were measured by irradiation of natCr or Eu2O3. Integral yields were calculated from measured excitation functions. A radiochemical separation of Mn from Cr was developed based on cation-exchange chromatography [1].

Cross section data of the natEu(d,x) and natEu(p,x) reactions were measured up to 70.9 MeV and 44.8 MeV, respectively. Integral yields of up to 177.3 MBq/μAh and 81.6 MBq/μAh for natEu(d,x)147,149Gd reactions and up to 43.3 MBq/μAh and 61.8 MBq/μAh for natEu(p,x)147,149Gd reactions, respectively, were calculated. Those were several times higher than for α- or 3He induced reactions on highly enriched 144Sm [2, 3].

With n.c.a. 52Mn, also cross sections of co-produced 48V, 48,49,51Cr, 52gMn were determined in the energy range of 7.6 to 45 MeV. The production rates of 52g,mMn were measured from 8.2 to 16.9 MeV with up to 13.1 MBq/μAh which was separated from natCr by column chromatography.

Production data of the SPECT nuclides 147,149Gd and the PET nuclide 52gMn were established. Different to Mn a practical isolation procedure for Gd is still required. Current work focuses on the radiolabelling of stable complexes of manganese (II) with the goal to develop PET/MRI tracers addressing molecular targets.

References

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    Buchholz M, Spahn I, Scholten B, Coenen HH: Cross-section measurements for the formation of manganese-52 and its isolation with a non-hazardous eluent. Radiochimica Acta 2013, 101: 491–9.

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    Denzler F-O, Rösch F, Qaim SM: Excitation functions of a- and 3 He-particle induced nuclear reactions on highly enriched 147 Sm and 144 Sm: Comparative evaluation of production routes for 147 Gd. Radiochimica Acta 1995, 69: 209–213.

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    Denzler F-O, Lebedev NA, Novgorodov AF, Rösch F, Qaim SM: Production and radiochemical separation of 147 Gd. Appl. Radiat. Isot. 1997, 48: 319–26. 10.1016/S0969-8043(96)00221-7

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Correspondence to Heinrich H Coenen.

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Coenen, H.H., Buchholz, M., Spahn, I. et al. Towards authentically labelled bi-modal PET(SPECT)/MR-probes. EJNMMI Phys 1, A79 (2014) doi:10.1186/2197-7364-1-S1-A79

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Keywords

  • Excitation Function
  • Reaction Cross Section
  • Radiochemical Separation
  • Integral Yield
  • Thick Target