Volume 1 Supplement 1
Generation of pseudo-CT from a single MRI for PET/MR attenuation correction purposes
© Monnier et al; licensee Springer 2014
Published: 29 July 2014
Current MR attenuation correction (AC) approaches suffer from the lack of precision in the detection of bone and the assigned attenuation coefficients. In general, no unique transformation of MR image intensities into attenuation coefficients exists. The purpose of this work is to derive attenuation coefficient maps from a single MR sequence through the generation of a pseudo-CT map using a derived MRI intensity - CT Hounsfield Units (HU) relationship.
where FF is the voxel-wise fat fraction, HUfat (-102HU) and HUwater (48HU) are reference HU values for fat and water obtained from our dataset.
Pseudo-CT scans were subsequently obtained using the proposed method after segmentation of bones from MRI data using a Fuzzy C-Means algorithm. Pseudo-CT and associated derived attenuations maps were compared with the corresponding acquired CT images. In addition, corresponding PET raw datasets were simulated with lesions placed on key regions of the pelvis.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.