Volume 1 Supplement 1
Identification and characterization of human brown adipose tissue (BAT) content and metabolism in adults using [18F]-FDG PET/MR – a pilot study
© Johannesen et al; licensee Springer 2014
Published: 29 July 2014
Brown adipose tissue (BAT) is present in human adults and when present visualised with [18F]-FDG PET. It contains large amounts of mitochondriae, which gives a higher water content compared to white adipose tissue and a high FDG avidity when activated .
Five adults underwent PET/MR. BAT was cold-activated using a water-perfused vest, with injection of 100Mbq FDG after 60 minutes . Hereafter cervical regions were scanned on an Siemens Biograph mMR 3T. PET was performed as single bed 10 minutes acquisition.
MRI included DIXON sequence for attenuation correction and axial T2 weighted sequences with and without water suppression, the latter for calculation of water percentage (W%).
No significant correlation was found between water percentage in fat tissue with or without BAT, maybe because the two modalities measures different physiological properties. Accordingly, BAT can be present but not activated and therefore measurements with both modalities seems necessary for fully characterization of BAT.
- Cypess AM, Lehman S, et al.: Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009,360(15):1509–17. 10.1056/NEJMoa0810780PubMed CentralPubMedView ArticleGoogle Scholar
- van Rooijen BD, van der Lans AA, et al.: Imaging cold-activated brown adipose tissue using dynamic T2*-weighted magnetic resonance imaging and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography. Invest Radiol 2013,48(10):708–14. 10.1097/RLI.0b013e31829363b8PubMedView ArticleGoogle Scholar
- Chen YC, Cypess AM, et al.: Measurement of human brown adipose tissue volume and activity using anatomic MR imaging and functional MR imaging. J Nucl Med 2013,54(9):1584–7. 10.2967/jnumed.112.117275PubMed CentralPubMedView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.