Skip to main content
EJNMMI Physics
Download PDF

Volume 1 Supplement 1

Proceedings of the 3rd PSMR Conference on PET/MR and SPECT/MR

Identification and characterization of human brown adipose tissue (BAT) content and metabolism in adults using [18F]-FDG PET/MR – a pilot study

EJNMMI Physics volume 1, Article number: A68 (2014) Cite this article

Brown adipose tissue (BAT) is present in human adults and when present visualised with [18F]-FDG PET. It contains large amounts of mitochondriae, which gives a higher water content compared to white adipose tissue and a high FDG avidity when activated [1].

Five adults underwent PET/MR. BAT was cold-activated using a water-perfused vest, with injection of 100Mbq FDG after 60 minutes [2]. Hereafter cervical regions were scanned on an Siemens Biograph mMR 3T. PET was performed as single bed 10 minutes acquisition.

MRI included DIXON sequence for attenuation correction and axial T2 weighted sequences with and without water suppression, the latter for calculation of water percentage (W%).

ROIs were drawn on T2 images omitting vessels and muscle and propagated to PET images and to calculated water percentage maps (Figure 1). Subcutaneous fat regions were used as reference (SC).

Figure 1
figure 1

T2, water % , T2/PET and PET images.

Full size image

FDG-PET identified activated BAT in 3 of 5 subjects. On each scan eight ROIs were drawn, including one reference region (SC). SUVmean for BAT, nBAT and SC were 1.60 (SD 0.26), 0.38 ( 0.12) and 0.64 (0.12) respectively (Figure 2). Calculated water percentage MRI maps for these regions were 19.6% (SD2.9%), 16.5% (4.2%) and 16.8% (1.6%) respectively (Figure 3). No significant difference in W% was found between BAT and nBAT.

Figure 2
figure 2

Box plot SUV value BAT, SC, nBAT

Full size image
Figure 3
figure 3

Box plot W% BAT, SC, nBAT

Full size image

No significant correlation was found between water percentage in fat tissue with or without BAT, maybe because the two modalities measures different physiological properties. Accordingly, BAT can be present but not activated and therefore measurements with both modalities seems necessary for fully characterization of BAT.

References

  1. Cypess AM, Lehman S, et al.: Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009,360(15):1509–17. 10.1056/NEJMoa0810780

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  2. van Rooijen BD, van der Lans AA, et al.: Imaging cold-activated brown adipose tissue using dynamic T2*-weighted magnetic resonance imaging and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography. Invest Radiol 2013,48(10):708–14. 10.1097/RLI.0b013e31829363b8

    CAS  PubMed  Article  Google Scholar 

  3. Chen YC, Cypess AM, et al.: Measurement of human brown adipose tissue volume and activity using anatomic MR imaging and functional MR imaging. J Nucl Med 2013,54(9):1584–7. 10.2967/jnumed.112.117275

    CAS  PubMed Central  PubMed  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept.of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Denmark

    Helle H Johannesen, Johan Löfgren, Adam E Hansen, Annika Loft, Liselotte Højgaard & Andreas Kjær

  2. The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

    Ida Donkin

Authors
  1. Helle H Johannesen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Johan Löfgren
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ida Donkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Adam E Hansen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Annika Loft
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Liselotte Højgaard
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Andreas Kjær
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Johannesen, H.H., Löfgren, J., Donkin, I. et al. Identification and characterization of human brown adipose tissue (BAT) content and metabolism in adults using [18F]-FDG PET/MR – a pilot study. EJNMMI Phys 1, A68 (2014). https://doi.org/10.1186/2197-7364-1-S1-A68

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/2197-7364-1-S1-A68

Keywords

  • Brown Adipose Tissue
  • White Adipose Tissue
  • Water Suppression
  • Water Percentage
  • Calculated Water