Adapting MR-BrainPET scans for comparison with conventional PET: experiences with dynamic FET-PET in brain tumours
© Lohmann et al; licensee Springer 2014
Published: 29 July 2014
Imaging results from subsequent measurements (preclinical 3T MR-BrainPET, HR+) are compared. O-(2-[18F]fluoroethyl)-L-tyrosine (FET) may exhibit non-uniform tracer uptake in gliomas. The aim was to analyse and adapt the physical properties of the scanners and study variations of biological tumour volume (BTV) in early and late FET-PET.
Spatial resolution of the BrainPET and HR+ was measured according to NEMA standard. For evaluation of a threshold-based volume determination -as used for BTV- volumes of an 18F-filled spheres phantom were evaluated. Influence of different filter kernels for correction of differences in spatial resolution hereon was compared.
Differences in BTV between early and late FET-PET of 45 patients were analysed. BTV was determined using a tumour-to-brain ratio ≥1.6 .
Spatial resolution (FWHM) of the BrainPET was 2.63mm–3.47mm and 4.39mm–5.10mm for the HR+ (10mm off-centre) . 3D-filtered backprojection was used for reconstruction . BTV of largest sphere was 22.8ml in HR+ and between 23.2ml (unfiltered) and 24.5ml (3D-Gaussian 3.5mm) in the BrainPET. BTV of smallest sphere was 0.1 ml in HR+ and between 0.2ml (unfiltered) and 0.06ml (3D-Gaussian 3.5mm) in the BrainPET. A 2.5mm filter showed the smallest deviation for all spheres and was applied to the BrainPET data for cross-scanner comparison. Changes in BTV >10% were considered significant and not related to physical differences between scanners.
41% of patients showed a considerable deviation between early and late FET-PET. BTV increased in 14 patients. Four patients showed a FET positive region only in late FET-PET.
- Pauleit D, Floeth F, Hamacher K, et al.: O-(2-[18F]fluoroethyl)-L-tyrosine PET combined with MRI improves the diagnostic assessment of cerebral gliomas. Brain 2005, 128: 678–687. 10.1093/brain/awh399PubMedView ArticleGoogle Scholar
- Herzog H, Tellmann L, Hocke C, et al.: NEMA NU2–2001 guided performance evaluation of four Siemens ECAT PET scanners. IEEE Trans. Nucl. Sci. 2004, 51: 2662–2669. 10.1109/TNS.2004.835778View ArticleGoogle Scholar
- Thielemans K, Tsoumpas C, Mustafovic S, et al.: STIR: software for tomographic image reconstruction release 2. Phys. Med. Biol. 2012, 57: 867–883. 10.1088/0031-9155/57/4/867PubMedView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.