Effects of regularisation priors on dynamic PET Data
© Caldeira et al; licensee Springer 2014
Published: 29 July 2014
Dynamic PET provides temporal information about tracer uptake. However, each PET frame has usually low statistics, resulting in noisy images. The goal is to study effects of prior regularisation on dynamic PET data. Quantification and noise in image-domain and time-domain as well as impact on parametric images is assessed.
Kinetic values used for simulation of two tissues: White-Matter (WM) and Gray-Matter (GM), extracted from real acquired volunteer data.
This study shows improvement on PET image quality in terms of noise (up to 50% reduction) as well as in parametric images when using prior regularisation in dynamic PET data. Both OP-OSEM and MRP OP-OSEM show similar quantification, with higher RCs for MRP OP-OSEM in low-count frames.
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