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- Open Access
GPU-accelerated Monte Carlo based scatter correction in brain PET/MR
EJNMMI Physics volume 1, Article number: A32 (2014)
To develop and evaluate a fast and accurate Monte Carlo simulation (MCS) based scatter correction for PET/MR imaging, based on Geant4 using graphical processing units (GPUs).
The GPU implementation by Bert et al.  including the photon tracking within a voxelized volume was extended with the modeling of the detection process in the Siemens MR-BrainPET. Using NVIDIA’s CUDA photon pairs undergo several kernel functions in parallel, from their generation according to the activity distribution up to their detection in the scanner. Subsequently, coincidences are sorted and stored in list-mode. The new GPU implementation (GeForce GTX690) was validated by comparison with Gate v6.2 on a single CPU (Intel Core i7, 3.4GHz), showing a speedup factor of 135. The use of multiple GPUs can further increase this acceleration.
For Compton scatter correction the reconstructed emission image, the patient MR-derived attenuation map and a CT-derived attenuation template of the MR coils are used as input for the simulation. The resulting simulated projection data are scaled to the normalized measured projection data. Thus, the often unstable fit to the distribution tails, necessary for single scatter simulation (SSS), is circumvented. The scaled simulated scatter distribution is then incorporated in the reconstruction. The proposed scatter correction methodology was evaluated and compared to the SSS approach using sphere phantom measurements. Finally, the effect on patient data was investigated.
Phantom results suggest an improved contrast with our new MC-based scatter correction, especially for measurements including the MR coils, where the contrast recovery was improved by 10-14%. First patient images also show improved grey/white matter contrast.
The new GPU-accelerated MCS allows for fast and accurate estimation of scattered coincidences in PET studies using the Siemens MR-BrainPET with a major speed-up compared to standard MCS and superior image quality compared with the standard correction based on SSS.
Bert J, et al.: Geant4-based Monte Carlo simulations on GPU for medical applications. Phys Med Biol 2013, 58: 5593–5611. 10.1088/0031-9155/58/16/5593
Watson CC, Newport D, Casey ME: A single scatter simulation technique for scatter correction in 3D PET. Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine 1996, 4: 255–268. 10.1007/978-94-015-8749-5_18
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Gaens, M., Bert, J., Pietrzyk, U. et al. GPU-accelerated Monte Carlo based scatter correction in brain PET/MR. EJNMMI Phys 1, A32 (2014). https://doi.org/10.1186/2197-7364-1-S1-A32
- Monte Carlo Simulation
- Graphical Processing Unit
- Scatter Correction
- Multiple GPUs
- Superior Image Quality