Table 1 Literature review of absorbed dose in bone marrow for ¹⁷⁷Lu-PRRT

[12]

Kwekkeboom, 2001

5

10, 20, 40, 60 and 90 min and 2, 5 and 24 h p.i

4 h, and 1, 3, 10, 17 days p.i

–

–

Planar

–

0.07

[13]

Wehrmann, 2007

27

3, 10, 20,40 min and 1, 2, 4, 6, 20, 32, 44, 66, 70 h p.i

–

–

Bi or tri exponential

Blood

OLINDA

0.04 ± 0.02

[9]

Forrer, 2009

15

5 samples between 0 and 168 h p.i

3 images between 24 and 168 h p.i

–

–

Blood + planar

OLINDA

0.034 ± 0.03

[2]

Bodei, 2011

12

–

–

–

–

–

–

0.033

[14]

Jackson, 2013

17

–

–

4, 24 72 h p.i

Tri exponential

SPECT/CT

Monte-Carlo simulations

0.0334 ± 0.012

[15]

Sandström, 2013

200

0.5, 1, 2.5,4,8, 24 h p.i

24, 96, 168 h p.i

24, 96, 168 h p.i

Mono exponential

Blood + planar

RADAR

0.007—0.054

[4]

Bodei, 2015

10

–

–

–

–

–

–

0.03

[16]

Denoyer, 2015

11

–

–

4, 24, 72h p.i

–

SPECT/CT

OLINDA

0.0315

[17]

Bergsma, 2016

24

0,10,30,60,90,120, 360 1440 min p.i

24, 96, 168 h p.i

–

–

Blood + planar

OLINDA

0.067 ± 0.007

[18]

Svensson, 2016

46

–

2, 24, 48 168 h p.i

24 h p.i

Bi-exponential

Planar

RADAR

0.027 ± 0.007

[19]

Del Prete, 2017

22

–

–

4, 24 72 h p.i

Mono exponential

SPECT/CT

OLINDA

0.046 ± 0.033

[20]

Gosewich, 2018

5

30, 80 min and 24,48, 72 h p.i

24, 48, 72 h p.i

24, 48, 72 h p.i

Mono and bi exponential

Blood + SPECT/CT

RADAR

0.012 ± 0.003

[21]

Del Prete, 2019

34

–

–

4, 24 72 h p.i

Linear + mono exponential

SPECT/CT

OLINDA

0.035

[22]

Santoro, 2018

12

–

–

4, 24, 72 192 h p.i

Mono exponential

SPECT/CT

OLINDA

0.04 ± 0.02

[23]

Marin, 2018

47

30 min, 1, 4, 24 and 144–192 h p.i

–

4, 24, 144–192 h p.i

Bi-exponential

Blood + SPECT/CT

OLINDA

0.028 ± 0.01

[24]

Thakral, 2018

10

–

2, 24, 96 h p.i

–

Mono/bi exponential

Planar

OLINDA

0.017 ± 0.016

[25]

Chicheportiche, 2018

24

18, 20—25 h p.i

–

18, 25 h and 7 d p.i

Mono exponential

Blood + SPECT/CT

OLINDA

0.0096

[8]

Garske-Roman, 2018

200

0.5, 1, 2.5, 4, 8, 24 h p.i

1, 4, 7 d p.i

1, 4, 7 d p.i

Mono exponential

Blood + planar

-

0.018

[7]

Hagmarker, 2019

46

–

2, 24, 48, 168 h p.i

24 h p.i

Mono/bi-exponential

Planar + SPECT/CT

ICRP 133

0.016–0.287

[26]

Hallqvist, 2021

17

–

2, 24, 48, 168 h p.i

24 h p.i

Mono/bi-exponential

Planar + SPECT/CT

–

0.041

[27]

Carter, 2021

2

–

–

–

–

SPECT/CT

ICRP, Monte-Carlo simulations

0.043–0.13

[28]

Vergnaud, 2022

13

–

–

1, 24, 96 or 144 h p.i

Tri-exponential

SPECT/CT

Monte-Carlo simulations

0.04 ± 0.02