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Table 1 Reconstruction parameters and options investigated

From: Development of a bespoke phantom to optimize molecular PET imaging of pituitary tumors

Parameter/correction

Algorithm

Options

Expert evaluation

Time of flight

OSEM, BPL*

Off and On

Not applicable

Point spread function correction (PSF)

OSEM, BPL*

Off and On

Off and On

Matrix size (with 30 cm2 FOV)

OSEM, BPL*

128 × 128 and 256 × 256

128 × 128 and 256 × 256

Post-reconstruction smoothing (Gaussian—full width half maximum [FWHM])

OSEM

1, 2 and 3 mm

2 mm

OSEM Iterations (all with 24 subsets)

OSEM

3, 5, 7 and 9

3, 5, 7 and 9

Regularization parameter (β)

BPL

50, 100, 200, 300, 400, 500, 600, 700, 800, 900 and 1000

50, 100, 200, 300, 400, 500, 600, 800 and 1000

  1. *Parameter applicable to both OSEM and BPL but was only compared for OSEM. The optimal option was then included in BPL optimization