Fig. 12

Comparison of phantom images with actual clinical images derived from the patient on whom the phantom was modeled. Images from the patient are shown next to the 2-mm 5:1 pituitary tumor phantom. Panels A and E show the CT images of the patient and phantom, respectively, the cross-hairs indicate the center of the pituitary gland, and the yellow box demarcates the area of interest. Panels B and F show the PET images of the patient and phantom that were reconstructed using OSEM with three iterations, 24 subsets, attenuation correction, time-of-flight, a 2-mm Gaussian filter without point-spread-function correction (PSF). Panels C and G show the PET images of the patient and phantom that were reconstructed in the same way but using PSF. Panels D and H show the PET images of the patient and phantom that were reconstructed using the optimized BPL reconstruction using a β value of 300 (PSF). The orange arrows correspond to the location in the gland where a 2-mm pituitary tumor was subsequently removed at surgery