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Table 4 Quantification errors between activity concentrations calculated with the conventional method and the SBVR method for different time per view settings for spheres and liver in the Torso Phantom (minus sign – overestimation)

From: Towards accurate 177Lu SPECT activity quantification and standardization using lesion-to-background voxel ratio

Organ/Sphere volume (VOI volume) [cc]

Torso Val. Phantom acquisition validation

Quantification error (%)

Time per view: 30-s

Time per view: 20-s

Time per view: 10-s

SBVR Method (CF/ SBVR)

Conv. Method (CF)

SBVR Method (CF/ SBVR)

Conv. Method (CF)

SBVR Method (CF/ SBVR)

Conv. Method (CF)

26.52 (22.7 cc)

− 7.30% (4.24/1.50)

− 16.06% (3.92)

− 8.14% (4.09/12.43)

− 12.83% (3.92)

− 10.07% (3.92/9.93)

− 10.63% (3.92)

5.71 (6.36 cc)

− 9.34% (2.98/63.90)

− 23.42% (2.64)

− 8.18% (2.98/105.61)

− 26.21% (2.64)

− 10.18% (2.98/70.61)

− 24.73% (2.64)

Liver (~ 1200 cc)

− 1.50% (4.87/15.0)

1.10% (5.0)

3.87% (4.87/12.0)

6.34% (5.0)

3.31% (4.87/11.0)

5.82% (5.0)

  1. VOI, Volume of interest; CF, Calibration factor [cps/MBq]; and SBVR, Sphere-to-background counts/voxel ratio