Assessment of different regions of interest-based methods for [99mTc]Tc DAT-SPECT quantification using an anthropomorphic striatal phantom

Alexandre-Santos, Leonardo; Trevisan, Ana Carolina; Pitella, Felipe Arriva; Tumas, Vitor; Silvah, Jose Henrique; Kato, Mery; de Moraes, Eder Rezende; Wichert-Ana, Lauro

doi:10.1186/s40658-022-00519-2

EJNMMI Physics

Table 3 Comparison of the performance parameters to quantitative methodsConcordance Correlation Coefficients (CCC) for the evaluation of the accuracy of each semiquantitative method, linear regression coefficients, Pearson coefficients (\(\rho\)) and Coefficient of Determination (\(\rho ^{\textrm{2}}\))

From: Assessment of different regions of interest-based methods for [99mTc]Tc DAT-SPECT quantification using an anthropomorphic striatal phantom

Method	Index measured\(^{1}\)	Concordance correlation coefficient-CCC			Coefficients of linear regression analysis\(^{2}\)
		High	Intermediary	Low	Coefficients of linear regression analysis\(^{2}\)
		(10:1 to 8:1)	(7:1 to 6:1)	(4:1 to 2:1)	Intercept (CI)	SE	Slope (CI)	SE	\(\rho\)	\(\rho ^{\textrm{2}}\)
Manual
	\(\hbox {BPI}_{\textrm{CA}}\)	0.021 (0.003 ; 0.039)	0.028 (0.007 ; 0.049)	0.095 (0.011 ; 0.177)	-0.435(-0.692;-0.178)	0.127	0.417 (0.38;0.452)	0.017	0.964	0.929
	\(\hbox {BPI}_{\textrm{PU}}\)	0.017 (-0.001 ; 0.035)	0.034 (0.009 ; 0.059)	0.096 (0.013 ; 0.177)	-0.504 (-0.789;-0.219)	0.141	0.414 (0.375;0.453)	0.019	0.959	0.913
	\(\hbox {BPI}_{\textrm{ST}}\)	0.013 (0.000 ; 0.026)	0.026 (0.007 ; 0.046)	0.081 (0.010 ; 0.152)	-0.457 (-0.700;-0.210)	0.121	0.38 (0.346;0.413)	0.016	0.961	0.923
MRI
	\(\hbox {BPI}_{\textrm{CA}}\)	0.235 (0.072 ; 0.386)	0.255 (0.099 ; 0.399)	0.495 (0.221 ; 0.697)	-0.464(-0.885;-0.043)	0.208	0.804(0.747;0.861)	0.028	0.974	0.947
	\(\hbox {BPI}_{\textrm{PU}}\)	0.243 (0.073 ; 0.398)	0.265 (0.106 ; 0.411)	0.456 (0.189 ; 0.661)	-0.722(-1.164;-0.28)	0.219	0.835(0.775;0.895)	0.029	0.973	0.946
	\(\hbox {BPI}_{\textrm{ST}}\)	0.239 (0.074 ; 0.391)	0.261 (0.104 ; 0.405)	0.473 (0.203 ; 0.677)	-0.608(-1.033;-0.182)	0.211	0.821(0.763;0.879)	0.028	0.974	0.949
CT
	\(\hbox {BPI}_{\textrm{CA}}\)	0.239 (0.072 ; 0.392)	0.244 (0.093 ; 0.383)	0.438 (0.177 ; 0.642)	-0.766(-1.21;-0.322)	0.22	0.835(0.775;0.896)	0.029	0.973	0.946
	\(\hbox {BPI}_{\textrm{PU}}\)	0.226 (0.065 ; 0.376)	0.252 (0.100 ; 0.393)	0.421(0.163 ; 0.625)	-0.878(-1.326;-0.43)	0.222	0.843(0.782;0.903)	0.03	0.973	0.946
	\(\hbox {BPI}_{\textrm{ST}}\)	0.233 (0.071 ; 0.383)	0.248 (0.097 ; 0.388)	0.428 (0.169 ; 0.632)	-0.828(-1266;-0.391)	0.217	0.839(0.78;0.899)	0.029	0.974	0.948
TwoBox
	SBR	0.535 (0.242 ; 0.738)	0.497 (0.241 ; 0.688)	0.750 (0.488 ; 0.888)	-0.293(-0.8;0.213)	0.251	0.902(0.833;0.971)	0.034	0.969	0.94
ThreeBox
	TBPI	0.002(0.000 ; 0.004)	0.005(0.004 ; 0.008)	0.027 (0.002 ; 0.053)	-4.467(-5.303;-3.633)	0.41	0.114(1.31;1.552)	0.056	0.972	0.944

\(^{1}\) The indexes are represented through of the quality parameter and confidence interval.
\(^{2}\) The coefficients are represented with the confidence interval (CI) and standard error(SE)

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