Intra- and inter-operator variability in MRI-based manual segmentation of HCC lesions and its impact on dosimetry

EJNMMI Physics

Table 3 Inter- and intra-observer reliability ICCs for all outcomes

	All lesions (n = 140)	Small lesions (n = 77)	Large lesions (n = 63)	Well-defined lesions (n = 84)	Poorly defined lesions (n = 56)
Volume
ρ_intra	0.992	0.878	0.989	0.983	0.997
ρ_inter	0.967	0.735	0.954	0.956	0.974
Mean dose (without RC)
ρ_intra	0.995	0.995	0.997	0.997	0.993
ρ_inter	0.987	0.988	0.987	0.989	0.986
Mean dose (with RC)
ρ_intra	0.818	0.788	0.993	0.957	0.790
ρ_inter	0.754	0.714	0.980	0.853	0.732
RECIST diameter
ρ_intra	0.991	0.898	0.985	0.994	0.989
ρ_inter	0.966	0.743	0.939	0.947	0.984

ρ_intra = intra-observer reliability coefficient; ρ_inter = inter-observer reliability coefficient