Fig. 6

Topical detector TACs and PET images for two outliers in the leave-one-out analysis. Subjects with (A) left antecubital fossa (\(I_{{{\text{TOT}}}}\) = 26.3 MBq and \(\hat{D}\) = 4.1 kcps on Fig. 4A) and (B) left forearm (\(I_{{{\text{TOT}}}}\) = 152 MBq and \(\hat{D}\) = 3.2 kcps on Fig. 4A) injections, respectively. Topical detector TACs (“Data”) are scaled to total extravasation activity to produce \(\hat{I}_{{{\text{TOT}}}}\), using the matched leave-one-out calibration factor. Extrapolation fits (“Fit”) (fit starts denoted by x’s) and ground truth PET extravasation activities, \(I_{{{\text{TOT}}}}\) (“Image”), are also displayed. Coronal maximum intensity projections are shown in two color scales to better visualize distribution of tracer extravasations