Assessment of mouse-specific pharmacokinetics in kidneys based on 131I activity measurements using micro-SPECT

EJNMMI Physics

Table 2 Acquisition settings of the longitudinal SPECT scans performed in experiment 2, in vivo, on 5 mice injected with the [¹³¹I]-labelled sdAb, corresponding to datasets LS1–LS5

Av. scan start time p.i. [max. range of variation between mice] (h)	No of bed positions per scan	Scan time per bed position (s)	Total effective scan time (min)
1.0 [± 0.0]	20	51	17^§
3.3 [± 0.0]	20	66	22
6.0 [± 0.1]	20	66	22
24.2 [± 2.0]	20	150	50
46.3 [± 3.7]	20	239 (159)*	80 (53)*
70.2 [± 3.3]	20	239 (159)*	80 (53)*

^§Scan duration limited by the start of the scans for the next time point
*Because of a logistical limitation, this specification was used for the two mice from datasets LS1 and LS2