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Table 4 Summary of 90Y dosimetric phantom and patient studies

From: EANM dosimetry committee series on standard operational procedures: a unified methodology for 99mTc-MAA pre- and 90Y peri-therapy dosimetry in liver radioembolization with 90Y microspheres

Study Type of study Results
Minarik et al. [111, 112] Physical phantom Activity error for liver and 113 mL sphere < 11%
Patient study (111In and 90Y Zevalin) Comparison to absorbed doses from quantitative 111In SPECT/CT (3 patients)
Liver, spleen, kidneys within 30%
Lungs within 66%
Elschot et al. [113] Patient study (90Y microspheres). Physical phantom Comparison to absorbed doses from 90Y PET/CT (5 patients): ROIs in liver within approximately 15–20%. ROIs in six-sphere phantom within approximately 5% (mean of all spheres). N.B. Data estimated from diagram
Rong et al. [114, 115] Phantoms, physical and simulated for 90Y Zevalin Physical phantom: activity error for 3 hot spheres in warm background < 10%.
XCAT MC study: activity error < approximately 12% for spleen, liver, kidneys, heart and lungs
Dewaraja et al. [116] Physical phantom Activity error for 3 hot spheres (or similar) in warm background < 15%, liver and lung < 4%