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Table 2 Model parameters of 223Ra: Transfer coefficients k (per day) taken from ICRP Publications 100 [21] and 137 [12]. Please note that the transfer rates from the compartment Blood to Other Soft Tissue (ST0, ST1, ST2) are lower than the values given in [12] because of the added compartments Trabecular Marrow, Cortical Marrow, Spleen, Skin and Testes

From: Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer

From

To

k (d−1)

Blood

ST0

18.412

Blood

ST1

3.079

Blood

ST2

0.062

Blood

Cortical bone surface

7.78

Blood

Trabecular bone surface

9.72

Blood

Kidneys 1

1.4

Blood

Liver 1

4.2

Blood

Right colon content

21.79

Blood

Urinary bladder content

0.606

Liver 1

Blood

0.691

Liver 2

Blood

0.0019

Liver 1

Liver 2

0.00208

ST0

Blood

6.98

ST1

Blood

0.693

ST2

Blood

0.00038

Cortical bone surface

Blood

0.578

Cortical bone surface

Exch cortical bone volume

0.116

Exch cortical bone volume

Cortical bone surface

0.0185

Exch cortical bone volume

Nonexch cortical bone volume

0.0046

Nonexch cortical bone volume

Blood

0.0000821

Trabecular bone surface

Blood

0.578

Trabecular bone surface

Exch trabecular bone volume

0.116

Exch trabecular bone volume

trabecular bone surface

0.0185

Exch trabecular bone volume

Nonexch trabecular bone volume

0.0046

Nonexch trabecular bone volume

Blood

0.000493

Trabecular marrow 0

Blood

6.98

Trabecular marrow 1

Blood

0.693

Trabecular marrow 2

Blood

0.00038

Blood

Trabecular marrow 0

1.190

Blood

Trabecular marrow 1

0.199

Blood

Trabecular marrow 2

0.00398

Cortical marrow 0

Blood

6.98

Cortical marrow 1

Blood

0.693

Cortical marrow 2

Blood

0.00038

Blood

Cortical marrow 0

0.098

Blood

Cortical marrow 1

0.016

Blood

Cortical marrow 2

0.00033

Blood

Skin 0

1.165

Blood

Skin 1

0.195

Blood

Skin 2

0.0039

Blood

Spleen 0

0.053

Blood

Spleen 1

0.0089

Blood

Spleen 2

0.00018

Blood

Testes 0

0.0124

Blood

Testes 1

0.0021

Blood

Testes 2

0.000041

Skin 0

Blood

6.98

Skin 1

Blood

0.693

Skin 2

Blood

0.00038

Spleen 0

Blood

6.98

Spleen 1

Blood

0.693

Spleen 2

Blood

0.00038

Testes 0

Blood

6.98

Testes 1

Blood

0.693

Testes 2

Blood

0.00038

Kidneys 1

Blood

2.073

Kidneys 1

Kidneys 2

0.00624

Kidneys 2

Blood

0.0019

Right colon content

Left colon content

2.0

Left colon content

Recto sigmoid content

2.0

Recto sigmoid content

Faeces

2.0

Urinary bladder content

Urine

12.0

  1. Exch, exchangeable; nonexch, non-exchangeable; ST, soft tissue
  2. The indication (0, 1, 2) refers to fast, intermediate and slow turnover