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EJNMMI Physics

Table 2 Model parameters of 223Ra: Transfer coefficients k (per day) taken from ICRP Publications 100 [21] and 137 [12]. Please note that the transfer rates from the compartment Blood to Other Soft Tissue (ST0, ST1, ST2) are lower than the values given in [12] because of the added compartments Trabecular Marrow, Cortical Marrow, Spleen, Skin and Testes

From: Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer

From To k (d−1)
Blood ST0 18.412
Blood ST1 3.079
Blood ST2 0.062
Blood Cortical bone surface 7.78
Blood Trabecular bone surface 9.72
Blood Kidneys 1 1.4
Blood Liver 1 4.2
Blood Right colon content 21.79
Blood Urinary bladder content 0.606
Liver 1 Blood 0.691
Liver 2 Blood 0.0019
Liver 1 Liver 2 0.00208
ST0 Blood 6.98
ST1 Blood 0.693
ST2 Blood 0.00038
Cortical bone surface Blood 0.578
Cortical bone surface Exch cortical bone volume 0.116
Exch cortical bone volume Cortical bone surface 0.0185
Exch cortical bone volume Nonexch cortical bone volume 0.0046
Nonexch cortical bone volume Blood 0.0000821
Trabecular bone surface Blood 0.578
Trabecular bone surface Exch trabecular bone volume 0.116
Exch trabecular bone volume trabecular bone surface 0.0185
Exch trabecular bone volume Nonexch trabecular bone volume 0.0046
Nonexch trabecular bone volume Blood 0.000493
Trabecular marrow 0 Blood 6.98
Trabecular marrow 1 Blood 0.693
Trabecular marrow 2 Blood 0.00038
Blood Trabecular marrow 0 1.190
Blood Trabecular marrow 1 0.199
Blood Trabecular marrow 2 0.00398
Cortical marrow 0 Blood 6.98
Cortical marrow 1 Blood 0.693
Cortical marrow 2 Blood 0.00038
Blood Cortical marrow 0 0.098
Blood Cortical marrow 1 0.016
Blood Cortical marrow 2 0.00033
Blood Skin 0 1.165
Blood Skin 1 0.195
Blood Skin 2 0.0039
Blood Spleen 0 0.053
Blood Spleen 1 0.0089
Blood Spleen 2 0.00018
Blood Testes 0 0.0124
Blood Testes 1 0.0021
Blood Testes 2 0.000041
Skin 0 Blood 6.98
Skin 1 Blood 0.693
Skin 2 Blood 0.00038
Spleen 0 Blood 6.98
Spleen 1 Blood 0.693
Spleen 2 Blood 0.00038
Testes 0 Blood 6.98
Testes 1 Blood 0.693
Testes 2 Blood 0.00038
Kidneys 1 Blood 2.073
Kidneys 1 Kidneys 2 0.00624
Kidneys 2 Blood 0.0019
Right colon content Left colon content 2.0
Left colon content Recto sigmoid content 2.0
Recto sigmoid content Faeces 2.0
Urinary bladder content Urine 12.0
  1. Exch, exchangeable; nonexch, non-exchangeable; ST, soft tissue
  2. The indication (0, 1, 2) refers to fast, intermediate and slow turnover
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