Fig. 1

Representative FP-CIT SPECT images. The left column shows a patient with Parkinson’s disease (top) and a healthy control subject (bottom) from the PPMI sample. The middle and right columns show the same patient with neurodegenerative PS (top) and the same patient with non-neurodegenerative PS (bottom) from the clinical sample reconstructed with iterative reconstruction (ordered subsets expectation maximization, OSEM) with resolution recovery (RR; middle column) or with filtered backprojection (right column). Shown are 4-mm-thick transaxial slices in MNI space with voxel intensities scaled to the individual 75th percentile of the voxel intensity in the reference region. The upper threshold of the colour table was adjusted separately for each of the three settings