Table 1 Percentage differences in absorbed dose from “original method” (combination trapezoidal/3-point mono-exponential fit)
From: Personalized radiation dosimetry for PRRT—how many scans are really required?
Comparison of estimated absorbed dose | Number | Mean % difference from “original method” | 95% confidence interval for mean % difference | 2.5–97.5 percentile interval | Number of organs/tumors with absolute difference > 10% | |
|---|---|---|---|---|---|---|
4-point mono-exponential fit 0–∞ | Tumors | 85 | 4.6% | 2.7–6.5% | − 12.8–22.2% | 8 |
Kidneys | 59 | 3.2% | 2.8–3.6% | 0.5–5.9% | 0 | |
Liver | 30 | 2.0% | 1.1–2.8% | − 2.5–6.4% | 0 | |
Spleen | 27 | 2.8% | 2.0–3.5% | − 1.0–6.6% | 1 | |
3-point (2, 3, 4) mono-exponential fit 0–∞ | Tumors | 85 | 0.8% | 0.4–1.3% | − 2.8–4.5% | 0 |
Kidneys | 59 | 2.4% | 1.8–3.1% | − 2.3–7.2% | 0 | |
Liver | 30 | 1.5% | 0.9–2.1% | − 1.6–4.6% | 0 | |
Spleen | 27 | 1.5% | 0.9–2.2% | − 1.6–4.7% | 0 | |
2-point (2, 4) mono-exponential fit 0–∞ | Tumors | 85 | 2.6% | 1.6–3.5% | − 5.1–10.2% | 7 |
Kidneys | 59 | 3.4% | 2.5–4.2% | − 3.0–9.7% | 1 | |
Liver | 30 | 2.7% | 0.5–4.8% | − 8.8–14.1% | 3 | |
Spleen | 27 | 2.2% | 0.9–3.5% | − 4.4–8.7% | 0 | |
2-point (2, 3) mono-exponential fit 0–∞ | Tumors | 85 | -0.4% | − 3.1–2.4% | − 18.5–17.7% | 20 |
Kidneys | 59 | 1.9% | 0.6–3.3% | − 8.3–12.2% | 4 | |
Liver | 30 | 2.1% | − 3.1–7.4% | − 25.6–29.9% | 7 | |
Spleen | 27 | 1.0% | − 1.9–3.9% | − 13.4–15.4% | 3 | |
2-point (3, 4) mono-exponential fit 0–∞ | Tumors | 85 | 7.7% | − 0.6–16.0% | − 67.1–82.6% | 23 |
Kidneys | 59 | 1.5% | 1.2–4.3% | − 18.8–21.8% | 21 | |
Liver | 30 | 8.5% | − 0.8–17.7% | − 40.2–57.2% | 5 | |
Spleen | 27 | 3.0% | − 0.4–6.4% | − 14.0–20.0% | 3 |