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Table 3 Effective half-lives of tumors and organs at risk determined using patient imaging data at {3 h, 24 h, 48 h},{3 h, 24 h}, {3 h, 48 h}, and {24 h, 48 h}. The data is compared to an effective half-life of 17 h (which would assume that AHDD-Lipiodol biological half-life is infinity, as in Zanzonico et al 2008 [29]). The data are presented as the average effective half-life across all patients ± SD in hours

From: Biodistribution, pharmacokinetics, and organ-level dosimetry for 188Re-AHDD-Lipiodol radioembolization based on quantitative post-treatment SPECT/CT scans

 

{3 h, 24 h, 48 h} (reference value)

{3 h, 24 h}

{3 h, 48 h}

{24 h, 48 h}

{3 h}

Tumor

12.5 ± 1.9

12.0 ± 1.4

13.8 ± 1.4

16.2 ± 2.0

17

Liver

12.6 ± 1.7

12.4 ± 1.1

13.9 ± 1.2

16.0 ± 1.9

17

Lungs

12.0 ± 1.9

12.1 ± 1.3

13.6 ± 1.2

15.6 ± 2.4

17

Stomach

10.9 ± 1.9

11.4 ± 1.5

12.8 ± 1.3

14.9 ± 2.3

17

Kidneys

12.8 ± 2.5

13.8 ± 1.8

14.5 ± 1.2

15.5 ± 2.8

17

Spleen

14.7 ± 2.3

14.1 ± 1.5

15.1 ± 1.8

16.4 ± 1.8

17