Fig. 3

Example of a large neuroendocrine tumor, which was treated with glass microspheres. Activity was prescribed according to the MIRD mono-compartment method to reach 120 Gy. According to the PM model, the average absorbed dose to the tumor was 150 Gy. The patient has shown no response after treatment (RECIST, mRECIST, and EASL). The contrast-enhanced CT shows the tumor as a large enhanced area (orange solid line) and necrosis (yellow dotted line) (a). A strong absorbed dose inhomogeneity can be observed (b). Voxel-based dosimetry and radiobiological models may account for such absorbed dose inhomogeneities