Fig. 3

Subject 8’s gallbladder dose without a meal (a) and simulated dose with a fatty meal (b). Legend: Example of the gallbladder dose in an individual volunteer without a fatty meal (a) and simulated gallbladder dose for the same patient after consumption of a fatty meal at 80 min to match this subject’s intervention consumption time (b) where the extrapolated no meal curve is based upon an exponential decay fit to the last two experimental data points. The dark gray area under the curve represents experimentally collected data, whereas the light gray shaded area in a represents the predicted portion of the dose. The striped area under the curve in b illustrates the predicted dose using the fatty meal simulation. Difference in total shaded areas under the curve in a and b represent a change in dose received by the gallbladder with the addition of a fatty meal