Fig. 5
From: Fast GPU-based Monte Carlo code for SPECT/CT reconstructions generates improved 177Lu images
SPECT reconstructions of the 177Lu distribution in two patients treated with 177Lu-DOTATATE. Panels a, d show the post-filtered AC-OSEM reconstructed SPECT images that are used in the clinical protocol, while panels b, e show SPECT images reconstructed with unfiltered AC-OSEM, and panels c, f show SPECT images reconstructed with SARec-OSEM. In the Monte Carlo-based reconstruction with SARec, an increased number of tumors and an improved visualization of the heterogeneous activity distribution in the kidney were observed (c), which become more evident when a post-filter is applied (data not shown). Also, in the tumor tissue, the improved heterogeneous activity distributions were more easily observed with SARec OSEM compared with AC-OSEM, an example is the marked uptake differences between the tumor border and tumor center (f versus d and e)