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EJNMMI Physics

Table 3 PET camera models and protocols used in clinical studies and physical parameters measured with phantoms

From: Phantom criteria for qualification of brain FDG and amyloid PET across different cameras

PET agent

Vendor, model

Reconstruction parameters

Study

Spatial resolution (mm)

%contrast

Uniformity (SD)

Image noise (CV [%])

FDG

GE, Advance

FORE + OSEM, subset = 20, iteration = 4, Z-axis; none

J-ADNIa

7

61

0.0249

13.7

Shimadzu, Eminence GM

HDE, FORE-DRAMA, filter cycle = 0, iteration = 4

7

55

0.0249

8.8

Shimadzu, HeadtomeV

FORE + OSEM, subset = 16, iteration = 4, Ramp × BW cf = 8 o = 2

7

61.6

0.0200

9.6

Shimadzu, HeadtomeV

FORE + OSEM, subset = 16, iteration = 4, Ramp x BW cf = 8 o = 2

7

65.5

0.0230

9.7

SIEMENS, biograph Hi-Rez

FORE + OSEM, subset = 14, iteration = 4

7

64.4

0.0130

7.6

SIEMENS, biograph Hi-Rez

FORE + OSEM, subset = 16, iteration = 4

7

63.1

0.0150

6.9

SIEMENS, biograph truePoint

FORE + OSEM, subset = 14, iteration = 4

6

61.3

0.0100

7.1

SIEMENS, biograph Hi-Rez

FORE + OSEM, subset = 16, iteration = 4, Gaussian (XxYxZ = 5.5 × 5.5 × 5.5)

ADNIa

9

52.8

0.0120

2.73

SIEMENS, ECAT Accel

FORE + OSEM, subset = 16, iteration = 6, Gaussian (XxYxZ = 2.0 × 2.0 × 3.0)

7

54.6

0.0200

6.03

Florbetapir

GE, Discovery690

3D-iteration, subset = 16, iteration = 4, Gaussian (XxYxZ = 5 mm)

*1

7

56.9

0.0120

6.2

GE, Discovery690

3D-iteration, subset = 18, iteration = 3, Gaussian (XxYxZ = 2 mm), PSF (+)

*2

6

58

0.0110

11.7

SIEMENS, biograph Hi-Rez

FORE + OSEM, subset = 16, iteration = 4, Gaussian (XxYxZ = 5.5 × 5.5 × 5.5)

ADNIa

7

62.8

0.0120

11

SIEMENS, ECAT Accel

FORE + OSEM, subset = 16, iteration = 6, Gaussian (XxYxZ = 2.0 × 2.0 × 3.0)

7

55.4

0.0200

10

Flutemetamol

GE, Discovery690

3D-iteration, subset = 32, iteration = 3, Gaussian (XxYxZ = 5 mm), TOF (+)

*3

6.5

55.7

0.0230

8.8

PiB

GE, Advance

FORE + OSEM, subset = 20, iteration = 4, Z-axis; none, Gaussian (XxYxZ = 4 mm)

J-ADNIa

7

58

0.0249

17.9

Shimadzu, Eminence GM

HDE, FORE-DRAMA, filter cycle = 0, iteration = 4, Gaussian (XxYxZ = 4 mm)

8

51

0.0249

13.7

Shimadzu, HeadtomeV

FORE + OSEM, subset = 16, iteration = 4, Ramp × BW cf = 8 o = 2, Gaussian (XxYxZ = 4 mm)

8

53.7

0.0200

18.4

Shimadzu, HeadtomeV

FORE + OSEM, subset = 16, iteration = 4, Ramp × BW cf = 8 o = 2, Gaussian (XxYxZ = 4 mm)

7

57.7

0.0230

16.1

SIEMENS, biograph Hi-Rez

FORE + OSEM, subset = 14, iteration = 4, Gaussian (XxYxZ = 4 mm)

8

59.5

0.0130

12.4

SIEMENS, biograph Hi-Rez

FORE + OSEM, subset = 16, iteration = 4, Gaussian (XxYxZ = 4 mm)

8

58.3

0.0150

11.8

SIEMENS, biograph truePoint

FORE + OSEM, subset = 14, iteration = 4, Gaussian (XxYxZ = 4 mm)

8

56.4

0.0100

10.9

SIEMENS, biograph Hi-Rez

FORE + OSEM, subset = 16, iteration = 4, Gaussian (XxYxZ = 5.5 × 5.5 × 5.5)

ADNIa

9

52.1

0.0120

7.78

SIEMENS, ECAT Accel

FORE + OSEM, subset = 16, iteration = 6, Gaussian (XxYxZ = 2.0 × 2.0 × 3.0)

9

51.8

0.0200

20.49

  1. Italic numbers represent performances deviated from the proposed criteria of phantom test. For *1 and *2, injection activity, accumulation time, and scan time are 370 MBq, 50 min, and 10 min, respectively, in clinical trials with florbetapir. For *3, injection activity, accumulation time, and scan time are 185 MBq, 90 min, and 30 min, respectively, in clinical trial with flutemetamol. See text and cited literatures
  2. aIn ADNI and J-ADNI, injection activity, accumulation time, and scan time are 185 MBq, 30 min, and 30 min for FDG, 555 MBq, 50 min, and 20 min for PiB, 370 MBq, 50 min, and 20 min for florbetapir, respectively
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