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Table 3 Maximal volumes of blood sampling

From: Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance

Species Body weight Blood volume per kilogramme body weight Blood volume at typical body weight Maximal volume for blood sampling
Human 70 kg 67 mL/kg 4.7 L  
Rat 400 g 64 mL/kg 26 mL 2.6 mL (10 %) at once
0.26 mL (1 %)/24 h repeatedly
6.5 mL (25 %) within 28 days
Mouse 25 g 59 mL/kg 1.5 mL 0.15 mL (10 %) at once
0.015 mL (1 %)/24 h repeatedly
0.37 mL (25 %) within 28 days