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Table 1 Percentage difference between volumes for different cut-offs using the tVOI method. Data are presented as median (min; max)

From: Method dependence, observer variability and kidney volumes in radiation dosimetry of 177Lu-DOTATATE therapy in patients with neuroendocrine tumours

 

Days

42 %

50 %

60 %

70 %

Right kidney

1 vs 4

−6.6 (−34.1; 6.1)*

−7.8 (−42.8; 4.3)**

−12.3 (−55.6; 12.2)**

−20.7 (−70.8; 32.9)**

1 vs 7

−23.3 (−60.5; 5.0)**

−27.8 (−71.8; 3.3)**

−35.2 (−83.5; −1.5)**

−44.7 (−93.6; 5.9)**

4 vs 7

−15.5 (−40.1; 15.3)**

−17.3 (−51.1; 16.3)**

−24.7 (−63.7; 13.0)**

−29.3 (−80.9; 38.3)**

Left kidney

1 vs 4

−5.9 (−35.8; 26.8)**

−6.0 (−37.0; 23.8)**

−8.9 (−46.3; 24.0)**

−15.9 (−68.2; 33.2)*

1 vs 7

−14.7 (−59.0; 7.1)**

−17.0 (−69.4; 7.6)**

−25.3 (−79.9; 13.7)**

−39.5 (−88.4; 17.3)**

4 vs 7

−9.0 (−44.5; 26.5)**

−11.8 (−55.1; 19.0)**

−17.0 (−65.9; 20.6)**

−27.4 (−76.3; 37.0)**

Spleen

1 vs 4

5.5 (−25.5; 50.9)*

8.1 (−27.6; 55.5)*

7.5 (−30.5; 46.0)*

1.3 (−33.6; 70.1)

1 vs 7

−2.1 (−33.8; 52.0)

−2.4 (−36.4; 53.3)

−6.1 (−41.9; 46.2)

−12.4 (−56.8; 46.2)*

4 vs 7

−6.6 (−33.7; 24.6)*

−9.6 (−36.7; 21.8)**

−13.4 (−48.7; 27.9)**

−16.0 (−57.3; 48.7)**

  1. Two-tailed P values from the Wilcoxon matched-pair signed rank tests between the functional volume measurements was also calculated to evaluate if the differences were significant
  2. *P values lower than 0.05 were significant; **P value lower than 0.001 was highly significant