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New nontoxic double information magnetic and fluorescent MRI agent

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Today sensitivity of the MRI is not enough compared to the nuclear methods, such as positron emission tomography and single photon emission computed tomography. Challenging its extension to the nanometre scale could provide a powerful new tool for the nanosciences and nanomedicine. To achieve this potential, innovative new detection strategies are required to overcome the severe sensitivity limitations of conventional inductive detection techniques. In this regard, we perform embodiment of nanodiamonds in dendrimer matrix as additional fluorescent optical and magnetic (together with Gd (III)) imaging modalities of the MRI. New hybrid system composed of dendrimer-gadolinium Gd (III) - nanodiamond as a new contrast agent for MRI was studied. Poly(propilene-imine) PPI and poly(amidoamine) PAMAM dendrimers with fixed size of nanocavities will be used as host material to protect organism against the toxicity and also to increase relaxivity of contrast agent (resulting in the increases MRI resolution). Nanodiamond as biocompatible platform to functionalize the contrast agent will be used. This bimodal hybrid system enables to use smaller amount of the contrast agent and could permit the decrease of the lateral toxicity. This bimodal hybrid system as MRI agent is providing double information (magnetic and fluorescent) about the damaged cell.

Aim

investigation of new hybrid system composed of dendrimer-gadolinium Gd(III)-nanodiamond as a new contrast agent to improve the MRI resolution and to reduce lateral toxicity in comparison with today used. The main idea is to use this bimodal contrast agent allowing more efficient performance of the MRI with attractive biological applications in diagnosis and therapy. In this report structural investigations by SEM and TEM, spectroscopic studies by Raman scattering, absorption, fluorescence and magnetic features by EPR measurements are discussed. Obtained results are demonstrating great potential of this bimodal imaging agent with unique magnetic and optical imaging capabilities.

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Correspondence to Augustinas Kublickas.

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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Kublickas, A., Rastenien, L., Bloznelytė-Plėšnienė, L. et al. New nontoxic double information magnetic and fluorescent MRI agent. EJNMMI Phys 2, A88 (2015) doi:10.1186/2197-7364-2-S1-A88

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Keywords

  • Positron Emission Tomography
  • Contrast Agent
  • Single Photon Emission Compute Tomography
  • Hybrid System
  • Single Photon Emission