Volume 2 Supplement 1

Proceedings of the 4th PSMR Conference on PET/MR and SPECT/MR

Open Access

The potential of TOF PET-MRI for reducing artifacts in PET images

  • Andrei Iagaru1,
  • Ryogo Minamimoto1,
  • Craig Levin1,
  • Amid Barkhodari1,
  • Mehran Jamali1,
  • Dawn Holley1 and
  • Zaharchuk Greg1
EJNMMI Physics20152(Suppl 1):A77


Published: 18 May 2015

Here we evaluated the potential of TOF PET/MRI to reduce various PET image artifacts, by comparing the images to non-TOF PET/MRI, TOF PET/CT and non-TOF PET/CT.

Methods and materials

All patients underwent a single-injection of FDG, followed first by PET-CT and subsequently by PET-MRI scan. The PET/CT exams were performed using a GE Discovery 690 PET/CT scanner. The PET/MRI images were acquired on a GE Signa PET/MRI scanner. All PET images were reconstructed with and without the TOF data. Visual analysis of these series was performed for dental metal / breathing artifcats and 3) artifacts caused by high excretion of FDG in the bladder. PET image quality was evaluated using a 3-point scale (1 - clinically significant artifact; 2 – non clinically-significant artifact; and 3 - no artifact). Data from 18 oncologic patients (mean ± SD age: 55 ± 10 years; female 7, male 11) were used. The average scores of TOF PET/MRI, non-TOF PET/MRI, TOF PET/CT and non-TOF PET/CT for dental artifacts were 3.0, 2.8, 2.4 and 2.3, respectively; for breathing artifacts were 3.0, 2.5, 2.5 and 2.3, respectively; and for pelvic artifacts were 2.9, 1.6, 2.1 and 1.4, respectively. TOF PET/MRI had the highest image quality scores among the 4 series of PET data analyzed for these types of artifacts. TOF PET/MRI showed promising results in reduction of various PET artifacts in this cohort, when compared to non-TOF PET/MRI, TOF PET/CT and non-TOF PET/CT. This may be due to the better timing resolution (<400 ps) for the PET/MR system compared to the PET/CT system (>600 ps).

Authors’ Affiliations

Stanford University


© Iagaru et al; licensee Springer. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.