Volume 2 Supplement 1

Proceedings of the 4th PSMR Conference on PET/MR and SPECT/MR

Open Access

The SAFIR project: an innovative high rate preclinical PET/MR detector towards dynamic multimodal imaging

  • Robert Becker1,
  • Chiara Casella1,
  • Gunther Dissertori1,
  • Jannis Fischer1,
  • Alexander Howard1,
  • Astrik Jeitler1,
  • Werner Lustermann1,
  • Ulf Roeser1,
  • Qiulin Wang1, 2 and
  • Bruno Weber3
EJNMMI Physics20152(Suppl 1):A15

https://doi.org/10.1186/2197-7364-2-S1-A15

Published: 18 May 2015

SAFIR (Small Animal Fast Insert for mRi) is an innovative, high rate, PET detector insert for MRI, to be used for quantitative dynamic pre-clinical imaging, with very high activities injected in the animals, up to 500 MBq. The PET detector will be designed to allow for ultra short acquisition periods (of the order of a few seconds) simultaneously with the MRI, permitting unprecedented temporal resolutions in preclinical dynamic multimodal imaging. High sensitivity (~ 6%), high spatial resolution (~1.5 mm FWHM), excellent coincidence timing resolution (CTR ~ 300 ps FWHM) and a fast DAQ system able to cope with the huge data throughput are required. Parallel with the hardware efforts, dedicated 4D algorithms for image reconstruction must be developed. The overall state of the project will be presented, including ongoing activities towards the choice and characterization of the detector components (crystals, SiPMs and readout chips), MonteCarlo simulations, and first reconstruction of various simulated sources. Special emphasis will be given to the results of a recent high rate test, where the TOFPET ASIC has been tested with Hamamatsu S12642-0404PB-50 SiPM arrays coupled to matrices of LYSO:Ce crystals (3.1x3.1x12 mm3 each), exposed to a 500 MBq activity of FDG radiotracer in a volume of about 0.5 cm3.

Authors’ Affiliations

(1)
ETH Zurich
(2)
Tsinghua University Beijing
(3)
University of Zurich

Copyright

© Becker et al; licensee Springer. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.