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EJNMMI Physics

Table 5 Mean value and standard deviation of the percentage of difference of the simplified kinetic parameters values (striatum Ki using Patlak linearization for [18F]FDG and frontal VT using Logan linearization for [18F]DPA-714) extracted from the different calibrated IDIF compared to the simplified kinetic parameters values as reference obtained using calibrated IDIF from EARL2 reconstruction for [18F]FDG and using calibrated input function from continuous blood sampler for [18F]DPA-714, with the same tissue time-activity curve from EARL 2

From: Validation of image-derived input function using a long axial field of view PET/CT scanner for two different tracers

 

[18F]FDG (N = 7)*

[18F]DPA-714 (N = 8)**

Continuous sampler

N/A

Reference

EARL 2_AA

Reference

− 5.3 (4.4)

EARL 2_DA

+1.0 (1.8)

+12.5 (7.5)

EARL 2_LV

+1.6 (1.8)

+19.1 (9.8)

EARL 2_MRD322_AA

+0.7 (1.3)

-4.4 (4.3)

it8_AA

+0.3 (0.5)

-8.0 (4.5)

it4_nogauss_AA

-0.3 (0.6)

-6.0 (4.4)

it6_nogauss_AA

-0.1 (0.7)

-8.0 (4.5)

it8_nogauss_AA

+0.1 (0.8)

-8.8 (4.7)

it8_nogauss_mat440_AA

-0.6 (1.4)

-8.2 (4.1)

it10_nogauss_AA

-0.5 (1.5)

-9.6 (5.2)

it10_nogauss_abs_AA

+0.6 (0.9)

+ 1.4 (6.4)

  1. *Striatum volume of interest was not available for 1 patient due to head movements. **Continuous blood sampler was not available for 2 patients. AA: Ascending Aorta; DA: Descending Aorta; LV: Left Ventricular Cavity; it: iterations; mat: matrix; gauss: Gaussian post-filtering, MRD: maximum ring differences; abs: absolute scatter correction method
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