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EJNMMI Physics
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  1. Lutetium oxyorthosilicate or lutetium yttrium oxyorthosilicate (LYSO) scintillation crystals used in most current PET scanner detectors contain 176Lu, which decays by beta emission to excited states of 176Hf acco...

    Authors: Francisco Eduardo Enríquez-Mier-y-Terán, Ana Saret Ortega-Galindo, Tirso Murrieta-Rodríguez, Mercedes Rodríguez-Villafuerte, Arnulfo Martínez-Dávalos and Héctor Alva-Sánchez
    Citation: EJNMMI Physics 2020 7:21
    Content type: Original research Published on:

  2. Optimization of injected gallium-68 (68Ga) activity for 68Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (68Ga-PSMA PET/CT) studies is relevant for image quality, radiation...

    Authors: J. Wielaard, J. B. A. Habraken, P. Brinks, J. Lavalaye and R. Boellaard
    Citation: EJNMMI Physics 2020 7:20
    Content type: Original research Published on:

  3. Respiratory motion in PET/CT leads to well-known image degrading effects commonly compensated using elastic motion correction approaches. Gate-to-gate motion correction techniques are promising tools for impro...

    Authors: Stefanie Pösse, Florian Büther, Dirk Mannweiler, Inki Hong, Judson Jones, Michael Schäfers and Klaus Peter Schäfers
    Citation: EJNMMI Physics 2020 7:19
    Content type: Original Research Published on:

  4. Evaluate the physical performance of the VERITON CzT camera (Spectrum Dynamics, Caesarea, Israel) that benefits from new detection architecture enabling whole-body imaging compared to that of a conventional du...

    Authors: Cédric Desmonts, Mohammed Abdeldjalil Bouthiba, Blandine Enilorac, Catherine Nganoa, Denis Agostini and Nicolas Aide
    Citation: EJNMMI Physics 2020 7:18
    Content type: Young investigators Published on:

  5. Currently, no consistent guidelines for CT scans used within PET/CT examinations are available. This systematic review provides an up-to-date overview of studies to answer the following questions: What are the...

    Authors: V. Bertolini, A. Palmieri, M. C. Bassi, M. Bertolini, V. Trojani, V. Piccagli, F. Fioroni, S. Cavuto, M. Guberti, A. Versari and S. Cola
    Citation: EJNMMI Physics 2020 7:17
    Content type: Review Published on:

  6. 44Sc has been increasingly investigated as a potential alternative to 68Ga in the development of tracers for positron emission tomography (PET). The lower mean positron energy of 44Sc (0.63 MeV) compared to 68Ga ...

    Authors: Florian Rosar, Hans-Georg Buchholz, Sebastian Michels, Manuela A. Hoffmann, Markus Piel, Christopher M. Waldmann, Frank Rösch, Stefan Reuss and Mathias Schreckenberger
    Citation: EJNMMI Physics 2020 7:16
    Content type: Original research Published on:

  7. The purpose of the EANM Dosimetry Committee Series on “Standard Operational Procedures for Dosimetry” (SOP) is to provide advice to scientists and clinicians on how to perform patient-specific absorbed dose as...

    Authors: Jonathan Gear, Carlo Chiesa, Michael Lassmann, Pablo Mínguez Gabiña, Johannes Tran-Gia, Caroline Stokke and Glenn Flux
    Citation: EJNMMI Physics 2020 7:15
    Content type: Opinion article Published on:

  8. New digital PET scanners with improved time of flight timing and extended axial field of view such as the Siemens Biograph Vision have come on the market and are expected to replace current generation photomul...

    Authors: Britt Kunnen, Casper Beijst, Marnix G. E. H. Lam, Max A. Viergever and Hugo W. A. M. de Jong
    Citation: EJNMMI Physics 2020 7:14
    Content type: Original research Published on:

  9. Intrahepatic dosimetry is paramount to optimize radioembolization treatment accuracy using radioactive holmium-166 microspheres (166Ho). This requires a practical protocol that combines quantitative imaging of mi...

    Authors: R. van Rooij, A. J. A. T. Braat, H. W. A. M. de Jong and M. G. E. H. Lam
    Citation: EJNMMI Physics 2020 7:13
    Content type: Original research Published on:

  10. The National Electrical Manufacturers Association’s (NEMA) NU 4-2008 standard specifies methodology for evaluating the performance of small-animal PET scanners. The standard’s goal is to enable comparison of d...

    Authors: Patrick Hallen, David Schug and Volkmar Schulz
    Citation: EJNMMI Physics 2020 7:12
    Content type: Opinion Article Published on:

  11. Routine PET exams are increasingly performed with reduced injected activities, leading to the use of different image reconstruction parameters than the NEMA parameters, in order to prevent from any deleterious...

    Authors: Julien Salvadori, Freddy Odille, Antoine Verger, Pierre Olivier, Gilles Karcher, Pierre-Yves Marie and Laetitia Imbert
    Citation: EJNMMI Physics 2020 7:11
    Content type: Original research Published on:

  12. Personalization of 177Lu-based radionuclide therapy requires implementation of dosimetry methods that are both accurate and practical enough for routine clinical use. Quantitative single-photon emission computed ...

    Authors: Andrea Frezza, Corentin Desport, Carlos Uribe, Wei Zhao, Anna Celler, Philippe Després and Jean-Mathieu Beauregard
    Citation: EJNMMI Physics 2020 7:10
    Content type: Original research Published on:

  13. Quantitative SPECT imaging in targeted radionuclide therapy with lutetium-177 holds great potential for individualized treatment based on dose assessment. The establishment of dose-effect relations requires a ...

    Authors: Steffie M. B. Peters, Sebastiaan L. Meyer Viol, Niels R. van der Werf, Nick de Jong, Floris H. P. van Velden, Antoi Meeuwis, Mark W. Konijnenberg, Martin Gotthardt, Hugo W. A. M. de Jong and Marcel Segbers
    Citation: EJNMMI Physics 2020 7:9
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Physics 2021 8:59

  14. Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate cellular dosimetry. Therefore, we have built a refined cellular dos...

    Authors: Giulia Tamborino, Marijke De Saint-Hubert, Lara Struelens, Dayana C. Seoane, Eline A. M. Ruigrok, An Aerts, Wiggert A. van Cappellen, Marion de Jong, Mark W. Konijnenberg and Julie Nonnekens
    Citation: EJNMMI Physics 2020 7:8
    Content type: Original research Published on:

  15. Conventional PET imaging has usually been limited to a single tracer per scan. We propose a new technique for multi-tracer PET imaging that uses dynamic imaging and multi-tracer compartment modeling including ...

    Authors: Carlos Velasco, Adriana Mota-Cobián, Jesús Mateo and Samuel España
    Citation: EJNMMI Physics 2020 7:7
    Content type: Original research Published on:

  16. Before radioiodine therapy for Graves’ disease, the estimated thyroid-absorbed dose is calculated based on various clinical parameters. However, the actual accumulation of iodine in the thyroid during radioiod...

    Authors: Naotoshi Fujita, Yumiko Koshiba, Shinji Abe and Katsuhiko Kato
    Citation: EJNMMI Physics 2020 7:6
    Content type: Original research Published on:

  17. After each cycle of [177Lu]-DOTA-TATE peptide receptor radionuclide therapy (PRRT) dosimetry is performed to enable precise calculation of the radiation-absorbed dose to tumors and normal organs. Absorbed doses a...

    Authors: Alexandre Chicheportiche, Simona Ben-Haim, Simona Grozinsky-Glasberg, Kira Oleinikov, Amichay Meirovitz, David J. Gross and Jeremy Godefroy
    Citation: EJNMMI Physics 2020 7:5
    Content type: Original research Published on:

  18. This article compares the physical performance of the 4-ring digital Discovery MI (DMI) and PMT-based Discovery MI-DR (DMI-DR) PET/CT systems. Physical performance was assessed according to the NEMA NU 2-2012 ...

    Authors: Alexandre Chicheportiche, Rami Marciano and Marina Orevi
    Citation: EJNMMI Physics 2020 7:4
    Content type: Original research Published on:

  20. Bayesian penalized likelihood reconstruction for PET (e.g., GE Q.Clear) aims at improving convergence of lesion activity while ensuring sufficient signal-to-noise ratio (SNR). This study evaluated reconstructe...

    Authors: Julian M. Rogasch, Said Suleiman, Frank Hofheinz, Stephanie Bluemel, Mathias Lukas, Holger Amthauer and Christian Furth
    Citation: EJNMMI Physics 2020 7:2
    Content type: Original research Published on:

  21. We assessed and compared image quality obtained with clinical 18F-FDG whole-body oncologic PET protocols used in three different, state-of-the-art digital PET/CT and two conventional PMT-based PET/CT devices.

    Authors: Silvano Gnesin, Christine Kieffer, Konstantinos Zeimpekis, Jean-Pierre Papazyan, Renaud Guignard, John O. Prior, Francis R. Verdun and Thiago V. M. Lima
    Citation: EJNMMI Physics 2020 7:1
    Content type: Original research Published on:

  22. Recently, a Bayesian penalized likelihood (BPL) reconstruction algorithm was introduced for a commercial PET/CT with the potential to improve image quality. We compared the performance of this BPL algorithm wi...

    Authors: Joost te Riet, Sjoerd Rijnsdorp, Mark J. Roef and Albert J. Arends
    Citation: EJNMMI Physics 2019 6:32
    Content type: Original research Published on:

  24. In ordered subsets expectation maximization (OSEM) reconstruction of electrocardiography (ECG)-gated myocardial perfusion single-photon emission computed tomography (SPECT), it is often assumed that the image ...

    Authors: Matti J. Kortelainen, Tuomas M. Koivumäki, Marko J. Vauhkonen and Mikko A. Hakulinen
    Citation: EJNMMI Physics 2019 6:30
    Content type: Original research Published on:

  25. Absolute quantification of radiotracer distribution using SPECT/CT imaging is of great importance for dosimetry aimed at personalized radionuclide precision treatment. However, its accuracy depends on many fac...

    Authors: Steffie M. B. Peters, Niels R. van der Werf, Marcel Segbers, Floris H. P. van Velden, Roel Wierts, Koos (J.) A. K. Blokland, Mark W. Konijnenberg, Sergiy V. Lazarenko, Eric P. Visser and Martin Gotthardt
    Citation: EJNMMI Physics 2019 6:29
    Content type: Original research Published on:

  26. Recently, updated EARL specifications (EARL2) have been developed and announced. This study aims at investigating the impact of the EARL2 specifications on the quantitative reads of clinical PET–CT studies and...

    Authors: Andres Kaalep, Coreline N. Burggraaff, Simone Pieplenbosch, Eline E. Verwer, Terez Sera, Josee Zijlstra, Otto S. Hoekstra, Daniela E. Oprea-Lager and Ronald Boellaard
    Citation: EJNMMI Physics 2019 6:28
    Content type: Original research Published on:

  27. We aim to provide a systematic study of the impact of white matter (WM) spill-in on the calculation of standardized uptake value ratios (SUVRs) on Aβ-negative subjects, and we study the effect of including WM ...

    Authors: Francisco Javier López-González, Alexis Moscoso, Nikos Efthimiou, Anxo Fernández-Ferreiro, Manuel Piñeiro-Fiel, Stephen J. Archibald, Pablo Aguiar and Jesús Silva-Rodríguez
    Citation: EJNMMI Physics 2019 6:27
    Content type: Original research Published on:

  28. Compartmental modelling is an established method of quantifying 18F-FDG uptake; however, only recently has it been applied to evaluate pulmonary inflammation. Implementation of compartmental models remains challe...

    Authors: Laurence D. Vass, Sarah Lee, Frederick J. Wilson, Marie Fisk, Joseph Cheriyan and Ian Wilkinson
    Citation: EJNMMI Physics 2019 6:26
    Content type: Original Research Published on:

  29. Multi-tracer positron emission tomography (PET) imaging can be accomplished by applying multi-tracer compartment modeling. Recently, a method has been proposed in which the arterial input functions (AIFs) of t...

    Authors: Carlos Velasco, Adriana Mota-Cobián, Jesús Mateo and Samuel España
    Citation: EJNMMI Physics 2019 6:25
    Content type: Original research Published on:

  30. Computed tomography (CT) scans are routinely performed in positron emission tomography (PET) and single photon emission computed tomography (SPECT) examinations globally, yet few surveys have been conducted to...

    Authors: Natalie A. Bebbington, Bryan T. Haddock, Henrik Bertilsson, Eero Hippeläinen, Ellen M. Husby, Virpi I. Tunninen and Marcus Söderberg
    Citation: EJNMMI Physics 2019 6:24
    Content type: Original research Published on:

  31. The decay characteristics of radionuclides in PET studies can impact image reconstruction. 44gSc has been the topic of recent research due to potential theranostic applications and is a promising radiometal for P...

    Authors: Simon Ferguson, Hans-Sonke Jans, Melinda Wuest, Terence Riauka and Frank Wuest
    Citation: EJNMMI Physics 2019 6:23
    Content type: Original research Published on:

  32. Q.Clear is a block sequential regularized expectation maximization (BSREM) penalized-likelihood reconstruction algorithm for PET. It tries to improve image quality by controlling noise amplification during ima...

    Authors: Paulo R. R. V. Caribé, M. Koole, Yves D’Asseler, B. Van Den Broeck and S. Vandenberghe
    Citation: EJNMMI Physics 2019 6:22
    Content type: Original research Published on:

  33. To determine the clinically acceptable level of reduction in the injected fluorine-18 (18F)-labeled fluorodeoxyglucose (18F-FDG) dose in dedicated breast positron emission tomography (dbPET).

    Authors: Yoko Satoh, Tetsuro Sekine, Yoshie Omiya, Hiroshi Onishi and Utaroh Motosugi
    Citation: EJNMMI Physics 2019 6:21
    Content type: Original research Published on:

  34. Volumes of usual PET phantoms are about four to sixfold that of a human liver. In order to avoid count rate saturation and handling of very high 90Y activity, reported TOF-PET phantom studies are performed using ...

    Authors: Michel Hesse and Stephan Walrand
    Citation: EJNMMI Physics 2019 6:20
    Content type: Artefact report Published on:

  35. Performance standards for quantitative 18F-FDG PET/CT studies are provided by the EANM Research Ltd. (EARL) to enable comparability of quantitative PET in multicentre studies. Yet, such specifications are not ava...

    Authors: Daphne M. V. Huizing, Daniëlle Koopman, Jorn A. van Dalen, Martin Gotthardt, Ronald Boellaard, Terez Sera, Michiel Sinaasappel, Marcel P. M. Stokkel and Berlinda J. de Wit-van der Veen
    Citation: EJNMMI Physics 2019 6:19
    Content type: Short communication Published on:

  37. Cerenkov Luminescence Imaging (CLI) is an emerging technology for intraoperative margin assessment. Previous research only evaluated radionuclide 18-Fluorine (18F); however, for future applications in prostate ca...

    Authors: J. olde Heuvel, B. J. de Wit-van der Veen, K. N. Vyas, D. S. Tuch, M. R. Grootendorst, M. P. M. Stokkel and C. H. Slump
    Citation: EJNMMI Physics 2019 6:17
    Content type: Original research Published on:

  38. The technology of modern positron emission tomography (PET) systems continuously improving, and with it the possibility to detect smaller lesions. Since first introduced in 2010, the number of hybrid PET/magne...

    Authors: Silje Kjærnes Øen, Lars Birger Aasheim, Live Eikenes and Anna Maria Karlberg
    Citation: EJNMMI Physics 2019 6:16
    Content type: Original research Published on:

  39. Software for Tomographic Image Reconstruction (STIR) is an open-source library for PET and SPECT image reconstruction, implementing iterative reconstruction as well as 2D- and 3D-filtered back projection. Quan...

    Authors: Parisa Khateri, Jannis Fischer, Werner Lustermann, Charalampos Tsoumpas and Günther Dissertori
    Citation: EJNMMI Physics 2019 6:15
    Content type: Original research Published on:

  40. Monte Carlo-based iterative reconstruction to correct for photon scatter and collimator effects has been proven to be superior over analytical correction schemes in single-photon emission computed tomography (...

    Authors: Martijn M. A. Dietze, Woutjan Branderhorst, Britt Kunnen, Max A. Viergever and Hugo W. A. M. de Jong
    Citation: EJNMMI Physics 2019 6:14
    Content type: Original research Published on:

  41. The α-emitting radionuclide radium-223 (223Ra) is widely used for the treatment of bone metastasis in patients with castration-resistant prostate cancer. However, 223Ra decays into radon-219 (219Rn) which is a no...

    Authors: Kazuhiro Ooe, Tadashi Watabe, Takashi Kamiya, Takashi Yoshimura, Makoto Hosono, Atsushi Shinohara and Jun Hatazawa
    Citation: EJNMMI Physics 2019 6:13
    Content type: Original research Published on:

  42. The heart-to-mediastinum (H/M) ratio is a commonly used parameter to measure cardiac I-123 metaiodobenzylguanidine (MIBG) uptake. Since the H/M ratio is substantially influenced by the collimator type, we inve...

    Authors: Joachim Brumberg, Ganna Blazhenets, Nils Schröter, Lars Frings, Wolfgang H. Jost, Constantin Lapa and Philipp T. Meyer
    Citation: EJNMMI Physics 2019 6:12
    Content type: Original research Published on:

  43. Fully integrated PET/MR systems are being used frequently in clinical research and routine. National Electrical Manufacturers Association (NEMA) characterization of these systems is generally done with 18F which ...

    Authors: Paulo R. R. V. Caribé, M. Koole, Yves D’Asseler, Timothy W. Deller, K. Van Laere and S. Vandenberghe
    Citation: EJNMMI Physics 2019 6:11
    Content type: Original research Published on:

  44. Squamous cell carcinoma in the head and neck region is one of the most widespread cancers with high morbidity. Classic treatment comprises the complete removal of the lymphatics together with the cancerous tis...

    Authors: Peter A. von Niederhäusern, Simon Pezold, Uri Nahum, Carlo Seppi, Guillaume Nicolas, Michael Rissi, Stephan K. Haerle and Philippe C. Cattin
    Citation: EJNMMI Physics 2019 6:10
    Content type: Original research Published on:

  45. Gadolinium nanoparticles (Gd-NP) combined with radiotherapy are investigated for radiation dose enhancement in radiotherapy treatment. Indeed, NPs concentrated in a tumor could enhance its radiosensitization. ...

    Authors: Olga Kochebina, Adrien Halty, Jacqueline Taleb, David Kryza, Marc Janier, Alexandre Bani Sadr, Thomas Baudier, Simon Rit and David Sarrut
    Citation: EJNMMI Physics 2019 6:9
    Content type: Original research Published on:

  47. 177Lu-DOTATATE peptide receptor radionuclide therapy is administered to patients on an inpatient and outpatient basis for the treatment of well-differentiated, metastatic neuroendocrine tumours. Following adminis...

    Authors: D. Levart, E. Kalogianni, B. Corcoran, N. Mulholland and G. Vivian
    Citation: EJNMMI Physics 2019 6:7
    Content type: Original research Published on:

  49. Recently, the block-sequential regularized expectation maximization (BSREM) reconstruction algorithm was commercially introduced (Q.Clear, GE Healthcare, Milwaukee, WI, USA). However, the combination of noise-...

    Authors: Mimmi Bjöersdorff, Jenny Oddstig, Nina Karindotter-Borgendahl, Helén Almquist, Sophia Zackrisson, David Minarik and Elin Trägårdh
    Citation: EJNMMI Physics 2019 6:5
    Content type: Original research Published on:

  50. Quantification is one of the key benefits of nuclear medicine imaging. Recently, driven by the demand for post radionuclide therapy imaging, quantitative SPECT has moved from relative and semiquantitative meas...

    Authors: John Dickson, James Ross and Stefan Vöö
    Citation: EJNMMI Physics 2019 6:4
    Content type: Opinion article Published on:
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