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EJNMMI Physics
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  1. Actinium-225 is an alpha-particle emitter under investigation for use in radiopharmaceutical therapy. To address limited supply, accelerator-produced 225Ac has been recently made available. Accelerator-produced 2...

    Authors: George Sgouros, Bin He, Nitya Ray, Dale L. Ludwig and Eric C. Frey
    Citation: EJNMMI Physics 2021 8:60
    Content type: Original research Published on:

  2. A significant proportion of the radiation dose from a PET-CT examination is dependent on the CT protocol, which should be optimised for clinical purposes. Matching protocols on different scanners within an ima...

    Authors: Sarah-May Gould, Jane Mackewn, Sugama Chicklore, Gary J. R. Cook, Andrew Mallia and Lucy Pike
    Citation: EJNMMI Physics 2021 8:58
    Content type: Original research Published on:

  3. The introduction of hybrid SPECT/CT devices enables quantitative imaging in SPECT, providing a methodological setup for quantitation using SPECT tracers comparable to PET/CT. We evaluated a specific quantitati...

    Authors: Dennis Kupitz, Heiko Wissel, Jan Wuestemann, Stephanie Bluemel, Maciej Pech, Holger Amthauer, Michael C. Kreissl and Oliver S. Grosser
    Citation: EJNMMI Physics 2021 8:57
    Content type: Original research Published on:

  4. PET imaging of 90Y-microsphere distribution following radioembolisation is challenging due to the count-starved statistics from the low branching ratio of e+/e− pair production during 90Y decay. PET systems using...

    Authors: Joey Labour, Philippe Boissard, Thomas Baudier, Fouzi Khayi, David Kryza, Pascale Veyrat Durebex, Sandrine Parisse-Di Martino, Thomas Mognetti, David Sarrut and Jean-Noël Badel
    Citation: EJNMMI Physics 2021 8:56
    Content type: Original research Published on:

  5. Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy and to predict response. Dosimetry involves several steps, the first of which is the determination of the activity of the r...

    Authors: Johannes Tran-Gia, Ana M. Denis-Bacelar, Kelley M. Ferreira, Andrew P. Robinson, Nicholas Calvert, Andrew J. Fenwick, Domenico Finocchiaro, Federica Fioroni, Elisa Grassi, Warda Heetun, Stephanie J. Jewitt, Maria Kotzassarlidou, Michael Ljungberg, Daniel R. McGowan, Nathaniel Scott, James Scuffham…
    Citation: EJNMMI Physics 2021 8:55
    Content type: Original research Published on:

  6. Partial-volume correction (PVC) using the Geometric Transfer Matrix (GTM) method is used in positron emission tomography (PET) to compensate for the effects of spatial resolution on quantitation. We evaluate t...

    Authors: Charles M. Laymon, Davneet S. Minhas, Sarah K. Royse, Howard J. Aizenstein, Ann D. Cohen, Dana L. Tudorascu and William E. Klunk
    Citation: EJNMMI Physics 2021 8:54
    Content type: Original research Published on:

  7. 99mTc-DMSA is one of the most commonly used pediatric nuclear medicine imaging agents. Nevertheless, there are no pharmacokinetic (PK) models for 99mTc-DMSA in children, and currently available pediatric dose est...

    Authors: Donika Plyku, Michael Ghaly, Ye Li, Justin L. Brown, Shannon O’Reilly, Kitiwat Khamwan, Alison B. Goodkind, Briana Sexton-Stallone, Xinhua Cao, David Zurakowski, Frederic H. Fahey, S. Ted Treves, Wesley E. Bolch, Eric C. Frey and George Sgouros
    Citation: EJNMMI Physics 2021 8:53
    Content type: Original research Published on:

  8. To assess the applicability of the Fluorine-18 performance specifications defined by EANM Research Ltd (EARL), in Gallium-68 multi-centre PET-CT trials using conventional (ordered subset expectation maximisati...

    Authors: Georgios Krokos, Lucy C. Pike, Gary J. R. Cook and Paul K. Marsden
    Citation: EJNMMI Physics 2021 8:52
    Content type: Original research Published on:

  9. A 2-m axial field-of-view, total-body PET/CT scanner (uEXPLORER) has been recently developed to provide total-body coverage and ultra-high sensitivity, which together, enables opportunities for in vivo time-ac...

    Authors: Pengcheng Hu, Xin Lin, Weihai Zhuo, Hui Tan, Tianwu Xie, Guobing Liu, Shuguang Chen, Xin Chen, Haojun Yu, Yiqiu Zhang, Hongcheng Shi and Haikuan Liu
    Citation: EJNMMI Physics 2021 8:51
    Content type: Original research Published on:

  10. The goal of this work was to determine the quantitative accuracy and optimal reconstruction parameters for 124I-PET imaging in the presence of therapeutic levels of 131I. In this effort, images were acquired on a...

    Authors: Louise M. Fanchon, Bradley J. Beattie, Keith Pentlow, Steven M. Larson and John L. Humm
    Citation: EJNMMI Physics 2021 8:50
    Content type: Original research Published on:

  11. In patients with pulmonary embolism (PE), there is a growing interest in quantifying the pulmonary vascular obtruction index (PVOI), which may be an independent risk factor for PE recurrence. Perfusion SPECT/C...

    Authors: David Bourhis, Laura Wagner, Julien Rioult, Philippe Robin, Romain Le Pennec, Cécile Tromeur, Pierre Yves Salaün and Pierre Yves Le Roux
    Citation: EJNMMI Physics 2021 8:49
    Content type: Original research Published on:

  12. Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction techni...

    Authors: Alina van de Burgt, Petra Dibbets-Schneider, Cornelis H. Slump, Arthur J. H. A. Scholte, Douwe E. Atsma, Lioe-Fee de Geus-Oei and Floris H. P. van Velden
    Citation: EJNMMI Physics 2021 8:48
    Content type: Original research Published on:

  13. Integrated whole-body PET/MR technology continues to mature and is now extensively used in clinical settings. However, due to the special design architecture, integrated whole-body PET/MR comes with a few inhe...

    Authors: Tianyi Zeng, Jiaxu Zheng, Xinyuan Xia, Xin Chen, Beien Wang, Shuangyue Zhang, Adam Chandler, Tuoyu Cao, Lingzhi Hu, Qun Chen and Xu Chu
    Citation: EJNMMI Physics 2021 8:47
    Content type: Original research Published on:

  14. Radiomics analysis usually involves, especially in multicenter and large hospital studies, different imaging protocols for acquisition, reconstruction, and processing of data. Differences in protocols can lead...

    Authors: Montserrat Carles, Tobias Fechter, Luis Martí-Bonmatí, Dimos Baltas and Michael Mix
    Citation: EJNMMI Physics 2021 8:46
    Content type: Original research Published on:

  15. Much progress has been made in implementing selective internal radiation therapy (SIRT) as a viable treatment option for hepatic malignancies. However, there is still much need for improved options for calcula...

    Authors: Benjamin J. Van, Yuni K. Dewaraja, Mamadou L. Sangogo and Justin K. Mikell
    Citation: EJNMMI Physics 2021 8:45
    Content type: Original research Published on:

  16. Ra-223 dichloride (223Ra, Xofigo®) is used for treatment of patients suffering from castration-resistant metastatic prostate cancer. The objective of this work was to apply the most recent biokinetic model for ra...

    Authors: Vera Höllriegl, Nina Petoussi-Henss, Kerstin Hürkamp, Juan Camilo Ocampo Ramos and Wei Bo Li
    Citation: EJNMMI Physics 2021 8:44
    Content type: Original research Published on:

  17. Changes in renal blood flow (RBF) may play a pathophysiological role in hypertension and kidney disease. However, RBF determination in humans has proven difficult. We aimed to confirm the feasibility of RBF es...

    Authors: Stine Sundgaard Langaa, Thomas Guldager Lauridsen, Frank Holden Mose, Claire Anne Fynbo, Jørn Theil and Jesper Nørgaard Bech
    Citation: EJNMMI Physics 2021 8:43
    Content type: Original research Published on:

  18. Left ventricular ejection fraction (LVEF) is usually measured by cine-cardiac magnetic resonance imaging (MRI), planar and single-photon emission-computerized tomography (SPECT) equilibrium radionuclide angioc...

    Authors: Emilie Verrecchia-Ramos, Olivier Morel, Paul Retif and Sinan Ben Mahmoud
    Citation: EJNMMI Physics 2021 8:42
    Content type: Original research Published on:

  19. Q.Clear is a Bayesian penalized likelihood (BPL) reconstruction algorithm that presents improvements in signal-to-noise ratio (SNR) in clinical positron emission tomography (PET) scans. Brain studies in resear...

    Authors: Daniela Ribeiro, William Hallett and Adriana A. S. Tavares
    Citation: EJNMMI Physics 2021 8:41
    Content type: Original research Published on:

  20. Dosimetry is of high importance for optimization of patient-individual PSMA-targeted radioligand therapy (PSMA-RLT). The aim of our study was to evaluate and compare the feasibility of different approaches of ...

    Authors: Florian Rosar, Niklas Schön, Hendrik Bohnenberger, Mark Bartholomä, Tobias Stemler, Stephan Maus, Fadi Khreish, Samer Ezziddin and Andrea Schaefer-Schuler
    Citation: EJNMMI Physics 2021 8:40
    Content type: Original research Published on:

  21. Quantitative positron emission tomography (PET) studies of neurodegenerative diseases typically require the measurement of arterial input functions (AIF), an invasive and risky procedure. This study aims to as...

    Authors: Mercy I. Akerele, Sara A. Zein, Sneha Pandya, Anastasia Nikolopoulou, Susan A. Gauthier, Ashish Raj, Claire Henchcliffe, P. David Mozley, Nicolas A. Karakatsanis, Ajay Gupta, John Babich and Sadek A. Nehmeh
    Citation: EJNMMI Physics 2021 8:39
    Content type: Original research Published on:

  22. Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by crea...

    Authors: Daniel Gillett, Daniel Marsden, Safia Ballout, Bala Attili, Nick Bird, Sarah Heard, Mark Gurnell, Iosif A. Mendichovszky and Luigi Aloj
    Citation: EJNMMI Physics 2021 8:38
    Content type: Original research Published on:

  23. [11C]-UCB-J is an emerging tool for the noninvasive measurement of synaptic vesicle density in vivo. Here, we report human biodistribution and dosimetry estimates derived from sequential whole-body PET using two ...

    Authors: Christopher Cawthorne, Paul Maguire, Joel Mercier, David Sciberras, Kim Serdons, Guy Bormans, Jan de Hoon, Koen Van Laere and Michel Koole
    Citation: EJNMMI Physics 2021 8:37
    Content type: Short communication Published on:

  24. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Julia Brosch-Lenz, Carlos Uribe, Astrid Gosewisch, Lena Kaiser, Andrei Todica, Harun Ilhan, Franz Josef Gildehaus, Peter Bartenstein, Arman Rahmim, Anna Celler, Sibylle Ziegler and Guido Böning
    Citation: EJNMMI Physics 2021 8:36
    Content type: Correction Published on:

    The original article was published in EJNMMI Physics 2021 8:26

  25. Time-of-flight (TOF) PET technology determines a reduction in the noise and improves the reconstructed image quality in low count acquisitions, such as in overweight patients, allowing a reduction of administe...

    Authors: Roberta Matheoud, Naema Al-Maymani, Alessia Oldani, Gian Mauro Sacchetti, Marco Brambilla and Alessandro Carriero
    Citation: EJNMMI Physics 2021 8:35
    Content type: Original research Published on:

  26. The amount of signal decreases when the acquisition duration is shortened. However, it is not clear how this affects the quantitative values. This study aims to clarify the effect of acquisition time shortenin...

    Authors: Masatoshi Morimoto, Nobuyuki Kudomi, Yukito Maeda, Takuya Kobata, Akihiro Oishi, Keisuke Matsumoto, Toshihide Monden, Takanobu Iwasaki, Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto and Yoshihiro Nishiyama
    Citation: EJNMMI Physics 2021 8:34
    Content type: Original research Published on:

  27. Extravasation of radiopharmaceuticals used for vectorized internal radiotherapy can lead to severe tissue damage (van der Pol et al., Eur J Nucl Med Mol Imaging 44:1234–1243, 2017). Clinical management of thes...

    Authors: Perrine Tylski, Géraldine Pina-Jomir, Claire Bournaud-Salinas and Patrice Jalade
    Citation: EJNMMI Physics 2021 8:33
    Content type: Original research Published on:

  28. [18F]-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography (PET-CT) is a well-established modality in the work-up of patients with suspected or confirmed diagnosis of lung cancer. Recent...

    Authors: Pablo Borrelli, John Ly, Reza Kaboteh, Johannes Ulén, Olof Enqvist, Elin Trägårdh and Lars Edenbrandt
    Citation: EJNMMI Physics 2021 8:32
    Content type: Original research Published on:

  29. Deep learning (DL)-based image quality improvement is a novel technique based on convolutional neural networks. The aim of this study was to compare the clinical value of 18F-fluorodeoxyglucose positron emission ...

    Authors: Junichi Tsuchiya, Kota Yokoyama, Ken Yamagiwa, Ryosuke Watanabe, Koichiro Kimura, Mitsuhiro Kishino, Chung Chan, Evren Asma and Ukihide Tateishi
    Citation: EJNMMI Physics 2021 8:31
    Content type: Original research Published on:

  31. Applied tube voltage (kilovolts, kV) and tube current (milliampere seconds, mAs) affect CT radiation dose and image quality and should be optimised for the individual patient. CARE kV determines the kV and mAs...

    Authors: Natalie A. Bebbington, Troels Jørgensen, Erik Dupont and Mille A. Micheelsen
    Citation: EJNMMI Physics 2021 8:29
    Content type: Original research Published on:

  32. Regular and precise inspection of the realization of the local nuclear medicine standard operation procedures (SOPs) is very complex and time-consuming, especially when large amount of patient data is obtained...

    Authors: Ferenc Nagy, Aron K. Krizsan, Kornél Kukuts, Melinda Szolikova, Zsolt Hascsi, Sandor Barna, Antonietta Acs, Peter Szabo, Lajos Tron, Laszlo Balkay, Magnus Dahlbom, Mihaly Zentai, Attila Forgacs and Ildiko Garai
    Citation: EJNMMI Physics 2021 8:28
    Content type: Original research Published on:

  33. Different gamma camera calibration factor (CF) geometries have been proposed to convert SPECT data into units of activity concentration. However, no consensus has been reached on a standardised geometry. The C...

    Authors: Keamogetswe Ramonaheng, Johannes A. van Staden and Hanlie du Raan
    Citation: EJNMMI Physics 2021 8:27
    Content type: Original research Published on:

  34. Patients with metastatic, castration-resistant prostate cancer (mCRPC) present with an increased tumor burden in the skeleton. For these patients, Lutetium-177 (Lu-177) radioligand therapy targeting the prosta...

    Authors: Julia Brosch-Lenz, Carlos Uribe, Astrid Gosewisch, Lena Kaiser, Andrei Todica, Harun Ilhan, Franz Josef Gildehaus, Peter Bartenstein, Arman Rahmim, Anna Celler, Sibylle Ziegler and Guido Böning
    Citation: EJNMMI Physics 2021 8:26
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Physics 2021 8:36

  35. To determine whether artificial intelligence (AI) processed PET/CT images of reduced by one-third of 18-F-FDG activity compared to the standard injected dose, were non-inferior to native scans and if so to ass...

    Authors: Katia Katsari, Daniele Penna, Vincenzo Arena, Giulia Polverari, Annarita Ianniello, Domenico Italiano, Rolando Milani, Alessandro Roncacci, Rowland O. Illing and Ettore Pelosi
    Citation: EJNMMI Physics 2021 8:25
    Content type: Original research Published on:

  36. Accurate quantification of radioactivity, measured by an integrated positron emission tomography (PET) and magnetic resonance imaging (MRI) system, is still a challenge. One aspect of such a challenge is to co...

    Authors: Adam Farag, R. Terry Thompson, Jonathan D. Thiessen, Frank S. Prato and Jean Théberge
    Citation: EJNMMI Physics 2021 8:24
    Content type: Original research Published on:

  37. Functional lung mapping from Ga68-ventilation/perfusion (V/Q) PET/CT, which has been shown to correlate with pulmonary function tests (PFTs), may be beneficial in a number of clinical applications where sparing r...

    Authors: Lachlan McIntosh, Price Jackson, Nicholas Hardcastle, Mathias Bressel, Tomas Kron, Jason W. Callahan, Daniel Steinfort, Nicholas Bucknell, Michael S. Hofman and Shankar Siva
    Citation: EJNMMI Physics 2021 8:23
    Content type: Original research Published on:

  38. High activities of holmium-166 (166Ho)–labeled microspheres are used for therapeutic radioembolization, ideally directly followed by SPECT imaging for dosimetry purposes. The resulting high-count rate potentially...

    Authors: Martina Stella, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong and Rob van Rooij
    Citation: EJNMMI Physics 2021 8:22
    Content type: Original research Published on:

  39. To identify the impact of segmentation methods and intensity discretization on radiomic features (RFs) extraction from 68Ga-DOTA-TOC PET images in patients with neuroendocrine tumors.

    Authors: Virginia Liberini, Bruno De Santi, Osvaldo Rampado, Elena Gallio, Beatrice Dionisi, Francesco Ceci, Giulia Polverari, Philippe Thuillier, Filippo Molinari and Désirée Deandreis
    Citation: EJNMMI Physics 2021 8:21
    Content type: Original research Published on:

  40. The Siemens high-resolution research tomograph (HRRT - a dedicated brain PET scanner) is to this day one of the highest resolution PET scanners; thus, it can serve as useful benchmark when evaluating performan...

    Authors: Julia G. Mannheim, Ju-Chieh (Kevin) Cheng, Nasim Vafai, Elham Shahinfard, Carolyn English, Jessamyn McKenzie, Jing Zhang, Laura Barlow and Vesna Sossi
    Citation: EJNMMI Physics 2021 8:20
    Content type: Original research Published on:

  41. A novel generation of PET scanners based on silicon (Si)-photomultiplier (PM) technology has recently been introduced. Concurrently, there has been development of new reconstruction methods aimed at increasing...

    Authors: Jenny Oddstig, Gustav Brolin, Elin Trägårdh and David Minarik
    Citation: EJNMMI Physics 2021 8:19
    Content type: Original research Published on:

  42. PET/MRI phantom studies are challenged by the need of phantom-specific attenuation templates to account for attenuation properties of the phantom material. We present a PET/MRI phantom built from MRI-visible m...

    Authors: Ivo Rausch, Alejandra Valladares, Lalith Kumar Shiyam Sundar, Thomas Beyer, Marcus Hacker, Martin Meyerspeer and Ewald Unger
    Citation: EJNMMI Physics 2021 8:18
    Content type: Original research Published on:

  43. To systematically evaluate the consistency of various standardized uptake value (SUV) lean body mass (LBM) normalization methods in a clinical positron emission tomography/magnetic resonance imaging (PET/MR) s...

    Authors: Jun Zhao, Qiaoyi Xue, Xing Chen, Zhiwen You, Zhe Wang, Jianmin Yuan, Hui Liu and Lingzhi Hu
    Citation: EJNMMI Physics 2021 8:17
    Content type: Original research Published on:

  44. SPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due to the limited spatial resolution of the gamma camera. Incorporating resolution modellin...

    Authors: H. Marquis, D. Deidda, A. Gillman, K. P. Willowson, Y. Gholami, T. Hioki, E. Eslick, K. Thielemans and D. L. Bailey
    Citation: EJNMMI Physics 2021 8:16
    Content type: Original research Published on:

  45. SPECT-CT using radiolabeled phosphonates is considered a standard for assessing bone metabolism (e.g., in patients with osteoarthritis of knee joints). However, SPECT can be influenced by metal artifacts in CT...

    Authors: Oliver S. Grosser, Marcus Klutzny, Heiko Wissel, Dennis Kupitz, Michael Finger, Simone Schenke, Jan Wuestemann, Christoph H. Lohmann, Christoph Hoeschen, Maciej Pech, Christian Staerke and Michael C. Kreissl
    Citation: EJNMMI Physics 2021 8:15
    Content type: Original research Published on:

  46. In recurrent differentiated thyroid cancer patients, detectability in 124I PET is limited for lesions with low radioiodine uptake. We assess the improvements in lesion detectability and image quality between thre...

    Authors: David Kersting, Walter Jentzen, Miriam Sraieb, Pedro Fragoso Costa, Maurizio Conti, Lale Umutlu, Gerald Antoch, Michael Nader, Ken Herrmann, Wolfgang Peter Fendler, Christoph Rischpler and Manuel Weber
    Citation: EJNMMI Physics 2021 8:14
    Content type: Original research Published on:

  47. Image quality and quantitative accuracy of positron emission tomography (PET) depend on several factors such as uptake time, scanner characteristics and image reconstruction methods. Ordered subset expectation...

    Authors: Alexandre Chicheportiche, Elinor Goshen, Jeremy Godefroy, Simona Grozinsky-Glasberg, Kira Oleinikov, Amichay Meirovitz, David J. Gross and Simona Ben-Haim
    Citation: EJNMMI Physics 2021 8:13
    Content type: Original research Published on:

  48. Standardized uptake value (SUV) normalized by lean body mass ([LBM] SUL) is recommended as metric by PERCIST 1.0. The James predictive equation (PE) is a frequently used formula for LBM estimation, but may cau...

    Authors: Jingjie Shang, Zhiqiang Tan, Yong Cheng, Yongjin Tang, Bin Guo, Jian Gong, Xueying Ling, Lu Wang and Hao Xu
    Citation: EJNMMI Physics 2021 8:12
    Content type: Original research Published on:

  49. Whole-body Patlak images can be obtained from an acquisition of first 6 min of dynamic imaging over the heart to obtain the arterial input function (IF), followed by multiple whole-body sweeps up to 60 min pi....

    Authors: Joyce van Sluis, Maqsood Yaqub, Adrienne H. Brouwers, Rudi A. J. O. Dierckx, Walter Noordzij and Ronald Boellaard
    Citation: EJNMMI Physics 2021 8:11
    Content type: Short communication Published on:

  50. The SwiftScan solution (General Electric Healthcare) combines a new low-energy high-resolution sensitivity collimator and a tomographic step-and-shoot continuous (SSC) mode acquisition. The purpose of this study ...

    Authors: Valentin Picone, Nikolaos Makris, Fanny Boutevin, Sarah Roy, Margot Playe and Michael Soussan
    Citation: EJNMMI Physics 2021 8:10
    Content type: Original research Published on:
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