Articles

PET/MR and SPECT/MR multimodal imaging constructs: Direct radiolabelling of silica shell iron oxide nanorods for use in liver imaging and potential for hyperthermia therapy

Authors: Haylay Bignell

Authentically radiolabelled Mn(II) complexes as bimodal PET/MR tracers

Authors: Christian Vanasschen, Marie Brandt, Johannes Ermert, Bernd Neumaier and Heinz H Coenen

Compatibility of metal additive manufactured tungsten collimator for SPECT/MRI integration

Authors: Amine M Samudi, Karen Van Audenhaege, Gunter Vermeeren, Luc Martens, Roel Van Holen and Wout Joseph

MRC-SPECT-DF: an MR-Compatible SPECT system with Dual-FOV collimation design for microscopic SPECT imaging

Authors: Xiaochun Lai, Chin-tu Chen and Ling-Jian Meng

The SAFIR project: an innovative high rate preclinical PET/MR detector towards dynamic multimodal imaging

Authors: Robert Becker, Chiara Casella, Gunther Dissertori, Jannis Fischer, Alexander Howard, Astrik Jeitler, Werner Lustermann, Ulf Roeser, Qiulin Wang and Bruno Weber

Evaluation of algorithms for photon depth of interaction estimation for the TRIMAGE PET component

Authors: Niccolo Camarlinghi, Nicola Belcari, Piergiorgio Cerello, Giancarlo Sportelli, Francesco Pennazio, Emanuele Zaccario and Alberto Del Guerra

Performance assessment of a NaI(Tl) gamma counter for PET applications with methods for improved quantitative accuracy and greater standardization

Although NaI(Tl) gamma counters play an important role in many quantitative positron emission tomography (PET) protocols, their calibration for positron-emitting samples has not been standardized across imagin...

Authors: Martin A Lodge, Daniel P Holt, Paul E Kinahan, Dean F Wong and Richard L Wahl

Increased absorbed liver dose in Selective Internal Radiation Therapy (SIRT) correlates with increased sphere-cluster frequency and absorbed dose inhomogeneity

The higher tolerated mean absorbed dose for selective internal radiation therapy (SIRT) with intra-arterially infused ⁹⁰Y microspheres compared to external beam therapy is speculated to be caused by absorbed dose...

Authors: Jonas Högberg, Magnus Rizell, Ragnar Hultborn, Johanna Svensson, Olof Henrikson, Johan Mölne, Peter Gjertsson and Peter Bernhardt

PET image segmentation using a Gaussian mixture model and Markov random fields

Classification algorithms for positron emission tomography (PET) images support computational treatment planning in radiotherapy. Common clinical practice is based on manual delineation and fixed or iterative ...

Authors: Thomas Layer, Matthias Blaickner, Barbara Knäusl, Dietmar Georg, Johannes Neuwirth, Richard P Baum, Christiane Schuchardt, Stefan Wiessalla and Gerald Matz

Dental artifacts in the head and neck region: implications for Dixon-based attenuation correction in PET/MR

In the absence of CT or traditional transmission sources in combined clinical positron emission tomography/magnetic resonance (PET/MR) systems, MR images are used for MR-based attenuation correction (MR-AC). T...

Authors: Claes N Ladefoged, Adam E Hansen, Sune H Keller, Barbara M Fischer, Jacob H Rasmussen, Ian Law, Andreas Kjær, Liselotte Højgaard, Francois Lauze, Thomas Beyer and Flemming L Andersen

Impact of injection dose, post-reconstruction filtering, and collimator choice on image quality of myocardial perfusion SPECT using cadmium-zinc telluride detectors in the rat

The aims of this study were (1) to evaluate the impact of injection dose, post-reconstruction filtering, and collimator choice on image quality of myocardial perfusion single-photon emission computed tomograph...

Authors: Asuka Mizutani, Ichiro Matsunari, Masato Kobayashi, Kodai Nishi, Wataru Fujita, Yoshiharu Miyazaki, Stephan G Nekolla and Keiichi Kawai

Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model

Simultaneous PET/MR imaging depends on MR-derived attenuation maps (mu-maps) for accurate attenuation correction of PET data. Currently, these maps are derived from gradient-echo-based MR sequences, which are ...

Authors: Ronald JH Borra, Hoon-Sung Cho, Spencer L Bowen, Ulrike Attenberger, Grae Arabasz, Ciprian Catana, Lee Josephson, Bruce R Rosen, Alexander R Guimaraes and Jacob M Hooker

Tumor and red bone marrow dosimetry: comparison of methods for prospective treatment planning in pretargeted radioimmunotherapy

Red bone marrow (RBM) toxicity is dose-limiting in (pretargeted) radioimmunotherapy (RIT). Previous blood-based and two-dimensional (2D) image-based methods have failed to show a clear dose-response relationsh...

Authors: Wietske Woliner-van der Weg, Rafke Schoffelen, Robert F Hobbs, Martin Gotthardt, David M Goldenberg, Robert M Sharkey, Cornelis H Slump, Winette TA van der Graaf, Wim JG Oyen, Otto C Boerman, George Sgouros and Eric P Visser

Clinical evaluation of respiration-induced attenuation uncertainties in pulmonary 3D PET/CT

In contemporary positron emission tomography (PET)/computed tomography (CT) scanners, PET attenuation correction is performed by means of a CT-based attenuation map. Respiratory motion can however induce offse...

Authors: Matthijs F Kruis, Jeroen B van de Kamer, Wouter V Vogel, José SA Belderbos, Jan-Jakob Sonke and Marcel van Herk

Intravenous contrast-enhanced CT can be used for CT-based attenuation correction in clinical ¹¹¹In-octreotide SPECT/CT

CT-based attenuation correction (CT-AC) using contrast-enhancement CT impacts ¹¹¹In-SPECT image quality and quantification. In this study we assessed and evaluated the effect.

Authors: Thomas Levin Klausen, Jann Mortensen, Robin de Nijs, Flemming Littrup Andersen, Liselotte Højgaard, Thomas Beyer and Søren Holm

Evaluation of inter-departmental variability of ejection fraction and cardiac volumes in myocardial perfusion scintigraphy using simulated data

Myocardial perfusion scintigraphy (MPS) is a clinically useful noninvasive imaging modality for diagnosing patients with suspected coronary artery disease. By utilizing gated MPS, the end diastolic volume (EDV...

Authors: Elin Trägårdh, Michael Ljungberg, Lars Edenbrandt, Eva Örndahl, Lena Johansson, Agneta Gustafsson, Cathrine Jonsson, Jessica Hagerman, Katrine Riklund and David Minarik

Development and performance test of an online blood sampling system for determination of the arterial input function in rats

For positron emission tomography (PET) kinetic modelling, an accurate determination of the arterial input function is required. In this study, a blood sampling system was developed and tested using different r...

Authors: Friedrich Roehrbacher, Jens P Bankstahl, Marion Bankstahl, Thomas Wanek, Johann Stanek, Michael Sauberer, Julia Muellauer, Thales Schroettner, Oliver Langer and Claudia Kuntner

The effect of object size on the sensitivity of single photon emission computed tomography: comparison of two CZT cardiac cameras and an Anger scintillation camera

Heart sizes vary greatly across the spectrum of patients referred for myocardial perfusion imaging. We therefore performed a phantom study to explore under controlled circumstances how count rates change when ...

Authors: Elazar A Bienenstock and Marguerite Ennis

Clinical image quality perception and its relation to NECR measurements in PET

The purpose of this study is to describe a clinical relation of noise equivalent count rate (NECR) - an objective measurement of positron emission tomography (PET) systems - measured in a large number of patie...

Authors: Marcelo A Queiroz, Scott D Wollenweber, Gustav von Schulthess, Gaspar Delso and Patrick Veit-Haibach

Metal artifact reduction in patients with dental implants using multispectral three-dimensional data acquisition for hybrid PET/MRI

Hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) shows high potential for patients with oropharyngeal cancer. Dental implants can cause substantial artifacts in the oral cavity impairin...

Authors: Jeanne M Gunzinger, Gaspar Delso, Andreas Boss, Miguel Porto, Helen Davison, Gustav K von Schulthess, Martin Huellner, Paul Stolzmann, Patrick Veit-Haibach and Irene A Burger

Impact of incorrect tissue classification in Dixon-based MR-AC: fat-water tissue inversion

The current MR-based attenuation correction (AC) used in combined PET/MR systems computes a Dixon attenuation map (MR-AC_Dixon) based on fat and water images derived from in- and opposed-phase MRI. We observed an ...

Authors: Claes Nøhr Ladefoged, Adam Espe Hansen, Sune Høgild Keller, Søren Holm, Ian Law, Thomas Beyer, Liselotte Højgaard, Andreas Kjær and Flemming Littrup Andersen

Chewing-gum stimulation did not reduce the absorbed dose to salivary glands during radioiodine treatment of thyroid cancer as inferred from pre-therapy ¹²⁴I PET/CT imaging

The goal of this prospective study was to estimate the absorbed (radiation) doses to salivary glands in radioiodine therapy of thyroid cancer under chewing-gum stimulation using ¹²⁴I positron emission tomography ...

Authors: Walter Jentzen, Marion Richter, James Nagarajah, Thorsten Dirk Poeppel, Wolfgang Brandau, Colin Dawes, Andreas Bockisch and Ina Binse

Impact of point spread function modelling and time of flight on FDG uptake measurements in lung lesions using alternative filtering strategies

The use of maximum standardised uptake value (SUV_max) is commonplace in oncology positron emission tomography (PET). Point spread function (PSF) modelling and time-of-flight (TOF) reconstructions have a significa...

Authors: Ian S Armstrong, Matthew D Kelly, Heather A Williams and Julian C Matthews

Unconstrained image reconstruction with resolution modelling does not have a unique solution

Positron emission tomography systems have a finite spatial resolution. When the system point spread function (PSF) is taken into account, the unconstrained reconstruction problem does not have a unique solutio...

Authors: Johan Nuyts

Effective dose to adult patients from 338 radiopharmaceuticals estimated using ICRP biokinetic data, ICRP/ICRU computational reference phantoms and ICRP 2007 tissue weighting factors

Effective dose represents the potential risk to a population of stochastic effects of ionizing radiation (mainly lethal cancer). In recent years, there have been a number of revisions and updates influencing t...

Authors: Martin Andersson, Lennart Johansson, David Minarik, Sigrid Leide-Svegborn and Sören Mattsson

The influence of different signal-to-background ratios on spatial resolution and F18-FDG-PET quantification using point spread function and time-of-flight reconstruction

F18-fluorodeoxyglucose positron-emission tomography (FDG-PET) reconstruction algorithms can have substantial influence on quantitative image data used, e.g., for therapy planning or monitoring in oncology. We ...

Authors: Julian MM Rogasch, Frank Hofheinz, Alexandr Lougovski, Christian Furth, Juri Ruf, Oliver S Großer, Konrad Mohnike, Peter Hass, Mathias Walke, Holger Amthauer and Ingo G Steffen

New prospects for PET in prostate cancer imaging: a physicist's viewpoint

Prostate cancer is one of the most common forms of cancer among men. Early diagnosis, correct staging, accurate detection of metastasis, and monitoring of the therapy are the key tasks that could greatly benef...

Authors: Maurizio Conti

Missing head and color banding in low-count SPECT reconstructions

Due to low counts in an ¹¹¹In single photon emission computed tomography (SPECT) scan, a large part of the head was missing in the reconstructed images on Philips Extended Brilliance Workspace (EBW) and IntelliSp...

Authors: Robin de Nijs, Björn Neumann Jensen and Jann Mortensen

Use of a clinical PET/MR scanner for preclinical research with first results

Authors: Karthik Chary, Jarmo Teuho, Jenni Virta, Hannu Sipilä, Virva Saunavaara, Anne Roivainen and Mika Teräs

Automated body-lung-air material map segmentation from pre-clinical MRI images for PET attenuation correction in Tera-Tomo 3D PET reconstruction engine of nanoScan PET/MRI system

Authors: Peter Bandi, Gabor Jakab, Norbert Zsoter, Domokos Mathe, Gabor Nemeth, Kalman Nagy, Sandor Hobor and Laszlo Papp

Preliminary in vitro and in vivo evaluation of liposomal nanoparticles for passive and active tumour targeting by scintigraphic and MRI imaging

Authors: Bianchi Patrick, Fragogeorgi Eirini, Efthymiadou Eleni, Xanthopoulos Stavros, Psimadas Dimitrios, Bouzioti Penelope, Kordas George, Loudos George and Silvio Aime

Whole body MR-PET: a new internal dosimetry method for radiation transport calculation from biokinetic model data

Authors: Ana Nunes, Francisco Alves and Miguel Patrício

Geometric distortions of diffusion weighted imaging of the head/neck in combined PET/MR: optimization of image acquisition and post-processing correction for oncology applications

Authors: Adam E Hansen, Jacob Rasmussen, Helle H Johannesen, Astrid M Engberg, Flemming L Andersen, Lena Specht, Andreas Kjaer, Liselotte Højgaard, Thomas Beyer and Barbara M Fischer

Effect of inherent misalignment and head motion in neurological PET/MR with the Philips Ingenuity TF – phantom and patient study

Authors: Jarmo Teuho, Jarkko Johansson, Virva Saunavaara, Nina Kemppainen and Mika Teräs

Numerical modeling of MR angiography for validation of image-driven quantitative diagnosis of intracranial aneurysm and carotid stenosis

Authors: Artur Klepaczko, Piotr Szczypiński, Michał Strzelecki and Andrzej Materka

MR constrained simultaneous reconstruction of activity and attenuation maps in brain TOF-PET/MR imaging

Authors: Abolfazl Mehranian and Habib Zaidi

PET motion correction using MR-derived motion parameters

Authors: Matthew Bickell, Thomas Koesters, Fernando Boada and Johan Nuyts

High-resolution, quantitative 3D PET image reconstruction for the Siemens hybrid 3T MR/BrainPET scanner using the PET reconstruction software toolkit (PRESTO)

Authors: Juergen Scheins, Christoph Weirich, Liliana Caldeira, Philipp Lohmann, Elena Rota Kops, Lutz Tellmann, Michaela Gaens, Hans Herzog, Uwe Pietrzyk and N Jon Shah

A robust MR-based attenuation map generation in short-TE MR images of the head employing hybrid spatial fuzzy C-means clustering and intensity inhomogeneity correction

Authors: Mohammad Hadi Aarabi, Anahita Fathi Kazerooni, Parisa Khateri, Mohammad Reza Ay and Hamidreza Saligheh Rad

Comparison template-based with CT-based attenuation correction for hybrid MR/PET scanners

Authors: Elena Rota Kops, Hans Herzog and N Jon Shah

Image derived input function applied in CBF Studies with [15O]water PET in an integrated MR-PET

Authors: Jörg Mauler, Nuno André da Silva, Christian Filss, Heinz H Coenen, Hans Herzog and N Jon Shah

Joint reconstruction of simultaneously acquired MR-PET data with multi sensor compressed sensing based on a joint sparsity constraint

Authors: Florian Knoll, Thomas Koesters, Ricardo Otazo, Tobias Block, Li Feng, Kathleen Vunckx, David Faul, Johan Nuyts, Fernando Boada and Daniel K Sodickson

Development of a high-resolution detection module for the INSERT SPECT/MRI system

Authors: Paolo Busca, Carlo Fiorini, Arslan D Butt, Michele Occhipinti, Riccardo Quaglia, Paolo Trigilio, Gabor Nemeth, Peter Major, Tamas Bukki, Kalman Nagy, Claudio Piemonte, Alessandro Ferri, Alberto Gola, Jan Rieger and Thoralf Niendorf

Temporal analysis of Z-Gradient coil eddy currents in tungsten collimator with different resistivities for SPECT/MRI

Authors: Amine Samoudi, Karen Van Audenhaege, Günter Vermeeren, Micahel Poole, Luc Martens, Roel Van Holen and Wout Joseph

ToF performance evaluation of a PET insert with Digital Silicon Photomultiplier technology during MR operation

Authors: David Schug, Jakob Wehner, Peter Michael Dueppenbecker, Bjoern Weissler, Pierre Gebhardt, Benjamin Goldschmidt, Torsten Solf and Volkmar Schulz

Effects of multiple photon scattering on maximum likelihood positioning in PET

Authors: Nicolas Groß-Weege, David Schug and Volkmar Schulz

Track-based detector alignment for PET scanners

Authors: Dennis Klöpping, David Schug and Volkmar Schulz

Characterization of linearly graded position-sensitive silicon photomultipliers

Authors: Alessandro Ferri, Fabio Acerbi, Alberto Gola, Giovanni Paternoster, Claudio Piemonte and Nicola Zorzi

Scintillation properties of Ca co-doped L(Y)SO:Ce between 193 K and 373 K for TOF-PET/MRI

Authors: David N ter Weele, Dennis R Schaart and Pieter Dorenbos

A fully digital approach for MR compatible Time-of-Flight PET techniques

Authors: Paul Lecoq