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EJNMMI Physics
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  1. This study aims to assess both feasibility and accuracy of renal dosimetry imaging protocols in patients receiving Lutate therapy for neuroendocrine tumours (NETs), when data acquisition over multiple days is ...

    Authors: Kathy P. Willowson, Enid Eslick, Hyunju Ryu, Aurora Poon, Elizabeth J. Bernard and Dale L. Bailey
    Citation: EJNMMI Physics 2018 5:33
    Content type: Original research Published on:

  2. 15O-oxygen inhalation PET is unique in its ability to provide fundamental information regarding cerebral hemodynamics and energy metabolism in man. However, the use of 15O-oxygen has been limited in a clinical en...

    Authors: Satoshi Iguchi, Tetsuaki Moriguchi, Makoto Yamazaki, Yuki Hori, Kazuhiro Koshino, Kazunori Toyoda, Jarmo Teuho, Saeka Shimochi, Yusuke Terakawa, Tetsuya Fukuda, Jun C. Takahashi, Jyoji Nakagawara, Shigehiko Kanaya and Hidehiro Iida
    Citation: EJNMMI Physics 2018 5:37
    Content type: Original research Published on:

  3. Radioiodine has been used for the treatment of benign thyroid diseases for over 70 years. However, internationally, there is no common standard for pretherapeutic dosimetry to optimally define the individual t...

    Authors: Jochen Hammes, Lutz van Heek, Melanie Hohberg, Manuel Reifegerst, Simone Stockter, Markus Dietlein, Markus Wild, Alexander Drzezga, Matthias Schmidt and Carsten Kobe
    Citation: EJNMMI Physics 2018 5:32
    Content type: Original research Published on:

  4. The aim of this study was to evaluate the predictive power of the absorbed dose to kidneys after the first course of treatment with [177Lu]-DOTA-TATE for neuroendocrine tumors (NETs) on the cumulative kidney abso...

    Authors: Alexandre Chicheportiche, Simona Grozinsky-Glasberg, David J. Gross, Yodphat Krausz, Asher Salmon, Amichay Meirovitz, Nanette Freedman and Jeremy Godefroy
    Citation: EJNMMI Physics 2018 5:36
    Content type: Original research Published on:

  5. The aim of this study was to compare liver and oncologic lesion standardized uptake values (SUV) obtained through two different reconstruction protocols, GE’s newest clinical lesion detection protocol (Q.Clear...

    Authors: Joke Devriese, Laurence Beels, Alex Maes, Christophe Van de Wiele and Hans Pottel
    Citation: EJNMMI Physics 2018 5:35
    Content type: Original research Published on:

  6. Rhenium-188-labelled-Lipiodol radioembolization is a safe and cost-effective treatment for primary liver cancer. In order to determine correlations between treatment doses and patient response to therapy, accu...

    Authors: Pedro L. Esquinas, Ajit Shinto, Koramadai K. Kamaleshwaran, Jephy Joseph and Anna Celler
    Citation: EJNMMI Physics 2018 5:30
    Content type: Original research Published on:

  7. Positron emission tomography (PET) imaging has a wide applicability in oncology, cardiology and neurology. However, a major drawback when imaging very active regions such as the bladder is the spill-in effect,...

    Authors: Mercy I. Akerele, Palak Wadhwa, Jesus Silva-Rodriguez, William Hallett and Charalampos Tsoumpas
    Citation: EJNMMI Physics 2018 5:34
    Content type: Young investigators Published on:

  8. Generation of a SPECT scan during procedure may aid in the optimization of treatments as liver radioembolization by offering image-guided dosimetry. This, however, requires both shortened acquisition times and...

    Authors: Martijn M. A. Dietze, Sandra van der Velden, Marnix G. E. H. Lam, Max A. Viergever and Hugo W. A. M. de Jong
    Citation: EJNMMI Physics 2018 5:28
    Content type: Original research Published on:

  9. PoleStar m660 is a newly developed clinical PET/CT system with time-of-flight (TOF) capability. The aim of this study is to characterize the performance of the new system. Spatial resolution, sensitivity, scat...

    Authors: Li Huo, Nan Li, Heyu Wu, Wenjia Zhu, Haiqun Xing, Jiantao Ba, Tong Wang, Fang Li and Hui Zhang
    Citation: EJNMMI Physics 2018 5:29
    Content type: Original research Published on:

  10. The purpose was to validate 90Y PET gradient-based tumor segmentation in phantoms and to evaluate the impact of the segmentation method on reported tumor absorbed dose (AD) and biological effective dose (BED) in

    Authors: Justin K. Mikell, Ravi K. Kaza, Peter L. Roberson, Kelly C. Younge, Ravi N. Srinivasa, Bill S. Majdalany, Kyle C. Cuneo, Dawn Owen, Theresa Devasia, Matthew J. Schipper and Yuni K. Dewaraja
    Citation: EJNMMI Physics 2018 5:31
    Content type: Original research Published on:

  12. To develop and evaluate the feasibility of a data-driven deep learning approach (deepAC) for positron-emission tomography (PET) image attenuation correction without anatomical imaging. A PET attenuation correc...

    Authors: Fang Liu, Hyungseok Jang, Richard Kijowski, Gengyan Zhao, Tyler Bradshaw and Alan B. McMillan
    Citation: EJNMMI Physics 2018 5:24
    Content type: Original research Published on:

  13. Radioembolization is an established treatment for chemoresistant and unresectable liver cancers. Currently, treatment planning is often based on semi-empirical methods, which yield acceptable toxicity profiles...

    Authors: Remco Bastiaannet, S. Cheenu Kappadath, Britt Kunnen, Arthur J. A. T. Braat, Marnix G. E. H. Lam and Hugo W. A. M. de Jong
    Citation: EJNMMI Physics 2018 5:22
    Content type: Review Published on:

  14. MRI does not offer a direct method to obtain attenuation correction maps as its predecessors (stand-alone PET and PET/CT), and bone visualisation is particularly challenging. Recently, zero-echo-time (ZTE) was...

    Authors: João M. Sousa, Lieuwe Appel, Mathias Engström, Stergios Papadimitriou, Dag Nyholm, Elna-Marie Larsson, Håkan Ahlström and Mark Lubberink
    Citation: EJNMMI Physics 2018 5:20
    Content type: Original research Published on:

  15. Routine dosimetry is essential for personalized 177Lu-octreotate peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs), but practical and robust dosimetry methods are needed for wide clinic...

    Authors: Michela Del Prete, Frédéric Arsenault, Nassim Saighi, Wei Zhao, François-Alexandre Buteau, Anna Celler and Jean-Mathieu Beauregard
    Citation: EJNMMI Physics 2018 5:25
    Content type: Original research Published on:

  16. [18F]Fluortriopride (FTP) was developed as a dopamine D3-selective radiotracer, thought to be important to neurobiological reward pathways and implicated in drug addiction, Parkinson’s disease, and schizophrenia....

    Authors: Robert K. Doot, Jacob G. Dubroff, Joshua S. Scheuermann, Kyle J. Labban, Jenny Cai, Chia-Ju Hsieh, Shihong Li, Hsiaoju Lee, Erin K. Schubert, Catherine Hou, Regan Sheffer, Alexander Schmitz, Kuiying Xu and Robert H. Mach
    Citation: EJNMMI Physics 2018 5:21
    Content type: Original research Published on:

  17. The aim of this study was to evaluate and compare PET image reconstruction algorithms on novel digital silicon photomultiplier PET/CT in patients with newly diagnosed and histopathologically confirmed lung can...

    Authors: Michael Messerli, Paul Stolzmann, Michèle Egger-Sigg, Josephine Trinckauf, Stefano D’Aguanno, Irene A. Burger, Gustav K. von Schulthess, Philipp A. Kaufmann and Martin W. Huellner
    Citation: EJNMMI Physics 2018 5:27
    Content type: Original research Published on:

  18. Positron-emission tomography (PET) simulators are frequently used for development and performance evaluation of segmentation methods or quantitative uptake metrics. To date, most PET simulation tools are based...

    Authors: Elisabeth Pfaehler, Johan R. De Jong, Rudi A. J. O. Dierckx, Floris H. P. van Velden and Ronald Boellaard
    Citation: EJNMMI Physics 2018 5:16
    Content type: Original research Published on:

  19. Dose rate variation is a critical factor affecting radionuclide therapy (RNT) efficacy. Relatively few studies to date have investigated the dose rate effect in RNT. Therefore, the aim of this study was to ben...

    Authors: Yaser H. Gholami, Kathy P. Willowson, Nicholas J. Forwood, Rozelle Harvie, Nicholas Hardcastle, Regina Bromley, HyunJu Ryu, Samuel Yuen, Viive M. Howell, Zdenka Kuncic and Dale L. Bailey
    Citation: EJNMMI Physics 2018 5:18
    Content type: Original research Published on:

  20. The aim of our study was to compare 90Y dosimetry obtained from PET/MRI versus PET/CT post-therapy imaging among patients with primary or metastatic hepatic tumors.

    Authors: Karin Knešaurek, Abbas Tuli, Edward Kim, Sherif Heiba and Lale Kostakoglu
    Citation: EJNMMI Physics 2018 5:23
    Content type: Original research Published on:

  21. Radiomercury 197mHg and 197Hg, henceforth referred to as 197(m)Hg, is a promising theranostic radionuclide endowed with properties that allow diagnostic and therapeutic applications. The aim of this work was to i...

    Authors: Robert Freudenberg, Rudi Apolle, Martin Walther, Holger Hartmann and Jörg Kotzerke
    Citation: EJNMMI Physics 2018 5:15
    Content type: Original research Published on:

  22. This inter-comparison exercise was performed to demonstrate the variability of quantitative SPECT/CT imaging for lutetium-177 (177Lu) in current clinical practice. Our aim was to assess the feasibility of using i...

    Authors: Jill Wevrett, Andrew Fenwick, James Scuffham, Lena Johansson, Jonathan Gear, Susanne Schlögl, Marcel Segbers, Katarina Sjögreen-Gleisner, Pavel Solný, Michael Lassmann, Jill Tipping and Andrew Nisbet
    Citation: EJNMMI Physics 2018 5:17
    Content type: Original research Published on:

  23. In patients with differentiated thyroid cancer (DTC), serial 124I PET/CT imaging is, for instance, used to assess the absorbed (radiation) dose to lesions. Frequently, the lesions are located in the neck and they...

    Authors: Walter Jentzen, Jinda Phaosricharoen, Benedikt Gomez, Philipp Hetkamp, Vanessa Stebner, Ina Binse, Sonja Kinner, Ken Herrmann, Amir Sabet and James Nagarajah
    Citation: EJNMMI Physics 2018 5:13
    Content type: Original research Published on:

  24. Recently, 177Lu-dotatate therapy for neuroendocrine tumours has received regulatory approval. Dosimetry can be used to optimize treatment on an individual basis, but there is no international consensus as to how ...

    Authors: Anna Sundlöv, Johan Gustafsson, Gustav Brolin, Nadja Mortensen, Rebecca Hermann, Peter Bernhardt, Johanna Svensson, Michael Ljungberg, Jan Tennvall and Katarina Sjögreen Gleisner
    Citation: EJNMMI Physics 2018 5:12
    Content type: Original research Published on:

  26. Peptide receptor radionuclide therapy (PRRT) with [177Lu]-DOTA-TATE is an effective treatment of neuroendocrine tumors (NETs). After each cycle of treatment, patient dosimetry evaluates the radiation dose to the ...

    Authors: Alexandre Chicheportiche, Faozi Artoul, Arnon Schwartz, Simona Grozinsky-Glasberg, Amichay Meirovitz, David J. Gross and Jeremy Godefroy
    Citation: EJNMMI Physics 2018 5:10
    Content type: Original research Published on:

  27. Matched attenuation maps are vital for obtaining accurate and reproducible kinetic and static parameter estimates from PET data. With increased interest in PET/CT imaging of diffuse lung diseases for assessing...

    Authors: Beverley F. Holman, Vesna Cuplov, Lynn Millner, Raymond Endozo, Toby M. Maher, Ashley M. Groves, Brian F. Hutton and Kris Thielemans
    Citation: EJNMMI Physics 2018 5:14
    Content type: Original research Published on:

  28. SPECT quantification is important for dosimetry in targeted radionuclide therapy (TRT) and the calibration of SPECT images is a crucial stage for image quantification. The current standardized calibration prot...

    Authors: Adrien Halty, Jean-Noël Badel, Olga Kochebina and David Sarrut
    Citation: EJNMMI Physics 2018 5:11
    Content type: Original research Published on:

  29. Camera calibration, which translates reconstructed count map into absolute activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and tomographic scans using different phantom ge...

    Authors: Wei Zhao, Pedro L. Esquinas, Xinchi Hou, Carlos F. Uribe, Marjorie Gonzalez, Jean-Mathieu Beauregard, Yuni K. Dewaraja and Anna Celler
    Citation: EJNMMI Physics 2018 5:8
    Content type: Original research Published on:

  30. A newly introduced PET/CT scanner (Discovery Meaningful Insights—DMI, GE Healthcare) includes the silicon photomultiplier (SiPM) with time-of-flight (TOF) technology first used in the GE SIGNA PET/MRI. In this...

    Authors: Ida Sonni, Lucia Baratto, Sonya Park, Negin Hatami, Shyam Srinivas, Guido Davidzon, Sanjiv Sam Gambhir and Andrei Iagaru
    Citation: EJNMMI Physics 2018 5:9
    Content type: Original research Published on:

  31. Yttrium-90 (90Y) radioembolization involves the intra-arterial delivery of radioactive microspheres to treat hepatic malignancies. Though this therapy involves careful pre-treatment planning and imaging, little i...

    Authors: Nichole M. Maughan, Mootaz Eldib, David Faul, Maurizio Conti, Mattijs Elschot, Karin Knešaurek, Francesca Leek, David Townsend, Frank P. DiFilippo, Kimberly Jackson, Stephan G. Nekolla, Mathias Lukas, Michael Tapner, Parag J. Parikh and Richard Laforest
    Citation: EJNMMI Physics 2018 5:7
    Content type: Original research Published on:

  32. The performance of a prototype novel digital single-photon emission computed tomography (SPECT) camera with multiple pixelated CZT detectors and high sensitivity collimators (Digital SPECT; Valiance X12 protot...

    Authors: Elinor Goshen, Leonid Beilin, Eli Stern, Tal Kenig, Ronen Goldkorn and Simona Ben-Haim
    Citation: EJNMMI Physics 2018 5:6
    Content type: Original research Published on:

  33. Single-photon emission computed tomography (SPECT) imaging is an important diagnostic tool for the early detection of the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease (PD) and similar neur...

    Authors: M. K. Stam, E. E. Verwer, J. Booij, S. M. Adriaanse, C. M. de Bruin and T. C. de Wit
    Citation: EJNMMI Physics 2018 5:4
    Content type: Original research Published on:

  34. Nuclear medicine imaging of neuroendocrine tumours is performed either by SPECT/CT imaging, using 111In-octreotide or by PET/CT imaging using 68Ga-radiolabelled somatostatin analogs. These imaging techniques will...

    Authors: L. Jönsson, A. Stenvall, E. Mattsson, E. Larsson, A. Sundlöv, T. Ohlsson and C. Hindorf
    Citation: EJNMMI Physics 2018 5:5
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Physics 2022 9:76

  35. Both cardiac and respiratory motions bias the kinetic parameters measured by dynamic PET. The aim of this study was to perform a realistic positron emission tomography-magnetic resonance (PET-MR) simulation st...

    Authors: Rong Guo, Yoann Petibon, Yixin Ma, Georges El Fakhri, Kui Ying and Jinsong Ouyang
    Citation: EJNMMI Physics 2018 5:3
    Content type: Original research Published on:

  36. The aim of this study was to investigate the deadtime (DT) effects that are present in 177Lu images acquired after radionuclide therapy injection, assess differences in DT based on the full spectrum and the photo...

    Authors: Carlos F. Uribe, Pedro L. Esquinas, Marjorie Gonzalez, Wei Zhao, Jesse Tanguay and Anna Celler
    Citation: EJNMMI Physics 2018 5:2
    Content type: Original research Published on:

  37. Full Monte Carlo (MC)-based SPECT reconstructions have a strong potential for correcting for image degrading factors, but the reconstruction times are long. The objective of this study was to develop a highly ...

    Authors: T. Rydén, J. Heydorn Lagerlöf, J. Hemmingsson, I. Marin, J. Svensson, M. Båth, P. Gjertsson and P. Bernhardt
    Citation: EJNMMI Physics 2018 5:1
    Content type: Original research Published on:

  39. PET-MRI is under investigation as a new strategy for quantitative myocardial perfusion imaging. Consideration is required as to the maximum scanner count rate in order to limit dead-time losses resulting from ...

    Authors: Jim O’ Doherty, Zacharias Chalampalakis, Paul Schleyer, Muhummad Sohaib Nazir, Amedeo Chiribiri and Paul K. Marsden
    Citation: EJNMMI Physics 2017 4:31
    Content type: Original research Published on:

  40.  Several criteria exist to identify the optimal model for quantification of tracer kinetics. The purpose of this study was to evaluate the correspondence in kinetic model preference identification for brain PE...

    Authors: Sandeep S. V. Golla, Sofie M. Adriaanse, Maqsood Yaqub, Albert D. Windhorst, Adriaan A. Lammertsma, Bart N. M. van Berckel and Ronald Boellaard
    Citation: EJNMMI Physics 2017 4:30
    Content type: Original research Published on:

  41. Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availabili...

    Authors: Katarina Sjögreen Gleisner, Emiliano Spezi, Pavel Solny, Pablo Minguez Gabina, Francesco Cicone, Caroline Stokke, Carlo Chiesa, Maria Paphiti, Boudewijn Brans, Mattias Sandström, Jill Tipping, Mark Konijnenberg and Glenn Flux
    Citation: EJNMMI Physics 2017 4:28
    Content type: Original research Published on:

  42. Semi-quantification methods are well established in the clinic for assisted reporting of (I123) Ioflupane images. Arguably, these are limited diagnostic tools. Recent research has demonstrated the potential fo...

    Authors: Jonathan Christopher Taylor and John Wesley Fenner
    Citation: EJNMMI Physics 2017 4:29
    Content type: Original research Published on:

  43. The European directive on basic safety standards (Council directive 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. The directive comes into operation February 2...

    Authors: Caroline Stokke, Pablo Minguez Gabiña, Pavel Solný, Francesco Cicone, Mattias Sandström, Katarina Sjögreen Gleisner, Carlo Chiesa, Emiliano Spezi, Maria Paphiti, Mark Konijnenberg, Matt Aldridge, Jill Tipping, Michael Wissmeyer, Boudewijn Brans, Klaus Bacher, Carsten Kobe…
    Citation: EJNMMI Physics 2017 4:27
    Content type: Original research Published on:

  44. Quantitative measurement of myocardial blood flow (MBF) is of increasing interest in the clinical assessment of patients with suspected coronary artery disease (CAD). 15O-water positron emission tomography (PET) ...

    Authors: Jonny Nordström, Tanja Kero, Hendrik Johannes Harms, Charles Widström, Frank A. Flachskampf, Jens Sörensen and Mark Lubberink
    Citation: EJNMMI Physics 2017 4:26
    Content type: Original research Published on:

  45. In the planning of selective internal radiation therapy (SIRT) for liver cancer treatment, one major aspect is to determine the prescribed activity and to estimate the resulting absorbed dose inside normal liv...

    Authors: Nadine Spahr, Philipp Schilling, Smita Thoduka, Nasreddin Abolmaali and Andrea Schenk
    Citation: EJNMMI Physics 2017 4:25
    Content type: Original research Published on:

  46. Technetium-99m-hydrazinonicotinamide-Tyr3-octreotide (99mTc-HYNIC-TOC) is recognized as a promising radiopharmaceutical for diagnosing neuroendocrine tumors (NETs). However, 99mTc-HYNIC-TOC dosimetry has been inv...

    Authors: Xinchi Hou, Bozena Birkenfeld, Hanna Piwowarska-Bilska and Anna Celler
    Citation: EJNMMI Physics 2017 4:24
    Content type: Original research Published on:

  47. To date, there is no published detailed checklist with parameters referencing the DICOM tag information with respect to the quality control (QC) of PET/CT scans. The aims of these guidelines are to provide the...

    Authors: Ivalina Hristova, Ronald Boellaard, Paul Galette, Lalitha K. Shankar, Yan Liu, Sigrid Stroobants, Otto S. Hoekstra and Wim J.G. Oyen
    Citation: EJNMMI Physics 2017 4:23
    Content type: Opinion article Published on:

  48. We have previously developed a novel and highly consistent PET segmentation algorithm using a multi-level Otsu method (MO-PET). The aim of this study was to evaluate the reliability of MO-PET compared to conve...

    Authors: Inki Lee, Hyung-Jun Im, Meiyappan Solaiyappan and Steve Y. Cho
    Citation: EJNMMI Physics 2017 4:22
    Content type: Original research Published on:

  49. Implementation of PET/CT in diagnosis of primary prostate cancer (PCa) requires a profound knowledge about the tracer, preferably from a quantitative evaluation. Direct visual comparison of PET/CT slices to wh...

    Authors: F. Schiller, T. Fechter, C. Zamboglou, A. Chirindel, N. Salman, C.A. Jilg, V. Drendel, M. Werner, P.T. Meyer, A.-L. Grosu and M. Mix
    Citation: EJNMMI Physics 2017 4:21
    Content type: Original research Published on:

  50. Developments in single photon emission tomography instrumentation and reconstruction methods present a potential for decreasing acquisition times. One of such recent options for myocardial perfusion imaging (M...

    Authors: Eero Hippeläinen, Teemu Mäkelä, Touko Kaasalainen and Erna Kaleva
    Citation: EJNMMI Physics 2017 4:20
    Content type: Original research Published on:
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