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Fig. 3 | EJNMMI Physics

Fig. 3

From: Developing a novel positronium biomarker for cardiac myxoma imaging

Fig. 3

Cardiac myxoma experiment workflow. a The clinical examination of a symptomatic patient by transthoracic echocardiography and surgical excision of cardiac myxoma (CM). b Sample preparation and examination of myxoma, adipose tissues and CM cells: one piece of CM was fixed for histopathology examination (H&E), while other piece of CM and adipose tissue samples have been used for studying their positronium properties and later fixed for the X-ray imaging (micro-CT). CM cell culture has been derived from the part of tissue designated for PALS experiment before fixation. c Micro-CT imaging: staining in Lugol solution for 5 days and micro-CT scanning; gray and blue arrows represent a workflow for two different scanning runs: before and after positronium measurement (PALS). d A chamber for ortho-Positronium lifetime measurement comprising CM or adipose sample with the 22Na radionuclide (red dot) emits (green arrow) a positron (+) and a prompt photon (yellow arrow). Positron and electron from a sample create a positronium atom (bound state of electron and positron), indicated pictorially by a white dotted circle. An example annihilation of positronium into two photons (blue arrows). Figure 4 contains a detailed description of positronium lifetime measurement

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